Search CTL/CD8+ T-Cell Epitope Database

Found 5 matching records:

Displaying record number 54399

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HXB2 Location	Gag(1-10) p17(1-10) DNA(790..819)	Gag Epitope Map
Author Location	Gag
Epitope	MGARASVLSG	Epitope Alignment
Subtype	CRF01_AE
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Thailand
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords	optimal epitope

Notes

• T cell responses in CRF01_AE infected individuals from Thailand were studied.
• A single peptide elicited IFN-gamma responses from three subjects and may be an A*1101 binding peptide. It may contain a novel T cell epitope, MGARASVLSG.

References

Kantakamalakul2006 Wannee Kantakamalakul, Mark De Souza, Sasitorn Bejrachandra, Silawun Ampol, Josephine Cox, and Ruengpung Sutthent. Identification of a Novel HIV Type 1 CRF01\_AE Cytotoxic T Lymphocyte (CTL) Epitope Restricted by an HLA-Cw0602 Allele and a Novel HLA-A0206/Peptide Restriction. AIDS Res. Hum. Retroviruses, 22(12):1271-1282, Dec 2006. PubMed ID: 17209771. Show all entries for this paper.

Displaying record number 54207

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HXB2 Location	Gag(341-349) p24(209-217) DNA(1810..1836)	Gag Epitope Map
Author Location	Gag
Epitope	ATLEEMMTA	Epitope Alignment
Subtype	CRF01_AE
Species (MHC/HLA)	human(A*02:06)
Immunogen	HIV-1 infection
Country	Thailand
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords	optimal epitope

Notes

• T cell responses in CRF01_AE infected individuals from Thailand were studied. Fine mapping of the peptides containing potentially novel epitopes revealed novel restriction of a previously identified epitope in this population.
• A novel restriction allele for this epitope (ATLEEMMTA) was found, HLA-A*0206.

References

Kantakamalakul2006 Wannee Kantakamalakul, Mark De Souza, Sasitorn Bejrachandra, Silawun Ampol, Josephine Cox, and Ruengpung Sutthent. Identification of a Novel HIV Type 1 CRF01\_AE Cytotoxic T Lymphocyte (CTL) Epitope Restricted by an HLA-Cw0602 Allele and a Novel HLA-A0206/Peptide Restriction. AIDS Res. Hum. Retroviruses, 22(12):1271-1282, Dec 2006. PubMed ID: 17209771. Show all entries for this paper.

Displaying record number 54396

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HXB2 Location	gp160(218-228) gp120(218-228) DNA(6876..6908)	gp160 Epitope Map
Author Location	Env(218-228)
Epitope	CTPAGYAILKC	Epitope Alignment
Subtype	CRF01_AE
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Thailand
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords	optimal epitope

Notes

• T cell responses in CRF01_AE infected individuals from Thailand were studied.
• Based on two overlapping peptide sequences that were both reactive, as well as conserved anchor residues, this peptide is suggested to contain an epitope, CTPAGYAILKC.
• CTPAGYAILKC may be a novel epitope that is promiscuously presented by HLA-A*0201, -A*0206 and -A*0207 as it matches the published binding motifs for the HLA, and is present in subjects recognizing the epitope.

References

Kantakamalakul2006 Wannee Kantakamalakul, Mark De Souza, Sasitorn Bejrachandra, Silawun Ampol, Josephine Cox, and Ruengpung Sutthent. Identification of a Novel HIV Type 1 CRF01\_AE Cytotoxic T Lymphocyte (CTL) Epitope Restricted by an HLA-Cw0602 Allele and a Novel HLA-A0206/Peptide Restriction. AIDS Res. Hum. Retroviruses, 22(12):1271-1282, Dec 2006. PubMed ID: 17209771. Show all entries for this paper.

Displaying record number 54206

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HXB2 Location	gp160(280-288) gp120(280-288) DNA(7062..7088)	gp160 Epitope Map
Author Location	Env
Epitope	NAKTIIVHL	Epitope Alignment
Subtype	CRF01_AE
Species (MHC/HLA)	human(C*06:02)
Immunogen	HIV-1 infection
Country	Thailand
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords	immunodominance, optimal epitope

Notes

• T cell responses in CRF01_AE infected individuals from Thailand were studied.
• Fine mapping of the peptide NAKTIIVHL, revealed a novel Cw*0602-restricted epitope.

References

Kantakamalakul2006 Wannee Kantakamalakul, Mark De Souza, Sasitorn Bejrachandra, Silawun Ampol, Josephine Cox, and Ruengpung Sutthent. Identification of a Novel HIV Type 1 CRF01\_AE Cytotoxic T Lymphocyte (CTL) Epitope Restricted by an HLA-Cw0602 Allele and a Novel HLA-A0206/Peptide Restriction. AIDS Res. Hum. Retroviruses, 22(12):1271-1282, Dec 2006. PubMed ID: 17209771. Show all entries for this paper.

Displaying record number 54397

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HXB2 Location	gp160(555-565) gp41(44-54) DNA(7887..7919)	gp160 Epitope Map
Author Location	gp41
Epitope	LLRAIEAQQHL	Epitope Alignment
Subtype	CRF01_AE
Species (MHC/HLA)	human(A11.1)
Immunogen	HIV-1 infection
Country	Thailand
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords	optimal epitope

Notes

• T cell responses in CRF01_AE infected individuals from Thailand were studied.
• Based on two overlapping peptide sequences that were both reactive, as well as conserved anchor residues, this peptide is suggested to contain a previously defined epitope, RAIEAQQHL, that is reported to be restricted by HLA-B51, -Cw*0304 and -Cw*0801.

References

Kantakamalakul2006 Wannee Kantakamalakul, Mark De Souza, Sasitorn Bejrachandra, Silawun Ampol, Josephine Cox, and Ruengpung Sutthent. Identification of a Novel HIV Type 1 CRF01\_AE Cytotoxic T Lymphocyte (CTL) Epitope Restricted by an HLA-Cw0602 Allele and a Novel HLA-A0206/Peptide Restriction. AIDS Res. Hum. Retroviruses, 22(12):1271-1282, Dec 2006. PubMed ID: 17209771. Show all entries for this paper.