Search CTL/CD8+ T-Cell Epitope Database

Found 36 matching records:

Displaying record number 55861

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HXB2 Location	Gag(148-158) p24(16-26) DNA(1231..1263)	Gag Epitope Map
Author Location	Gag
Epitope	SPRTLNAWVKV	Epitope Alignment
Subtype	A, D
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Country	Sweden
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• HLA-B7-restricted epitope SPRTLNAWVKV is from a subtype A library, and is reactive in a subtype D-carrying subject. This epitope is part of reacting peptide VTSPRTLNAWVKVIE.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55749

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HXB2 Location	Gag(151-159) p24(19-27) DNA(1240..1266)	Gag Epitope Map
Author Location	Gag
Epitope	TLNAWVKVI	Epitope Alignment
Subtype	A, C, D
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	Sweden
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• HLA-A02-restricted epitope TLNAWVKVI is from subtype A and subtype C libraries, and is reactive in 2 subtype D-carrying subjects. This epitope is part of 2 reacting peptides, VTSPRTLNAWVKVIE and TLNAWVKVIEEKAFS.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55862

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HXB2 Location	Gag(160-168) p24(28-36) DNA(1267..1293)	Gag Epitope Map
Author Location	Gag
Epitope	EEKAFSPEV	Epitope Alignment
Subtype	B, D
Species (MHC/HLA)	human(B*45:01)
Immunogen	HIV-1 infection
Country	Sweden
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• HLA-B*4501-restricted epitope EEKAFSPEV is from a subtype B library, and is reactive as part of peptide VKVVEEKAFSPEVIP in a subtype D-carrying subject.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55864

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HXB2 Location	Gag(162-170) p24(30-38) DNA(1273..1299)	Gag Epitope Map
Author Location	Gag
Epitope	RAFSPEVIP	Epitope Alignment
Subtype	A, B, C
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Country	Sweden
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• HLA-B57-restricted epitope RAFSPEVIP is from subtype A and B libraries, and is reactive as part of peptide ERAFSPEVIPMFSAL in a subtype C-carrying subject.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55863

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HXB2 Location	Gag(162-172) p24(30-40) DNA(1273..1305)	Gag Epitope Map
Author Location	Gag
Epitope	KAFSPEVIPMF	Epitope Alignment
Subtype	A, B
Species (MHC/HLA)	human(B58)
Immunogen	HIV-1 infection
Country	Sweden
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• HLA-B58-restricted epitope KAFSPEVIPMF is from subtype A and B libraries, and is reactive as part of peptide EKAFSPEVIPMFSAL in a subtype B-carrying subject.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55865

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HXB2 Location	Gag(168-175) p24(36-43) DNA(1291..1314)	Gag Epitope Map
Author Location	Gag
Epitope	VIPMFSAL	Epitope Alignment
Subtype	B, D
Species (MHC/HLA)	human(Cw1)
Immunogen	HIV-1 infection
Country	Sweden
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• HLA-Cw1-restricted epitope VIPMFSAL is from a subtype D librariy, and is reactive as part of peptide PEVIPMFSALSEGAT in a subtype B-carrying subject.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55890

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HXB2 Location	Gag(171-185) p24(39-53) DNA(1300..1344)	Gag Epitope Map
Author Location	Gag
Epitope	MFSALSEGATPHDLN	Epitope Alignment
Subtype	A, D
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A*02, A*11, B*07, B*35, C*04, C*07, DPA1*01:03, DPB1*02:01, DPB1*04:01, DQB1*06, DRB1*13, DRB1*15, DRB3
Country	Sweden
Experimental methods	CD4 T-cell Elispot - IFNγ, CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• Epitope-containing reacting peptide MFSALSEGATPHDLN, seen in a subtype-D carrying subject was derived from a subtype A library and was not previously associated with host class I alleles A*02/*11; B*07/*35, Cw*04/*07.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55867

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HXB2 Location	Gag(180-189) p24(48-57) DNA(1327..1356)	Gag Epitope Map
Author Location	Gag
Epitope	TPQDLNTMLN	Epitope Alignment
Subtype	B, C, D
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Country	Sweden
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• HLA-B7-restricted epitope TPQDLNTMLN is from subtype B and C libraries, and is reactive as part of peptide SEGATPQDLNTMLNT in a subtype D-carrying subject.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55866

