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Displaying record number 745

HXB2 Location	gp160(311-320) gp120(311-320) DNA(7155..7184)	gp160 Epitope Map
Author Location	gp160
Epitope	`RGPGRAFVTI`	Epitope Alignment
Species (MHC/HLA)	mouse(H-2^d)
Immunogen	vaccine
Experimental methods
Keywords

Vaccine Details

Vaccine type	DNA, vaccinia
Vaccine component	Env
Adjuvant	IL-12

Notes

Induction of HIV-1 specific CD8 gamma IFN secreting cells was enhanced when IL-12 and Env were given together in a prime, followed by a VV expressing Env boost.
If IL-12 was also delivered as a boost from the viral vector, impairment of the IL-12 effects was noted, indicating that the vaccination schedule can be a critical parameter for success with DNA and vaccinia vectors used in combination with immunomodulators.
The negative effect observed when IL-12 was delivered with the boost involved nitric oxide.

References

Gherardi2000 M. M. Gherardi, J. C. Ramirez, and M. Esteban. Interleukin-12 (IL-12) Enhancement of the Cellular Immune Response against Human Immunodeficiency Virus Type 1 Env Antigen in a DNA Prime/Vaccinia Virus Boost Vaccine Regimen Is Time and Dose Dependent: Suppressive Effects of IL-12 Boost Are Mediated by Nitric Oxide. J. Virol., 74:6278-6286, 2000. PubMed ID: 10864637. Show all entries for this paper.