Search CTL/CD8+ T-Cell Epitope Database

Found 35 matching records:

Displaying record number 54836

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HXB2 Location	Gag(6-15) p17(6-15) DNA(805..834)	Gag Epitope Map
Author Location	Gag( Henan isolate)
Epitope	`SVLSGGQLDR`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.

References

Gong2006 Xiaoyan Gong, Xien Gui, Yuxia Zhang, and Po Tien. Screening for CD8 Cytotoxic T Lymphocytes Specific for Gag of Human Immunodeficiency Virus Type 1 Subtype B' Henan Isolate from China and Identification of Novel Epitopes Restricted by the HLA-A2 and HLA-A11 Alleles. J. Gen. Virol., 87(Pt 1):151-158, Jan 2006. PubMed ID: 16361427. Show all entries for this paper.

Displaying record number 54831

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HXB2 Location	Gag(18-26) p17(18-26) DNA(841..867)	Gag Epitope Map
Author Location	Gag( Henan isolate)
Epitope	`KIRLRPGGK`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.

References

Displaying record number 54839

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HXB2 Location	Gag(18-27) p17(18-27) DNA(841..870)	Gag Epitope Map
Author Location	Gag( Henan isolate)
Epitope	`KIRLRPGGKK`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.

References

Displaying record number 54838

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HXB2 Location	Gag(20-28) p17(20-28) DNA(847..873)	Gag Epitope Map
Author Location	Gag( Henan isolate)
Epitope	`RLRPGGKKK`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.

References

Displaying record number 54832

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HXB2 Location	Gag(34-43) p17(34-43) DNA(889..918)	Gag Epitope Map
Author Location	Gag( Henan isolate)
Epitope	`IVWASRELER`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.

References

Displaying record number 54848

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HXB2 Location	Gag(49-57) p17(49-57) DNA(934..960)	Gag Epitope Map
Author Location	Gag( Henan isolate)
Epitope	`GLLESSEGC`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.

References

Displaying record number 54854

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HXB2 Location	Gag(59-67) p17(59-67) DNA(964..990)	Gag Epitope Map
Author Location	Gag( Henan isolate)
Epitope	`QILEQLQPA`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.

References

Displaying record number 54850

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HXB2 Location	Gag(59-68) p17(59-68) DNA(964..993)	Gag Epitope Map
Author Location	Gag( Henan isolate)
Epitope	`QILEQLQPAL`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.

References

Displaying record number 54860

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HXB2 Location	Gag(77-85) p17(77-85) DNA(1018..1044)	Gag Epitope Map
Author Location	Gag(77-85 Henan isolate)
Epitope	`SLYNTVAVL`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.
SLYNTVAVL was recognized by 61% HLA-A2-positive individuals.

References

Displaying record number 54845

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HXB2 Location	Gag(83-91) p17(83-91) DNA(1036..1062)	Gag Epitope Map
Author Location	Gag( Henan isolate)
Epitope	`AVLYCVHQR`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.

References

Displaying record number 54853

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HXB2 Location	Gag(84-92) p17(84-92) DNA(1039..1065)	Gag Epitope Map
Author Location	Gag( Henan isolate)
Epitope	`VLYCVHQRI`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.

References

Displaying record number 54841

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HXB2 Location	Gag(87-95) p17(87-95) DNA(1048..1074)	Gag Epitope Map
Author Location	Gag( Henan isolate)
Epitope	`CVHQRIEIK`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.

References

Displaying record number 54840

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HXB2 Location	Gag(89-98) p17(89-98) DNA(1054..1083)	Gag Epitope Map
Author Location	Gag( Henan isolate)
Epitope	`HQRIEIKDTK`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.

References

Displaying record number 54834

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HXB2 Location	Gag(103-112) p17(103-112) DNA(1096..1125)	Gag Epitope Map
Author Location	Gag( Henan isolate)
Epitope	`KIEEEQNKSK`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.

References

Displaying record number 54835

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HXB2 Location	Gag(194-202) p24(62-70) DNA(1369..1395)	Gag Epitope Map
Author Location	Gag( Henan isolate)
Epitope	`HQAAMQMLK`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.

References

Displaying record number 54856

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HXB2 Location	Gag(210-218) p24(78-86) DNA(1417..1443)	Gag Epitope Map
Author Location	p24( Henan isolate)
Epitope	`AEWDRLHPV`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.
AEWDRLHPV was among 5 mostly recognized epitopes (69%).

References

Displaying record number 54857

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HXB2 Location	Gag(242-250) p24(110-118) DNA(1513..1539)	Gag Epitope Map
Author Location	Gag(242-250 Henan isolate)
Epitope	`NLQEQIGWM`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.
NLQEQIGWM was among 5 mostly recognized epitopes (69%).

References

Displaying record number 54852

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HXB2 Location	Gag(242-251) p24(110-119) DNA(1513..1542)	Gag Epitope Map
Author Location	Gag( Henan isolate)
Epitope	`NLQEQIGWMT`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.

References

Displaying record number 54858

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HXB2 Location	Gag(249-258) p24(117-126) DNA(1534..1563)	Gag Epitope Map
Author Location	p24( Henan isolate)
Epitope	`WMTNNPPIPV`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.
WMTNNPPIPV was among 5 mostly recognized epitopes (69%).

