Search CTL/CD8+ T-Cell Epitope Database

Found 15 matching records:

Displaying record number 61957

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HXB2 Location	Gag(148-156) p24(16-24) DNA(1231..1257)	Gag Epitope Map
Author Location	Gag(148-)
Epitope	SPRTLNAWV	Epitope Alignment
Epitope Name	AV9
Subtype	A3, B, C, CRF02_AG
Species (MHC/HLA)	human(B*07:02)
Immunogen	HIV-1 infection
Patient MHC/HLA	1127: A*02:02, A*30:02, B*07:05, B*18:01; 1214: A*02:01, A*34:02, B*44:03, B*82:01; 1224: A*30:01, B*15:03, B*42:01
Country	Denmark, Guinea-Bissau
Experimental methods	HLA binding, Intracellular cytokine staining, Tetramer binding
Keywords	binding affinity, vaccine antigen design

Notes

• 95% and 100% of untreated, asymptomatic HIV-1-infected patients, from Guinea-Bissau and Denmark respectively, were able to subdominantly recognize 15 predicted CTL epitopes restricted by at least one of the 5 most common HLA supertypes, HLA-A*01, -A*02, -A*03, -B*07 and -B*44.
• Epitope AV9, SPRTLNAWV, predicted and validated to be restricted by supertype B07, was found across geographic regions in 94% of HIV-1 sequences in Denmark clade-B and 98% Guinea-Bissau/Western Africa subtypes A3, C and CRF02_AG. Its equivalent peptide, Gag148 was able to elicit cytokine production and bound the following HLA alleles moderately or well: B*0702 (B07 supertype).

References

Karlsson2012 Ingrid Karlsson, Henrik Kløverpris, Kristoffer Jarlov Jensen, Anette Stryhn, Søren Buus, Annika Karlsson, Lasse Vinner, Philip Goulder, and Anders Fomsgaard. Identification of Conserved Subdominant HIV Type 1 CD8+ T Cell Epitopes Restricted within Common HLA Supertypes for Therapeutic HIV Type 1 Vaccines. AIDS Res. Hum. Retroviruses, 28(11):1434-1443, Nov 2012. PubMed ID: 22747336. Show all entries for this paper.

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Displaying record number 61947

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HXB2 Location	Gag(150-158) p24(18-26) DNA(1237..1263)	Gag Epitope Map
Author Location	Gag(150-)
Epitope	RTLNAWVKV	Epitope Alignment
Epitope Name	RV9
Subtype	A3, B, C, CRF02_AG
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Denmark, Guinea-Bissau
Experimental methods	HLA binding, Intracellular cytokine staining, Tetramer binding
Keywords	binding affinity, vaccine antigen design, non-susceptible form

Notes

• 95% and 100% of untreated, asymptomatic HIV-1-infected patients, from Guinea-Bissau and Denmark respectively, were able to subdominantly recognize 15 predicted CTL epitopes restricted by at least one of the 5 most common HLA supertypes, HLA-A*01, -A*02, -A*03, -B*07 and -B*44.
• Epitope RV9, RTLNAWVKV, predicted and validated to be restricted by supertype A02, was found across geographic regions in 100% of HIV-1 sequences in Denmark clade-B and 88% Guinea-Bissau/Western Africa subtypes A3, C and CRF02_AG. Its equivalent peptide, Gag150 of the Gag/Pol A02 pool did not elicit cytokine production.

References

Karlsson2012 Ingrid Karlsson, Henrik Kløverpris, Kristoffer Jarlov Jensen, Anette Stryhn, Søren Buus, Annika Karlsson, Lasse Vinner, Philip Goulder, and Anders Fomsgaard. Identification of Conserved Subdominant HIV Type 1 CD8+ T Cell Epitopes Restricted within Common HLA Supertypes for Therapeutic HIV Type 1 Vaccines. AIDS Res. Hum. Retroviruses, 28(11):1434-1443, Nov 2012. PubMed ID: 22747336. Show all entries for this paper.

