HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 22 matching records:

Displaying record number 6

HXB2 Location Gag(18-26)
p17(18-26)
DNA(841..867)
Gag Epitope Map
Author Location p17(18-26 IIIB)
Epitope KIRLRPGGK Epitope Alignment
KIRLRPGGK epitope logo
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Patient MHC/HLA 003: A*02, A*03, B*07, B*51
Experimental methods  
Keywords review, escape

Notes

References

Goulder1997 P. J. Goulder, A. K. Sewell, D. G. Lalloo, D. A. Price, J. A. Whelan, J. Evans, G. P. Taylor, G. Luzzi, P. Giangrande, R. E. Phillips, and A. J. McMichael. Patterns of Immunodominance in HIV-1-Specific Cytotoxic T Lymphocyte Responses in Two Human Histocompatibility Leukocyte Antigens (HLA)-Identical Siblings with HLA-A*0201 Are Influenced by Epitope Mutation. J. Exp. Med., 8:1423-1433, 1997. Primary human immunodeficiency virus (HIV) infection is controlled principally by HIV-specific cytotoxic T lymphocytes (CTL) to a steady- state level of virus load, which strongly influences the ultimate rate of progression to disease. Epitope selection by CTL may be an important determinant of the degree of immune control over the virus. This report describes the CTL responses of two HLA-identical hemophiliac brothers who were exposed to identical batches of Factor VIII and became seropositive within 10 wk of one another. Both have HLA-A*0201. The CTL responses of the two siblings were very dissimilar, one donor making strong responses to two epitopes within p17 Gag (HLA-A*0201-restricted SLYNTVATL and HLA-A3-restricted RLRPGGKKK). The sibling responded to neither epitope, but made strong responses to two epitopes presented by HLA-B7. This was not the result of differences in presentation of the epitopes. However, mutations in both immunodominant epitopes of the p17 Gag responder were seen in proviral sequences of the nonresponder. We then documented the CTL responses to two HLA-A*0201-restricted epitopes, in Gag (SLYNTVATL) and Pol (ILKEPVHGV) in 22 other HIV-infected donors with HLA-A*0201. The majority (71\%) generated responses to the Gag epitope. In the 29\% of donors failing to respond to the Gag epitope in standard assays, there was evidence of low frequency memory CTL responses using peptide stimulation of PBMC, and most of these donors also showed mutations in or around the Gag epitope. PubMed ID: 9126923. Show all entries for this paper.

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.


Displaying record number 18

HXB2 Location Gag(20-28)
p17(20-28)
DNA(847..873)
Gag Epitope Map
Author Location p17(20-28)
Epitope RLRPGGKKK Epitope Alignment
RLRPGGKKK epitope logo
Show epitope variants
Species (MHC/HLA) human(A*03)
Immunogen HIV-1 infection
Patient MHC/HLA 003: A*02, A*03, B*07, B*51
Experimental methods  
Keywords review, escape

Notes

References

Goulder1997 P. J. Goulder, A. K. Sewell, D. G. Lalloo, D. A. Price, J. A. Whelan, J. Evans, G. P. Taylor, G. Luzzi, P. Giangrande, R. E. Phillips, and A. J. McMichael. Patterns of Immunodominance in HIV-1-Specific Cytotoxic T Lymphocyte Responses in Two Human Histocompatibility Leukocyte Antigens (HLA)-Identical Siblings with HLA-A*0201 Are Influenced by Epitope Mutation. J. Exp. Med., 8:1423-1433, 1997. Primary human immunodeficiency virus (HIV) infection is controlled principally by HIV-specific cytotoxic T lymphocytes (CTL) to a steady- state level of virus load, which strongly influences the ultimate rate of progression to disease. Epitope selection by CTL may be an important determinant of the degree of immune control over the virus. This report describes the CTL responses of two HLA-identical hemophiliac brothers who were exposed to identical batches of Factor VIII and became seropositive within 10 wk of one another. Both have HLA-A*0201. The CTL responses of the two siblings were very dissimilar, one donor making strong responses to two epitopes within p17 Gag (HLA-A*0201-restricted SLYNTVATL and HLA-A3-restricted RLRPGGKKK). The sibling responded to neither epitope, but made strong responses to two epitopes presented by HLA-B7. This was not the result of differences in presentation of the epitopes. However, mutations in both immunodominant epitopes of the p17 Gag responder were seen in proviral sequences of the nonresponder. We then documented the CTL responses to two HLA-A*0201-restricted epitopes, in Gag (SLYNTVATL) and Pol (ILKEPVHGV) in 22 other HIV-infected donors with HLA-A*0201. The majority (71\%) generated responses to the Gag epitope. In the 29\% of donors failing to respond to the Gag epitope in standard assays, there was evidence of low frequency memory CTL responses using peptide stimulation of PBMC, and most of these donors also showed mutations in or around the Gag epitope. PubMed ID: 9126923. Show all entries for this paper.

