Search CTL/CD8+ T-Cell Epitope Database

Found 3 matching records:

Displaying record number 53707

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HXB2 Location	Gag(77-85) p17(77-85) DNA(1018..1044)	Gag Epitope Map
Author Location
Epitope	SLYNTVATL	Epitope Alignment
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	Germany
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression, escape, variant cross-reactivity, optimal epitope

Notes

• An HLA-B13-restricted optimal epitope was defined in Nef, RI9. The frequency of CTLs specific for this epitope in B13-positive patients exceeded the number of CTLs against other epitopes, indicating that this is a dominant epitope in B13-positive subjects. Three B13-positive patients who had an immunodominant response to this epitope were good controllers of their infection, with low viral loads over long periods.
• Five A2+ B13+ patients were found to make an immunodominant response to the B13 epitope RI9. 0/5 recognized ILKEPVHGV, and only 1/5 recognized SLYNTAVTL, with a much lower frequency than the B13 response.

References

Harrer2005b Ellen G. Harrer, Silke Bergmann, Kathrin Eismann, Marion Rittmaier, Andreas Goldwich, Sandra M. Müller, Bernd M. Spriewald, and Thomas Harrer. A Conserved HLA B13-Restricted Cytotoxic T Lymphocyte Epitope in Nef is a Dominant Epitope in HLA B13-Positive HIV-1-Infected Patients. AIDS, 19(7):734-735, 29 Apr 2005. PubMed ID: 15821402. Show all entries for this paper.

Displaying record number 53708

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HXB2 Location	Pol(464-472) RT(309-317) DNA(3474..3500)	Pol Epitope Map
Author Location
Epitope	ILKEPVHGV	Epitope Alignment
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	Germany
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression, escape, variant cross-reactivity, optimal epitope

Notes

• An HLA-B13-restricted optimal epitope was defined in Nef, RI9. The frequency of CTLs specific for this epitope in B13-positive patients exceeded the number of CTLs against other epitopes, indicating that this is a dominant epitope in B13-positive subjects. Three B13-positive patients who had an immunodominant response to this epitope were good controllers of their infection, with low viral loads over long periods.
• 5 HLA A2+ B13+ patients were found to make an immunodominant response to the B13 epitope RI9. 0/5 recognized the A2 epitope ILKEPVHGV, and only 1/5 recognized the A2 epitope SLYNTAVTL, with a much lower frequency than the B13 response.

References

Harrer2005b Ellen G. Harrer, Silke Bergmann, Kathrin Eismann, Marion Rittmaier, Andreas Goldwich, Sandra M. Müller, Bernd M. Spriewald, and Thomas Harrer. A Conserved HLA B13-Restricted Cytotoxic T Lymphocyte Epitope in Nef is a Dominant Epitope in HLA B13-Positive HIV-1-Infected Patients. AIDS, 19(7):734-735, 29 Apr 2005. PubMed ID: 15821402. Show all entries for this paper.

Displaying record number 53706

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HXB2 Location	Nef(106-114) DNA(9112..9138)	Nef Epitope Map
Author Location	Nef(106-114)
Epitope	RQDILDLWI	Epitope Alignment
		Show epitope variants
Epitope Name	RI9
Species (MHC/HLA)	human(B13)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression, escape, variant cross-reactivity, optimal epitope

Notes

• An HLA-B13-restricted optimal epitope was defined in Nef, RI9. The frequency of CTLs specific for this epitope in B13-positive patients exceeded the number of CTLs against other epitopes, indicating that this is a dominant epitope in B13-positive subjects. Three B13-positive patients who had an immunodominant response to this epitope were good controllers of their infection, with low viral loads over long periods.
• In B13-positive patients with a previous diagnosis of AIDS, an RrDILDLWI escape variant was found.
• This is a well conserved epitope but natural variants were tested. Peptide titation experiments indicate a V9I RQDILDLWv variant and RQDILDLWI are equally well recognized. Other natural substitutions are less well recognized: RkDILDLWI, RQeILDLWI, aQDILDLWI, RQaILDLWI, RrDILDLWv.

References

Harrer2005b Ellen G. Harrer, Silke Bergmann, Kathrin Eismann, Marion Rittmaier, Andreas Goldwich, Sandra M. Müller, Bernd M. Spriewald, and Thomas Harrer. A Conserved HLA B13-Restricted Cytotoxic T Lymphocyte Epitope in Nef is a Dominant Epitope in HLA B13-Positive HIV-1-Infected Patients. AIDS, 19(7):734-735, 29 Apr 2005. PubMed ID: 15821402. Show all entries for this paper.