Search CTL/CD8+ T-Cell Epitope Database

Found 19 matching records:

Displaying record number 1334

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HXB2 Location	Gag(28-36) p17(28-36) DNA(871..897)	Gag Epitope Map
Author Location
Epitope	`KYRLKHLVW`	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

This study examines CTL responses in HIV exposed, persistently seronegative individuals, HEPS, who eventually seroconverted -- 11/114 HEPS Nairobi sex workers eventually seroconverted, and for six of these HIV CTL reactive epitopes had been defined while seronegative.
The epidemiological factor associated with seroconversion was stopping sex work. HIV-specific CTL activity declined when HEPS sex workers stopped working for a period or retired.
This epitope was recognized in 1/22 HEPS sex worker controls (ML1573).

References

Kaul2001 R. Kaul, S. L. Rowland-Jones, J. Kimani, T. Dong, H. B. Yang, P. Kiama, T. Rostron, E. Njagi, J. J. Bwayo, K. S. MacDonald, A. J. McMichael, and F. A. Plummer. Late Seroconversion in HIV-Resistant Nairobi Prostitutes Despite Pre-Existing HIV-Specific CD8+ Responses. J. Clin. Invest., 107(3):341-349, Feb 2001. URL: http://www.jci.org/cgi/content/full/107/3/341. PubMed ID: 11160158. Show all entries for this paper.

Displaying record number 1333

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HXB2 Location	Gag(147-155) p24(15-23) DNA(1228..1254)	Gag Epitope Map
Author Location
Epitope	`LSPRTLNAW`	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 exposed seronegative, HIV-1 infection
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

This study examines CTL responses in HIV exposed, persistently seronegative individuals, HEPS, who eventually seroconverted -- 11/114 HEPS Nairobi sex workers eventually seroconverted, and for six of these HIV CTL reactive epitopes had been defined while seronegative.
The epidemiological factor associated with seroconversion was stopping sex work. HIV-specific CTL activity declined when HEPS sex workers stopped working for a period or retired.
ISPRTLNAW was consistently recognized by 1/22 HEPS sex worker controls (ML1250), and LSPRTLNAW was recognized by 2 additional HEPS sex worker controls (ML1693 and ML1589).

References

Displaying record number 1336

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HXB2 Location	Gag(162-172) p24(30-40) DNA(1273..1305)	Gag Epitope Map
Author Location	p24
Epitope	`KAFSPEVIPMF`	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 exposed seronegative, HIV-1 infection
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

This study examines CTL responses in HIV exposed, persistently seronegative individuals, HEPS, who eventually seroconverted -- 11/114 HEPS Nairobi sex workers eventually seroconverted, and for six of these HIV CTL reactive epitopes had been defined while seronegative.
The epidemiological factor associated with seroconversion was stopping sex work. HIV-specific CTL activity declined when HEPS sex workers stopped working for a period or retired.
This epitope was recognized by 1/22 HEPS sex worker controls, ML1250.

References

Displaying record number 1327

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HXB2 Location	Gag(183-191) p24(51-59) DNA(1336..1362)	Gag Epitope Map
Author Location	p24
Epitope	`DLNMMLNIV`	Epitope Alignment
Species (MHC/HLA)	human(B14)
Immunogen	HIV-1 infection
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

This study examines CTL responses in HIV exposed, persistently seronegative individuals, HEPS, who eventually seroconverted -- 11/114 HEPS Nairobi sex workers eventually seroconverted, and for six of these HIV CTL reactive epitopes had been defined while seronegative.
The epidemiological factor associated with seroconversion was stopping sex work. HIV-specific CTL activity declined when HEPS sex workers stopped working for a period or retired.
This epitope was recognized in 1/22 HEPS sex worker controls, ML1792.

References

Displaying record number 1335

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HXB2 Location	Gag(240-249) p24(108-117) DNA(1507..1536)	Gag Epitope Map
Author Location
Epitope	`TSTLQRQIGW`	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

This study examines CTL responses in HIV exposed, persistently seronegative individuals, HEPS, who eventually seroconverted -- 11/114 HEPS Nairobi sex workers eventually seroconverted, and for six of these HIV CTL reactive epitopes had been defined while seronegative.
The epidemiological factor associated with seroconversion was stopping sex work. HIV-specific CTL activity declined when HEPS sex workers stopped working for a period or retired.
This epitope was recognized in 1/22 HEPS sex worker controls (ML1250).