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.


Displaying record number 49

HXB2 Location Gag(24-35)
p17(24-35)
DNA(859..894)
Gag Epitope Map
Author Location p17(25-35 SF2)
Epitope GGKKKYKLKHIV Epitope Alignment
GGKKKYKLKHIV epitope logo
Show epitope variants
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords review, immunodominance, escape

Notes

References

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.

Phillips1991 R. E. Phillips, S. Rowland-Jones, D. F. Nixon, F. M. Gotch, J. P. Edwards, A. O. Ogunlesi, J. G. Elvin, J. A. Rothbard, C. R. Bangham, C. R. Rizza, and A. J. McMichael. Human Immunodeficiency Virus Genetic Variation That Can Escape Cytotoxic T Cell Recognition. Nature, 354:453-459, 1991. Fluctuations in the specificity of cytotoxic T-cells for HIV were correlated with variability in proviral gag (DNA) epitope sequences. PubMed ID: 1721107. Show all entries for this paper.


Displaying record number 97

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Show epitope variants
Epitope Name SL9
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Patient MHC/HLA 003: A*02, A*03, B*07, B*51
Experimental methods  
Keywords review, escape

Notes

References

Goulder1997 P. J. Goulder, A. K. Sewell, D. G. Lalloo, D. A. Price, J. A. Whelan, J. Evans, G. P. Taylor, G. Luzzi, P. Giangrande, R. E. Phillips, and A. J. McMichael. Patterns of Immunodominance in HIV-1-Specific Cytotoxic T Lymphocyte Responses in Two Human Histocompatibility Leukocyte Antigens (HLA)-Identical Siblings with HLA-A*0201 Are Influenced by Epitope Mutation. J. Exp. Med., 8:1423-1433, 1997. Primary human immunodeficiency virus (HIV) infection is controlled principally by HIV-specific cytotoxic T lymphocytes (CTL) to a steady- state level of virus load, which strongly influences the ultimate rate of progression to disease. Epitope selection by CTL may be an important determinant of the degree of immune control over the virus. This report describes the CTL responses of two HLA-identical hemophiliac brothers who were exposed to identical batches of Factor VIII and became seropositive within 10 wk of one another. Both have HLA-A*0201. The CTL responses of the two siblings were very dissimilar, one donor making strong responses to two epitopes within p17 Gag (HLA-A*0201-restricted SLYNTVATL and HLA-A3-restricted RLRPGGKKK). The sibling responded to neither epitope, but made strong responses to two epitopes presented by HLA-B7. This was not the result of differences in presentation of the epitopes. However, mutations in both immunodominant epitopes of the p17 Gag responder were seen in proviral sequences of the nonresponder. We then documented the CTL responses to two HLA-A*0201-restricted epitopes, in Gag (SLYNTVATL) and Pol (ILKEPVHGV) in 22 other HIV-infected donors with HLA-A*0201. The majority (71\%) generated responses to the Gag epitope. In the 29\% of donors failing to respond to the Gag epitope in standard assays, there was evidence of low frequency memory CTL responses using peptide stimulation of PBMC, and most of these donors also showed mutations in or around the Gag epitope. PubMed ID: 9126923. Show all entries for this paper.

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.


