Search CTL/CD8+ T-Cell Epitope Database

Found 16 matching records:

Displaying record number 59012

HXB2 Location	Gag(22-30) p17(22-30) DNA(853..879)	Gag Epitope Map
Author Location	Gag(22-30)
Epitope	RPGGKKHYM	Epitope Alignment
		Show epitope variants
Epitope Name	RM9-p17
Subtype	C
Species (MHC/HLA)	human(B*0702)
Immunogen	HIV-1 infection
Patient MHC/HLA	R045: B*0702; H034: A*2902, A*6802, B*0702, B*4403, Cw*0401, Cw*0702
Country	Japan, South Africa, United Kingdom, United States
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, subtype comparisons, optimal epitope, novel epitope

Notes

• HLA-B*0702 is associated with rapid progression to disease in B-clade HIV-1 infected subjects. B*0702+ C-clade infected subjects however are not associated with a high viral setpoint of infection, and target a broader range of Gag epitopes at higher magnitudes. Increased magnitudes of Nef-specific responses were also detected in C-clade infected B*0702+ cohorts. A C-clade specific, B*0702-restricted novel p17 epitope, RPGGKKHYM, RM9, was defined.
• Epitope RM9, RPGGKKHYM, a novel Gag epitope is not targeted in B-clade infections. The B-clade consensus epitope differs at H7K and M9K, and is RPGGKKkYk (RK9). RM9 but not RK9 is stable in complex with HLA-B*0702; while the binding affinity of RM9 to B*0702 is K_d = 14nM, that of RK9 is >20,000 nM; RM9-specific CTL do not cross-recognize RK9. 7% of B-clade infected can recognize C-clade RM9, but that is significantly less than the >50% C-clade-infected subjects who do. RM9 is contained within OLP3, EKIRLRPGGKKHYMLKHL.

References

Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.

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Displaying record number 59042

HXB2 Location	Gag(148-156) p24(16-24) DNA(1231..1257)	Gag Epitope Map
Author Location	p24
Epitope	SPRTLNAWV	Epitope Alignment
Epitope Name	SV9-p24
Subtype	B, C
Species (MHC/HLA)	human(B*0702)
Immunogen	HIV-1 infection
Country	Japan, South Africa, United Kingdom, United States
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, subtype comparisons

Notes

• HLA-B*0702 is associated with rapid progression to disease in B-clade HIV-1 infected subjects. B*0702+ C-clade infected subjects however are not associated with a high viral setpoint of infection, and target a broader range of Gag epitopes at higher magnitudes. Increased magnitudes of Nef-specific responses were also detected in C-clade infected B*0702+ cohorts. A C-clade specific, B*0702-restricted novel p17 epitope, RPGGKKHYM, RM9, was defined.
• Epitope SV9, SPRTLNAWV, a B- and C-clade Gag epitope was targeted more by C-clade infected subjects than B-clade ones. The B-clade and C-clade consensus epitope is the same. Binding affinity of SV9 to B*0702 was K_d = 3 nM. SV9 is contained within OLP20, QMVHQAISPRTLNAWVKV.

References

Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.

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Displaying record number 59040

HXB2 Location	Gag(180-188) p24(48-56) DNA(1327..1353)	Gag Epitope Map
Author Location	p24
Epitope	TPQDLNTML	Epitope Alignment
Epitope Name	TL9-p24
Subtype	B, C
Species (MHC/HLA)	human(B*0702)
Immunogen	HIV-1 infection
Country	Japan, South Africa, United Kingdom, United States
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, subtype comparisons

Notes

• HLA-B*0702 is associated with rapid progression to disease in B-clade HIV-1 infected subjects. B*0702+ C-clade infected subjects however are not associated with a high viral setpoint of infection, and target a broader range of Gag epitopes at higher magnitudes. Increased magnitudes of Nef-specific responses were also detected in C-clade infected B*0702+ cohorts. A C-clade specific, B*0702-restricted novel p17 epitope, RPGGKKHYM, RM9, was defined.
• Epitope TL9, TPQDLNTML, a B- and C-clade Gag epitope was targeted more by C-clade infected subjects than B-clade ones. The B-clade and C-clade consensus epitope is the same. Binding affinity of TL9 to B*0702 was K_d = 1,162 nM. TL9 is contained within OLP25, GATPQDLNTMLNTVGGH.