References

Displaying record number 1326

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HXB2 Location	Gag(254-262) p24(122-130) DNA(1549..1575)	Gag Epitope Map
Author Location	p24
Epitope	`PPIPVGDIH`	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

This study examines CTL responses in HIV exposed, persistently seronegative individuals, HEPS, who eventually seroconverted -- 11/114 HEPS Nairobi sex workers eventually seroconverted, and for six of these HIV CTL reactive epitopes had been defined while seronegative.
The epidemiological factor associated with seroconversion was stopping sex work. HIV-specific CTL activity declined when HEPS sex workers stopped working for a period or retired.
This epitope was recognized in 1/22 HEPS sex worker controls, ML887.

References

Displaying record number 1330

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HXB2 Location	Gag(293-302) p24(161-170) DNA(1666..1695)	Gag Epitope Map
Author Location
Epitope	`FRDYVDRFFK`	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

This study examines CTL responses in HIV exposed, persistently seronegative individuals, HEPS, who eventually seroconverted -- 11/114 HEPS Nairobi sex workers eventually seroconverted, and for six of these HIV CTL reactive epitopes had been defined while seronegative.
The epidemiological factor associated with seroconversion was stopping sex work. HIV-specific CTL activity declined when HEPS sex workers stopped working for a period or retired.
This epitope was recognized in 1/22 HEPS sex worker controls, ML1732.

References

Displaying record number 1328

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HXB2 Location	Gag(305-313) p24(173-181) DNA(1702..1728)	Gag Epitope Map
Author Location
Epitope	`RAEQASQEV`	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

This study examines CTL responses in HIV exposed, persistently seronegative individuals, HEPS, who eventually seroconverted -- 11/114 HEPS Nairobi sex workers eventually seroconverted, and for six of these HIV CTL reactive epitopes had been defined while seronegative.
The epidemiological factor associated with seroconversion was stopping sex work. HIV-specific CTL activity declined when HEPS sex workers stopped working for a period or retired.
This epitope was recognized in 1/22 HEPS sex worker controls ML1792.

References

Displaying record number 58299

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HXB2 Location	Pol(59-67) Protease(3-11) DNA(2259..2285)	Pol Epitope Map
Author Location	Pol-Protease(58-67)
Epitope	`ITLWQRPLV`	Epitope Alignment
Epitope Name	IV9
Subtype	C
Species (MHC/HLA)	human(A*74:01)
Immunogen	HIV-1 infection
Country	Botswana, Malawi, South Africa, Zimbabwe
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, HLA binding
Keywords	binding affinity

Notes

The contribution of an HLA-A allele to disease control of HIV-infected subjects was studied in 2126 southern African treatment-naive subjects chronically infected with HIV-clade C. Though it is in linkage disequilibrium with HLA-B*5703 for South African populations, HLA-A*7401 has an independent protective effect, lowering viral load (VL), and the effect is additive with that of HLA-B*5703. Another protective, additive effect to HLA-A*7401 was also identified - HLA-B*81.
The mechanism of action of this control of VL appears to be the selection of escapes in its presenting epitopes that reduce viral replicative capacity.
8 novel epitopes restricted by HLA-A*7401 were discovered, of which three were defined by truncations to their optimal length and efficacy.
ITLWQRPLV, epitope IV9, is the only epitope previously reported by the Los Alamos HIV database Kaul2001 to bind HLA-A*7401, and here it is shown to not match motif prediction as a putative A*7401-epitope. It is also shown by EliSpot to be a low binder.

References

Matthews2011 Philippa C. Matthews, Emily Adland, Jennifer Listgarten, Alasdair Leslie, Nompumelelo Mkhwanazi, Jonathan M. Carlson, Mikkel Harndahl, Anette Stryhn, Rebecca P. Payne, Anthony Ogwu, Kuan-Hsiang Gary Huang, John Frater, Paolo Paioni, Henrik Kloverpris, Pieter Jooste, Dominique Goedhals, Cloete van Vuuren, Dewald Steyn, Lynn Riddell, Fabian Chen, Graz Luzzi, Thambiah Balachandran, Thumbi Ndung'u, Søren Buus, Mary Carrington, Roger Shapiro, David Heckerman, and Philip J. R. Goulder. HLA-A*7401-Mediated Control of HIV Viremia Is Independent of Its Linkage Disequilibrium with HLA-B*5703. J. Immunol., 186(10):5675-5686, 15 May 2011. PubMed ID: 21498667. Show all entries for this paper.