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Displaying record number 61948

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HXB2 Location	Gag(433-440) p2p7p1p6(70-77) DNA(2086..2109)	Gag Epitope Map
Author Location	Gag(433-)
Epitope	FLGKIWPS	Epitope Alignment
Epitope Name	FS8
Subtype	A3, B, C, CRF02_AG
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Denmark, Guinea-Bissau
Experimental methods	HLA binding, Intracellular cytokine staining, Tetramer binding
Keywords	binding affinity, vaccine antigen design, non-susceptible form

Notes

• 95% and 100% of untreated, asymptomatic HIV-1-infected patients, from Guinea-Bissau and Denmark respectively, were able to subdominantly recognize 15 predicted CTL epitopes restricted by at least one of the 5 most common HLA supertypes, HLA-A*01, -A*02, -A*03, -B*07 and -B*44.
• Epitope FS8, FLGKIWPS, predicted and validated to be restricted by supertype A02, was found across geographic regions in 83% of HIV-1 sequences in Denmark clade-B and 88% Guinea-Bissau/Western Africa subtypes A3, C and CRF02_AG. Its equivalent peptide, Gag433 of the Gag/Pol A02 pool did not elicit cytokine production.

References

Karlsson2012 Ingrid Karlsson, Henrik Kløverpris, Kristoffer Jarlov Jensen, Anette Stryhn, Søren Buus, Annika Karlsson, Lasse Vinner, Philip Goulder, and Anders Fomsgaard. Identification of Conserved Subdominant HIV Type 1 CD8+ T Cell Epitopes Restricted within Common HLA Supertypes for Therapeutic HIV Type 1 Vaccines. AIDS Res. Hum. Retroviruses, 28(11):1434-1443, Nov 2012. PubMed ID: 22747336. Show all entries for this paper.

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Displaying record number 61958

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HXB2 Location	Pol(311-319) RT(156-164) DNA(3015..3041)	Pol Epitope Map
Author Location	Pol(311-)
Epitope	SPAIFQSSM	Epitope Alignment
Epitope Name	SM9
Subtype	A3, B, C, CRF02_AG
Species (MHC/HLA)	human(B*07:02, B*35:01)
Immunogen	HIV-1 infection
Patient MHC/HLA	1127: A*02:02, A*30:02, B*07:05, B*18:01; 1214: A*02:01, A*34:02, B*44:03, B*82:01; 1224: A*30:01, B*15:03, B*42:01
Country	Denmark, Guinea-Bissau
Experimental methods	HLA binding, Intracellular cytokine staining, Tetramer binding
Keywords	binding affinity, vaccine antigen design

Notes

• 95% and 100% of untreated, asymptomatic HIV-1-infected patients, from Guinea-Bissau and Denmark respectively, were able to subdominantly recognize 15 predicted CTL epitopes restricted by at least one of the 5 most common HLA supertypes, HLA-A*01, -A*02, -A*03, -B*07 and -B*44.
• Epitope SM9, SPAIFQSSM, predicted and validated to be restricted by supertype B07, was found across geographic regions in 94% of HIV-1 sequences in Denmark clade-B and 49% Guinea-Bissau/Western Africa subtypes A3, C and CRF02_AG. Its equivalent peptide, Pol311 was able to elicit cytokine production and bound the following HLA alleles moderately or well: B*0702, B*3501 (B07 supertype).

References

Karlsson2012 Ingrid Karlsson, Henrik Kløverpris, Kristoffer Jarlov Jensen, Anette Stryhn, Søren Buus, Annika Karlsson, Lasse Vinner, Philip Goulder, and Anders Fomsgaard. Identification of Conserved Subdominant HIV Type 1 CD8+ T Cell Epitopes Restricted within Common HLA Supertypes for Therapeutic HIV Type 1 Vaccines. AIDS Res. Hum. Retroviruses, 28(11):1434-1443, Nov 2012. PubMed ID: 22747336. Show all entries for this paper.