References

Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.

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Displaying record number 59043

HXB2 Location	Gag(216-224) p24(84-92) DNA(1435..1461)	Gag Epitope Map
Author Location	p24
Epitope	HPVHAGPIA	Epitope Alignment
Epitope Name	HA9-p24
Subtype	B, C
Species (MHC/HLA)	human(B*0702)
Immunogen	HIV-1 infection
Country	Japan, South Africa, United Kingdom, United States
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, subtype comparisons

Notes

• HLA-B*0702 is associated with rapid progression to disease in B-clade HIV-1 infected subjects. B*0702+ C-clade infected subjects however are not associated with a high viral setpoint of infection, and target a broader range of Gag epitopes at higher magnitudes. Increased magnitudes of Nef-specific responses were also detected in C-clade infected B*0702+ cohorts. A C-clade specific, B*0702-restricted novel p17 epitope, RPGGKKHYM, RM9, was defined.
• Epitope HA9, HPVHAGPIA, a B- and C-clade Gag epitope was targeted more by C-clade infected subjects than B-clade ones. The B-clade and C-clade consensus epitope is the same. Binding affinity of HA9 to B*0702 was K_d = 32 nM. HA9 is contained within OLP29, AAEWDRLHPVHAGPIA.

References

Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.

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Displaying record number 59039

HXB2 Location	Gag(355-363) p24(223-231) DNA(1852..1878)	Gag Epitope Map
Author Location	p24(355-363)
Epitope	GPSHKARVL	Epitope Alignment
		Show epitope variants
Epitope Name	GL9-p24
Subtype	C
Species (MHC/HLA)	human(B*0702)
Immunogen	HIV-1 infection
Country	Japan, South Africa, United Kingdom, United States
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, subtype comparisons

Notes

• HLA-B*0702 is associated with rapid progression to disease in B-clade HIV-1 infected subjects. B*0702+ C-clade infected subjects however are not associated with a high viral setpoint of infection, and target a broader range of Gag epitopes at higher magnitudes. Increased magnitudes of Nef-specific responses were also detected in C-clade infected B*0702+ cohorts. A C-clade specific, B*0702-restricted novel p17 epitope, RPGGKKHYM, RM9, was defined.
• Epitope GL9, GPSHKARVL, (3S), a C-clade Gag epitope was the only one studied that was associated with a low viral setpoint in C-clade infected subjects. In B-clade infections GL9-3S, though recognized, had a high frequency of its S357G escape mutant, at 70% escape for B*0702+ subjects versus 43% escape in B*0702-, B-clade infected subjects. GL9 was also cross-recognized to equal extents as its B-clade variant, (3G), at 55% and 29% in C- or B-clade infected cohorts. The B-clade consensus epitope differs at S3G, and is GPgHKARVL. The binding affinity of GL9-3S to B*0702 was K_d = 9 nM, while that of variant GL9-3G is 342 nM. GL9 is contained within OLP48, ACQGVGGPSHKARVLAEA.

References

Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.

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Displaying record number 59049

HXB2 Location	Pol(311-319) RT(156-164) DNA(3015..3041)	Pol Epitope Map
Author Location	RT
Epitope	SPAIFQSSM	Epitope Alignment
Epitope Name	SM9-RT
Subtype	B, C
Species (MHC/HLA)	human(B*0702)
Immunogen	HIV-1 infection
Country	Japan, South Africa, United Kingdom, United States
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, subtype comparisons

Notes

• HLA-B*0702 is associated with rapid progression to disease in B-clade HIV-1 infected subjects. B*0702+ C-clade infected subjects however are not associated with a high viral setpoint of infection, and target a broader range of Gag epitopes at higher magnitudes. Increased magnitudes of Nef-specific responses were also detected in C-clade infected B*0702+ cohorts. A C-clade specific, B*0702-restricted novel p17 epitope, RPGGKKHYM, RM9, was defined.
• Epitope SM9, SPAIFQSSM, a B- and C-clade RT epitope was targeted more by C-clade infected subjects than by B-clade infected individuals. The B-clade and C-clade consensus epitope is the same. Binding affinity of SM9 to B*0702 was K_d = 37 nM. SM9 is contained within OLP187, QGWKGSPAIFQSSMTKIL.

References

Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.