Displaying record number 98

HXB2 Location Gag(77-85)
p17(77-85)
DNA(1018..1044)
Gag Epitope Map
Author Location p17(77-85)
Epitope SLYNTVATL Epitope Alignment
SLYNTVATL epitope logo
Epitope Name SL9
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Experimental methods  
Keywords review

Notes

References

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.


Displaying record number 230

HXB2 Location Gag(253-267)
p24(121-135)
DNA(1546..1590)
Gag Epitope Map
Author Location p24(255-274 SF2)
Epitope NPPIPVGEIYKRWII Epitope Alignment
NPPIPVGEIYKRWII epitope logo
Show epitope variants
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords review, immunodominance, escape

Notes

References

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.

Phillips1991 R. E. Phillips, S. Rowland-Jones, D. F. Nixon, F. M. Gotch, J. P. Edwards, A. O. Ogunlesi, J. G. Elvin, J. A. Rothbard, C. R. Bangham, C. R. Rizza, and A. J. McMichael. Human Immunodeficiency Virus Genetic Variation That Can Escape Cytotoxic T Cell Recognition. Nature, 354:453-459, 1991. Fluctuations in the specificity of cytotoxic T-cells for HIV were correlated with variability in proviral gag (DNA) epitope sequences. PubMed ID: 1721107. Show all entries for this paper.


Displaying record number 279

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(265-274 SF2)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Experimental methods  
Keywords dynamics, review, immunodominance, escape

Notes

References

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.

Phillips1991 R. E. Phillips, S. Rowland-Jones, D. F. Nixon, F. M. Gotch, J. P. Edwards, A. O. Ogunlesi, J. G. Elvin, J. A. Rothbard, C. R. Bangham, C. R. Rizza, and A. J. McMichael. Human Immunodeficiency Virus Genetic Variation That Can Escape Cytotoxic T Cell Recognition. Nature, 354:453-459, 1991. Fluctuations in the specificity of cytotoxic T-cells for HIV were correlated with variability in proviral gag (DNA) epitope sequences. PubMed ID: 1721107. Show all entries for this paper.


Displaying record number 280

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(263-272)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Experimental methods  
Keywords review, escape

Notes

References

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.

Nietfeld1995 W. Nietfeld, M. Bauer, M. Fevrier, R. Maier, B. Holzwarth, R. Frank, B. Maier, Y. Riviere, and A. Meyerhans. Sequence Constraints and Recognition by CTL of an HLA-B27-Restricted HIV-1 Gag Epitope. J. Immunol., 154:2188-2197, 1995. Single point mutations were introduced into this epitope in the viral strain LAI, and the ability of comparable peptides to sensitize target strains was tested. The change of anchor residue R 264 to (L or G), results in infectious virus, and corresponding peptide has reduced binding affinities for HLA-B27. The change of G 267 to K or E abrogated infectivity, and the peptide bound to HLA-B27, but did not serve as a target; thus nonrecognition of peptides derived from quasispecies analysis of a small region might not really be associated with an escape mutant, but rather a non-viable mutant. PubMed ID: 7868892. Show all entries for this paper.


Displaying record number 283

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(263-272)
Epitope KRWIIMGLNK Epitope Alignment
KRWIIMGLNK epitope logo
Show epitope variants
Species (MHC/HLA) human(B27)
Immunogen HIV-1 infection
Experimental methods  
Keywords review, immunodominance, escape

Notes

References

Goulder1997b P. J. R. Goulder, R. E. Phillips, R. A. Colbert, S. McAdam, G. Ogg, M. A. Nowak, P. Giangrande, G. Luzzi, B. Morgan, A. Edwards, A. McMichael, and S. Rowland-Jones. Late Escape from an Immunodominant Cytotoxic T-Lymphocyte Response Associated with Progression to AIDS. Nat. Med., 3:212-216, 1997. The CTL response was studied in six HIV+ individuals who make a strong immunodominat response to the same B27 epitope. In two donors an escape mutation arose after close to 10 years of epitope stability, around the time of progression to AIDS. PubMed ID: 9018241. Show all entries for this paper.

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.


