Search CTL/CD8+ T-Cell Epitope Database

Found 10 matching records:

Displaying record number 57607

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HXB2 Location	Gag(20-28) p17(20-28) DNA(847..873)	Gag Epitope Map
Author Location
Epitope	`RLRPGGKKK`	Epitope Alignment
Epitope Name	RK9
Subtype	B
Species (MHC/HLA)	human(A*03)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Proliferation
Keywords	acute/early infection

Notes

The study examined which CD8+ T cells are able to control viremia in early infection. Only a subset of patients in primary infection had CD4-independent CD8 proliferation. The remainder lacked HIV-1-specific CD8 T cells with proliferative capacity.
This epitope was used to examine CD8 T cells for proliferative capacity in patients identified and administered antiretroviral therapy within 4 months of seroconversion.

References

Heath2011 Sonya L. Heath, Steffanie Sabbaj, Anju Bansal, J Michael Kilby, and Paul A. Goepfert. CD8 T-Cell Proliferative Capacity Is Compromised in Primary HIV-1 Infection. J. Acquir. Immune Defic. Syndr., 56(3):213-221, Mar 2011. PubMed ID: 21079516. Show all entries for this paper.

Displaying record number 57609

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HXB2 Location	Gag(77-85) p17(77-85) DNA(1018..1044)	Gag Epitope Map
Author Location
Epitope	`SLYNTVATL`	Epitope Alignment
Epitope Name	SL9
Subtype	B
Species (MHC/HLA)	(A*02)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Proliferation
Keywords	acute/early infection

Notes

The study examined which CD8+ T cells are able to control viremia in early infection. Only a subset of patients in primary infection had CD4-independent CD8 proliferation. The remainder lacked HIV-1-specific CD8 T cells with proliferative capacity.
This epitope was used to examine CD8 T cells for proliferative capacity in patients identified and administered antiretroviral therapy within 4 months of seroconversion.

References

Displaying record number 57637

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HXB2 Location	Gag(263-272) p24(131-140) DNA(1576..1605)	Gag Epitope Map
Author Location
Epitope	`KRWIILGLNK`	Epitope Alignment
Epitope Name	RK10
Subtype	B
Species (MHC/HLA)	(B*27)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Proliferation
Keywords	acute/early infection

Notes

The study examined which CD8+ T cells are able to control viremia in early infection. Only a subset of patients in primary infection had CD4-independent CD8 proliferation. The remainder lacked HIV-1-specific CD8 T cells with proliferative capacity.
This epitope was used to study CD4-independent CD8 T-cell proliferation in 2 individuals. Even in the absence of CD4 T cells or exogenous IL-2, CD8 T cells were able to maintain proliferative capacity to this epitope.

References

Displaying record number 57612

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HXB2 Location	Pol(262-270) RT(107-115) DNA(2868..2894)	Pol Epitope Map
Author Location
Epitope	`TVLDVGDAY`	Epitope Alignment
Epitope Name	TY9
Subtype	B
Species (MHC/HLA)	(B*35)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Proliferation
Keywords	acute/early infection

Notes

The study examined which CD8+ T cells are able to control viremia in early infection. Only a subset of patients in primary infection had CD4-independent CD8 proliferation. The remainder lacked HIV-1-specific CD8 T cells with proliferative capacity.
This epitope was used to examine CD8 T cells for proliferative capacity in patients identified and administered antiretroviral therapy within 4 months of seroconversion.

References

Displaying record number 57608

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HXB2 Location	Pol(273-282) RT(118-127) DNA(2901..2930)	Pol Epitope Map
Author Location
Epitope	`VPLDEDFRKY`	Epitope Alignment
Epitope Name	VY10
Subtype	B
Species (MHC/HLA)	(B*35)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Proliferation
Keywords	acute/early infection

Notes

The study examined which CD8+ T cells are able to control viremia in early infection. Only a subset of patients in primary infection had CD4-independent CD8 proliferation. The remainder lacked HIV-1-specific CD8 T cells with proliferative capacity.
This epitope was used to examine CD8 T cells for proliferative capacity in patients identified and administered antiretroviral therapy within 4 months of seroconversion.

