HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 4 matching records:

Displaying record number 631

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location gp120(37-46 LAI)
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Subtype B
Species (MHC/HLA) human(A*0301)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type vaccinia
Vaccine component gp160

Notes

References

Johnson1994 R. P. Johnson, S. A. Hammond, A. Trocha, R. F. Siliciano, and B. D. Walker. Induction of a Major Histocompatibility Complex Class I-Restricted Cytotoxic T-Lymphocyte Response to a Highly Conserved Region of Human Immunodeficiency Virus Type 1 (HIV-1) gp120 in Seronegative Humans Immunized with a Candidate HIV-1 Vaccine. J. Virol., 68:3145-3153, 1994. In two volunteers, immunization with a single strain of HIV-1 induced CD4+ and CD8+ CTL that are specific for multiple conserved regions of HIV-1 and would be expected to recognize a broad range of viral isolates. The immunodominant gp120 epitope, gp120 TVYYGVPVWK, elicited CD8+ HLA-A3.1 restricted CTL, and this epitope is highly conserved. CTL specific for this epitope could lyse target cells sensitized with all known natural sequence variants. Additionally, CD8+ HLA-B35 and CD8+ HLA-B18 restricted epitopes were defined as well as two CD4+ cytotoxic T-cell gp120 epitopes: ITQACPKVSFEPIPHYCAPAGFAI and NNTLKQIDSKLREQFG. PubMed ID: 7908700. Show all entries for this paper.


Displaying record number 680

HXB2 Location gp160(201-225)
gp120(201-225)
DNA(6825..6899)
gp160 Epitope Map
Author Location gp120(201-225 LAI)
Epitope ITQACPKVSFEPIPHYCAPAGFAI Epitope Alignment
Subtype B
Species (MHC/HLA) human
Immunogen vaccine
Experimental methods  
Keywords CD4+ CTL

Vaccine Details

Vaccine type vaccinia
Vaccine component gp160

Notes

References

Johnson1994 R. P. Johnson, S. A. Hammond, A. Trocha, R. F. Siliciano, and B. D. Walker. Induction of a Major Histocompatibility Complex Class I-Restricted Cytotoxic T-Lymphocyte Response to a Highly Conserved Region of Human Immunodeficiency Virus Type 1 (HIV-1) gp120 in Seronegative Humans Immunized with a Candidate HIV-1 Vaccine. J. Virol., 68:3145-3153, 1994. In two volunteers, immunization with a single strain of HIV-1 induced CD4+ and CD8+ CTL that are specific for multiple conserved regions of HIV-1 and would be expected to recognize a broad range of viral isolates. The immunodominant gp120 epitope, gp120 TVYYGVPVWK, elicited CD8+ HLA-A3.1 restricted CTL, and this epitope is highly conserved. CTL specific for this epitope could lyse target cells sensitized with all known natural sequence variants. Additionally, CD8+ HLA-B35 and CD8+ HLA-B18 restricted epitopes were defined as well as two CD4+ cytotoxic T-cell gp120 epitopes: ITQACPKVSFEPIPHYCAPAGFAI and NNTLKQIDSKLREQFG. PubMed ID: 7908700. Show all entries for this paper.

Johnson1994c R. P. Johnson, S. A. Hammond, A. Trocha, R. F. Siliciano, and B. D. Walker. Epitope Specificity of MHC Restricted Cytotoxic T Lymphocytes Induced by Candidate HIV-1 Vaccine. AIDS Res. Hum. Retroviruses, 10, Supp 2:S73-S75, 1994. Volunteers were immunized with recombinant vaccinia virus expressing HIV-1 gp160 (vac-env) and boosted with recombinant gp160 (rgp160). CTL clones were analyzed for HLA restriction and specificity. An immunodominant HLA-A3.1 restricted epitope was observed that showed very little sequence variation among B subtype sequences, (TVYYGVPVWK). Naturally occurring variants of this peptide were able to stimulate reactivity. Two additional CD8+ CTL epitopes from vaccinees were characterized, as well as two CD4+ CTL epitopes. PubMed ID: 7532425. Show all entries for this paper.


Displaying record number 773

HXB2 Location gp160(339-354)
gp120(339-354)
DNA(7239..7286)
gp160 Epitope Map
Author Location gp120(339-361 LAI)
Epitope NNTLKQIDSKLREQFG Epitope Alignment
NNTLKQIDSKLREQFG epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen vaccine
Experimental methods  
Keywords CD4+ CTL

Vaccine Details

Vaccine type vaccinia
Vaccine component gp160

Notes

References

Johnson1994 R. P. Johnson, S. A. Hammond, A. Trocha, R. F. Siliciano, and B. D. Walker. Induction of a Major Histocompatibility Complex Class I-Restricted Cytotoxic T-Lymphocyte Response to a Highly Conserved Region of Human Immunodeficiency Virus Type 1 (HIV-1) gp120 in Seronegative Humans Immunized with a Candidate HIV-1 Vaccine. J. Virol., 68:3145-3153, 1994. In two volunteers, immunization with a single strain of HIV-1 induced CD4+ and CD8+ CTL that are specific for multiple conserved regions of HIV-1 and would be expected to recognize a broad range of viral isolates. The immunodominant gp120 epitope, gp120 TVYYGVPVWK, elicited CD8+ HLA-A3.1 restricted CTL, and this epitope is highly conserved. CTL specific for this epitope could lyse target cells sensitized with all known natural sequence variants. Additionally, CD8+ HLA-B35 and CD8+ HLA-B18 restricted epitopes were defined as well as two CD4+ cytotoxic T-cell gp120 epitopes: ITQACPKVSFEPIPHYCAPAGFAI and NNTLKQIDSKLREQFG. PubMed ID: 7908700. Show all entries for this paper.


Displaying record number 846

HXB2 Location gp160(606-614)
gp41(95-103)
DNA(8040..8066)
gp160 Epitope Map
Author Location gp41(605-615 LAI)
Epitope TAVPWNASW Epitope Alignment
TAVPWNASW epitope logo
Subtype B
Species (MHC/HLA) human(B35)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type vaccinia
Vaccine component gp160

Notes

References

Johnson1994 R. P. Johnson, S. A. Hammond, A. Trocha, R. F. Siliciano, and B. D. Walker. Induction of a Major Histocompatibility Complex Class I-Restricted Cytotoxic T-Lymphocyte Response to a Highly Conserved Region of Human Immunodeficiency Virus Type 1 (HIV-1) gp120 in Seronegative Humans Immunized with a Candidate HIV-1 Vaccine. J. Virol., 68:3145-3153, 1994. In two volunteers, immunization with a single strain of HIV-1 induced CD4+ and CD8+ CTL that are specific for multiple conserved regions of HIV-1 and would be expected to recognize a broad range of viral isolates. The immunodominant gp120 epitope, gp120 TVYYGVPVWK, elicited CD8+ HLA-A3.1 restricted CTL, and this epitope is highly conserved. CTL specific for this epitope could lyse target cells sensitized with all known natural sequence variants. Additionally, CD8+ HLA-B35 and CD8+ HLA-B18 restricted epitopes were defined as well as two CD4+ cytotoxic T-cell gp120 epitopes: ITQACPKVSFEPIPHYCAPAGFAI and NNTLKQIDSKLREQFG. PubMed ID: 7908700. Show all entries for this paper.


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