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HXB2 Location	Gag(180-190) p24(48-58) DNA(1327..1359)	Gag Epitope Map
Author Location	Gag
Epitope	TPQDLNTMLNT	Epitope Alignment
Subtype	B, C
Species (MHC/HLA)	human(B14)
Immunogen	HIV-1 infection
Country	Sweden
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• HLA-B14-restricted epitope TPQDLNTMLNT is from subtype B and C libraries, and is reactive as part of peptide SEGATPQDLNTMLNT in a subtype B-carrying subject.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55868

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HXB2 Location	Gag(181-191) p24(49-59) DNA(1330..1362)	Gag Epitope Map
Author Location	Gag
Epitope	PQDLNTMLNTV	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B14)
Immunogen	HIV-1 infection
Country	Sweden
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• HLA-B14-restricted epitope PQDLNTMLNTV is from a subtype B peptide library, and is reactive as part of peptide PQDLNTMLNTVGGHQ in a subtype B-carrying subject.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55870

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HXB2 Location	Gag(193-203) p24(61-71) DNA(1366..1398)	Gag Epitope Map
Author Location	Gag
Epitope	GHQAAMQMLKD	Epitope Alignment
Subtype	C, D
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	Sweden
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• HLA-A2-restricted epitope GHQAAMEMLKD is from a subtype C peptide library, and is reactive as part of peptide VGHQAAMEMLKDTI in a subtype D-carrying subject.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55869

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HXB2 Location	Gag(193-203) p24(61-71) DNA(1366..1398)	Gag Epitope Map
Author Location	Gag
Epitope	GHQAAMEMLKD	Epitope Alignment
Subtype	A, B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	Sweden
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• HLA-A2-restricted epitope GHQAAMEMLKD is from a subtype A peptide library, and is reactive as part of peptide GGHQAAMEMLKDTI in a subtype B-carrying subject.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55891

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HXB2 Location	Gag(196-210) p24(64-78) DNA(1375..1419)	Gag Epitope Map
Author Location	Gag
Epitope	AAMQMLKDTINEEAA	Epitope Alignment
Subtype	B, C
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A*02, A*03, B*07, B*08, C*07, C*16, DPA1*01:03, DPA1*02:02, DPB1, DQB1*06, DRB1*13:01, DRB1*15:01, DRB3
Country	Sweden
Experimental methods	CD4 T-cell Elispot - IFNγ, CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• Epitope-containing peptide AAMQMLKDTINEEAA, seen in a subtype-B carrying subject is derived from subtype B and C libraries and was not previously associated with host class I alleles A*02/*03; B*07/*08, Cw*07/*16.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55871

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HXB2 Location	Gag(211-218) p24(79-86) DNA(1420..1443)	Gag Epitope Map
Author Location	Gag
Epitope	EWDRVHPV	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	Sweden
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• HLA-A2-restricted epitope EWDRVHPV is from a subtype B peptide library, and is reactive as part of peptide EWDRVHPVHAGPIA in a subtype B-carrying subject.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55873

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HXB2 Location	Gag(216-223) p24(84-91) DNA(1435..1458)	Gag Epitope Map
Author Location	Gag
Epitope	HPVHAGPV	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B35)
Immunogen	HIV-1 infection
Country	Sweden
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• HLA-B35-restricted epitope HPVHAGPV is from a subtype B peptide library, and is reactive as part of peptide HPVHAGPVAPGQMRE in a subtype B-carrying subject.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55872

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HXB2 Location	Gag(216-224) p24(84-92) DNA(1435..1461)	Gag Epitope Map
Author Location	Gag
Epitope	HPVHAGPIA	Epitope Alignment
Subtype	B, C, D
Species (MHC/HLA)	human(B35, B7)
Immunogen	HIV-1 infection
Country	Sweden
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• HLA-B7-restricted epitope HPVHAGPIA is from a subtype B peptide library, and is reactive as part of peptide EWDRVHPVHAGPIAP in a subtype B-carrying subject. HLA-B35-restricted epitope HPVHAGPIA is from a subtype C peptide library, and is reactive as part of peptide HPVHAGPIAPGQMRE in a subtype D-carrying subject.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55874

