Search CTL/CD8+ T-Cell Epitope Database

Found 12 matching records:

Displaying record number 57939

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HXB2 Location	Gag(20-28) p17(20-28) DNA(847..873)	Gag Epitope Map
Author Location	p17(20-28)
Epitope	`RLRPGGKKK`	Epitope Alignment
Epitope Name	RK9
Subtype	A1, B, C
Species (MHC/HLA)	human(A3)
Immunogen	vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	vaccine-induced immune responses

Vaccine Details

Vaccine type	adenovirus
Vaccine strain	B clade HXB2, A clade 92RW020, C clade 97ZA012
Vaccine component	Env, Gag-Pol

Notes

The study evaluated vaccine-induced T-cell responses in 40 uninfected volunteers. 12 epitopes were targeted. Certain HLA alleles (B27, B57, B35, B14) were preferentially utilized, while other alleles (A02, B07) were rarely utilized. This preference was explained by 4 factors: higher affinity of specific peptides to specific HLAs, higher avidity of certain T-cell receptors, HLA and peptide interactions, and higher surface expression of certain HLAs.
5/11 A3-positive vaccinees responded to RLRPGGKKK. This epitope sequence is an exact match for 45% of M-clade and 65% of B-clade sequences in the LANL HIV sequence database.

References

Friedrich2011 David Friedrich, Emilie Jalbert, Warren L. Dinges, John Sidney, Alex Sette, Yunda Huang, M. Juliana McElrath, and Helen Horton. Vaccine-Induced HIV-Specific CD8+ T Cells Utilize Preferential HLA Alleles and Target-Specific Regions of HIV-1. J. Acquir. Immune Defic. Syndr., 58(3):248-252, 1 Nov 2011. PubMed ID: 21709567. Show all entries for this paper.

Displaying record number 57952

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HXB2 Location	Gag(240-249) p24(108-117) DNA(1507..1536)	Gag Epitope Map
Author Location	p24(108-117)
Epitope	`TSTLQEQIGW`	Epitope Alignment
Epitope Name	TW10
Subtype	A1, B, C
Species (MHC/HLA)	human(B57, B58)
Immunogen	vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	vaccine-induced immune responses

Vaccine Details

Vaccine type	adenovirus
Vaccine strain	B clade HXB2, A clade 92RW020, C clade 97ZA012
Vaccine component	Env, Gag-Pol

Notes

The study evaluated vaccine-induced T-cell responses in 40 uninfected volunteers. 12 epitopes were targeted. Certain HLA alleles (B27, B57, B35, B14) were preferentially utilized, while other alleles (A02, B07) were rarely utilized. This preference was explained by 4 factors: higher affinity of specific peptides to specific HLAs, higher avidity of certain T-cell receptors, HLA and peptide interactions, and higher surface expression of certain HLAs.
4/4 B57, B58-positive vaccinees responded to TSTLQEQIGW. This epitope sequence is an exact match for 40% of M-clade and 73% of B-clade sequences in the LANL HIV sequence database.

References

Displaying record number 57945

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HXB2 Location	Gag(263-272) p24(131-140) DNA(1576..1605)	Gag Epitope Map
Author Location	p24(131-140)
Epitope	`KRWIILGLNK`	Epitope Alignment
Epitope Name	KK10
Subtype	A1, B, C
Species (MHC/HLA)	human(B*27:05)
Immunogen	vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	vaccine-induced immune responses

Vaccine Details

Vaccine type	adenovirus
Vaccine strain	B clade HXB2, A clade 92RW020, C clade 97ZA012
Vaccine component	Env, Gag-Pol

Notes

The study evaluated vaccine-induced T-cell responses in 40 uninfected volunteers. 12 epitopes were targeted. Certain HLA alleles (B27, B57, B35, B14) were preferentially utilized, while other alleles (A02, B07) were rarely utilized. This preference was explained by 4 factors: higher affinity of specific peptides to specific HLAs, higher avidity of certain T-cell receptors, HLA and peptide interactions, and higher surface expression of certain HLAs.
4/4 B*2705-positive vaccinees responded to KRWIILGLNK. This epitope sequence is an exact match for 87% of M-clade and 82% of B-clade sequences in the LANL HIV sequence database.