Displaying record number 271

HXB2 Location Gag(263-272)
p24(131-140)
DNA(1576..1605)
Gag Epitope Map
Author Location p24(263-272 LAI)
Epitope KRWIILGLNK Epitope Alignment
KRWIILGLNK epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B*2705, B27)
Immunogen HIV-1 infection
Experimental methods  
Keywords review, rate of progression, immunodominance, escape

Notes

References

Goulder1997d P. J. Goulder, A. Edwards, R. E. Phillips, and A. J. McMichael. Identification of a Novel HLA-B*2705-Restricted Cytotoxic T Lymphocyte Epitope within a Conserved Region of HIV-1 Nef. AIDS, 11:536-538, 1997. PubMed ID: 9084804. Show all entries for this paper.

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.


Displaying record number 301

HXB2 Location Gag(269-277)
p24(137-145)
DNA(1594..1620)
Gag Epitope Map
Author Location p24(272-280 LAI)
Epitope GLNKIVRMY Epitope Alignment
GLNKIVRMY epitope logo
Subtype B
Species (MHC/HLA) human(B62)
Immunogen HIV-1 infection
Experimental methods  
Keywords review, escape

Notes

References

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.


Displaying record number 345

HXB2 Location Gag(323-337)
p24(191-205)
DNA(1756..1800)
Gag Epitope Map
Author Location p24(325-339 SF2)
Epitope VQNANPDCKTILKAL Epitope Alignment
VQNANPDCKTILKAL epitope logo
Show epitope variants
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords review, immunodominance, escape

Notes

References

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.

Phillips1991 R. E. Phillips, S. Rowland-Jones, D. F. Nixon, F. M. Gotch, J. P. Edwards, A. O. Ogunlesi, J. G. Elvin, J. A. Rothbard, C. R. Bangham, C. R. Rizza, and A. J. McMichael. Human Immunodeficiency Virus Genetic Variation That Can Escape Cytotoxic T Cell Recognition. Nature, 354:453-459, 1991. Fluctuations in the specificity of cytotoxic T-cells for HIV were correlated with variability in proviral gag (DNA) epitope sequences. PubMed ID: 1721107. Show all entries for this paper.


Displaying record number 362

HXB2 Location Gag(355-363)
p24(223-231)
DNA(1852..1878)
Gag Epitope Map
Author Location p24(355-363 LAI)
Epitope GPGHKARVL Epitope Alignment
GPGHKARVL epitope logo
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Patient MHC/HLA 003: A*02, A*03, B*07, B*51; 023: A*02, A*03, B*07, B*51
Experimental methods  
Keywords review, escape

Notes

References

Goulder1997 P. J. Goulder, A. K. Sewell, D. G. Lalloo, D. A. Price, J. A. Whelan, J. Evans, G. P. Taylor, G. Luzzi, P. Giangrande, R. E. Phillips, and A. J. McMichael. Patterns of Immunodominance in HIV-1-Specific Cytotoxic T Lymphocyte Responses in Two Human Histocompatibility Leukocyte Antigens (HLA)-Identical Siblings with HLA-A*0201 Are Influenced by Epitope Mutation. J. Exp. Med., 8:1423-1433, 1997. Primary human immunodeficiency virus (HIV) infection is controlled principally by HIV-specific cytotoxic T lymphocytes (CTL) to a steady- state level of virus load, which strongly influences the ultimate rate of progression to disease. Epitope selection by CTL may be an important determinant of the degree of immune control over the virus. This report describes the CTL responses of two HLA-identical hemophiliac brothers who were exposed to identical batches of Factor VIII and became seropositive within 10 wk of one another. Both have HLA-A*0201. The CTL responses of the two siblings were very dissimilar, one donor making strong responses to two epitopes within p17 Gag (HLA-A*0201-restricted SLYNTVATL and HLA-A3-restricted RLRPGGKKK). The sibling responded to neither epitope, but made strong responses to two epitopes presented by HLA-B7. This was not the result of differences in presentation of the epitopes. However, mutations in both immunodominant epitopes of the p17 Gag responder were seen in proviral sequences of the nonresponder. We then documented the CTL responses to two HLA-A*0201-restricted epitopes, in Gag (SLYNTVATL) and Pol (ILKEPVHGV) in 22 other HIV-infected donors with HLA-A*0201. The majority (71\%) generated responses to the Gag epitope. In the 29\% of donors failing to respond to the Gag epitope in standard assays, there was evidence of low frequency memory CTL responses using peptide stimulation of PBMC, and most of these donors also showed mutations in or around the Gag epitope. PubMed ID: 9126923. Show all entries for this paper.

