Search CTL/CD8+ T-Cell Epitope Database

Found 3 matching records:

Displaying record number 536

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HXB2 Location	Pol(464-472) RT(309-317) DNA(3474..3500)	Pol Epitope Map
Author Location	Pol
Epitope	ILKEPVHGV	Epitope Alignment
Species (MHC/HLA)	transgenic mouse(A*02:01)
Immunogen	vaccine
Experimental methods
Keywords

Vaccine Details

Notes

• A minigene vaccine construct encoding 6 HLA 2.1 and 3 HLA A11 restricted CTL epitopes, the universal Th cell epitope PADRE (pan-DR epitope) and an ER translocating signal sequence was constructed.
• The epitopes were chosen for dominant recognition by CTLs during HBV and HIV infections in humans.
• HLA transgenic mice were used for quantitating in vivo immunogenicity of DNA vaccines encoding HLA-restricted CTL epitopes -- strong responses were observed to all nine epitopes, and CTL memory persisted up to four months after a single injection.

References

Ishioka1999 G. Y. Ishioka, J. Fikes, G. Hermanson, B. Livingston, C. Crimi, M. Qin, M. F. del Guercio, C. Oseroff, C. Dahlberg, J. Alexander, R. W. Chesnut, and A. Sette. Utilization of MHC Class I Transgenic Mice for Development of Minigene. J. Immunol., 162:3915-3925, 1999. PubMed ID: 10201910. Show all entries for this paper.

Displaying record number 636

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HXB2 Location	gp160(37-46) gp120(37-46) DNA(6333..6362)	gp160 Epitope Map
Author Location	Env
Epitope	TVYYGVPVWK	Epitope Alignment
Species (MHC/HLA)	transgenic mouse(A11)
Immunogen	vaccine
Experimental methods
Keywords

Vaccine Details

Notes

• A minigene vaccine construct encoding 6 HLA 2.1 and 3 HLA A11 restricted CTL epitopes, the universal Th cell epitope PADRE (pan-DR epitope) and an ER translocating signal sequence was constructed.
• The epitopes were chosen for dominant recognition by CTLs during HBV and HIV infections in humans.
• HLA transgenic mice were used for quantitating in vivo immunogenicity of DNA vaccines encoding HLA-restricted CTL epitopes.

References

Ishioka1999 G. Y. Ishioka, J. Fikes, G. Hermanson, B. Livingston, C. Crimi, M. Qin, M. F. del Guercio, C. Oseroff, C. Dahlberg, J. Alexander, R. W. Chesnut, and A. Sette. Utilization of MHC Class I Transgenic Mice for Development of Minigene. J. Immunol., 162:3915-3925, 1999. PubMed ID: 10201910. Show all entries for this paper.

Displaying record number 670

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HXB2 Location	gp160(121-129) gp120(121-129) DNA(6585..6611)	gp160 Epitope Map
Author Location	Env
Epitope	KLTPLCVTL	Epitope Alignment
Species (MHC/HLA)	transgenic mouse(A*02:01)
Immunogen	vaccine
Experimental methods
Keywords

Vaccine Details

Notes

• A minigene vaccine construct encoding 6 HLA 2.1 and 3 HLA A11 restricted CTL epitopes, the universal Th cell epitope PADRE (pan-DR epitope) and an ER translocating signal sequence was constructed.
• The epitopes were chosen for dominant recognition by CTLs during HBV and HIV infections in humans.
• HLA transgenic mice were used for quantitating in vivo immunogenicity of DNA vaccines encoding HLA-restricted CTL epitopes -- strong responses were observed to all nine epitopes, and CTL memory persisted up to four months after a single injection.

References

Ishioka1999 G. Y. Ishioka, J. Fikes, G. Hermanson, B. Livingston, C. Crimi, M. Qin, M. F. del Guercio, C. Oseroff, C. Dahlberg, J. Alexander, R. W. Chesnut, and A. Sette. Utilization of MHC Class I Transgenic Mice for Development of Minigene. J. Immunol., 162:3915-3925, 1999. PubMed ID: 10201910. Show all entries for this paper.