Search CTL/CD8+ T-Cell Epitope Database

Found 18 matching records:

Displaying record number 59135

HXB2 Location	Gag(77-85) p17(77-85) DNA(1018..1044)	Gag Epitope Map
Author Location	p17
Epitope	`SLYNTVATL`	Epitope Alignment
Epitope Name	SL9
Subtype	B
Species (MHC/HLA)	human(A*02)
Immunogen	HIV-1 infection
Country	Germany
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	elite controllers

Notes

In a follow-up on the anonymous 1999 Berlin patient (not Timothy Brown of 2008), viral replication suppression was seen after 15 years of absence of ART. Half the HIV-specific CTL responses in this patient were restricted by HLA-B*57, with the most immunodominant being against Nef HW9, HTQGYFPDW.
Patient autologous sequence of A*02-restricted p17 SL9, SLYNTVATL, elicited a CTL response of >1000 sfu/106 PBMC when tested by EliSpot.

References

Jessen2014 Heiko Jessen, Todd M. Allen, and Hendrik Streeck. How a Single Patient Influenced HIV Research — 15-Year Follow-Up. N. Engl. J. Med., 370(7):682-683, 13 Feb 2014. PubMed ID: 24521131. Show all entries for this paper.

Displaying record number 59137

HXB2 Location	Gag(147-155) p24(15-23) DNA(1228..1254)	Gag Epitope Map
Author Location	p24
Epitope	`ISPRTLNAW`	Epitope Alignment
		Show epitope variants
Epitope Name	IW9
Subtype	B
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Country	Germany
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	elite controllers

Notes

In a follow-up on the anonymous 1999 Berlin patient (not Timothy Brown of 2008), viral replication suppression was seen after 15 years of absence of ART. Half the HIV-specific CTL responses in this patient were restricted by HLA-B*57, with the most immunodominant being against Nef HW9, HTQGYFPDW.
B*57-restricted p24 IW9, ISPRTLNAW, elicited a CTL response of >1000 sfu/106 PBMC when tested by EliSpot. Patient autologous sequence was plPRTLNAW.

References

Displaying record number 59139

HXB2 Location	Gag(162-172) p24(30-40) DNA(1273..1305)	Gag Epitope Map
Author Location	p24
Epitope	`KAFSPEVIPMF`	Epitope Alignment
Epitope Name	KF11
Subtype	B
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Country	Germany
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	elite controllers

Notes

In a follow-up on the anonymous 1999 Berlin patient (not Timothy Brown of 2008), viral replication suppression was seen after 15 years of absence of ART. Half the HIV-specific CTL responses in this patient were restricted by HLA-B*57, with the most immunodominant being against Nef HW9, HTQGYFPDW.
Patient autologous sequence of B*57-restricted p24 KF11, KAFSPEVIPMF, elicited a CTL response of <500 sfu/106 PBMC when tested by EliSpot.

References

Displaying record number 59142

HXB2 Location	Gag(216-224) p24(84-92) DNA(1435..1461)	Gag Epitope Map
Author Location	p24
Epitope	`HPVHAGPIA`	Epitope Alignment
		Show epitope variants
Epitope Name	HA9
Subtype	B
Species (MHC/HLA)	human(B*07)
Immunogen	HIV-1 infection
Country	Germany
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	elite controllers

Notes

In a follow-up on the anonymous 1999 Berlin patient (not Timothy Brown of 2008), viral replication suppression was seen after 15 years of absence of ART. Half the HIV-specific CTL responses in this patient were restricted by HLA-B*57, with the most immunodominant being against Nef HW9, HTQGYFPDW.
B*07-restricted p24 HA9, HPVHAGPIA, elicited no CTL response when tested by EliSpot. Patient autologous sequence was HPVHAGPvA.

References

Displaying record number 59143

HXB2 Location	Gag(240-249) p24(108-117) DNA(1507..1536)	Gag Epitope Map
Author Location	p24
Epitope	`TSTLQEQIGW`	Epitope Alignment
		Show epitope variants
Epitope Name	TW10
Subtype	B
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Country	Germany
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	elite controllers

Notes

In a follow-up on the anonymous 1999 Berlin patient (not Timothy Brown of 2008), viral replication suppression was seen after 15 years of absence of ART. Half the HIV-specific CTL responses in this patient were restricted by HLA-B*57, with the most immunodominant being against Nef HW9, HTQGYFPDW.
B*57-restricted p24 TW10, TSTLQEQIGW, elicited no CTL response when tested by EliSpot. Patient autologous sequence of TnTLQEQIGW previously suggested to partially impair viral replication.

References

Displaying record number 59146

HXB2 Location	Gag(308-316) p24(176-184) DNA(1711..1737)	Gag Epitope Map
Author Location	p24
Epitope	`QASQEVKNW`	Epitope Alignment
Epitope Name	QW9
Subtype	B
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Country	Germany
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	elite controllers

Notes

In a follow-up on the anonymous 1999 Berlin patient (not Timothy Brown of 2008), viral replication suppression was seen after 15 years of absence of ART. Half the HIV-specific CTL responses in this patient were restricted by HLA-B*57, with the most immunodominant being against Nef HW9, HTQGYFPDW.
Patient autologous sequence of B*57-restricted p24 QW9, QASQEVKNW, elicited a CTL response of <500 sfu/106 PBMC when tested by EliSpot.