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.


Displaying record number 522

HXB2 Location Pol(464-472)
RT(309-317)
DNA(3474..3500)
Pol Epitope Map
Author Location RT(476-484)
Epitope ILKEPVHGV Epitope Alignment
ILKEPVHGV epitope logo
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection
Patient MHC/HLA 023: A*02, A*03, B*07, B*51
Experimental methods  
Keywords review, escape

Notes

References

Goulder1997 P. J. Goulder, A. K. Sewell, D. G. Lalloo, D. A. Price, J. A. Whelan, J. Evans, G. P. Taylor, G. Luzzi, P. Giangrande, R. E. Phillips, and A. J. McMichael. Patterns of Immunodominance in HIV-1-Specific Cytotoxic T Lymphocyte Responses in Two Human Histocompatibility Leukocyte Antigens (HLA)-Identical Siblings with HLA-A*0201 Are Influenced by Epitope Mutation. J. Exp. Med., 8:1423-1433, 1997. Primary human immunodeficiency virus (HIV) infection is controlled principally by HIV-specific cytotoxic T lymphocytes (CTL) to a steady- state level of virus load, which strongly influences the ultimate rate of progression to disease. Epitope selection by CTL may be an important determinant of the degree of immune control over the virus. This report describes the CTL responses of two HLA-identical hemophiliac brothers who were exposed to identical batches of Factor VIII and became seropositive within 10 wk of one another. Both have HLA-A*0201. The CTL responses of the two siblings were very dissimilar, one donor making strong responses to two epitopes within p17 Gag (HLA-A*0201-restricted SLYNTVATL and HLA-A3-restricted RLRPGGKKK). The sibling responded to neither epitope, but made strong responses to two epitopes presented by HLA-B7. This was not the result of differences in presentation of the epitopes. However, mutations in both immunodominant epitopes of the p17 Gag responder were seen in proviral sequences of the nonresponder. We then documented the CTL responses to two HLA-A*0201-restricted epitopes, in Gag (SLYNTVATL) and Pol (ILKEPVHGV) in 22 other HIV-infected donors with HLA-A*0201. The majority (71\%) generated responses to the Gag epitope. In the 29\% of donors failing to respond to the Gag epitope in standard assays, there was evidence of low frequency memory CTL responses using peptide stimulation of PBMC, and most of these donors also showed mutations in or around the Gag epitope. PubMed ID: 9126923. Show all entries for this paper.

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.


Displaying record number 622

HXB2 Location gp160(31-39)
gp120(31-39)
DNA(6315..6341)
gp160 Epitope Map
Author Location gp160(30-39 WEAU)
Epitope AENLWVTVY Epitope Alignment
AENLWVTVY epitope logo
Show epitope variants
Species (MHC/HLA) human(B44)
Immunogen HIV-1 infection
Experimental methods  
Keywords immunodominance, escape

Notes

References

Borrow1997 P. Borrow, H. Lewicki, X. Wei, M. S. Horwitz, N. Peffer, H. Meyers, J. A. Nelson, J. E. Gairin, B. H. Hahn, M. B. Oldstone, and G. M. Shaw. Anti-Viral Pressure Exerted by HIV-1-Specific Cytotoxic T Lymphocytes (CTLs) During Primary Infection Demonstrated by Rapid Selection of CTL Escape Virus. Nat. Med., 3:205-211, 1997. Genetic pathways of virus escape from CTL pressure resembled virus escape from antiretroviral therapy. PubMed ID: 9018240. Show all entries for this paper.

