Search CTL/CD8+ T-Cell Epitope Database

Found 3 matching records:

Displaying record number 44

HXB2 Location	Gag(24-32) p17(24-32) DNA(859..885)	Gag Epitope Map
Author Location	p17(24-32)
Epitope	GGKKKYKLK	Epitope Alignment
Species (MHC/HLA)	human(B8)
Immunogen	HIV-1 infection
Experimental methods
Keywords

Notes

• Naturally occurring variants GGKKKYQLK and GGKKRYRLK may act as antagonists.

References

Klenerman1994 P. Klenerman, S. Rowland-Jones, S. McAdam, J. Edwards, S. Daenke, D. Lalloo, B. Koppe, W. Rosenberg, D. Boyd, A. Edwards, P. Giangrande, R. E. Phillips, and A. J. McMichael. Cytotoxic T Cell Activity Antagonized by Naturally Occurring HIV-1 Gag Variants. Nature, 369:403-407, 1994. This paper documents that naturally occurring peptide variants can serve as antagonists, that is they can inhibit normal lysis of cells presenting the original epitope. The variants studied could serve as antagonists when they were processed from recombinant vaccinia, replicated HIV, or when they were synthetic peptides. Both agonist and antagonist sequences were found in the study subjects from whom the CTL clones were derived. PubMed ID: 7515165. Show all entries for this paper.

Displaying record number 250

HXB2 Location	Gag(259-267) p24(127-135) DNA(1564..1590)	Gag Epitope Map
Author Location	p24(259-267 LAI)
Epitope	GEIYKRWII	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B8)
Immunogen	HIV-1 infection
Experimental methods
Keywords

Notes

• Naturally occurring variant GDIYKRWII may act as antagonist.

References

Klenerman1994 P. Klenerman, S. Rowland-Jones, S. McAdam, J. Edwards, S. Daenke, D. Lalloo, B. Koppe, W. Rosenberg, D. Boyd, A. Edwards, P. Giangrande, R. E. Phillips, and A. J. McMichael. Cytotoxic T Cell Activity Antagonized by Naturally Occurring HIV-1 Gag Variants. Nature, 369:403-407, 1994. This paper documents that naturally occurring peptide variants can serve as antagonists, that is they can inhibit normal lysis of cells presenting the original epitope. The variants studied could serve as antagonists when they were processed from recombinant vaccinia, replicated HIV, or when they were synthetic peptides. Both agonist and antagonist sequences were found in the study subjects from whom the CTL clones were derived. PubMed ID: 7515165. Show all entries for this paper.

Displaying record number 275

HXB2 Location	Gag(263-272) p24(131-140) DNA(1576..1605)	Gag Epitope Map
Author Location	p24(263-272)
Epitope	KRWIIMGLNK	Epitope Alignment
Species (MHC/HLA)	human(B27)
Immunogen	HIV-1 infection
Experimental methods
Keywords

Notes

• Naturally occurring variant KRWIILGLNK may act as antagonist.

References

Klenerman1994 P. Klenerman, S. Rowland-Jones, S. McAdam, J. Edwards, S. Daenke, D. Lalloo, B. Koppe, W. Rosenberg, D. Boyd, A. Edwards, P. Giangrande, R. E. Phillips, and A. J. McMichael. Cytotoxic T Cell Activity Antagonized by Naturally Occurring HIV-1 Gag Variants. Nature, 369:403-407, 1994. This paper documents that naturally occurring peptide variants can serve as antagonists, that is they can inhibit normal lysis of cells presenting the original epitope. The variants studied could serve as antagonists when they were processed from recombinant vaccinia, replicated HIV, or when they were synthetic peptides. Both agonist and antagonist sequences were found in the study subjects from whom the CTL clones were derived. PubMed ID: 7515165. Show all entries for this paper.