Search CTL/CD8+ T-Cell Epitope Database

Found 7 matching records:

Displaying record number 55080

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HXB2 Location	Gag(180-188) p24(48-56) DNA(1327..1353)	Gag Epitope Map
Author Location	p24(48-56)
Epitope	TPQDLNTML	Epitope Alignment
Species (MHC/HLA)	human(B*39:10)
Immunogen	peptide-HLA interaction
Country	South Africa
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding, Intracellular cytokine staining
Keywords	optimal epitope

Notes

• Novel epitopes are defined for four HLA-alleles common in South African Zulu/Xhosa populations: B*3910, B*4201, B*8101 and Cw*1801, by motif inference. HLA-A*2902 was found to overlap those of A1 and A24 supertypes.
• TPQDLNTML was the optimal epitope for HLA-B*3910 with variants TPQDLNTM, PQDLNTML, TPQDLNTMLn, aTPQDLNTML having been tested.

References

Honeyborne2006 Isobella Honeyborne, Almas Rathod, Rico Buchli, Dhanwanthie Ramduth, Eshia Moodley, Prinisha Rathnavalu, Senica Chetty, Cheryl Day, Christian Brander, William Hildebrand, Bruce D. Walker, Photini Kiepiela, and Philip J. R. Goulder. Motif Inference Reveals Optimal CTL Epitopes Presented by HLA Class I Alleles Highly Prevalent in Southern Africa. J. Immunol., 176(8):4699-4705, 15 Apr 2006. PubMed ID: 16585563. Show all entries for this paper.

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Displaying record number 55083

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HXB2 Location	Gag(274-282) p24(142-150) DNA(1609..1635)	Gag Epitope Map
Author Location	p24(142-150)
Epitope	VRMYSPVSI	Epitope Alignment
Species (MHC/HLA)	human(C*18:01)
Immunogen	peptide-HLA interaction
Country	South Africa
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding, Intracellular cytokine staining
Keywords	optimal epitope

Notes

• Novel epitopes are defined for four HLA-alleles common in South African Zulu/Xhosa populations: B*3910, B*4201, B*8101 and Cw*1801, by motif inference. HLA-A*2902 was found to overlap those of A1 and A24 supertypes.
• VRMYSPVSI was the optimal epitope for HLA-Cw*1801 with variants VRMYSPVS, RMYSPVSI, VRMYSPVSIl, iVRMYSPVSI having been tested.

References

Honeyborne2006 Isobella Honeyborne, Almas Rathod, Rico Buchli, Dhanwanthie Ramduth, Eshia Moodley, Prinisha Rathnavalu, Senica Chetty, Cheryl Day, Christian Brander, William Hildebrand, Bruce D. Walker, Photini Kiepiela, and Philip J. R. Goulder. Motif Inference Reveals Optimal CTL Epitopes Presented by HLA Class I Alleles Highly Prevalent in Southern Africa. J. Immunol., 176(8):4699-4705, 15 Apr 2006. PubMed ID: 16585563. Show all entries for this paper.

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Displaying record number 55082

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HXB2 Location	Gag(293-301) p24(161-169) DNA(1666..1692)	Gag Epitope Map
Author Location	p24(161-169)
Epitope	FRDYVDRFF	Epitope Alignment
Species (MHC/HLA)	human(C*18:01)
Immunogen	peptide-HLA interaction
Country	South Africa
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding, Intracellular cytokine staining
Keywords	optimal epitope

Notes

• Novel epitopes are defined for four HLA-alleles common in South African Zulu/Xhosa populations: B*3910, B*4201, B*8101 and Cw*1801, by motif inference. HLA-A*2902 was found to overlap those of A1 and A24 supertypes.
• FRDYVDRFF was the optimal epitope for HLA-Cw*1801 with variants FRDYVDRF, RDYVDRFF, FRDYVDRFFk, pFRDYVDRFF having been tested.

References

Honeyborne2006 Isobella Honeyborne, Almas Rathod, Rico Buchli, Dhanwanthie Ramduth, Eshia Moodley, Prinisha Rathnavalu, Senica Chetty, Cheryl Day, Christian Brander, William Hildebrand, Bruce D. Walker, Photini Kiepiela, and Philip J. R. Goulder. Motif Inference Reveals Optimal CTL Epitopes Presented by HLA Class I Alleles Highly Prevalent in Southern Africa. J. Immunol., 176(8):4699-4705, 15 Apr 2006. PubMed ID: 16585563. Show all entries for this paper.

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Displaying record number 55081

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HXB2 Location	Pol(136-146) Protease(80-90) DNA(2490..2522)	Pol Epitope Map
Author Location	Protease(80-90)
Epitope	TPVNIIGRNML	Epitope Alignment
Epitope Name	TL11
Species (MHC/HLA)	human(B*81:01)
Immunogen	peptide-HLA interaction
Country	South Africa
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding, Intracellular cytokine staining
Keywords	optimal epitope

Notes

• Novel epitopes are defined for four HLA-alleles common in South African Zulu/Xhosa populations: B*3910, B*4201, B*8101 and Cw*1801, by motif inference. HLA-A*2902 was found to overlap those of A1 and A24 supertypes.
• TPVNIIGRNML (TL11) was the optimal epitope for HLA-B*8101 with variants TPVNIIGRNM, PVNIIGRNML, TPVNIIGRNMLt, pTPVNIIGRNML having been tested.