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HXB2 Location	Gag(216-224) p24(84-92) DNA(1435..1461)	Gag Epitope Map
Author Location	Gag
Epitope	HPVHAGPVA	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Country	Sweden
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• HLA-B7-restricted epitope HPVHAGPVA is from a subtype B peptide library, and is reactive as part of peptide HPVHAGPVAQMRE in a subtype B-carrying subject.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55875

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HXB2 Location	Gag(241-250) p24(109-118) DNA(1510..1539)	Gag Epitope Map
Author Location	Gag
Epitope	STLQEQIGWM	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	Sweden
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• HLA-A2-restricted epitope STLQEQIGWM is from a subtype B peptide library, and is reactive as part of peptide STLQEQIGWMTNNPP in a subtype B-carrying subject.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55893

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HXB2 Location	Gag(246-260) p24(114-128) DNA(1525..1569)	Gag Epitope Map
Author Location	Gag
Epitope	QIGWMTNNPPIPVGE	Epitope Alignment
Subtype	A, B, CRF02_AG
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A*23, B*15, B*49, C*02, C*07, DPA1*02:01, DPB1*01:01, DPB1*13:01, DQB1*05, DRB1*11, DRB1*13:01
Country	Sweden
Experimental methods	CD4 T-cell Elispot - IFNγ, CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• Epitope-containing peptide QIGWMTNNPPIPVGE, seen in a subtype-A/G carrying subject was derived from subtype A and B libraries and was not previously associated with host class I alleles A*23/*23; B*15/*49, Cw*02/*07.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55876

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HXB2 Location	Gag(256-270) p24(124-138) DNA(1555..1599)	Gag Epitope Map
Author Location	Gag
Epitope	IPVGEIYKRWIILGL	Epitope Alignment
Subtype	A, B, C
Species (MHC/HLA)	human(B8)
Immunogen	HIV-1 infection
Country	Sweden
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• HLA-B8-restricted epitope IPVGEIYKRWIILGL is from subtype A,B and C peptide libraries, and is reactive in a subtype B-carrying subject.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55881

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HXB2 Location	Gag(261-272) p24(129-140) DNA(1570..1605)	Gag Epitope Map
Author Location	Gag
Epitope	IYKRWIILGLNK	Epitope Alignment
Subtype	A, B, C, CRF01_AE
Species (MHC/HLA)	human(A24)
Immunogen	HIV-1 infection
Country	Sweden
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• HLA-A24-restricted epitope IYKRWIILGLNK is from subtype A,B and C peptide libraries, and is reactive in subtype B and subtype AE-carrying subjects. This epitope is part of reacting peptide IYKRWIILGLNKIVR.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55879

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HXB2 Location	Gag(266-275) p24(134-143) DNA(1585..1614)	Gag Epitope Map
Author Location	Gag
Epitope	IILGLNKIVR	Epitope Alignment
Subtype	A, B, C
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Country	Sweden
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• HLA-A3-restricted epitope IILGLNKIVR is from subtype A,B and C peptide libraries, and is reactive in subtype B and subtype C-carrying subjects. This epitope is part of reacting peptide IYKRWIILGNKIVR.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55877

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HXB2 Location	Gag(269-277) p24(137-145) DNA(1594..1620)	Gag Epitope Map
Author Location	Gag
Epitope	GLNKIVRMY	Epitope Alignment
Subtype	A, B
Species (MHC/HLA)	human(B15)
Immunogen	HIV-1 infection
Country	Sweden
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• HLA B15-restricted epitope GLNKIVRMY is from subtype A and B peptide libraries, and is reactive in subtype A and B-carrying subjects as part of peptides IILGLNKIVRMYSPV and IIVGLNKIVRMYSPV respectively.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55892

