Search CTL/CD8+ T-Cell Epitope Database

Found 4 matching records:

Displaying record number 57642

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HXB2 Location	Gag(325-333) p24(193-201) DNA(1762..1788)	Gag Epitope Map
Author Location	Gag(327-329)
Epitope	NANPDCKTI	Epitope Alignment
Epitope Name	Gag327-9
Subtype	B
Species (MHC/HLA)	human(B*51:01)
Immunogen	HIV-1 infection
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords	rate of progression

Notes

• HLA B*5101 is associated with slow progression to AIDS. Responses to previously-documented epitopes were studied in ART-naive slow-progressing and non-progressing B*5101-positive hemophiliacs.
• 8/10 HLA B*5101-positive slow- and non-progressing individuals had CD8+ T cells specific for NANPDCKTI.

References

Kawashima2010 Yuka Kawashima, Nozomi Kuse, Hiroyuki Gatanaga, Takuya Naruto, Mamoru Fujiwara, Sachi Dohki, Tomohiro Akahoshi, Katsumi Maenaka, Philip Goulder, Shinichi Oka, and Masafumi Takiguchi. Long-Term Control of HIV-1 in Hemophiliacs Carrying Slow-Progressing Allele HLA-B*5101. J. Virol., 84(14):7151-7160, Jul 2010. PubMed ID: 20410273. Show all entries for this paper.

Displaying record number 57636

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HXB2 Location	Pol(283-290) RT(128-135) DNA(2931..2954)	Pol Epitope Map
Author Location	Pol(283-288)
Epitope	TAFTIPSI	Epitope Alignment
		Show epitope variants
Epitope Name	Pol 283-8
Subtype	B
Species (MHC/HLA)	human(B*51:01)
Immunogen	HIV-1 infection
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords	rate of progression

Notes

• HLA B*5101 is associated with slow progression to AIDS. Responses to previously-documented epitopes were studied in ART-naive slow-progressing and non-progressing B*5101-positive hemophiliacs.
• 8/10 HLA B*5101-positive slow- and non-progressing individuals had CD8+ T cells specific for TAFTIPSI. Slow progression and control over HIV were positively correlated with responses to TAFTIPSI, and lack of control was associated with TAFTIPSI-specific escape mutants TAFTIPSl, TAFTIPSr, and TAFTIPSt.

References

Kawashima2010 Yuka Kawashima, Nozomi Kuse, Hiroyuki Gatanaga, Takuya Naruto, Mamoru Fujiwara, Sachi Dohki, Tomohiro Akahoshi, Katsumi Maenaka, Philip Goulder, Shinichi Oka, and Masafumi Takiguchi. Long-Term Control of HIV-1 in Hemophiliacs Carrying Slow-Progressing Allele HLA-B*5101. J. Virol., 84(14):7151-7160, Jul 2010. PubMed ID: 20410273. Show all entries for this paper.

Displaying record number 57641

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HXB2 Location	Pol(743-751) Integrase(28-36) DNA(4311..4337)	Pol Epitope Map
Author Location	Pol(743-749)
Epitope	LPPVVAKEI	Epitope Alignment
Epitope Name	Pol 743-9
Subtype	B
Species (MHC/HLA)	human(B*51:01)
Immunogen	HIV-1 infection
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords	rate of progression

Notes

• HLA B*5101 is associated with slow progression to AIDS. Responses to previously-documented epitopes were studied in ART-naive slow-progressing and non-progressing B*5101-positive hemophiliacs.
• 10/10 HLA B*5101-positive slow- and non-progressing individuals had CD8+ T cells specific for LPPVVAKEI.

References

Kawashima2010 Yuka Kawashima, Nozomi Kuse, Hiroyuki Gatanaga, Takuya Naruto, Mamoru Fujiwara, Sachi Dohki, Tomohiro Akahoshi, Katsumi Maenaka, Philip Goulder, Shinichi Oka, and Masafumi Takiguchi. Long-Term Control of HIV-1 in Hemophiliacs Carrying Slow-Progressing Allele HLA-B*5101. J. Virol., 84(14):7151-7160, Jul 2010. PubMed ID: 20410273. Show all entries for this paper.

Displaying record number 57643

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HXB2 Location	Rev(71-78) DNA(8513..8536)	Rev Epitope Map
Author Location	Rev(71-78)
Epitope	VPLQLPPL	Epitope Alignment
Epitope Name	Rev71-11
Subtype	B
Species (MHC/HLA)	human(B*51:01)
Immunogen	HIV-1 infection
Country	Japan
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords	rate of progression

Notes

• HLA B*5101 is associated with slow progression to AIDS. Responses to previously-documented epitopes were studied in ART-naive slow-progressing and non-progressing B*5101-positive hemophiliacs.
• 5/10 HLA B*5101-positive slow- and non-progressing individuals had CD8+ T cells specific for VPLQLPPL.

References

Kawashima2010 Yuka Kawashima, Nozomi Kuse, Hiroyuki Gatanaga, Takuya Naruto, Mamoru Fujiwara, Sachi Dohki, Tomohiro Akahoshi, Katsumi Maenaka, Philip Goulder, Shinichi Oka, and Masafumi Takiguchi. Long-Term Control of HIV-1 in Hemophiliacs Carrying Slow-Progressing Allele HLA-B*5101. J. Virol., 84(14):7151-7160, Jul 2010. PubMed ID: 20410273. Show all entries for this paper.