Borrow1998 P. Borrow and G. M. Shaw. Cytotoxic T-Lymphocyte Escape Viral Variants: How Important Are They in Viral Evasion of Immune Clearance In Vivo? Immunol. Rev., 164:37-51, 1998. PubMed ID: 9795762. Show all entries for this paper.

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.


Displaying record number 635

HXB2 Location gp160(37-46)
gp120(37-46)
DNA(6333..6362)
gp160 Epitope Map
Author Location gp120(37-46 LAI)
Epitope TVYYGVPVWK Epitope Alignment
TVYYGVPVWK epitope logo
Subtype B
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Patient MHC/HLA 003: A*02, A*03, B*07, B*51
Experimental methods  
Keywords review, escape

Notes

References

Goulder1997 P. J. Goulder, A. K. Sewell, D. G. Lalloo, D. A. Price, J. A. Whelan, J. Evans, G. P. Taylor, G. Luzzi, P. Giangrande, R. E. Phillips, and A. J. McMichael. Patterns of Immunodominance in HIV-1-Specific Cytotoxic T Lymphocyte Responses in Two Human Histocompatibility Leukocyte Antigens (HLA)-Identical Siblings with HLA-A*0201 Are Influenced by Epitope Mutation. J. Exp. Med., 8:1423-1433, 1997. Primary human immunodeficiency virus (HIV) infection is controlled principally by HIV-specific cytotoxic T lymphocytes (CTL) to a steady- state level of virus load, which strongly influences the ultimate rate of progression to disease. Epitope selection by CTL may be an important determinant of the degree of immune control over the virus. This report describes the CTL responses of two HLA-identical hemophiliac brothers who were exposed to identical batches of Factor VIII and became seropositive within 10 wk of one another. Both have HLA-A*0201. The CTL responses of the two siblings were very dissimilar, one donor making strong responses to two epitopes within p17 Gag (HLA-A*0201-restricted SLYNTVATL and HLA-A3-restricted RLRPGGKKK). The sibling responded to neither epitope, but made strong responses to two epitopes presented by HLA-B7. This was not the result of differences in presentation of the epitopes. However, mutations in both immunodominant epitopes of the p17 Gag responder were seen in proviral sequences of the nonresponder. We then documented the CTL responses to two HLA-A*0201-restricted epitopes, in Gag (SLYNTVATL) and Pol (ILKEPVHGV) in 22 other HIV-infected donors with HLA-A*0201. The majority (71\%) generated responses to the Gag epitope. In the 29\% of donors failing to respond to the Gag epitope in standard assays, there was evidence of low frequency memory CTL responses using peptide stimulation of PBMC, and most of these donors also showed mutations in or around the Gag epitope. PubMed ID: 9126923. Show all entries for this paper.

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.


Displaying record number 981

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82 LAI)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Experimental methods  
Keywords review, escape

Notes

References

Couillin1994 I. Couillin, B. Culmann-Penciolelli, E. Gomard, J. Choppin, J. P Levy, J. G. Guillet, and S. Sarasgosti. Impaired Cytotoxic T Lymphocyte Recognition Due to Genetic Variations in the Main Immunogenic Region of the Human Immunodeficiency Virus 1 NEF Protein. J. Exp. Med., 180:1129-11234, 1994. HIV-1 HLA-A11 and -B18 restricted epitopes were sequenced from donors who do and do not express the HLA-A11 and B18 molecule. Selective variations were only detected in virus isolated from individuals expressing the appropriate HLA type. Variant peptides with single substitutions within the minimal epitope did not always completely abrogate HLA binding, suggesting that multiple alterations within a particular epitope may need to accumulate during disease progression to allow viral escape. PubMed ID: 7520468. Show all entries for this paper.

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.


