Search CTL/CD8+ T-Cell Epitope Database

Found 21 matching records:

Displaying record number 53022

HXB2 Location	Gag(18-26) p17(18-26) DNA(841..867)	Gag Epitope Map
Author Location	p17(18-26)
Epitope	`KIRLRPGGK`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A*0301)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B
Keywords	Th1, characterizing CD8+ T cells

Notes

Only 20% of CD8+ T-cells produce IFN-gamma and granzyme B simultaneously (Tc1a). Two additional subpopulations of HIV specific CD8+ cells are found, each one constituting 30-40% of the CD8+ cell pool. One of these (Tc1b) secretes IFN-gamma only, and the other one (Tc1c) secretes GzB only.
Two of seven patients responded to this peptide with GzB producing cells, while none of the patients responded with IFN-gamma producing cells.

References

Kleen2004 Thomas O. Kleen, Robert Asaad, Samuel J. Landry, Bernhard O. Boehm, and Magdalena Tary-Lehmann. Tc1 Effector Diversity Shows Dissociated Expression of Granzyme B and Interferon-gamma in HIV Infection. AIDS, 18(3):383-392, 20 Feb 2004. PubMed ID: 15090789. Show all entries for this paper.

Displaying record number 53030

HXB2 Location	Gag(148-156) p24(16-24) DNA(1231..1257)	Gag Epitope Map
Author Location	p24(148-156)
Epitope	`SPRTLNAWV`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B
Keywords	characterizing CD8+ T cells

Notes

Only 20% of CD8+ T-cells produce IFN-gamma and granzyme B simultaneously (Tc1a). Two additional subpopulations of HIV specific CD8 cells are found, each one constituting 30-40% of the CD8 cell pool. One of these (Tc1b) secretes IFN-gamma only, and the other one (Tc1c) secretes GzB only.
None of seven patients responded to this peptide with GzB producing cells or IFN-gamma producing cells.
The authors describe the epitope as SPRTLNNQWV -- the double N's may be a typo or an unusual form of the epitope; it is atypical and may be why there was no response.

References

Displaying record number 53031

HXB2 Location	Gag(203-212) p24(71-80) DNA(1396..1425)	Gag Epitope Map
Author Location	p24(202-211)
Epitope	`ETINEEAAEW`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A25)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B
Keywords	Th1, characterizing CD8+ T cells

Notes

Only 20% of CD8+ T-cells produce IFN-gamma and granzyme B simultaneously (Tc1a). Two additional subpopulations of HIV specific CD8+ cells are found, each one constituting 30-40% of the CD8+ cell pool. One of these (Tc1b) secretes IFN-gamma only, and the other one (Tc1c) secretes GzB only.
1/3 patients responded to this peptide with GzB producing cells, and the other two responded with IFN-gamma producing cells.

References

Displaying record number 53033

HXB2 Location	Gag(254-262) p24(122-130) DNA(1549..1575)	Gag Epitope Map
Author Location	p24(260-268)
Epitope	`PPIPVGDIY`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B35)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B
Keywords	characterizing CD8+ T cells

Notes

Only 20% of CD8+ T-cells produce IFN-gamma and granzyme B simultaneously (Tc1a). Two additional subpopulations of HIV specific CD8 cells are found, each one constituting 30-40% of the CD8 cell pool. One of these (Tc1b) secretes IFN-gamma only, and the other one (Tc1c) secretes GzB only.
None of three patients responded to this peptide with GzB producing cells and one of the patients responded with IFN-gamma producing cells.

References

Displaying record number 53032

HXB2 Location	Gag(259-267) p24(127-135) DNA(1564..1590)	Gag Epitope Map
Author Location	p24(259-267)
Epitope	`GEIYKRWII`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B8)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B
Keywords	Th1, characterizing CD8+ T cells

Notes

Only 20% of CD8+ T-cells produce IFN-gamma and granzyme B simultaneously (Tc1a). Two additional subpopulations of HIV specific CD8 cells are found, each one constituting 30-40% of the CD8 cell pool. One of these (Tc1b) secretes IFN-gamma only, and the other one (Tc1c) secretes GzB only.
None of three patients responded to this peptide with GzB producing cells and one of the patients responded with IFN-gamma producing cells.