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Displaying record number 61952

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HXB2 Location	Pol(313-321) RT(158-166) DNA(3021..3047)	Pol Epitope Map
Author Location	Pol(973-)
Epitope	AIFQSSMTK	Epitope Alignment
Epitope Name	AK9
Subtype	A3, B, C, CRF02_AG
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Denmark, Guinea-Bissau
Experimental methods	HLA binding, Intracellular cytokine staining, Tetramer binding
Keywords	binding affinity, vaccine antigen design, non-susceptible form

Notes

• 95% and 100% of untreated, asymptomatic HIV-1-infected patients, from Guinea-Bissau and Denmark respectively, were able to subdominantly recognize 15 predicted CTL epitopes restricted by at least one of the 5 most common HLA supertypes, HLA-A*01, -A*02, -A*03, -B*07 and -B*44.
• Epitope AK9, AIFQSSMTK, predicted and validated to be restricted by supertype A03, was found across geographic regions in 89% of HIV-1 sequences in Denmark clade-B and 40% Guinea-Bissau/Western Africa subtypes A3, C and CRF02_AG. Its equivalent peptide, Pol313 of the A03 pool did not elicit cytokine production, but bound the following HLA alleles moderately or well: A*3002, A*2902, A*3201 (A01 supertype); A*0301, A*1101, A*7401 (A03 supertype); A*3001 (A0103 supertype).

References

Karlsson2012 Ingrid Karlsson, Henrik Kløverpris, Kristoffer Jarlov Jensen, Anette Stryhn, Søren Buus, Annika Karlsson, Lasse Vinner, Philip Goulder, and Anders Fomsgaard. Identification of Conserved Subdominant HIV Type 1 CD8+ T Cell Epitopes Restricted within Common HLA Supertypes for Therapeutic HIV Type 1 Vaccines. AIDS Res. Hum. Retroviruses, 28(11):1434-1443, Nov 2012. PubMed ID: 22747336. Show all entries for this paper.

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Displaying record number 61959

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HXB2 Location	Pol(592-600) RT(437-445) DNA(3858..3884)	Pol Epitope Map
Author Location	Pol(592-)
Epitope	AETFYVDGA	Epitope Alignment
Epitope Name	AA9
Subtype	A3, B, C, CRF02_AG
Species (MHC/HLA)	human(B*45:01, B*50:01)
Immunogen	HIV-1 infection
Patient MHC/HLA	1108: ; 1115: A*02:01, A*68:01, B*50:01, B*58:01
Country	Denmark, Guinea-Bissau
Experimental methods	HLA binding, Intracellular cytokine staining, Tetramer binding
Keywords	binding affinity, vaccine antigen design

Notes

• 95% and 100% of untreated, asymptomatic HIV-1-infected patients, from Guinea-Bissau and Denmark respectively, were able to subdominantly recognize 15 predicted CTL epitopes restricted by at least one of the 5 most common HLA supertypes, HLA-A*01, -A*02, -A*03, -B*07 and -B*44.
• Epitope AA9, AETFYVDGA, predicted and validated to be restricted by supertype B44, was found across geographic regions in 94% of HIV-1 sequences in Denmark clade-B and 86% Guinea-Bissau/Western Africa subtypes A3, C and CRF02_AG. Its equivalent peptide, Pol311 was able to elicit cytokine production and bound the following HLA alleles moderately or well: B*4501, B*5001 (B44 supertype).

References

Karlsson2012 Ingrid Karlsson, Henrik Kløverpris, Kristoffer Jarlov Jensen, Anette Stryhn, Søren Buus, Annika Karlsson, Lasse Vinner, Philip Goulder, and Anders Fomsgaard. Identification of Conserved Subdominant HIV Type 1 CD8+ T Cell Epitopes Restricted within Common HLA Supertypes for Therapeutic HIV Type 1 Vaccines. AIDS Res. Hum. Retroviruses, 28(11):1434-1443, Nov 2012. PubMed ID: 22747336. Show all entries for this paper.

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Displaying record number 61949

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HXB2 Location	Pol(606-614) RT(451-459) DNA(3900..3926)	Pol Epitope Map
Author Location	Pol(606-)
Epitope	KLGKAGYVT	Epitope Alignment
Epitope Name	KT9
Subtype	A3, B, C, CRF02_AG
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Denmark, Guinea-Bissau
Experimental methods	HLA binding, Intracellular cytokine staining, Tetramer binding
Keywords	binding affinity, vaccine antigen design, non-susceptible form

Notes

• 95% and 100% of untreated, asymptomatic HIV-1-infected patients, from Guinea-Bissau and Denmark respectively, were able to subdominantly recognize 15 predicted CTL epitopes restricted by at least one of the 5 most common HLA supertypes, HLA-A*01, -A*02, -A*03, -B*07 and -B*44.
• Epitope KT9, KLGKAGYVT, predicted and validated to be restricted by supertype A02, was found across geographic regions in 61% of HIV-1 sequences in Denmark clade-B and 79% Guinea-Bissau/Western Africa subtypes A3, C and CRF02_AG. Its equivalent peptide, Pol606 of the Gag/Pol A02 pool did not elicit cytokine production.

