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Displaying record number 57505

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HXB2 Location	Pol(283-290) RT(128-135) DNA(2931..2954)	Pol Epitope Map
Author Location	RT
Epitope	TAFTIPSI	Epitope Alignment
		Show epitope variants
Species (MHC/HLA)	human(B*51)
Immunogen	HIV-1 infection
Country	Japan
Experimental methods
Keywords	escape, drug resistance

Notes

• This epitope is increasingly seen to harbor escape I135X, conferring resistance to the nonnucleoside reverse transcriptase inhitors (NNRTIs) efavirenz (EFV), nevirapine (NVP) or etravirine (ETR). I135X is detected in B*51-positive and -negative subjects.

References

Gatanaga2010 Hiroyuki Gatanaga, Hirotaka Ode, Atsuko Hachiya, Tsunefusa Hayashida, Hironori Sato, Masafumi Takiguchi, and Shinichi Oka. Impact of Human Leukocyte Antigen-B*51-Restricted Cytotoxic T-Lymphocyte Pressure on Mutation Patterns of Nonnucleoside Reverse Transcriptase Inhibitor Resistance. AIDS, 24(5):F15-F22, 13 Mar 2010. PubMed ID: 20160632. Show all entries for this paper.