References

Displaying record number 53023

HXB2 Location	Pol(173-181) RT(18-26) DNA(2601..2627)	Pol Epitope Map
Author Location	Pol(171-180)
Epitope	`GPKVKQWPL`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B8)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B
Keywords	Th1, characterizing CD8+ T cells

Notes

Only 20% of CD8+ T-cells produce IFN-gamma and granzyme B simultaneously (Tc1a). Two additional subpopulations of HIV specific CD8 cells are found, each one constituting 30-40% of the CD8 cell pool. One of these (Tc1b) secretes IFN-gamma only, and the other one (Tc1c) secretes GzB only.
One of the patients responded to this peptide with GzB producing cells, while two different patients responded with IFN-gamma producing cells.

References

Displaying record number 53024

HXB2 Location	Pol(313-321) RT(158-166) DNA(3021..3047)	Pol Epitope Map
Author Location	Pol(325-333)
Epitope	`AIFQSSMTK`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A*0301, A11, A33)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B
Keywords	Th1, characterizing CD8+ T cells

Notes

Only 20% of CD8+ T-cells produce IFN-gamma and granzyme B simultaneously (Tc1a). Two additional subpopulations of HIV specific CD8 cells are found, each one constituting 30-40% of the CD8 cell pool. One of these (Tc1b) secretes IFN-gamma only, and the other one (Tc1c) secretes GzB only.
One of the patients responded to this peptide with GzB producing cells, while none of the patients responded with IFN-gamma producing cells.

References

Displaying record number 53025

HXB2 Location	Pol(330-338) RT(175-183) DNA(3072..3098)	Pol Epitope Map
Author Location	Pol(342-350)
Epitope	`HPDIVIYQY`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B35)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B
Keywords	Th1, characterizing CD8+ T cells

Notes

Only 20% of CD8+ T-cells produce IFN-gamma and granzyme B simultaneously (Tc1a). Two additional subpopulations of HIV specific CD8 cells are found, each one constituting 30-40% of the CD8 cell pool. One of these (Tc1b) secretes IFN-gamma only, and the other one (Tc1c) secretes GzB only.
None of three patients responded to this peptide with GzB producing cells, while one of the patients responded with IFN-gamma producing cells.

References

Displaying record number 53026

HXB2 Location	Pol(334-342) RT(179-187) DNA(3084..3110)	Pol Epitope Map
Author Location	Pol(346-354)
Epitope	`VIYQYMDDL`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A*0201)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B
Keywords	Th1, characterizing CD8+ T cells

Notes

Only 20% of CD8+ T-cells produce IFN-gamma and granzyme B simultaneously (Tc1a). Two additional subpopulations of HIV specific CD8 cells are found, each one constituting 30-40% of the CD8 cell pool. One of these (Tc1b) secretes IFN-gamma only, and the other one (Tc1c) secretes GzB only.
One of seven patients responded to this peptide with GzB producing cells, while none of the patients responded with IFN-gamma producing cells.

References

Displaying record number 53027

HXB2 Location	Pol(587-596) RT(432-441) DNA(3843..3872)	Pol Epitope Map
Author Location	Pol(587-596)
Epitope	`EPIVGAETFY`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B35, B51)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B
Keywords	characterizing CD8+ T cells

Notes

Only 20% of CD8+ T-cells produce IFN-gamma and granzyme B simultaneously (Tc1a). Two additional subpopulations of HIV specific CD8 cells are found, each one constituting 30-40% of the CD8 cell pool. One of these (Tc1b) secretes IFN-gamma only, and the other one (Tc1c) secretes GzB only.
None of seven patients responded to this peptide with GzB producing cells, while two of the patients responded with IFN-gamma producing cells.