References

Karlsson2012 Ingrid Karlsson, Henrik Kløverpris, Kristoffer Jarlov Jensen, Anette Stryhn, Søren Buus, Annika Karlsson, Lasse Vinner, Philip Goulder, and Anders Fomsgaard. Identification of Conserved Subdominant HIV Type 1 CD8+ T Cell Epitopes Restricted within Common HLA Supertypes for Therapeutic HIV Type 1 Vaccines. AIDS Res. Hum. Retroviruses, 28(11):1434-1443, Nov 2012. PubMed ID: 22747336. Show all entries for this paper.

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Displaying record number 61946

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HXB2 Location	Pol(934-942) Integrase(219-227) DNA(4884..4910)	Pol Epitope Map
Author Location	Pol(934-)
Epitope	KIQNFRVYY	Epitope Alignment
Epitope Name	KY9
Subtype	A3, B, C, CRF02_AG
Species (MHC/HLA)	human(A*03:01, A*11:01, A*29:02, A*30:01, A*30:02, A*32:01, A*80:01)
Immunogen	HIV-1 infection
Patient MHC/HLA	1213: A*30:01, A*30:02, B*07:02, B*58:01
Country	Denmark, Guinea-Bissau
Experimental methods	HLA binding, Intracellular cytokine staining, Tetramer binding
Keywords	binding affinity, vaccine antigen design

Notes

• 95% and 100% of untreated, asymptomatic HIV-1-infected patients, from Guinea-Bissau and Denmark respectively, were able to subdominantly recognize 15 predicted CTL epitopes restricted by at least one of the 5 most common HLA supertypes, HLA-A*01, -A*02, -A*03, -B*07 and -B*44.
• Epitope KY9, KIQNFRVYY, predicted and validated to be restricted by supertype A01, was found across geographic regions in 100% of HIV-1 sequences in Denmark clade-B and 86% Guinea-Bissau/Western Africa subtypes A3, C and CRF02_AG. Its equivalent peptide, Pol934 was able to elicit cytokine production and bound the following HLA alleles moderately or well: A*3002, A*2902, A*3201 (A01 supertype); A*0301, A*1101, A*8001 (A03 supertype); A*3001 (A0103 supertype).

References

Karlsson2012 Ingrid Karlsson, Henrik Kløverpris, Kristoffer Jarlov Jensen, Anette Stryhn, Søren Buus, Annika Karlsson, Lasse Vinner, Philip Goulder, and Anders Fomsgaard. Identification of Conserved Subdominant HIV Type 1 CD8+ T Cell Epitopes Restricted within Common HLA Supertypes for Therapeutic HIV Type 1 Vaccines. AIDS Res. Hum. Retroviruses, 28(11):1434-1443, Nov 2012. PubMed ID: 22747336. Show all entries for this paper.

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Displaying record number 61951

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HXB2 Location	Pol(973-981) Integrase(258-266) DNA(5001..5027)	Pol Epitope Map
Author Location	Pol(973-)
Epitope	KVVPRRKAK	Epitope Alignment
Epitope Name	KK9
Subtype	A3, B, C, CRF02_AG
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Denmark, Guinea-Bissau
Experimental methods	HLA binding, Intracellular cytokine staining, Tetramer binding
Keywords	binding affinity, vaccine antigen design, non-susceptible form

Notes

• 95% and 100% of untreated, asymptomatic HIV-1-infected patients, from Guinea-Bissau and Denmark respectively, were able to subdominantly recognize 15 predicted CTL epitopes restricted by at least one of the 5 most common HLA supertypes, HLA-A*01, -A*02, -A*03, -B*07 and -B*44.
• Epitope KK9, KVVPRRKAK, predicted and validated to be restricted by supertype A03, was found across geographic regions in 94% of HIV-1 sequences in Denmark clade-B and 88% Guinea-Bissau/Western Africa subtypes A3, C and CRF02_AG. Its equivalent peptide, Pol973 of the A03 pool did not elicit cytokine production, but bound the following HLA alleles moderately or well: A*3002, A*2902, A*3201 (A01 supertype); A*0301, A*1101 (A03 supertype); A*3001 (A0103 supertype).