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Displaying record number 59051

HXB2 Location	Pol(743-751) Integrase(28-36) DNA(4311..4337)	Pol Epitope Map
Author Location	Integrase
Epitope	LPPVVAKEI	Epitope Alignment
		Show epitope variants
Epitope Name	LI9-Int
Subtype	B
Species (MHC/HLA)	human(B*0702)
Immunogen	HIV-1 infection
Country	Japan, South Africa, United Kingdom, United States
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, subtype comparisons

Notes

• HLA-B*0702 is associated with rapid progression to disease in B-clade HIV-1 infected subjects. B*0702+ C-clade infected subjects however are not associated with a high viral setpoint of infection, and target a broader range of Gag epitopes at higher magnitudes. Increased magnitudes of Nef-specific responses were also detected in C-clade infected B*0702+ cohorts. A C-clade specific, B*0702-restricted novel p17 epitope, RPGGKKHYM, RM9, was defined.
• Epitope LI9, LPPVVAKEI, a B-clade Integrase epitope was targeted exclusively by B-clade infected subjects and not the C-clade variant LPPiVAKEI. The affinity of LI9 to B*0702 was K_d = 12,353 nM. Clade-B LI9 is contained within OLP244, MASDFNLPPVVAKEIVA.

References

Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.

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Displaying record number 59041

HXB2 Location	Vif(48-57) DNA(5182..5211)	Vif Epitope Map
Author Location	Vif
Epitope	HPRISSEVHI	Epitope Alignment
		Show epitope variants
Epitope Name	HI10-Vif
Subtype	B
Species (MHC/HLA)	human(B*0702)
Immunogen	HIV-1 infection
Country	Japan, South Africa, United Kingdom, United States
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, subtype comparisons

Notes

• HLA-B*0702 is associated with rapid progression to disease in B-clade HIV-1 infected subjects. B*0702+ C-clade infected subjects however are not associated with a high viral setpoint of infection, and target a broader range of Gag epitopes at higher magnitudes. Increased magnitudes of Nef-specific responses were also detected in C-clade infected B*0702+ cohorts. A C-clade specific, B*0702-restricted novel p17 epitope, RPGGKKHYM, RM9, was defined.
• Epitope HI10, HPRISSEVHI, a B-clade Vif epitope was targeted exclusively by B-clade infected subjects and not C-clade ones. The C-clade variant epitope is HPkISSEVHI. Binding affinity of B-clade HI10 to B*0702 was K_d = 4 nM, and 178 nM for the C-clade variant. HI10 is contained within OLP407, RHHYESTHPRISSEVHI.

References

Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.

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Displaying record number 59052

HXB2 Location	Vpr(34-42) DNA(5658..5684)	Vpr Epitope Map
Author Location	Vpr
Epitope	FPRIWLHSL	Epitope Alignment
		Show epitope variants
Epitope Name	FL9-Vpr
Subtype	B
Species (MHC/HLA)	human(B*0702)
Immunogen	HIV-1 infection
Country	Japan, South Africa, United Kingdom, United States
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, subtype comparisons

Notes

• HLA-B*0702 is associated with rapid progression to disease in B-clade HIV-1 infected subjects. B*0702+ C-clade infected subjects however are not associated with a high viral setpoint of infection, and target a broader range of Gag epitopes at higher magnitudes. Increased magnitudes of Nef-specific responses were also detected in C-clade infected B*0702+ cohorts. A C-clade specific, B*0702-restricted novel p17 epitope, RPGGKKHYM, RM9, was defined.
• Epitope FL9, FPRIWLHSL, a B-clade Vpr epitope was targeted more by C-clade infected subjects to the C-clade variant FPRpWLHgL, than B-clade FL9. The affinity of B-clade FL9 to B*0702 was K_d = 3 nM. Clade-B FL9 is contained within OLP281, ELKNEAVRHFPRpIWLHSL.

References

Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.