References

Displaying record number 59147

HXB2 Location	Gag(433-442) p2p7p1p6(70-79) DNA(2086..2115)	Gag Epitope Map
Author Location	p15
Epitope	`FLGKIWPSYK`	Epitope Alignment
Epitope Name	FK10
Subtype	B
Species (MHC/HLA)	human(A*02)
Immunogen	HIV-1 infection
Country	Germany
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	elite controllers

Notes

In a follow-up on the anonymous 1999 Berlin patient (not Timothy Brown of 2008), viral replication suppression was seen after 15 years of absence of ART. Half the HIV-specific CTL responses in this patient were restricted by HLA-B*57, with the most immunodominant being against Nef HW9, HTQGYFPDW.
Patient autologous sequence of A*02-restricted p15 FK10, FLGKIWPSYK, elicited a CTL response of <500 sfu/106 PBMC when tested by EliSpot.

References

Displaying record number 59138

HXB2 Location	Pol(126-133) Protease(70-77) DNA(2460..2483)	Pol Epitope Map
Author Location	Protease
Epitope	`KAIGTVLV`	Epitope Alignment
Epitope Name	KV8
Subtype	B
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Country	Germany
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	elite controllers

Notes

In a follow-up on the anonymous 1999 Berlin patient (not Timothy Brown of 2008), viral replication suppression was seen after 15 years of absence of ART. Half the HIV-specific CTL responses in this patient were restricted by HLA-B*57, with the most immunodominant being against Nef HW9, HTQGYFPDW.
Patient autologous sequence of B*57-restricted Protease KV8, KAIGTVLV, elicited a CTL response of >500 sfu/106 PBMC when tested by EliSpot.

References

Displaying record number 59136

HXB2 Location	Pol(311-319) RT(156-164) DNA(3015..3041)	Pol Epitope Map
Author Location	RT
Epitope	`SPAIFQSSM`	Epitope Alignment
Epitope Name	SM9
Subtype	B
Species (MHC/HLA)	human(B*07)
Immunogen	HIV-1 infection
Country	Germany
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	elite controllers

Notes

In a follow-up on the anonymous 1999 Berlin patient (not Timothy Brown of 2008), viral replication suppression was seen after 15 years of absence of ART. Half the HIV-specific CTL responses in this patient were restricted by HLA-B*57, with the most immunodominant being against Nef HW9, HTQGYFPDW.
Patient autologous sequence of B*07-restricted RT SM9, SPAIFQSSM, elicited a CTL response of >1000 sfu/106 PBMC when tested by EliSpot.

References

Displaying record number 59148

HXB2 Location	Pol(334-342) RT(179-187) DNA(3084..3110)	Pol Epitope Map
Author Location	RT
Epitope	`VIYQYMDDL`	Epitope Alignment
Epitope Name	VL9
Subtype	B
Species (MHC/HLA)	human(A*02)
Immunogen	HIV-1 infection
Country	Germany
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	elite controllers

Notes

In a follow-up on the anonymous 1999 Berlin patient (not Timothy Brown of 2008), viral replication suppression was seen after 15 years of absence of ART. Half the HIV-specific CTL responses in this patient were restricted by HLA-B*57, with the most immunodominant being against Nef HW9, HTQGYFPDW.
Patient autologous sequence of A*02-restricted RT VL9, VIYQYMDDL, elicited a CTL response of <500 sfu/106 PBMC when tested by EliSpot.

References

Displaying record number 59144

HXB2 Location	Pol(399-407) RT(244-252) DNA(3279..3305)	Pol Epitope Map
Author Location	RT
Epitope	`IVLPEKDSW`	Epitope Alignment
		Show epitope variants
Epitope Name	ISW9
Subtype	B
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Country	Germany
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	elite controllers

Notes

In a follow-up on the anonymous 1999 Berlin patient (not Timothy Brown of 2008), viral replication suppression was seen after 15 years of absence of ART. Half the HIV-specific CTL responses in this patient were restricted by HLA-B*57, with the most immunodominant being against Nef HW9, HTQGYFPDW.
B*57-restricted RT ISW9, IVLPEKDSW, elicited no CTL response when tested by EliSpot. Patient autologous sequence of IVkPEKDSW previously suggested to partially impair viral replication.

References

Displaying record number 59140

HXB2 Location	Pol(838-847) Integrase(123-132) DNA(4596..4625)	Pol Epitope Map
Author Location	Integrase
Epitope	`STTVKAACWW`	Epitope Alignment
		Show epitope variants
Epitope Name	SW10
Subtype	B
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Country	Germany
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	elite controllers

Notes

In a follow-up on the anonymous 1999 Berlin patient (not Timothy Brown of 2008), viral replication suppression was seen after 15 years of absence of ART. Half the HIV-specific CTL responses in this patient were restricted by HLA-B*57, with the most immunodominant being against Nef HW9, HTQGYFPDW.
B*57-restricted Integrase SW10, STTVKAACWW, elicited a very low CTL response when tested by EliSpot. Patient autologous sequence was SaTVKAACWW.