Displaying record number 983

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82 LAI)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Subtype B
Species (MHC/HLA) human(A3)
Immunogen HIV-1 infection
Patient MHC/HLA 003: A*02, A*03, B*07, B*51; 023: A*02, A*03, B*07, B*51
Experimental methods  
Keywords review, escape

Notes

References

Goulder1997 P. J. Goulder, A. K. Sewell, D. G. Lalloo, D. A. Price, J. A. Whelan, J. Evans, G. P. Taylor, G. Luzzi, P. Giangrande, R. E. Phillips, and A. J. McMichael. Patterns of Immunodominance in HIV-1-Specific Cytotoxic T Lymphocyte Responses in Two Human Histocompatibility Leukocyte Antigens (HLA)-Identical Siblings with HLA-A*0201 Are Influenced by Epitope Mutation. J. Exp. Med., 8:1423-1433, 1997. Primary human immunodeficiency virus (HIV) infection is controlled principally by HIV-specific cytotoxic T lymphocytes (CTL) to a steady- state level of virus load, which strongly influences the ultimate rate of progression to disease. Epitope selection by CTL may be an important determinant of the degree of immune control over the virus. This report describes the CTL responses of two HLA-identical hemophiliac brothers who were exposed to identical batches of Factor VIII and became seropositive within 10 wk of one another. Both have HLA-A*0201. The CTL responses of the two siblings were very dissimilar, one donor making strong responses to two epitopes within p17 Gag (HLA-A*0201-restricted SLYNTVATL and HLA-A3-restricted RLRPGGKKK). The sibling responded to neither epitope, but made strong responses to two epitopes presented by HLA-B7. This was not the result of differences in presentation of the epitopes. However, mutations in both immunodominant epitopes of the p17 Gag responder were seen in proviral sequences of the nonresponder. We then documented the CTL responses to two HLA-A*0201-restricted epitopes, in Gag (SLYNTVATL) and Pol (ILKEPVHGV) in 22 other HIV-infected donors with HLA-A*0201. The majority (71\%) generated responses to the Gag epitope. In the 29\% of donors failing to respond to the Gag epitope in standard assays, there was evidence of low frequency memory CTL responses using peptide stimulation of PBMC, and most of these donors also showed mutations in or around the Gag epitope. PubMed ID: 9126923. Show all entries for this paper.

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.


Displaying record number 1007

HXB2 Location Nef(84-92)
DNA(9046..9072)
Nef Epitope Map
Author Location Nef(84-92 LAI)
Epitope AVDLSHFLK Epitope Alignment
AVDLSHFLK epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Experimental methods  
Keywords review, escape, variant cross-reactivity

Notes

References

Couillin1994 I. Couillin, B. Culmann-Penciolelli, E. Gomard, J. Choppin, J. P Levy, J. G. Guillet, and S. Sarasgosti. Impaired Cytotoxic T Lymphocyte Recognition Due to Genetic Variations in the Main Immunogenic Region of the Human Immunodeficiency Virus 1 NEF Protein. J. Exp. Med., 180:1129-11234, 1994. HIV-1 HLA-A11 and -B18 restricted epitopes were sequenced from donors who do and do not express the HLA-A11 and B18 molecule. Selective variations were only detected in virus isolated from individuals expressing the appropriate HLA type. Variant peptides with single substitutions within the minimal epitope did not always completely abrogate HLA binding, suggesting that multiple alterations within a particular epitope may need to accumulate during disease progression to allow viral escape. PubMed ID: 7520468. Show all entries for this paper.

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.


Displaying record number 1015

HXB2 Location Nef(90-97)
DNA(9064..9087)
Nef Epitope Map
Author Location Nef(89-97 LAI)
Epitope FLKEKGGL Epitope Alignment
FLKEKGGL epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Patient MHC/HLA A1, B7, B8, Cw*0701, Cw*0702
Experimental methods Chromium-release assay, HLA binding
Keywords review, escape

Notes

References

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.

Price1997 D. A. Price, P. J. Goulder, P. Klenerman, A. K. Sewell, P. J. Easterbrook, M. Troop, C. R. Bangham, and R. E. Phillips. Positive Selection of HIV-1 Cytotoxic T Lymphocyte Escape Variants during Primary Infection. Proc. Natl. Acad. Sci. U.S.A., 94:1890-1895, 1997. Cytotoxic T lymphocytes (CTLs) are thought to play a crucial role in the termination of the acute primary HIV-1 syndrome, but clear evidence for this presumption has been lacking. Here we demonstrate positive selection of HIV-1 proviral sequences encoding variants within a CTL epitope in Nef, a gene product critical for viral pathogenicity, during and after seroconversion. These positively selected HIV-1 variants carried epitope sequence changes that either diminished or escaped CTL recognition. Other proviruses had mutations that abolished the Nef epitope altogether. These results provide clear evidence that CTLs exert selection pressure on the viral population in acute HIV-1 infection. PubMed ID: 9050875. Show all entries for this paper.