References

Karlsson2012 Ingrid Karlsson, Henrik Kløverpris, Kristoffer Jarlov Jensen, Anette Stryhn, Søren Buus, Annika Karlsson, Lasse Vinner, Philip Goulder, and Anders Fomsgaard. Identification of Conserved Subdominant HIV Type 1 CD8+ T Cell Epitopes Restricted within Common HLA Supertypes for Therapeutic HIV Type 1 Vaccines. AIDS Res. Hum. Retroviruses, 28(11):1434-1443, Nov 2012. PubMed ID: 22747336. Show all entries for this paper.

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Displaying record number 61954

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HXB2 Location	Vif(23-31) DNA(5107..5133)	Vif Epitope Map
Author Location	Vif(23-)
Epitope	SLVKHHMYI	Epitope Alignment
Epitope Name	SI9
Subtype	A3, B, C, CRF02_AG
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	1100: A*03:01, A*23:01, B*07:02, B*15:03; 1127: A*02:02, A*30:02, B*07:05, B*18:01; 1211: A*02:01, B*07:05, B*08:01; 1214: A*02:01, A*34:02, B*44:03, B*82:01
Country	Denmark, Guinea-Bissau
Experimental methods	HLA binding, Intracellular cytokine staining, Tetramer binding
Keywords	binding affinity, vaccine antigen design

Notes

• 95% and 100% of untreated, asymptomatic HIV-1-infected patients, from Guinea-Bissau and Denmark respectively, were able to subdominantly recognize 15 predicted CTL epitopes restricted by at least one of the 5 most common HLA supertypes, HLA-A*01, -A*02, -A*03, -B*07 and -B*44.
• Epitope SI9, SLVKHHMYI, predicted and validated to be restricted by supertype A02, was found across geographic regions in 50% of HIV-1 sequences in Denmark clade-B and 56% Guinea-Bissau/Western Africa subtypes A3, C and CRF02_AG. Its equivalent peptide, Vif23 was able to elicit cytokine production.

References

Karlsson2012 Ingrid Karlsson, Henrik Kløverpris, Kristoffer Jarlov Jensen, Anette Stryhn, Søren Buus, Annika Karlsson, Lasse Vinner, Philip Goulder, and Anders Fomsgaard. Identification of Conserved Subdominant HIV Type 1 CD8+ T Cell Epitopes Restricted within Common HLA Supertypes for Therapeutic HIV Type 1 Vaccines. AIDS Res. Hum. Retroviruses, 28(11):1434-1443, Nov 2012. PubMed ID: 22747336. Show all entries for this paper.

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Displaying record number 61955

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HXB2 Location	Vif(101-109) DNA(5341..5367)	Vif Epitope Map
Author Location	Vif(101-)
Epitope	GLADQLIHM	Epitope Alignment
Epitope Name	GM9
Subtype	A3, B, C, CRF02_AG
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	1100: A*03:01, A*23:01, B*07:02, B*15:03; 1127: A*02:02, A*30:02, B*07:05, B*18:01; 1211: A*02:01, B*07:05, B*08:01; 1214: A*02:01, A*34:02, B*44:03, B*82:01
Country	Denmark, Guinea-Bissau
Experimental methods	HLA binding, Intracellular cytokine staining, Tetramer binding
Keywords	binding affinity, vaccine antigen design

Notes

• 95% and 100% of untreated, asymptomatic HIV-1-infected patients, from Guinea-Bissau and Denmark respectively, were able to subdominantly recognize 15 predicted CTL epitopes restricted by at least one of the 5 most common HLA supertypes, HLA-A*01, -A*02, -A*03, -B*07 and -B*44.
• Epitope GM9, GLADQLIHM, predicted and validated to be restricted by supertype A02, was found across geographic regions in 56% of HIV-1 sequences in Denmark clade-B and 65% Guinea-Bissau/Western Africa subtypes A3, C and CRF02_AG. Its equivalent peptide, Vif101 was able to elicit cytokine production.