References

Displaying record number 57949

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HXB2 Location	Pol(8-16) Gag/Pol-TF(8-16) DNA(2106..2132)	Pol Epitope Map
Author Location	Gag/Pol(8-16)
Epitope	`FPQGKAREF`	Epitope Alignment
Epitope Name	FF9
Subtype	A1, B, C
Species (MHC/HLA)	human(B35)
Immunogen	vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	vaccine-induced immune responses

Vaccine Details

Vaccine type	adenovirus
Vaccine strain	B clade HXB2, A clade 92RW020, C clade 97ZA012
Vaccine component	Env, Gag-Pol

Notes

The study evaluated vaccine-induced T-cell responses in 40 uninfected volunteers. 12 epitopes were targeted. Certain HLA alleles (B27, B57, B35, B14) were preferentially utilized, while other alleles (A02, B07) were rarely utilized. This preference was explained by 4 factors: higher affinity of specific peptides to specific HLAs, higher avidity of certain T-cell receptors, HLA and peptide interactions, and higher surface expression of certain HLAs.
3/7 B35-positive vaccinees responded to FPQGKAREF. This epitope sequence is an exact match for 9% of M-clade and 30% of B-clade sequences in the LANL HIV sequence database.

References

Displaying record number 57948

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HXB2 Location	Pol(330-338) RT(175-183) DNA(3072..3098)	Pol Epitope Map
Author Location	RT(175-183)
Epitope	`NPDIVIYQY`	Epitope Alignment
Epitope Name	NY9
Subtype	A1, B, C
Species (MHC/HLA)	human(B35)
Immunogen	vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	vaccine-induced immune responses

Vaccine Details

Vaccine type	adenovirus
Vaccine strain	B clade HXB2, A clade 92RW020, C clade 97ZA012
Vaccine component	Env, Gag-Pol

Notes

The study evaluated vaccine-induced T-cell responses in 40 uninfected volunteers. 12 epitopes were targeted. Certain HLA alleles (B27, B57, B35, B14) were preferentially utilized, while other alleles (A02, B07) were rarely utilized. This preference was explained by 4 factors: higher affinity of specific peptides to specific HLAs, higher avidity of certain T-cell receptors, HLA and peptide interactions, and higher surface expression of certain HLAs.
5/7 B35-positive vaccinees responded to NPDIVIYQY. This epitope sequence is an exact match for 24% of M-clade and 66% of B-clade sequences in the LANL HIV sequence database.

References

Displaying record number 57951

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HXB2 Location	Pol(399-407) RT(244-252) DNA(3279..3305)	Pol Epitope Map
Author Location	RT(244-252)
Epitope	`IVLPEKDSW`	Epitope Alignment
Epitope Name	IVW9
Subtype	A1, B, C
Species (MHC/HLA)	human(B57, B58)
Immunogen	vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	vaccine-induced immune responses

Vaccine Details

Vaccine type	adenovirus
Vaccine strain	B clade HXB2, A clade 92RW020, C clade 97ZA012
Vaccine component	Env, Gag-Pol

Notes

The study evaluated vaccine-induced T-cell responses in 40 uninfected volunteers. 12 epitopes were targeted. Certain HLA alleles (B27, B57, B35, B14) were preferentially utilized, while other alleles (A02, B07) were rarely utilized. This preference was explained by 4 factors: higher affinity of specific peptides to specific HLAs, higher avidity of certain T-cell receptors, HLA and peptide interactions, and higher surface expression of certain HLAs.
2/4 B57, B58-positive vaccinees responded to IVLPEKDSW. This epitope sequence is an exact match for 14% of M-clade and 62% of B-clade sequences in the LANL HIV sequence database.