References

Displaying record number 54851

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HXB2 Location	Gag(266-274) p24(134-142) DNA(1585..1611)	Gag Epitope Map
Author Location	Gag( Henan isolate)
Epitope	`IILGLNKIV`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.

References

Displaying record number 54849

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HXB2 Location	Gag(275-283) p24(143-151) DNA(1612..1638)	Gag Epitope Map
Author Location	Gag( Henan isolate)
Epitope	`RMYSPTSIL`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.

References

Displaying record number 54833

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HXB2 Location	Gag(281-290) p24(149-158) DNA(1630..1659)	Gag Epitope Map
Author Location	Gag
Epitope	`SILDIRQGPK`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.

References

Displaying record number 54830

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HXB2 Location	Gag(305-314) p24(173-182) DNA(1702..1731)	Gag Epitope Map
Author Location	Gag( Henan isolate)
Epitope	`RAEQASQEVK`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.

References

Displaying record number 54828

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HXB2 Location	Gag(322-331) p24(190-199) DNA(1753..1782)	Gag Epitope Map
Author Location	Gag( Henan isolate)
Epitope	`LVQNSNPDCK`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.

References

Displaying record number 54847

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HXB2 Location	Gag(323-331) p24(191-199) DNA(1756..1782)	Gag Epitope Map
Author Location	p24(323-331 Henan isolate)
Epitope	`VQNSNPDCK`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.
Newly identified HLA-A11-restricted epitope.
VQNSNPDCK was 1 of 2 most frequently recognized peptides restricted by HLA-A11 (54%).

References

Displaying record number 54846

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HXB2 Location	Gag(350-359) p24(218-227) DNA(1837..1866)	Gag Epitope Map
Author Location	Gag(350-359 Henan isolate)
Epitope	`CQGVGGPGHK`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.
CQGVGGPGHK was 1 of 2 most frequently recognized peptides restricted by HLA-A11 (59%).

References

Displaying record number 54829

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HXB2 Location	Gag(352-361) p24(220-229) DNA(1843..1872)	Gag Epitope Map
Author Location	Gag( Henan isolate)
Epitope	`GVGGPGHKAR`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.

References

Displaying record number 54862

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HXB2 Location	Gag(361-370) p24(229)-p2p7p1p6(7) DNA(1870..1899)	Gag Epitope Map
Author Location	Gag(361-370)
Epitope	`RVLAEAMSQV`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.
RVLAEAMSQV was seen in 69% HLA-A2-positive individuals.

References

Displaying record number 54855

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HXB2 Location	Gag(362-370) p24(230)-p2p7p1p6(7) DNA(1873..1899)	Gag Epitope Map
Author Location	p2p7p1p6(362-370 Henan isolate)
Epitope	`VLAEAMSQV`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.
While VLAEAMSQV was described previously to have strong CTL response in HLA-A2 individuals, in this study 8 of 13 (61%) A2-positive individuals demonstrated moderate response to this peptide.

References

Displaying record number 54861

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HXB2 Location	Gag(362-371) p24(230)-p2p7p1p6(8) DNA(1873..1902)	Gag Epitope Map
Author Location	p2p7p1p6(362-371 Henan isolate)
Epitope	`VLAEAMSQVT`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.
VLAEAMSQVT was among 5 most recognized peptides (69%).

References

Displaying record number 54842

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HXB2 Location	Gag(388-397) p2p7p1p6(25-34) DNA(1951..1980)	Gag Epitope Map
Author Location	Gag( Henan isolate)
Epitope	`KTVKCFNCGR`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.

References

Displaying record number 54843

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HXB2 Location	Gag(406-415) p2p7p1p6(43-52) DNA(2005..2034)	Gag Epitope Map
Author Location	Gag( Henan isolate)
Epitope	`KAPRKKGCWK`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.

References

Displaying record number 54837

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HXB2 Location	Gag(415-424) p2p7p1p6(52-61) DNA(2032..2061)	Gag Epitope Map
Author Location	( Henan isolate)
Epitope	`KCGKEGHQMK`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.

References

Displaying record number 54859

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HXB2 Location	Gag(448-457) p2p7p1p6(85-94) DNA(2131..2160)	Gag Epitope Map
Author Location	Gag(448-457 Henan isolate)
Epitope	`FLQSRPEPTA`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.
Newly identified HLA-A2-restricted epitope.
FLQSRPEPTA was among 5 mostly recognized peptides (77%).

References

Displaying record number 54844

Download this epitope record as JSON.

HXB2 Location	Gag(473-481) p2p7p1p6(110-118) DNA(2206..2232)	Gag Epitope Map
Author Location	Gag( Henan isolate)
Epitope	`SQKQEQIDK`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

CTL responses were studied in treated and untreated donors from China, using Gag peptides from Henan isolate. All peptides were predicted to have A2 or A11 restriction (two of the most prominent alleles in Chinese population) and HLA restriction was further analyzed by CTL recognition in patients carrying corresponding allele. Among treated donors, HLA-A2 donors had higher CTL response than than HLA-A11 donors. Chronically infected untreated individuals had higher magnitude of CTL response than treated ones.