References

Karlsson2012 Ingrid Karlsson, Henrik Kløverpris, Kristoffer Jarlov Jensen, Anette Stryhn, Søren Buus, Annika Karlsson, Lasse Vinner, Philip Goulder, and Anders Fomsgaard. Identification of Conserved Subdominant HIV Type 1 CD8+ T Cell Epitopes Restricted within Common HLA Supertypes for Therapeutic HIV Type 1 Vaccines. AIDS Res. Hum. Retroviruses, 28(11):1434-1443, Nov 2012. PubMed ID: 22747336. Show all entries for this paper.

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Displaying record number 61953

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HXB2 Location	Vpu(66-74) DNA(6257..6283)	Vpu Epitope Map
Author Location	Vpu(66-)
Epitope	ALVEMGHHA	Epitope Alignment
Epitope Name	AA9
Subtype	A3, B, C, CRF02_AG
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	1100: A*03:01, A*23:01, B*07:02, B*15:03; 1127: A*02:02, A*30:02, B*07:05, B*18:01; 1211: A*02:01, B*07:05, B*08:01; 1214: A*02:01, A*34:02, B*44:03, B*82:01
Country	Denmark, Guinea-Bissau
Experimental methods	HLA binding, Intracellular cytokine staining, Tetramer binding
Keywords	binding affinity, vaccine antigen design

Notes

• 95% and 100% of untreated, asymptomatic HIV-1-infected patients, from Guinea-Bissau and Denmark respectively, were able to subdominantly recognize 15 predicted CTL epitopes restricted by at least one of the 5 most common HLA supertypes, HLA-A*01, -A*02, -A*03, -B*07 and -B*44.
• Epitope AA9, ALVEMGHHA, predicted and validated to be restricted by supertype A02, was found across geographic regions in 33% of HIV-1 sequences in Denmark clade-B and 0% Guinea-Bissau/Western Africa subtypes A3, C and CRF02_AG. Its equivalent peptide, Vpu66 was able to elicit cytokine production.

References

Karlsson2012 Ingrid Karlsson, Henrik Kløverpris, Kristoffer Jarlov Jensen, Anette Stryhn, Søren Buus, Annika Karlsson, Lasse Vinner, Philip Goulder, and Anders Fomsgaard. Identification of Conserved Subdominant HIV Type 1 CD8+ T Cell Epitopes Restricted within Common HLA Supertypes for Therapeutic HIV Type 1 Vaccines. AIDS Res. Hum. Retroviruses, 28(11):1434-1443, Nov 2012. PubMed ID: 22747336. Show all entries for this paper.

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Displaying record number 61950

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HXB2 Location	gp160(67-75) gp120(67-75) DNA(6423..6449)	gp160 Epitope Map
Author Location	Env(67-)
Epitope	NVWATHACV	Epitope Alignment
Epitope Name	NV9
Subtype	A3, B, C, CRF02_AG
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Denmark, Guinea-Bissau
Experimental methods	HLA binding, Intracellular cytokine staining, Tetramer binding
Keywords	binding affinity, vaccine antigen design, non-susceptible form

Notes

• 95% and 100% of untreated, asymptomatic HIV-1-infected patients, from Guinea-Bissau and Denmark respectively, were able to subdominantly recognize 15 predicted CTL epitopes restricted by at least one of the 5 most common HLA supertypes, HLA-A*01, -A*02, -A*03, -B*07 and -B*44.
• Epitope NV9, NVWATHACV, predicted and validated to be restricted by supertype A02, was found across geographic regions in 94% of HIV-1 sequences in Denmark clade-B and 100% Guinea-Bissau/Western Africa subtypes A3, C and CRF02_AG. Its equivalent peptide, Env67 of the Vif/Vpu A02 pool did not elicit cytokine production.

References

Karlsson2012 Ingrid Karlsson, Henrik Kløverpris, Kristoffer Jarlov Jensen, Anette Stryhn, Søren Buus, Annika Karlsson, Lasse Vinner, Philip Goulder, and Anders Fomsgaard. Identification of Conserved Subdominant HIV Type 1 CD8+ T Cell Epitopes Restricted within Common HLA Supertypes for Therapeutic HIV Type 1 Vaccines. AIDS Res. Hum. Retroviruses, 28(11):1434-1443, Nov 2012. PubMed ID: 22747336. Show all entries for this paper.