References

Displaying record number 59141

HXB2 Location	Vpr(30-38) DNA(5646..5672)	Vpr Epitope Map
Author Location	Vpr
Epitope	`AVRHFPRIW`	Epitope Alignment
		Show epitope variants
Epitope Name	AW9
Subtype	B
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Country	Germany
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	elite controllers

Notes

In a follow-up on the anonymous 1999 Berlin patient (not Timothy Brown of 2008), viral replication suppression was seen after 15 years of absence of ART. Half the HIV-specific CTL responses in this patient were restricted by HLA-B*57, with the most immunodominant being against Nef HW9, HTQGYFPDW.
B*57-restricted Vpr AW9, AVRHFPRIW, elicited a CTL response of >500 sfu/106 PBMC when tested by EliSpot. Patient autologous sequence was AVRHFPRvW.

References

Displaying record number 59145

HXB2 Location	Rev(14-23) DNA(6009..6038)	Rev Epitope Map
Author Location	Rev
Epitope	`KAVRLIKFLY`	Epitope Alignment
Epitope Name	KY10
Subtype	B
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Country	Germany
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	elite controllers

Notes

In a follow-up on the anonymous 1999 Berlin patient (not Timothy Brown of 2008), viral replication suppression was seen after 15 years of absence of ART. Half the HIV-specific CTL responses in this patient were restricted by HLA-B*57, with the most immunodominant being against Nef HW9, HTQGYFPDW.
Patient autologous sequence of B*57-restricted Rev KY10, KAVRLIKFLY, elicited a CTL response of ˜500 sfu/106 PBMC when tested by EliSpot.

References

Displaying record number 59150

HXB2 Location	gp160(298-307) gp120(298-307) DNA(7116..7145)	gp160 Epitope Map
Author Location	gp120
Epitope	`RPNNNTRKSI`	Epitope Alignment
Epitope Name	RI10
Subtype	B
Species (MHC/HLA)	human(B*07)
Immunogen	HIV-1 infection
Country	Germany
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	elite controllers

Notes

In a follow-up on the anonymous 1999 Berlin patient (not Timothy Brown of 2008), viral replication suppression was seen after 15 years of absence of ART. Half the HIV-specific CTL responses in this patient were restricted by HLA-B*57, with the most immunodominant being against Nef HW9, HTQGYFPDW.
Patient autologous sequence of B*07-restricted gp120 RI10, RPNNNTRKSI, elicited almost no CTL response when tested by EliSpot.

References

Displaying record number 59149

HXB2 Location	Nef(106-115) DNA(9112..9141)	Nef Epitope Map
Author Location	Nef
Epitope	`RQDILDLWIY`	Epitope Alignment
Epitope Name	RY10
Subtype	B
Species (MHC/HLA)	human(B*07)
Immunogen	HIV-1 infection
Country	Germany
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	elite controllers

Notes

In a follow-up on the anonymous 1999 Berlin patient (not Timothy Brown of 2008), viral replication suppression was seen after 15 years of absence of ART. Half the HIV-specific CTL responses in this patient were restricted by HLA-B*57, with the most immunodominant being against Nef HW9, HTQGYFPDW.
Patient autologous sequence of B*07-restricted Nef RY10, RQDILDLWIY, elicited a very low CTL when tested by EliSpot.

References

Displaying record number 59134

HXB2 Location	Nef(116-124) DNA(9142..9168)	Nef Epitope Map
Author Location	Nef
Epitope	`HTQGYFPDW`	Epitope Alignment
Epitope Name	HW9
Subtype	B
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Country	Germany
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	elite controllers

Notes

In a follow-up on the anonymous 1999 Berlin patient (not Timothy Brown of 2008), viral replication suppression was seen after 15 years of absence of ART. Half the HIV-specific CTL responses in this patient were restricted by HLA-B*57, with the most immunodominant being against Nef HW9, HTQGYFPDW.
Patient autologous sequence of B*57-restricted Nef HW9, HTQGYFPDW, elicited a CTL response of >2500 SFU/106 PBMC when tested by EliSpot.

References

Displaying record number 59151

HXB2 Location	Nef(128-137) DNA(9178..9207)	Nef Epitope Map
Author Location	Nef
Epitope	`TPGPGVRYPL`	Epitope Alignment
Epitope Name	TL10
Subtype	B
Species (MHC/HLA)	human(B*07)
Immunogen	HIV-1 infection
Country	Germany
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	elite controllers

Notes

In a follow-up on the anonymous 1999 Berlin patient (not Timothy Brown of 2008), viral replication suppression was seen after 15 years of absence of ART. Half the HIV-specific CTL responses in this patient were restricted by HLA-B*57, with the most immunodominant being against Nef HW9, HTQGYFPDW.
Patient autologous sequence of B*07-restricted Nef TL10, TPGPGVRYPL, elicited almost no CTL response when tested by EliSpot.