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Displaying record number 59048

HXB2 Location	Rev(66-75) DNA(8498..8527)	Rev Epitope Map
Author Location	Rev
Epitope	RPAEPVPLQL	Epitope Alignment
Epitope Name	RL10-Rev
Subtype	B, C
Species (MHC/HLA)	human(B*0702)
Immunogen	HIV-1 infection
Country	Japan, South Africa, United Kingdom, United States
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, subtype comparisons

Notes

• HLA-B*0702 is associated with rapid progression to disease in B-clade HIV-1 infected subjects. B*0702+ C-clade infected subjects however are not associated with a high viral setpoint of infection, and target a broader range of Gag epitopes at higher magnitudes. Increased magnitudes of Nef-specific responses were also detected in C-clade infected B*0702+ cohorts. A C-clade specific, B*0702-restricted novel p17 epitope, RPGGKKHYM, RM9, was defined.
• Epitope RL10, RPAEPVPLQL, a B- and C-clade Rev epitope was targeted more by B-clade infected subjects than by C-clade infected individuals. The B-clade and C-clade consensus epitope is the same. Binding affinity of RL10 to B*0702 was K_d = 65 nM. RL10 is contained within OLP102, ILSTCLGRPAEPVPLQL.

References

Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.

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Displaying record number 59050

HXB2 Location	gp160(298-307) gp120(298-307) DNA(7116..7145)	gp160 Epitope Map
Author Location	Env
Epitope	RPNNNTRKSI	Epitope Alignment
Epitope Name	RI10-Env
Subtype	B, C
Species (MHC/HLA)	human(B*0702)
Immunogen	HIV-1 infection
Country	Japan, South Africa, United Kingdom, United States
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, subtype comparisons

Notes

• HLA-B*0702 is associated with rapid progression to disease in B-clade HIV-1 infected subjects. B*0702+ C-clade infected subjects however are not associated with a high viral setpoint of infection, and target a broader range of Gag epitopes at higher magnitudes. Increased magnitudes of Nef-specific responses were also detected in C-clade infected B*0702+ cohorts. A C-clade specific, B*0702-restricted novel p17 epitope, RPGGKKHYM, RM9, was defined.
• Epitope RI10, RPNNNTRKSI, a B- and C-clade Env epitope was targeted more by C-clade infected subjects than by B-clade infected individuals. The B-clade and C-clade consensus epitope is the same. Binding affinity of RI10 to B*0702 was K_d = 3 nM. RI10 is contained within OLP328, NCTRPNNNTRKSIHI in Clade-B and vCTRPNNNTRKSIrI in Clade-C.

References

Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.

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Displaying record number 59053

HXB2 Location	gp160(843-851) gp41(332-340) DNA(8751..8777)	gp160 Epitope Map
Author Location	Env
Epitope	IPRRIRQGL	Epitope Alignment
		Show epitope variants
Epitope Name	IL9-Env
Subtype	B
Species (MHC/HLA)	human(B*0702)
Immunogen	HIV-1 infection
Country	Japan, South Africa, United Kingdom, United States
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, subtype comparisons

Notes

• HLA-B*0702 is associated with rapid progression to disease in B-clade HIV-1 infected subjects. B*0702+ C-clade infected subjects however are not associated with a high viral setpoint of infection, and target a broader range of Gag epitopes at higher magnitudes. Increased magnitudes of Nef-specific responses were also detected in C-clade infected B*0702+ cohorts. A C-clade specific, B*0702-restricted novel p17 epitope, RPGGKKHYM, RM9, was defined.
• Epitope IL9, IPRRIRQGL, a B-clade Env epitope was targeted more by B-clade infected subjects than by C-clade infected individuals. Binding affinity of IL9 to B*0702 was K_d = 95 nM. IL9 is contained within OLP401, HIPRRIRQGLERALL.

References

Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.

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Displaying record number 59045

HXB2 Location	Nef(68-76) DNA(8998..9024)	Nef Epitope Map
Author Location	Nef
Epitope	FPVRPQVPL	Epitope Alignment
Epitope Name	FL9-Nef
Subtype	B, C
Species (MHC/HLA)	human(B*0702)
Immunogen	HIV-1 infection
Country	Japan, South Africa, United Kingdom, United States
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, subtype comparisons

Notes

• HLA-B*0702 is associated with rapid progression to disease in B-clade HIV-1 infected subjects. B*0702+ C-clade infected subjects however are not associated with a high viral setpoint of infection, and target a broader range of Gag epitopes at higher magnitudes. Increased magnitudes of Nef-specific responses were also detected in C-clade infected B*0702+ cohorts. A C-clade specific, B*0702-restricted novel p17 epitope, RPGGKKHYM, RM9, was defined.
• Epitope FL9, FPVRPQVPL, a B- and C-clade Nef epitope was targeted exclusively by B-clade infected subjects and not by C-clade infected individuals. The B-clade and C-clade consensus epitope is the same. Binding affinity of FL9 to B*0702 was K_d = 21 nM. FL9 is contained within OLP76, EVGFPVRPQVPLRPMTYK in clade-B and EVGFPVRPQVPLRPMTfK in clade-C.