References

Honeyborne2006 Isobella Honeyborne, Almas Rathod, Rico Buchli, Dhanwanthie Ramduth, Eshia Moodley, Prinisha Rathnavalu, Senica Chetty, Cheryl Day, Christian Brander, William Hildebrand, Bruce D. Walker, Photini Kiepiela, and Philip J. R. Goulder. Motif Inference Reveals Optimal CTL Epitopes Presented by HLA Class I Alleles Highly Prevalent in Southern Africa. J. Immunol., 176(8):4699-4705, 15 Apr 2006. PubMed ID: 16585563. Show all entries for this paper.

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Displaying record number 55079

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HXB2 Location	Pol(743-751) Integrase(28-36) DNA(4311..4337)	Pol Epitope Map
Author Location	Integrase(28-36)
Epitope	LPPIVAKEI	Epitope Alignment
Epitope Name	LI9
Species (MHC/HLA)	human(B*42:01)
Immunogen	peptide-HLA interaction
Country	South Africa
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding, Intracellular cytokine staining
Keywords	optimal epitope

Notes

• Novel epitopes are defined for four HLA-alleles common in South African Zulu/Xhosa populations: B*3910, B*4201, B*8101 and Cw*1801, by motif inference. HLA-A*2902 was found to overlap those of A1 and A24 supertypes.
• LPPIVAKEI (LI9) was the optimal epitope for HLA-B*4201 with variants LPPIVAKE, PPIVAKEI, LPPIVAKEIv, nLPPIVAKEI having been tested.

References

Honeyborne2006 Isobella Honeyborne, Almas Rathod, Rico Buchli, Dhanwanthie Ramduth, Eshia Moodley, Prinisha Rathnavalu, Senica Chetty, Cheryl Day, Christian Brander, William Hildebrand, Bruce D. Walker, Photini Kiepiela, and Philip J. R. Goulder. Motif Inference Reveals Optimal CTL Epitopes Presented by HLA Class I Alleles Highly Prevalent in Southern Africa. J. Immunol., 176(8):4699-4705, 15 Apr 2006. PubMed ID: 16585563. Show all entries for this paper.

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Displaying record number 55085

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HXB2 Location	Pol(880-887) Integrase(165-172) DNA(4722..4745)	Pol Epitope Map
Author Location	Integrase(165-172)
Epitope	VRDQAEHL	Epitope Alignment
Species (MHC/HLA)	human(C*18:01)
Immunogen	peptide-HLA interaction
Country	South Africa
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding, Intracellular cytokine staining
Keywords	optimal epitope

Notes

• Novel epitopes are defined for four HLA-alleles common in South African Zulu/Xhosa populations: B*3910, B*4201, B*8101 and Cw*1801, by motif inference. HLA-A*2902 was found to overlap those of A1 and A24 supertypes.
• VRDQAEHL was the optimal epitope for HLA-Cw*1801 with variants VRDQAEH, RDQAEHL, VRDQAEHLk, qVRDQAEHL having been tested.

References

Honeyborne2006 Isobella Honeyborne, Almas Rathod, Rico Buchli, Dhanwanthie Ramduth, Eshia Moodley, Prinisha Rathnavalu, Senica Chetty, Cheryl Day, Christian Brander, William Hildebrand, Bruce D. Walker, Photini Kiepiela, and Philip J. R. Goulder. Motif Inference Reveals Optimal CTL Epitopes Presented by HLA Class I Alleles Highly Prevalent in Southern Africa. J. Immunol., 176(8):4699-4705, 15 Apr 2006. PubMed ID: 16585563. Show all entries for this paper.

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Displaying record number 55084

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HXB2 Location	Vpu(5-13) DNA(6074..6100)	Vpu Epitope Map
Author Location	gp41(1-8)
Epitope	YRLGVGALI	Epitope Alignment
Subtype	C
Species (MHC/HLA)	human(C*18:01)
Immunogen	peptide-HLA interaction
Country	South Africa
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding, Intracellular cytokine staining
Keywords	optimal epitope

Notes

• Novel epitopes are defined for four HLA-alleles common in South African Zulu/Xhosa populations: B*3910, B*4201, B*8101 and Cw*1801, by motif inference. HLA-A*2902 was found to overlap those of A1 and A24 supertypes.
• YRLGVGALI was the optimal epitope for HLA-Cw*1801 with variants YRLGVGAL, RLGVGALI, YRLGVGALIi, dYRLGVGALI having been tested.
• YRLGVGALI has weak similarity to subtype B gp41. However, its correct localization is Vpu 5-13, where its sequence matches subtype C well.

References

Honeyborne2006 Isobella Honeyborne, Almas Rathod, Rico Buchli, Dhanwanthie Ramduth, Eshia Moodley, Prinisha Rathnavalu, Senica Chetty, Cheryl Day, Christian Brander, William Hildebrand, Bruce D. Walker, Photini Kiepiela, and Philip J. R. Goulder. Motif Inference Reveals Optimal CTL Epitopes Presented by HLA Class I Alleles Highly Prevalent in Southern Africa. J. Immunol., 176(8):4699-4705, 15 Apr 2006. PubMed ID: 16585563. Show all entries for this paper.

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