Displaying record number 1023

HXB2 Location Nef(102-115)
DNA(9100..9141)
Nef Epitope Map
Author Location Nef(102-115 LAI)
Epitope HSQRRQDILDLWIY Epitope Alignment
HSQRRQDILDLWIY epitope logo
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Patient MHC/HLA 023: A*02, A*03, B*07, B*51
Experimental methods  
Keywords review, escape

Notes

References

Goulder1997 P. J. Goulder, A. K. Sewell, D. G. Lalloo, D. A. Price, J. A. Whelan, J. Evans, G. P. Taylor, G. Luzzi, P. Giangrande, R. E. Phillips, and A. J. McMichael. Patterns of Immunodominance in HIV-1-Specific Cytotoxic T Lymphocyte Responses in Two Human Histocompatibility Leukocyte Antigens (HLA)-Identical Siblings with HLA-A*0201 Are Influenced by Epitope Mutation. J. Exp. Med., 8:1423-1433, 1997. Primary human immunodeficiency virus (HIV) infection is controlled principally by HIV-specific cytotoxic T lymphocytes (CTL) to a steady- state level of virus load, which strongly influences the ultimate rate of progression to disease. Epitope selection by CTL may be an important determinant of the degree of immune control over the virus. This report describes the CTL responses of two HLA-identical hemophiliac brothers who were exposed to identical batches of Factor VIII and became seropositive within 10 wk of one another. Both have HLA-A*0201. The CTL responses of the two siblings were very dissimilar, one donor making strong responses to two epitopes within p17 Gag (HLA-A*0201-restricted SLYNTVATL and HLA-A3-restricted RLRPGGKKK). The sibling responded to neither epitope, but made strong responses to two epitopes presented by HLA-B7. This was not the result of differences in presentation of the epitopes. However, mutations in both immunodominant epitopes of the p17 Gag responder were seen in proviral sequences of the nonresponder. We then documented the CTL responses to two HLA-A*0201-restricted epitopes, in Gag (SLYNTVATL) and Pol (ILKEPVHGV) in 22 other HIV-infected donors with HLA-A*0201. The majority (71\%) generated responses to the Gag epitope. In the 29\% of donors failing to respond to the Gag epitope in standard assays, there was evidence of low frequency memory CTL responses using peptide stimulation of PBMC, and most of these donors also showed mutations in or around the Gag epitope. PubMed ID: 9126923. Show all entries for this paper.

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.


Displaying record number 1066

HXB2 Location Nef(134-144)
DNA(9196..9228)
Nef Epitope Map
Author Location Nef(134-144 LAI)
Epitope RYPLTFGWCYK Epitope Alignment
RYPLTFGWCYK epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B18)
Immunogen HIV-1 infection
Experimental methods  
Keywords review, escape

Notes

References

Couillin1994 I. Couillin, B. Culmann-Penciolelli, E. Gomard, J. Choppin, J. P Levy, J. G. Guillet, and S. Sarasgosti. Impaired Cytotoxic T Lymphocyte Recognition Due to Genetic Variations in the Main Immunogenic Region of the Human Immunodeficiency Virus 1 NEF Protein. J. Exp. Med., 180:1129-11234, 1994. HIV-1 HLA-A11 and -B18 restricted epitopes were sequenced from donors who do and do not express the HLA-A11 and B18 molecule. Selective variations were only detected in virus isolated from individuals expressing the appropriate HLA type. Variant peptides with single substitutions within the minimal epitope did not always completely abrogate HLA binding, suggesting that multiple alterations within a particular epitope may need to accumulate during disease progression to allow viral escape. PubMed ID: 7520468. Show all entries for this paper.

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.


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