References

Displaying record number 53013

HXB2 Location	gp160(52-61) gp120(52-61) DNA(6378..6407)	gp160 Epitope Map
Author Location	gp120(53-62)
Epitope	`LFCASDAKAY`	Epitope Alignment
Species (MHC/HLA)	human(A24)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B, T-cell Elispot
Keywords	characterizing CD8+ T cells

Notes

Only 20% of CD8+ T-cells produce IFN-gamma and granzyme B simultaneously (Tc1a). Two additional subpopulations of HIV specific CD8 cells are found, each one constituting 30-40% of the CD8 cell pool. One of these (Tc1b) secretes IFN-gamma only, and the other one (Tc1c) secretes GzB only.
Two of seven patients responded to this peptide with GzB producing cells, and a different patient with IFN-gamma producing cells.

References

Displaying record number 53014

HXB2 Location	gp160(314-322) gp120(314-322) DNA(7164..7190)	gp160 Epitope Map
Author Location	gp120(312-320)
Epitope	`GRAFVTIGK`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B*2705)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B
Keywords	Th1, characterizing CD8+ T cells

Notes

Only 20% of CD8+ T-cells produce IFN-gamma and granzyme B simultaneously (Tc1a). Two additional subpopulations of HIV specific CD8 cells are found, each one constituting 30-40% of the CD8 cell pool. One of these (Tc1b) secretes IFN-gamma only, and the other one (Tc1c) secretes GzB only.
One of seven patients responded to this peptide with GzB producing cells and with IFN-gamma producing cells.

References

Displaying record number 53028

HXB2 Location	gp160(586-593) gp41(75-82) DNA(7980..8003)	gp160 Epitope Map
Author Location	gp41(591-598)
Epitope	`YLKDQQLL`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A24)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B
Keywords	Th1, characterizing CD8+ T cells

Notes

Only 20% of CD8+ T-cells produce IFN-gamma and granzyme B simultaneously (Tc1a). Two additional subpopulations of HIV specific CD8 cells are found, each one constituting 30-40% of the CD8 cell pool. One of these (Tc1b) secretes IFN-gamma only, and the other one (Tc1c) secretes GzB only.
One of seven patients responded to this peptide with GzB producing cells, and a different patient responded with IFN-gamma producing cells.

References

Displaying record number 53029

HXB2 Location	gp160(786-794) gp41(275-283) DNA(8580..8606)	gp160 Epitope Map
Author Location	gp41(751-759)
Epitope	`GRRGWEALK`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B*2705)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B
Keywords	Th1, characterizing CD8+ T cells

Notes

Only 20% of CD8+ T-cells produce IFN-gamma and granzyme B simultaneously (Tc1a). Two additional subpopulations of HIV specific CD8 cells are found, each one constituting 30-40% of the CD8 cell pool. One of these (Tc1b) secretes IFN-gamma only, and the other one (Tc1c) secretes GzB only.
One of seven patients responded to this peptide with GzB producing cells, and a different patient responded with IFN-gamma producing cells.

References

Displaying record number 53015

HXB2 Location	Nef(72-81) DNA(9010..9039)	Nef Epitope Map
Author Location	Nef(72-82)
Epitope	`PQVPLRPMTY`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B35, B51)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B
Keywords	Th1, characterizing CD8+ T cells

Notes

Only 20% of CD8+ T-cells produce IFN-gamma and granzyme B simultaneously (Tc1a). Two additional subpopulations of HIV specific CD8 cells are found, each one constituting 30-40% of the CD8 cell pool. One of these (Tc1b) secretes IFN-gamma only, and the other one (Tc1c) secretes GzB only.
Three of nine patients responded to this peptide with GzB producing and IFN-gamma producing cells, and one additional with IFN-gamma producing cells.

References

Displaying record number 53016

HXB2 Location	Nef(73-82) DNA(9013..9042)	Nef Epitope Map
Author Location	Nef(73-82)
Epitope	`QVPLRPMTYK`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A*0301, A11)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B
Keywords	Th1, characterizing CD8+ T cells

Notes

Only 20% of CD8+ T-cells produce IFN-gamma and granzyme B simultaneously (Tc1a). Two additional subpopulations of HIV specific CD8 cells are found, each one constituting 30-40% of the CD8 cell pool. One of these (Tc1b) secretes IFN-gamma only, and the other one (Tc1c) secretes GzB only.
None of three patients responded to this peptide with GzB producing cells, while all three responded with IFN-gamma producing cells.

