Search CTL/CD8+ T-Cell Epitope Database

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Displaying record number 54603

HXB2 Location	gp160(311-320) gp120(311-320) DNA(7155..7184)	gp160 Epitope Map
Author Location	gp120
Epitope	RGPGRAFVTI	Epitope Alignment
Subtype	B
Species (MHC/HLA)	macaque, mouse(H-2Dd)
Immunogen	vaccine
Experimental methods	CD4 T-cell Elispot - IFNγ, Chromium-release assay, Other, Proliferation, Tetramer binding
Keywords	adjuvant comparison, vaccine antigen design, SIV

Vaccine Details

Notes

• HIV-epitope, RGPGRAFVTI, was fused to a Heptatis B core antigen (HBcAg) gene in order to improve immunogenicity of an epitope-based vaccine in mice. A vaccine containing hybrid HBcAg-epitope linked to an HIV-specific T helper epitope induced significantly higher responses than a hybrid HBcAG-epitope vaccine which perfomed better than epitope alone. The authors suggest that HBcAg could be a better carrier of foreign epitopes than even Hepatitis B surface antigen (HBsAg) - (previously studied).
• This work also deals with a multi-epitope SIV-based vaccine in non-human primates.

References

Fuller2007 Deborah Heydenburg Fuller, Tim Shipley, Todd M. Allen, James T. Fuller, Mary S. Wu, Helen Horton, Nancy Wilson, Georg Widera, and David I. Watkins. Immunogenicity of Hybrid DNA Vaccines Expressing Hepatitis B Core Particles Carrying Human AND Simian Immunodeficiency Virus Epitopes in Mice and Rhesus Macaques. Virology, 364(2):245-255, 1 Aug 2007. PubMed ID: 17428516. Show all entries for this paper.