Search CTL/CD8+ T-Cell Epitope Database

Found 5 matching records:

Displaying record number 52090

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HXB2 Location	gp160(121-129) gp120(121-129) DNA(6585..6611)	gp160 Epitope Map
Author Location	gp120(121-129 IIIB)
Epitope	KLTPLCVTL	Epitope Alignment
Epitope Name	D1
Subtype	B
Species (MHC/HLA)	transgenic mouse(A2)
Immunogen	vaccine
Experimental methods
Keywords	vaccine-induced immune responses

Vaccine Details

Notes

• Transgenic mice expressing a HLA-A2/Kb chimeric protein were vaccinated with a full length gp160 or with gp160deltaV3, with the V3 loop deleted. Mice given gp160deltaV3 had a broader immune response than those given gp160, with increased responses to conserved HLA-A2 epitopes in the C1 region of gp120, KLTPLCVTL, and the C-term region of gp41, SLLNATAIAV.
• Greater resistance was conferred by the gp160deltaV3 than the gp160 vaccine to a challenge of vaccinia expressing heterologous gp160 from primary isolates (VI-06 and 89.6), and the resistance was conferred by CD8+ T-cells.

References

Kiszka2002 Irena Kiszka, Dariusz Kmieciak, Jaroslaw Gzyl, Toshio Naito, Elizabeth Bolesta, Aleksander Sieron, Satya P. Singh, Alagarsamy Srinivasan, Giorgio Trinchieri, Yutaro Kaneko, and Danuta Kozbor. Effect of the V3 Loop Deletion of Envelope Glycoprotein on Cellular Responses and Protection against Challenge with Recombinant Vaccinia Virus Expressing gp160 of Primary Human Immunodeficiency Virus Type 1 Isolates. J. Virol., 76(9):4222-4232, May 2002. PubMed ID: 11932387. Show all entries for this paper.

Displaying record number 52092

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HXB2 Location	gp160(291-307) gp120(291-307) DNA(7095..7145)	gp160 Epitope Map
Author Location	gp120(291-307 IIIB)
Epitope	SVEINCTRPNNNTRKRI	Epitope Alignment
Subtype	B
Species (MHC/HLA)	transgenic mouse(A2)
Immunogen	vaccine
Experimental methods
Keywords	vaccine-induced immune responses

Vaccine Details

Notes

• Transgenic mice expressing a HLA-A2/Kb chimeric protein were vaccinated with a full length gp160 or with gp160deltaV3, with the V3 loop deleted. Mice given gp160deltaV3 had a broader immune response than those given gp160, with increased responses to conserved HLA-A2 epitopes in the C1 region of gp120, KLTPLCVTL, and the C-term region of gp41, SLLNATAIAV.
• Greater resistance was conferred by the gp160deltaV3 than the gp160 vaccine to a challenge of vaccinia expressing heterologous gp160 from primary isolates (VI-06 and 89.6), and the resistance was conferred by CD8+ T-cells.
• The most intense CTL responses to the intact gp160 vaccine were directed at three V3 peptides.

References

Kiszka2002 Irena Kiszka, Dariusz Kmieciak, Jaroslaw Gzyl, Toshio Naito, Elizabeth Bolesta, Aleksander Sieron, Satya P. Singh, Alagarsamy Srinivasan, Giorgio Trinchieri, Yutaro Kaneko, and Danuta Kozbor. Effect of the V3 Loop Deletion of Envelope Glycoprotein on Cellular Responses and Protection against Challenge with Recombinant Vaccinia Virus Expressing gp160 of Primary Human Immunodeficiency Virus Type 1 Isolates. J. Virol., 76(9):4222-4232, May 2002. PubMed ID: 11932387. Show all entries for this paper.

Displaying record number 52093

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HXB2 Location	gp160(308-322) gp120(308-322) DNA(7146..7190)	gp160 Epitope Map
Author Location	gp120(308-322 IIIB)
Epitope	RIQRGPGRAFVTIGK	Epitope Alignment
Subtype	B
Species (MHC/HLA)	transgenic mouse(A2)
Immunogen	vaccine
Experimental methods
Keywords	vaccine-induced immune responses

Vaccine Details

Notes

• Transgenic mice expressing a HLA-A2/Kb chimeric protein were vaccinated with a full length gp160 or with gp160deltaV3, with the V3 loop deleted. Mice given gp160deltaV3 had a broader immune response than those given gp160, with increased responses to conserved HLA-A2 epitopes in the C1 region of gp120, KLTPLCVTL, and the C-term region of gp41, SLLNATAIAV.
• Greater resistance was conferred by the gp160deltaV3 than the gp160 vaccine to a challenge of vaccinia expressing heterologous gp160 from primary isolates (VI-06 and 89.6), and the resistance was conferred by CD8+ T-cells.
• The most intense CTL responses to the intact gp160 vaccine were directed at three V3 peptides.