Displaying record number 1320

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HXB2 Location	Pol(86-94) Protease(30-38) DNA(2340..2366)	Pol Epitope Map
Author Location	Pol( subtype A)
Epitope	`DTVLEDINL`	Epitope Alignment
Subtype	A
Species (MHC/HLA)	human(A*68:02)
Immunogen	HIV-1 infection
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS), escape

Notes

This study examines CTL responses in HIV exposed, persistently seronegative individuals, HEPS, who eventually seroconverted -- 11/114 HEPS Nairobi sex workers eventually seroconverted, and for six of these HIV CTL reactive epitopes had been defined while seronegative.
DTVLEDINL was recognized in 3 of the 6 women (ML857, ML1203, and ML1707), and the response was present in the last available sample prior to seroconversion, 3-7 months.
In each of the three women, 20/20 sequences of the infecting strain had no substitutions in this epitope, all were DTVLEDINL, so there was no evidence for escape.
The epidemiological factor associated with seroconversion was stopping sex work. HIV-specific CTL activity declined when HEPS sex workers stopped working for a period or retired.
This epitope was recognized in 3/22 HEPS sex worker controls, ML851, ML1432, and ML1601.

References

Displaying record number 1331

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HXB2 Location	Pol(313-321) RT(158-166) DNA(3021..3047)	Pol Epitope Map
Author Location
Epitope	`AIFQSSMTK`	Epitope Alignment
Species (MHC/HLA)	human(A33)
Immunogen	HIV-1 infection
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

This study examines CTL responses in HIV exposed, persistently seronegative individuals, HEPS, who eventually seroconverted -- 11/114 HEPS Nairobi sex workers eventually seroconverted, and for six of these HIV CTL reactive epitopes had been defined while seronegative.
The epidemiological factor associated with seroconversion was stopping sex work. HIV-specific CTL activity declined when HEPS sex workers stopped working for a period or retired.
This epitope was recognized in 1/22 HEPS sex worker controls, ML1668.

References

Displaying record number 1322

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HXB2 Location	Pol(330-338) RT(175-183) DNA(3072..3098)	Pol Epitope Map
Author Location	Pol( subtype A)
Epitope	`HPDIVIYQY`	Epitope Alignment
Subtype	A
Species (MHC/HLA)	human(B35)
Immunogen	HIV-1 infection
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

This study examines CTL responses in HIV exposed, persistently seronegative individuals, HEPS, who eventually seroconverted -- 11/114 HEPS Nairobi sex workers eventually seroconverted, and for six of these HIV CTL reactive epitopes had been defined while seronegative.
HPDIVIYQY or NPDIVIYQY was recognized in 1 of the 6 women (ML857), and the response was present in the last available sample prior to seroconversion, 7 months.
20/20 sequences of the infecting strain had three substitutions in this epitope, all 20 were NpQiIiyqy, and this form was not recognized by CTL from ML 857 -- this was the only case in the study where a virus carrying an unrecognized form of the epitope broke through.
The epidemiological factor associated with seroconversion was stopping sex work. HIV-specific CTL activity declined when HEPS sex workers stopped working for a period or retired.
NPDIVIYQY was recognized by 1/22 HEPS control sex workers, ML887.

References

Displaying record number 1323

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HXB2 Location	Pol(464-472) RT(309-317) DNA(3474..3500)	Pol Epitope Map
Author Location	Pol( subtype A)
Epitope	`ILKDPVHGV`	Epitope Alignment
Subtype	A
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS), escape

Notes

This study examines CTL responses in HIV exposed, persistently seronegative individuals, HEPS, who eventually seroconverted -- 11/114 HEPS Nairobi sex workers eventually seroconverted, and for six of these HIV CTL reactive epitopes had been defined while seronegative.
ILKDPVHGV or ILKEPVHGV was recognized in 1 of the 6 women (ML1760), and the response was present in the last available sample prior to seroconversion, 12 months.
20/20 sequences of the infecting strain had no substitutions in this epitope, all were ILKDPVHGV, so there was no evidence for escape.
The epidemiological factor associated with seroconversion was stopping sex work. HIV-specific CTL activity declined when HEPS sex workers stopped working for a period or retired.
This epitope was recognized by 4/22 HEPS control sex workers: ML887, ML1192, ML1250, and ML1749.