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Displaying record number 61956

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HXB2 Location	Nef(73-81) DNA(9013..9039)	Nef Epitope Map
Author Location	Nef(73-)
Epitope	QVPLRPMTY	Epitope Alignment
Epitope Name	QY9
Subtype	A3, B, C, CRF02_AG
Species (MHC/HLA)	human(A*80:01)
Immunogen	HIV-1 infection
Patient MHC/HLA	1213: A*30:01, A*30:02, B*07:02, B*58:01
Country	Denmark, Guinea-Bissau
Experimental methods	HLA binding, Intracellular cytokine staining, Tetramer binding
Keywords	binding affinity, vaccine antigen design

Notes

• 95% and 100% of untreated, asymptomatic HIV-1-infected patients, from Guinea-Bissau and Denmark respectively, were able to subdominantly recognize 15 predicted CTL epitopes restricted by at least one of the 5 most common HLA supertypes, HLA-A*01, -A*02, -A*03, -B*07 and -B*44.
• Epitope QY9, QVPLRPMTY, predicted and validated to be restricted by supertype B07, was found across geographic regions in 83% of HIV-1 sequences in Denmark clade-B and 65% Guinea-Bissau/Western Africa subtypes A3, C and CRF02_AG. Its equivalent peptide, Nef73 was able to elicit cytokine production and bound the following HLA alleles moderately or well: A*8001 (B07 supertype).

References

Karlsson2012 Ingrid Karlsson, Henrik Kløverpris, Kristoffer Jarlov Jensen, Anette Stryhn, Søren Buus, Annika Karlsson, Lasse Vinner, Philip Goulder, and Anders Fomsgaard. Identification of Conserved Subdominant HIV Type 1 CD8+ T Cell Epitopes Restricted within Common HLA Supertypes for Therapeutic HIV Type 1 Vaccines. AIDS Res. Hum. Retroviruses, 28(11):1434-1443, Nov 2012. PubMed ID: 22747336. Show all entries for this paper.

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Displaying record number 61960

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HXB2 Location	Nef(107-115) DNA(9115..9141)	Nef Epitope Map
Author Location	Nef(107-)
Epitope	QEILDLWVY	Epitope Alignment
Epitope Name	QY9
Subtype	A3, B, C, CRF02_AG
Species (MHC/HLA)	human(B*18:01, B*44:02)
Immunogen	HIV-1 infection
Patient MHC/HLA	1108: ; 1115: A*02:01, A*68:01, B*50:01, B*58:01
Country	Denmark, Guinea-Bissau
Experimental methods	HLA binding, Intracellular cytokine staining, Tetramer binding
Keywords	binding affinity, vaccine antigen design

Notes

• 95% and 100% of untreated, asymptomatic HIV-1-infected patients, from Guinea-Bissau and Denmark respectively, were able to subdominantly recognize 15 predicted CTL epitopes restricted by at least one of the 5 most common HLA supertypes, HLA-A*01, -A*02, -A*03, -B*07 and -B*44.
• Epitope QY9, QEILDLWVY, predicted and validated to be restricted by supertype B44, was found across geographic regions in 17% of HIV-1 sequences in Denmark clade-B and 65% Guinea-Bissau/Western Africa subtypes A3, C and CRF02_AG. Its equivalent peptide, Pol311 was able to elicit cytokine production and bound the following HLA alleles moderately or well: B*1801, B*4402 (B44 supertype).

References

Karlsson2012 Ingrid Karlsson, Henrik Kløverpris, Kristoffer Jarlov Jensen, Anette Stryhn, Søren Buus, Annika Karlsson, Lasse Vinner, Philip Goulder, and Anders Fomsgaard. Identification of Conserved Subdominant HIV Type 1 CD8+ T Cell Epitopes Restricted within Common HLA Supertypes for Therapeutic HIV Type 1 Vaccines. AIDS Res. Hum. Retroviruses, 28(11):1434-1443, Nov 2012. PubMed ID: 22747336. Show all entries for this paper.

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