Search CTL/CD8+ T-Cell Epitope Database

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Displaying record number 985

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HXB2 Location	Nef(73-82) DNA(9013..9042)	Nef Epitope Map
Author Location	Nef(73-82)
Epitope	QVPLRPMTYK	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods
Keywords

Notes

• The anti-Nef CTL line P1 specific for this epitope is able to kill target cells via two mechanisms.
• First: Ca²⁺-dependent, perforin-dependent Nef-specific lysis.
• Second: Ca²⁺-independent, CD95-dependent apoptosis that could also kill non-specific targets.
• Findings indicate that the two mechanisms are not mutually exclusive in human CTL, as they are in mice.
• CTL mediated CD95-dependent apoptosis may play a role in pathogenesis.

References

Garcia1997 S. Garcia, M. Fevrier, G. Dadaglio, H. Lecoeur, Y. Riviere, and M.-L. Gougeon. Potential Deleterious Effect of Anti-Viral Cytotoxic Lymphocyte through the CD95 (FAS/APO-1)-Mediated Pathway during Chronic HIV Infection. Immunol. Lett., 57:53-58, 1997. PubMed ID: 9232425. Show all entries for this paper.