References

Displaying record number 1332

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HXB2 Location	Pol(811-819) Integrase(96-104) DNA(4515..4541)	Pol Epitope Map
Author Location	Pol
Epitope	`ETAYFILKL`	Epitope Alignment
Species (MHC/HLA)	human(A*68:02)
Immunogen	HIV-1 infection
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

This study examines CTL responses in HIV exposed, persistently seronegative individuals, HEPS, who eventually seroconverted -- 11/114 HEPS Nairobi sex workers eventually seroconverted, and for six of these HIV CTL reactive epitopes had been defined while seronegative.
The epidemiological factor associated with seroconversion was stopping sex work. HIV-specific CTL activity declined when HEPS sex workers stopped working for a period or retired.
This epitope was recognized in 1/22 HEPS sex worker controls (ML1671)

References

Displaying record number 1325

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HXB2 Location	gp160(586-593) gp41(75-82) DNA(7980..8003)	gp160 Epitope Map
Author Location	gp160
Epitope	`YLRDQQLL`	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

This study examines CTL responses in HIV exposed, persistently seronegative individuals, HEPS, who eventually seroconverted -- 11/114 HEPS Nairobi sex workers eventually seroconverted, and for six of these HIV CTL reactive epitopes had been defined while seronegative.
The epidemiological factor associated with seroconversion was stopping sex work. HIV-specific CTL activity declined when HEPS sex workers stopped working for a period or retired.
This epitope was recognized in 1/22 HEPS sex worker controls, ML887.

References

Displaying record number 1321

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HXB2 Location	Nef(68-77) DNA(8998..9027)	Nef Epitope Map
Author Location	Nef( subtype B)
Epitope	`FPVTPQVPLR`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS), escape

Notes

This study examines CTL responses in HIV exposed, persistently seronegative individuals, HEPS, who eventually seroconverted -- 11/114 HEPS Nairobi sex workers eventually seroconverted, and for six of these HIV CTL reactive epitopes had been defined while seronegative.
FPVTPQVPLR was recognized in 1 of the 6 women (ML1203), and the response was present in the last available sample prior to seroconversion, 7 months.
20/20 sequences of the infecting strain had no substitutions in this epitope, all were FPVTPQVPLR, so there was no evidence for escape.
The epidemiological factor associated with seroconversion was stopping sex work. HIV-specific CTL activity declined when HEPS sex workers stopped working for a period or retired.
This epitope was recognized in 1/22 HEPS sex worker controls, ML851.

References

Displaying record number 1324

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HXB2 Location	Nef(128-137) DNA(9178..9207)	Nef Epitope Map
Author Location	Nef
Epitope	`TPGPGIRYPL`	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

This study examines CTL responses in HIV exposed, persistently seronegative individuals, HEPS, who eventually seroconverted -- 11/114 HEPS Nairobi sex workers eventually seroconverted, and for six of these HIV CTL reactive epitopes had been defined while seronegative.
The epidemiological factor associated with seroconversion was stopping sex work. HIV-specific CTL activity declined when HEPS sex workers stopped working for a period or retired.
This epitope was recognized by 1/22 HEPS control sex workers, ML851.

References

Displaying record number 1337

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HXB2 Location	Nef(135-143) DNA(9199..9225)	Nef Epitope Map
Author Location
Epitope	`YPLTFGWCY`	Epitope Alignment
Species (MHC/HLA)	human(B49)
Immunogen	HIV-1 infection
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

This study examines CTL responses in HIV exposed, persistently seronegative individuals, HEPS, who eventually seroconverted -- 11/114 HEPS Nairobi sex workers eventually seroconverted, and for six of these HIV CTL reactive epitopes had been defined while seronegative.
The epidemiological factor associated with seroconversion was stopping sex work. HIV-specific CTL activity declined when HEPS sex workers stopped working for a period or retired.
This epitope, YPLTFGWC(Y/F), was recognized in 1/22 HEPS sex worker controls (ML1668)

References

Displaying record number 1329

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HXB2 Location	Nef(190-198) DNA(9364..9390)	Nef Epitope Map
Author Location
Epitope	`ALKHRAYEL`	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

This study examines CTL responses in HIV exposed, persistently seronegative individuals, HEPS, who eventually seroconverted -- 11/114 HEPS Nairobi sex workers eventually seroconverted, and for six of these HIV CTL reactive epitopes had been defined while seronegative.
The epidemiological factor associated with seroconversion was stopping sex work. HIV-specific CTL activity declined when HEPS sex workers stopped working for a period or retired.
This epitope was in 1/22 HEPS controls, ML1749.