References

Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.

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Displaying record number 59044

HXB2 Location	Nef(71-79) DNA(9007..9033)	Nef Epitope Map
Author Location	Nef
Epitope	RPQVPLRPM	Epitope Alignment
Epitope Name	RM9-Nef
Subtype	B, C
Species (MHC/HLA)	human(B*0702)
Immunogen	HIV-1 infection
Country	Japan, South Africa, United Kingdom, United States
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, subtype comparisons

Notes

• HLA-B*0702 is associated with rapid progression to disease in B-clade HIV-1 infected subjects. B*0702+ C-clade infected subjects however are not associated with a high viral setpoint of infection, and target a broader range of Gag epitopes at higher magnitudes. Increased magnitudes of Nef-specific responses were also detected in C-clade infected B*0702+ cohorts. A C-clade specific, B*0702-restricted novel p17 epitope, RPGGKKHYM, RM9, was defined.
• Epitope RM9, RPQVPLRPM, a B- and C-clade Nef epitope was targeted more by B-clade infected subjects than C-clade ones. The B-clade and C-clade consensus epitope is the same. Binding affinity of RM9 to B*0702 was K_d = 13 nM. RM9 is contained within OLP76, EVGFPVRPQVPLRPMTYK in clade-B and EVGFPVRPQVPLRPMTfK in clade-C.

References

Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.

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Displaying record number 59046

HXB2 Location	Nef(77-85) DNA(9025..9051)	Nef Epitope Map
Author Location	Nef
Epitope	RPMTYKAAV	Epitope Alignment
		Show epitope variants
Epitope Name	RV9-Nef
Subtype	B
Species (MHC/HLA)	human(B*0702)
Immunogen	HIV-1 infection
Country	Japan, South Africa, United Kingdom, United States
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, subtype comparisons

Notes

• HLA-B*0702 is associated with rapid progression to disease in B-clade HIV-1 infected subjects. B*0702+ C-clade infected subjects however are not associated with a high viral setpoint of infection, and target a broader range of Gag epitopes at higher magnitudes. Increased magnitudes of Nef-specific responses were also detected in C-clade infected B*0702+ cohorts. A C-clade specific, B*0702-restricted novel p17 epitope, RPGGKKHYM, RM9, was defined.
• Epitope RV9, RPMTYKAAV, a B-clade Nef epitope was targeted by B-clade infected subjects but the C-clade variant RF9, RPMTYKAAf, was targeted more robustly in C-clade subjects. The affinity of RV9 to B*0702 was K_d = 2 nM. Clade-B RV9 is contained within OLP77, QVPLRPMTYKAAVDLSHF.

References

Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.

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Displaying record number 59047

HXB2 Location	Nef(128-137) DNA(9178..9207)	Nef Epitope Map
Author Location	Nef
Epitope	TPGPGIRYPL	Epitope Alignment
		Show epitope variants
Epitope Name	TL10-Nef
Subtype	B
Species (MHC/HLA)	human(B*0702)
Immunogen	HIV-1 infection
Country	Japan, South Africa, United Kingdom, United States
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, subtype comparisons

Notes

• HLA-B*0702 is associated with rapid progression to disease in B-clade HIV-1 infected subjects. B*0702+ C-clade infected subjects however are not associated with a high viral setpoint of infection, and target a broader range of Gag epitopes at higher magnitudes. Increased magnitudes of Nef-specific responses were also detected in C-clade infected B*0702+ cohorts. A C-clade specific, B*0702-restricted novel p17 epitope, RPGGKKHYM, RM9, was defined.
• Epitope TL10-Nef, TPGPGIRYPL, a B-clade Nef epitope was targeted by B-clade infected subjects but the C-clade variant TL10, TPGPGvRYPL, was targeted more robustly in C-clade subjects. The affinity of TL10 to B*0702 was K_d = 6 nM. Clade-B TL10 is contained within OLP84, NYTPGPGIRYPLTFGWCF.

References

Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.

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