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HXB2 Location	Gag(271-285) p24(139-153) DNA(1600..1644)	Gag Epitope Map
Author Location	Gag
Epitope	NKIVRMYSPVSILDI	Epitope Alignment
Subtype	A, CRF02_AG
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A*23, B*15, B*49, C*02, C*07, DPA1*02:01, DPB1*01:01, DPB1*13:01, DQB1*05, DRB1*11, DRB1*13:01
Country	Sweden
Experimental methods	CD4 T-cell Elispot - IFNγ, CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• Epitope-containing peptide NKIVRMYSPVSILDI, seen in a subtype-A/G carrying subject was derived from a subtype A library and was not previously associated with host class I alleles A*23/*23; B*15/*49, Cw*02/*07.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55898

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HXB2 Location	Gag(281-295) p24(149-163) DNA(1630..1674)	Gag Epitope Map
Author Location	Gag
Epitope	SILDIKQGPKEPFRD	Epitope Alignment
Subtype	A
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A*03:08, A*24, B*15, B*18, DPA1*01:03, DPB1, DQB1*03, DQB1*06, DRB1*12, DRB1*15, DRB3, DRB5
Country	Sweden
Experimental methods	CD4 T-cell Elispot - IFNγ, CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• Epitope-containing peptide SILDIKQGPKEPFRD, seen in a subtype-A carrying subject was derived from a subtype A library and was not previously associated with host class I alleles A*0308,A*24,B*15,B*18.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55895

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HXB2 Location	Gag(286-300) p24(154-168) DNA(1645..1689)	Gag Epitope Map
Author Location	Gag
Epitope	RQGPKEPFRDYVDRF	Epitope Alignment
Subtype	A, B, CRF02_AG
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A*23, B*15, B*49, C*02, C*07, DPA1*02:01, DPB1*01:01, DPB1*13:01, DQB1*05, DRB1*11, DRB1*13:01
Country	Sweden
Experimental methods	CD4 T-cell Elispot - IFNγ, CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• Epitope-containing peptide RQGPKEPFRDYVDRF, seen in a subtype-A/G carrying subject was derived from subtype A and B libraries and was not previously associated with host class I alleles A*23/*23, B*15/B*49, Cw*02/Cw*07.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55882

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HXB2 Location	Gag(291-300) p24(159-168) DNA(1660..1689)	Gag Epitope Map
Author Location	Gag
Epitope	EPFRDYVDRF	Epitope Alignment
Subtype	B, D
Species (MHC/HLA)	human(A*02:01, A2)
Immunogen	HIV-1 infection
Country	Sweden
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• HLA A2-restricted epitope EPFRDYVDRF is from a subtype B peptide library, and is reactive in subtype B-carrying subjects. The HLA A*0201-restricted epitope is from a subtype B peptide library, and is reactive in subtype D-carrying subjects. The epitope is part of reacting peptides EPFRDYVDRFYKTLR and RQGPKEPFRDYVDRF.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55883

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HXB2 Location	Gag(293-304) p24(161-172) DNA(1666..1701)	Gag Epitope Map
Author Location	Gag
Epitope	FRDYVDRFFKAL	Epitope Alignment
Subtype	A
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Country	Sweden
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• HLA-A3-restricted epitope FRDYVDRFFKAL is from a subtype A peptide library, and is reactive as part of EPFRDYVDRFFKALR in subtype A-carrying subjects.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55884

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HXB2 Location	Gag(296-304) p24(164-172) DNA(1675..1701)	Gag Epitope Map
Author Location	Gag
Epitope	YVDRFFKAL	Epitope Alignment
Subtype	A, CRF01_AE
Species (MHC/HLA)	human(B15, C*03:03)
Immunogen	HIV-1 infection
Country	Sweden
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• HLA B15-restricted epitope YVDRFFKAL is from a subtype A peptide library (peptide EPFRDYVDRFFKALR), and was reactive in a subtype A-carrying subject. The HLA Cw*0303-restricted epitope is from a subtype A peptide library (peptide YVDRFFKALRAEQAT), and was reactive in a subtype AE-carrying subject.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55885

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HXB2 Location	Gag(298-308) p24(166-176) DNA(1681..1713)	Gag Epitope Map
Author Location	Gag
Epitope	DRFYKTLRAEQ	Epitope Alignment
Subtype	A, B
Species (MHC/HLA)	human(B14)
Immunogen	HIV-1 infection
Country	Sweden
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• HLA-B14-restricted epitope DRFYKTLRAEQ is from subtype A and B peptide libraries, and is reactive as part of peptide YVDRFYKTLRAEQAS in a subtype B-carrying subject.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55888