References

Displaying record number 53017

HXB2 Location	Nef(86-94) DNA(9052..9078)	Nef Epitope Map
Author Location	Nef(86-94)
Epitope	`DLSHFLKEK`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A*0301, A11)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B
Keywords	Th1, characterizing CD8+ T cells

Notes

Only 20% of CD8+ T-cells produce IFN-gamma and granzyme B simultaneously (Tc1a). Two additional subpopulations of HIV specific CD8 cells are found, each one constituting 30-40% of the CD8 cell pool. One of these (Tc1b) secretes IFN-gamma only, and the other one (Tc1c) secretes GzB only.
Two of nine patients responded to this peptide with GzB producing cells, while three of the patients responded with IFN-gamma producing cells. Only one patient had both GzB and IFN-gamma responses.

References

Displaying record number 53018

HXB2 Location	Nef(136-145) DNA(9202..9231)	Nef Epitope Map
Author Location	Nef(136-145)
Epitope	`PLTFGWCYKL`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A*0201)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B
Keywords	Th1, characterizing CD8+ T cells

Notes

Only 20% of CD8+ T-cells produce IFN-gamma and granzyme B simultaneously (Tc1a). Two additional subpopulations of HIV specific CD8 cells are found, each one constituting 30-40% of the CD8 cell pool. One of these (Tc1b) secretes IFN-gamma only, and the other one (Tc1c) secretes GzB only.
Three of seven patients responded to this peptide with GzB producing cells and three of the patients responded with IFN-gamma producing cells. Only one patient had both a GzB and IFN-gamma response.

References

Displaying record number 53019

HXB2 Location	Nef(180-189) DNA(9334..9363)	Nef Epitope Map
Author Location	Nef(180-189)
Epitope	`VLEWRFDSRL`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A*0201)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B
Keywords	Th1, characterizing CD8+ T cells

Notes

Only 20% of CD8+ T-cells produce IFN-gamma and granzyme B simultaneously (Tc1a). Two additional subpopulations of HIV specific CD8 cells are found, each one constituting 30-40% of the CD8 cell pool. One of these (Tc1b) secretes IFN-gamma only, and the other one (Tc1c) secretes GzB only.
Three of seven patients responded to this peptide with GzB producing cells, while one of the three patients responded with IFN-gamma producing cells.

References

Displaying record number 53020

HXB2 Location	Nef(186-194) DNA(9352..9378)	Nef Epitope Map
Author Location	Nef(186-194)
Epitope	`DSRLAFHHM`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A24)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B
Keywords	Th1, characterizing CD8+ T cells

Notes

Only 20% of CD8+ T-cells produce IFN-gamma and granzyme B simultaneously (Tc1a). Two additional subpopulations of HIV specific CD8 cells are found, each one constituting 30-40% of the CD8 cell pool. One of these (Tc1b) secretes IFN-gamma only, and the other one (Tc1c) secretes GzB only.
Two of seven patients responded to this peptide with GzB producing cells, while none of the patients responded with IFN-gamma producing cells.

References

Displaying record number 53021

HXB2 Location	Nef(190-198) DNA(9364..9390)	Nef Epitope Map
Author Location	Nef(190-198)
Epitope	`AFHHVAREL`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A2, B52)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B
Keywords	Th1, characterizing CD8+ T cells

Notes

Only 20% of CD8+ T-cells produce IFN-gamma and granzyme B simultaneously (Tc1a). Two additional subpopulations of HIV specific CD8 cells are found, each one constituting 30-40% of the CD8 cell pool. One of these (Tc1b) secretes IFN-gamma only, and the other one (Tc1c) secretes GzB only.
Three of seven patients responded to this peptide with GzB producing cells, while one of three patients also responded with IFN-gamma producing cells.