Search CTL/CD8+ T-Cell Epitope Database

Found 6 matching records:

Displaying record number 57432

Download this epitope record as JSON.

HXB2 Location	Gag(216-224) p24(84-92) DNA(1435..1461)	Gag Epitope Map
Author Location	p24(84-92)
Epitope	HPVHAGPVA	Epitope Alignment
		Show epitope variants
Epitope Name	HA9
Subtype	A1, C, D
Species (MHC/HLA)	human(B7 supertype)
Immunogen	HIV-1 infection
Country	Sweden, Uganda
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity

Notes

• 6 epitopes and their variants were tested for quantitative CTL recognition in a genetically diverse cohort of 26 HIV-1+ subjects from 12 countries, to determine response pattern as correlating to autologous virus sequence. Cross-reactive epitopes were more similar, with a single substitution decreasing recognition by 40%. Central residues in an epitope were more important for recognition.
• Epitope HA9, HPVHAGPVA, elicited CTL response when tested in patients 2295 (Caucasian female, experienced some treatment, autologous virus Clade C); 2632 (African female, experienced some treatment, autologous virus Clade A1); 2840 (African female, treated, autologous virus Clade D).

References

Hoof2010 Ilka Hoof, Carina L. Pérez, Marcus Buggert, Rasmus K. L. Gustafsson, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Interdisciplinary Analysis of HIV-Specific CD8+ T Cell Responses against Variant Epitopes Reveals Restricted TCR Promiscuity. J Immunol, 184(9):5383-5391, 1 May 2010. PubMed ID: 20363973. Show all entries for this paper.

Displaying record number 57493

Download this epitope record as JSON.

HXB2 Location	Gag(259-267) p24(127-135) DNA(1564..1590)	Gag Epitope Map
Author Location	p24(127-135)
Epitope	GEIYKRWII	Epitope Alignment
		Show epitope variants
Epitope Name	GI9
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Chile, Finland, Sweden
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity

Notes

• 6 epitopes and their variants were tested for quantitative CTL recognition in a genetically diverse cohort of 26 HIV-1+ subjects from 12 countries, to determine response pattern as correlating to HLA genotype & autologous virus sequence. Cross-reactive epitopes were more similar, with a single substitution decreasing recognition by 40%. Central residues in an epitope were more important for recognition.
• Epitope GI9, GEIYKRWII, elicited CTL response when tested in 3 patients - 2275 (Latin male, experienced some treatment, autologous virus Clade B); 2792 (Caucasian female, treatment naive, autologous virus Clade B); 2902 (Caucasian male, treated, autologous virus Clade B).

References

Hoof2010 Ilka Hoof, Carina L. Pérez, Marcus Buggert, Rasmus K. L. Gustafsson, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Interdisciplinary Analysis of HIV-Specific CD8+ T Cell Responses against Variant Epitopes Reveals Restricted TCR Promiscuity. J Immunol, 184(9):5383-5391, 1 May 2010. PubMed ID: 20363973. Show all entries for this paper.

Displaying record number 57497

Download this epitope record as JSON.

HXB2 Location	Pol(311-319) RT(156-164) DNA(3015..3041)	Pol Epitope Map
Author Location	RT Pol(156-164)
Epitope	SPAIFQSSM	Epitope Alignment
		Show epitope variants
Epitope Name	SM9
Subtype	A1, B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Somalia, Uganda, United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity

Notes

• 6 epitopes and their variants were tested for quantitative CTL recognition in a genetically diverse cohort of 26 HIV-1+ subjects from 12 countries, to determine response pattern as correlating to HLA genotype & autologous virus sequence. Cross-reactive epitopes were more similar, with a single substitution decreasing recognition by 40%. Central residues in an epitope were more important for recognition.
• Epitope SM9, SPAIFQSSM, elicited CTL response in 3 patients - 2059 (Caucasian male, treated, autologous virus Clade B); 2632 (African female, experienced some treatment, autologous virus Clade A1); 3076 (African female, treatment naive, autologous virus Clade A1).

References

Hoof2010 Ilka Hoof, Carina L. Pérez, Marcus Buggert, Rasmus K. L. Gustafsson, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Interdisciplinary Analysis of HIV-Specific CD8+ T Cell Responses against Variant Epitopes Reveals Restricted TCR Promiscuity. J Immunol, 184(9):5383-5391, 1 May 2010. PubMed ID: 20363973. Show all entries for this paper.