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HXB2 Location	Gag(326-334) p24(194-202) DNA(1765..1791)	Gag Epitope Map
Author Location	Gag
Epitope	ANPDCKTIL	Epitope Alignment
Subtype	B, C, CRF01_AE
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Country	Sweden
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• HLA-B7-restricted epitope ANPDCKTIL is from subtype B and C peptide libraries, and is reactive as part of peptide LLVQNANPDCKTILK in a subtype AE-carrying subject.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55887

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HXB2 Location	Gag(327-334) p24(195-202) DNA(1768..1791)	Gag Epitope Map
Author Location	Gag
Epitope	NPDCKTIL	Epitope Alignment
Subtype	B, C
Species (MHC/HLA)	human(B35)
Immunogen	HIV-1 infection
Country	Sweden
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• HLA B35-restricted epitope NPDCKTIL is from subtype B and C peptide libraries, and is reactive as part of peptide LLVQNANPDCKTILK in a subtype B-carrying subject.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55896

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HXB2 Location	Gag(331-345) p24(199-213) DNA(1780..1824)	Gag Epitope Map
Author Location	Gag
Epitope	KSILRGLGAGATLEE	Epitope Alignment
Subtype	A
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	6094: A*03:08, A*24, B*15, B*18, DPA1*01:03, DQB1*03, DQB1*06, DRB1*12, DRB1*15, DRB3, DRB5
Country	Sweden
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• Epitope-containing peptide KSILRGLGAGATLEE, seen in a subtype-A carrying subject was derived from a subtype A library and was not previously associated with host class I alleles A*24/*0308; B*15/*18; Cw.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55889

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HXB2 Location	Gag(341-349) p24(209-217) DNA(1810..1836)	Gag Epitope Map
Author Location	Gag
Epitope	ATLEEMMTA	Epitope Alignment
Subtype	B, D
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	Sweden
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• HLA-A2-restricted epitope ATLEEMMTA is from a subtype B peptide library, and is reactive as part of peptide ATLEEMMTACQGVGG in a subtype D-carrying subject.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55897

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HXB2 Location	Gag(351-363) p24(219-231) DNA(1840..1878)	Gag Epitope Map
Author Location	Gag
Epitope	QGVGGPGHKARVL	Epitope Alignment
Subtype	B, C
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A*02, A*33, B*14, B*35, C*07, C*12:14, DPA1*01, DPA1*02:01, DPB1*02:01, DPB1*10:01, DQB1*05, DRB1*01, DRB1*11
Country	Sweden
Experimental methods	CD4 T-cell Elispot - IFNγ, CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• Epitope-containing peptide QGVGGPGHKARVL, seen in a subtype-B carrying subject was derived from subtype B and C libraries and was not previously associated with host class I alleles A*02/*33; B*14/*35, Cw*04/*1214.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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Displaying record number 55886

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HXB2 Location	Gag(353-363) p24(221-231) DNA(1846..1878)	Gag Epitope Map
Author Location	Gag
Epitope	VGGPGHKARVL	Epitope Alignment
Subtype	C, CRF01_AE
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Country	Sweden
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	subtype comparisons

Notes

• By studying Gag p24 in different subtypes of subjects, previously discovered and new epitopes were identified. New T cell epitopes, both CD8 and CD4, related to the patients' HLA are described.
• T cells cross-reacted to peptides from different patient subtypes, and this cross-reactivity was distributed along the entire p24 protein.
• HLA-B7-restricted epitope VGGPGHKARVL is from a subtype C peptide library, and is reactive as part of peptide QGVGGPGHKARVL in a subtype AE-carrying subject.

References

Gudmundsdotter2008 L. Gudmundsdotter, D. Bernasconi, B. Hejdeman, E. Sandstrom, A. Alaeus, K. Lidman, B. Ensoli, B. Wahren, and S. Buttò. Cross-Clade Immune Responses to Gag p24 in Patients Infected with Different HIV-1 Subtypes and Correlation with HLA Class I and II Alleles. Vaccine, 26(40):5182-5187, 19 Sep 2008. PubMed ID: 18479789. Show all entries for this paper.

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