HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 3 matching records:

Displaying record number 44

HXB2 Location Gag(24-32)
p17(24-32)
DNA(859..885)
Gag Epitope Map
Author Location p17(24-32)
Epitope GGKKKYKLK Epitope Alignment
GGKKKYKLK epitope logo
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Klenerman1994 P. Klenerman, S. Rowland-Jones, S. McAdam, J. Edwards, S. Daenke, D. Lalloo, B. Koppe, W. Rosenberg, D. Boyd, A. Edwards, P. Giangrande, R. E. Phillips, and A. J. McMichael. Cytotoxic T Cell Activity Antagonized by Naturally Occurring HIV-1 Gag Variants. Nature, 369:403-407, 1994. This paper documents that naturally occurring peptide variants can serve as antagonists, that is they can inhibit normal lysis of cells presenting the original epitope. The variants studied could serve as antagonists when they were processed from recombinant vaccinia, replicated HIV, or when they were synthetic peptides. Both agonist and antagonist sequences were found in the study subjects from whom the CTL clones were derived. PubMed ID: 7515165. Show all entries for this paper.


Displaying record number 250

HXB2 Location Gag(259-267)
p24(127-135)
DNA(1564..1590)
Gag Epitope Map
Author Location p24(259-267 LAI)
Epitope GEIYKRWII Epitope Alignment
GEIYKRWII epitope logo
Subtype B
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Klenerman1994 P. Klenerman, S. Rowland-Jones, S. McAdam, J. Edwards, S. Daenke, D. Lalloo, B. Koppe, W. Rosenberg, D. Boyd, A. Edwards, P. Giangrande, R. E. Phillips, and A. J. McMichael. Cytotoxic T Cell Activity Antagonized by Naturally Occurring HIV-1 Gag Variants. Nature, 369:403-407, 1994. This paper documents that naturally occurring peptide variants can serve as antagonists, that is they can inhibit normal lysis of cells presenting the original epitope. The variants studied could serve as antagonists when they were processed from recombinant vaccinia, replicated HIV, or when they were synthetic peptides. Both agonist and antagonist sequences were found in the study subjects from whom the CTL clones were derived. PubMed ID: 7515165. Show all entries for this paper.


Displaying record number 275

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(263-272)
Epitope KRWIIMGLNK Epitope Alignment
KRWIIMGLNK epitope logo
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Klenerman1994 P. Klenerman, S. Rowland-Jones, S. McAdam, J. Edwards, S. Daenke, D. Lalloo, B. Koppe, W. Rosenberg, D. Boyd, A. Edwards, P. Giangrande, R. E. Phillips, and A. J. McMichael. Cytotoxic T Cell Activity Antagonized by Naturally Occurring HIV-1 Gag Variants. Nature, 369:403-407, 1994. This paper documents that naturally occurring peptide variants can serve as antagonists, that is they can inhibit normal lysis of cells presenting the original epitope. The variants studied could serve as antagonists when they were processed from recombinant vaccinia, replicated HIV, or when they were synthetic peptides. Both agonist and antagonist sequences were found in the study subjects from whom the CTL clones were derived. PubMed ID: 7515165. Show all entries for this paper.


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