Displaying record number 57494

Download this epitope record as JSON.

HXB2 Location	Nef(73-81) DNA(9013..9039)	Nef Epitope Map
Author Location	Nef(73-81)
Epitope	QVPLRPMTY	Epitope Alignment
		Show epitope variants
Epitope Name	QY9
Subtype	B, C, D
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Finland, Sweden, Uganda
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity

Notes

• 6 epitopes and their variants were tested for quantitative CTL recognition in a genetically diverse cohort of 26 HIV-1+ subjects from 12 countries, to determine response pattern as correlating to HLA genotype & autologous virus sequence. Cross-reactive epitopes were more similar, with a single substitution decreasing recognition by 40%. Central residues in an epitope were more important for recognition.
• Epitope QY9(73-81), QVPLRPMTY, elicited CTL response when tested in 3 patients - 2295 (Caucasian female, experienced some treatment, autologous virus Clade C); 2792 (Caucasian male, treatment naive, autologous virus Clade B); 2840 (African female, treated, autologous virus Clade D).

References

Hoof2010 Ilka Hoof, Carina L. Pérez, Marcus Buggert, Rasmus K. L. Gustafsson, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Interdisciplinary Analysis of HIV-Specific CD8+ T Cell Responses against Variant Epitopes Reveals Restricted TCR Promiscuity. J Immunol, 184(9):5383-5391, 1 May 2010. PubMed ID: 20363973. Show all entries for this paper.

Displaying record number 57495

Download this epitope record as JSON.

HXB2 Location	Nef(84-92) DNA(9046..9072)	Nef Epitope Map
Author Location	Nef(84-92)
Epitope	AVDLSHFLK	Epitope Alignment
		Show epitope variants
Epitope Name	AK9
Subtype	A1, B, D
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Chile, Somalia
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity

Notes

• 6 epitopes and their variants were tested for quantitative CTL recognition in a genetically diverse cohort of 26 HIV-1+ subjects from 12 countries, to determine response pattern as correlating to HLA genotype & autologous virus sequence. Cross-reactive epitopes were more similar, with a single substitution decreasing recognition by 40%. Central residues in an epitope were more important for recognition.
• Epitope AK9, AVDLSHFLK, elicited CTL response in 2 patients - 2632 (African female, experienced some treatment, autologous virus Clade A1) and 2840 (African female, treated, autologous virus Clade D) but not in 2275 (Latin male, experienced some treatment, autologous virus Clade B).

References

Hoof2010 Ilka Hoof, Carina L. Pérez, Marcus Buggert, Rasmus K. L. Gustafsson, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Interdisciplinary Analysis of HIV-Specific CD8+ T Cell Responses against Variant Epitopes Reveals Restricted TCR Promiscuity. J Immunol, 184(9):5383-5391, 1 May 2010. PubMed ID: 20363973. Show all entries for this paper.

Displaying record number 57496

Download this epitope record as JSON.

HXB2 Location	Nef(107-115) DNA(9115..9141)	Nef Epitope Map
Author Location	Nef(107-115)
Epitope	QEILDLWVY	Epitope Alignment
		Show epitope variants
Epitope Name	QY9
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Sweden
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity

Notes

• 6 epitopes and their variants were tested for quantitative CTL recognition in a genetically diverse cohort of 26 HIV-1+ subjects from 12 countries, to determine response pattern as correlating to HLA genotype & autologous virus sequence. Cross-reactive epitopes were more similar, with a single substitution decreasing recognition by 40%. Central residues in an epitope were more important for recognition.
• Epitope QY9(107-115), QEILDLWVY, elicited CTL response in patient 2255 (Caucasian female, treated, autologous virus Clade B).

References

Hoof2010 Ilka Hoof, Carina L. Pérez, Marcus Buggert, Rasmus K. L. Gustafsson, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Interdisciplinary Analysis of HIV-Specific CD8+ T Cell Responses against Variant Epitopes Reveals Restricted TCR Promiscuity. J Immunol, 184(9):5383-5391, 1 May 2010. PubMed ID: 20363973. Show all entries for this paper.