References

Kiszka2002 Irena Kiszka, Dariusz Kmieciak, Jaroslaw Gzyl, Toshio Naito, Elizabeth Bolesta, Aleksander Sieron, Satya P. Singh, Alagarsamy Srinivasan, Giorgio Trinchieri, Yutaro Kaneko, and Danuta Kozbor. Effect of the V3 Loop Deletion of Envelope Glycoprotein on Cellular Responses and Protection against Challenge with Recombinant Vaccinia Virus Expressing gp160 of Primary Human Immunodeficiency Virus Type 1 Isolates. J. Virol., 76(9):4222-4232, May 2002. PubMed ID: 11932387. Show all entries for this paper.

Displaying record number 52094

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HXB2 Location	gp160(311-319) gp120(311-319) DNA(7155..7181)	gp160 Epitope Map
Author Location	gp120(311-320 IIIB)
Epitope	RGPGRAFVT	Epitope Alignment
Subtype	B
Species (MHC/HLA)	transgenic mouse(A2)
Immunogen	vaccine
Experimental methods
Keywords	vaccine-induced immune responses

Vaccine Details

Notes

• Transgenic mice expressing a HLA-A2/Kb chimeric protein were vaccinated with a full length gp160 or with gp160deltaV3, with the V3 loop deleted. Mice given gp160deltaV3 had a broader immune response than those given gp160, with increased responses to conserved HLA-A2 epitopes in the C1 region of gp120, KLTPLCVTL, and the C-term region of gp41, SLLNATAIAV.
• Greater resistance was conferred by the gp160deltaV3 than the gp160 vaccine to a challenge of vaccinia expressing heterologous gp160 from primary isolates (VI-06 and 89.6), and the resistance was conferred by CD8+ T-cells.
• The most intense CTL responses to the intact gp160 vaccine were directed at three V3 peptides.

References

Kiszka2002 Irena Kiszka, Dariusz Kmieciak, Jaroslaw Gzyl, Toshio Naito, Elizabeth Bolesta, Aleksander Sieron, Satya P. Singh, Alagarsamy Srinivasan, Giorgio Trinchieri, Yutaro Kaneko, and Danuta Kozbor. Effect of the V3 Loop Deletion of Envelope Glycoprotein on Cellular Responses and Protection against Challenge with Recombinant Vaccinia Virus Expressing gp160 of Primary Human Immunodeficiency Virus Type 1 Isolates. J. Virol., 76(9):4222-4232, May 2002. PubMed ID: 11932387. Show all entries for this paper.

Displaying record number 52091

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HXB2 Location	gp160(813-822) gp41(302-311) DNA(8661..8690)	gp160 Epitope Map
Author Location	gp41(813-822 IIIB)
Epitope	SLLNATAIAV	Epitope Alignment
Epitope Name	D2
Subtype	B
Species (MHC/HLA)	transgenic mouse(A2)
Immunogen	vaccine
Experimental methods
Keywords	vaccine-induced immune responses

Vaccine Details

Notes

• Transgenic mice expressing a HLA-A2/Kb chimeric protein were vaccinated with a full length gp160 or with gp160deltaV3, with the V3 loop deleted. Mice given gp160deltaV3 had a broader immune response than those given gp160, with increased responses to conserved HLA-A2 epitopes in the C1 region of gp120, KLTPLCVTL, and the C-term region of gp41, SLLNATAIAV.
• Greater resistance was conferred by the gp160deltaV3 than the gp160 vaccine to a challenge of vaccinia expressing heterologous gp160 from primary isolates (VI-06 and 89.6), and the resistance was conferred by CD8+ T-cells.

References

Kiszka2002 Irena Kiszka, Dariusz Kmieciak, Jaroslaw Gzyl, Toshio Naito, Elizabeth Bolesta, Aleksander Sieron, Satya P. Singh, Alagarsamy Srinivasan, Giorgio Trinchieri, Yutaro Kaneko, and Danuta Kozbor. Effect of the V3 Loop Deletion of Envelope Glycoprotein on Cellular Responses and Protection against Challenge with Recombinant Vaccinia Virus Expressing gp160 of Primary Human Immunodeficiency Virus Type 1 Isolates. J. Virol., 76(9):4222-4232, May 2002. PubMed ID: 11932387. Show all entries for this paper.