Search CTL/CD8+ T-Cell Epitope Database

Found 9 matching records:

Displaying record number 626

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HXB2 Location	gp160(31-55) gp120(31-55) DNA(6315..6389)	gp160 Epitope Map
Author Location	gp120(32-56 LAI)
Epitope	`TEKLWVTVYYGVPVWKEATTTLFCA`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B18)
Immunogen	vaccine
Experimental methods
Keywords

Vaccine Details

Vaccine type	vaccinia
Vaccine component	gp160

Notes

This peptide can be processed for HLA-B18 presentation by both TAP-1/2 independent and dependent pathways.

References

Ferris1999 R. L. Ferris, C. Hall, N. V. Sipsas, J. T. Safrit, A. Trocha, R. A. Koup, R. P. Johnson, and R. F. Siliciano. Processing of HIV-1 Envelope Glycoprotein for Class I-Restricted Recognition: Dependence on TAP1/2 and Mechanisms for Cytosolic Localization. J. Immunol., 162:1324-1332, 1999. PubMed ID: 9973386. Show all entries for this paper.

Hammond1995 S. A. Hammond, R. P. Johnson, S. A. Kalams, B. D. Walker, M. Takiguchi, J. T. Safrit, R. A. Koup, and R. F. Siliciano. An Epitope-Selective Transporter Associated with Antigen Presentation TAP-1/2-Independent Pathway and a More General TAP-1/2-Dependent Antigen-Processing Pathway Allow Recognition of the HIV-1 Envelope Glycoprotein by CD8+ CTL. J. Immunol., 154:6140-6156, 1995. Two peptide-processing pathways are utilized for MHC class I presentation of HIV-1 Env epitopes. The previously characterized TAP-1 and TAP-2 dependent pathway can generate all Env epitopes and uses Env protein mislocalized in the cytosol to produce peptides. The second, novel pathway uses a TAP-1/2 independent pathway, and allows a subset of MHC-restricted epitopes to be processed in the endoplasmic reticulum or a Golgi compartment. PubMed ID: 7538543. Show all entries for this paper.

Displaying record number 634

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HXB2 Location	gp160(37-46) gp120(37-46) DNA(6333..6362)	gp160 Epitope Map
Author Location	gp120(37-46 LAI)
Epitope	`TVYYGVPVWK`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A*03:01)
Immunogen	vaccine
Experimental methods
Keywords

Vaccine Details

Vaccine type	vaccinia
Vaccine component	gp160

Notes

This peptide can be processed for HLA-A3.1 presentation by TAP-1/2 independent and dependent pathways.

References

Displaying record number 706

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HXB2 Location	gp160(298-307) gp120(298-307) DNA(7116..7145)	gp160 Epitope Map
Author Location	gp120(298-307)
Epitope	`RPNNNTRKSI`	Epitope Alignment
Species (MHC/HLA)	human(B*07)
Immunogen	HIV-1 infection
Experimental methods
Keywords	epitope processing, TCR usage

Notes

The processing of this epitope is TAP1/2-dependent, as are most Env epitopes, and it contains an N-linked glycosylation site that is glycosylated in Env.
Peptide that had been deglycosylated, a process that changes asparagine (N) to aspartic acid (D) (RPNDNTRKSI) was recognized a 100-fold more efficiently than either glycosylated or non-glycosylated RPNNNTRKSI.
Position 5 is not involved with HLA B*07 binding, so is probably important for TCR recognition.
HIV-1 Env epitopes are typically processed by a TAP1/2 dependent mechanism, which involves cotranslational translocation into the ER, glycosylation, export back into the cytosol, and deglycosylation for processing, and retransport into the ER for the association with class I molecules.
The particular pathway of generating an epitope may have an impact on the presentation of that epitope, quantitatively as well as qualitatively.

References

Displaying record number 703

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HXB2 Location	gp160(298-307) gp120(298-307) DNA(7116..7145)	gp160 Epitope Map
Author Location	gp120(302-312 HXB2)
Epitope	`RPNNNTRKSI`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods
Keywords

Notes

Peptide processed by a TAP-1/2-dependent pathway only.
CTL from an acute seroconverter.

References

Displaying record number 829

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HXB2 Location	gp160(584-592) gp41(73-81) DNA(7974..8000)	gp160 Epitope Map
Author Location	gp41(584-592)
Epitope	`ERYLKDQQL`	Epitope Alignment
Species (MHC/HLA)	human(B14)
Immunogen	HIV-1 infection
Experimental methods
Keywords

Notes

This peptide can be processed for HLA-B14 presentation in a TAP-1/2 independent pathway.

References

Displaying record number 832

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HXB2 Location	gp160(584-592) gp41(73-81) DNA(7974..8000)	gp160 Epitope Map
Author Location	gp120(584-592)
Epitope	`ERYLKDQQL`	Epitope Alignment
Species (MHC/HLA)	human(B14)
Immunogen	HIV-1 infection
Experimental methods
Keywords

Notes

This epitope is processed by both TAP1/2 dependent and independent mechanisms.

References

Displaying record number 849

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HXB2 Location	gp160(606-614) gp41(95-103) DNA(8040..8066)	gp160 Epitope Map
Author Location	gp41(606-614 LAI)
Epitope	`TAVPWNASW`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B35)
Immunogen	vaccine
Experimental methods
Keywords

Vaccine Details

Vaccine type	vaccinia
Vaccine component	gp160

Notes

Peptide only processed by a TAP-1/2-dependent pathway.

References

Displaying record number 861

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HXB2 Location	gp160(767-780) gp41(256-269) DNA(8523..8564)	gp160 Epitope Map
Author Location	gp41(606-614 LAI)
Epitope	`SYHRLRDLLLIVTR`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A31)
Immunogen	HIV-1 infection
Experimental methods
Keywords

Notes

Peptide only processed by a TAP-1/2-dependent pathway.
CTL from an acute seroconverter.

References

Displaying record number 866

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HXB2 Location	gp160(770-780) gp41(259-269) DNA(8532..8564)	gp160 Epitope Map
Author Location	gp41(770-780)
Epitope	`RLRDLLLIVTR`	Epitope Alignment
Species (MHC/HLA)	human(A31)
Immunogen	HIV-1 infection
Experimental methods
Keywords

Notes

This epitope is processed by a TAP1/2 dependent mechanism.