References

Displaying record number 57619

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HXB2 Location	Vif(33-47) DNA(5137..5181)	Vif Epitope Map
Author Location
Epitope	`GKAKGWFYRHHYEST`	Epitope Alignment
Subtype	B
Species (MHC/HLA)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Proliferation
Keywords	acute/early infection

Notes

The study examined which CD8+ T cells are able to control viremia in early infection. Only a subset of patients in primary infection had CD4-independent CD8 proliferation. The remainder lacked HIV-1-specific CD8 T cells with proliferative capacity.
This epitope was used to study rescuing HIV-specific responses by adding exogenous IL-2 in patients lacking and HIV-1-specific CD8 T-cell proliferative response. Only 1 of 8 absent proliferative responses was recovered (to this epitope). This epitope elicited CD8 but not CD4 T-cell responses.

References

Displaying record number 57610

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HXB2 Location	Vif(57-71) DNA(5209..5253)	Vif Epitope Map
Author Location
Epitope	`IPLGDAKLVITTYWG`	Epitope Alignment
Epitope Name	IG15
Subtype	B
Species (MHC/HLA)	(B*51)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Proliferation
Keywords	acute/early infection

Notes

The study examined which CD8+ T cells are able to control viremia in early infection. Only a subset of patients in primary infection had CD4-independent CD8 proliferation. The remainder lacked HIV-1-specific CD8 T cells with proliferative capacity.
This epitope was used to examine CD8 T cells for proliferative capacity in patients identified and administered antiretroviral therapy within 4 months of seroconversion.

References

Displaying record number 57638

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HXB2 Location	Vif(97-111) DNA(5329..5373)	Vif Epitope Map
Author Location
Epitope	`QVDPDLADQLIHLYY`	Epitope Alignment
Epitope Name	vif 70
Subtype	B
Species (MHC/HLA)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Proliferation
Keywords	acute/early infection

Notes

The study examined which CD8+ T cells are able to control viremia in early infection. Only a subset of patients in primary infection had CD4-independent CD8 proliferation. The remainder lacked HIV-1-specific CD8 T cells with proliferative capacity.
This epitope was used to study CD4-independent CD8 T-cell proliferation in 2 individuals. Even in the absence of CD4 T cells or exogenous IL-2, CD8 T cells were able to maintain proliferative capacity to this epitope. Moreover, the magnitude of proliferation in response to this epitope as comparable, regardless of CD4 T cell presence.

References

Displaying record number 57639

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HXB2 Location	Vpr(29-43) DNA(5643..5687)	Vpr Epitope Map
Author Location
Epitope	`EAVRHFPRIWLHSLG`	Epitope Alignment
Epitope Name	vpr 31
Subtype	B
Species (MHC/HLA)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Proliferation
Keywords	acute/early infection

Notes

The study examined which CD8+ T cells are able to control viremia in early infection. Only a subset of patients in primary infection had CD4-independent CD8 proliferation. The remainder lacked HIV-1-specific CD8 T cells with proliferative capacity.
This epitope was used to study CD4-independent CD8 T-cell proliferation in 2 individuals. Even in the absence of CD4 T cells or exogenous IL-2, CD8 T cells were able to maintain proliferative capacity to this epitope. Moreover, the magnitude of proliferation in response to this epitope as comparable, regardless of CD4 T cell presence.

References

Displaying record number 57611

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HXB2 Location	Nef(74-81) DNA(9016..9039)	Nef Epitope Map
Author Location
Epitope	`VPLRPMTY`	Epitope Alignment
Epitope Name	VY8
Subtype	B
Species (MHC/HLA)	(B*35)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Proliferation
Keywords	acute/early infection

Notes

The study examined which CD8+ T cells are able to control viremia in early infection. Only a subset of patients in primary infection had CD4-independent CD8 proliferation. The remainder lacked HIV-1-specific CD8 T cells with proliferative capacity.
This epitope was used to examine CD8 T cells for proliferative capacity in patients identified and administered antiretroviral therapy within 4 months of seroconversion.