References

Displaying record number 57947

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HXB2 Location	Pol(448-456) RT(293-301) DNA(3426..3452)	Pol Epitope Map
Author Location	RT(293-301)
Epitope	`IPLTEEAEL`	Epitope Alignment
Epitope Name	IL9
Subtype	A1, B, C
Species (MHC/HLA)	human(B35)
Immunogen	vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	vaccine-induced immune responses

Vaccine Details

Vaccine type	adenovirus
Vaccine strain	B clade HXB2, A clade 92RW020, C clade 97ZA012
Vaccine component	Env, Gag-Pol

Notes

The study evaluated vaccine-induced T-cell responses in 40 uninfected volunteers. 12 epitopes were targeted. Certain HLA alleles (B27, B57, B35, B14) were preferentially utilized, while other alleles (A02, B07) were rarely utilized. This preference was explained by 4 factors: higher affinity of specific peptides to specific HLAs, higher avidity of certain T-cell receptors, HLA and peptide interactions, and higher surface expression of certain HLAs.
4/4 B35-positive vaccinees responded to IPLTEEAEL. This epitope sequence is an exact match for 9% of M-clade and 34% of B-clade sequences in the LANL HIV sequence database.

References

Displaying record number 57950

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HXB2 Location	Pol(552-561) RT(397-406) DNA(3738..3767)	Pol Epitope Map
Author Location	RT(397-406)
Epitope	`TWEAWWTEYW`	Epitope Alignment
Epitope Name	TWW10
Subtype	A1, B, C
Species (MHC/HLA)	human(B44, B49)
Immunogen	vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	vaccine-induced immune responses

Vaccine Details

Vaccine type	adenovirus
Vaccine strain	B clade HXB2, A clade 92RW020, C clade 97ZA012
Vaccine component	Env, Gag-Pol

Notes

The study evaluated vaccine-induced T-cell responses in 40 uninfected volunteers. 12 epitopes were targeted. Certain HLA alleles (B27, B57, B35, B14) were preferentially utilized, while other alleles (A02, B07) were rarely utilized. This preference was explained by 4 factors: higher affinity of specific peptides to specific HLAs, higher avidity of certain T-cell receptors, HLA and peptide interactions, and higher surface expression of certain HLAs.
6/7 B44,B49-positive vaccinees responded to TWEAWWTEYW. This epitope sequence is an exact match for 6% of M-clade and 25% of B-clade sequences in the LANL HIV sequence database.

References

Displaying record number 57944

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HXB2 Location	Pol(900-909) Integrase(185-194) DNA(4782..4811)	Pol Epitope Map
Author Location	Integrase(185-194)
Epitope	`FKRKGGIGGY`	Epitope Alignment
Epitope Name	FY10
Subtype	A1, B, C
Species (MHC/HLA)	human(B*27:05)
Immunogen	vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	vaccine-induced immune responses

Vaccine Details

Vaccine type	adenovirus
Vaccine strain	B clade HXB2, A clade 92RW020, C clade 97ZA012
Vaccine component	Env, Gag-Pol

Notes

The study evaluated vaccine-induced T-cell responses in 40 uninfected volunteers. 12 epitopes were targeted. Certain HLA alleles (B27, B57, B35, B14) were preferentially utilized, while other alleles (A02, B07) were rarely utilized. This preference was explained by 4 factors: higher affinity of specific peptides to specific HLAs, higher avidity of certain T-cell receptors, HLA and peptide interactions, and higher surface expression of certain HLAs.
4/4 B*2705-positive vaccinees responded to FKRKGGIGGY. This epitope sequence is an exact match for 86% of M-clade and 80% of B-clade sequences in the LANL HIV sequence database.

References

Displaying record number 57942

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HXB2 Location	gp160(37-46) gp120(37-46) DNA(6333..6362)	gp160 Epitope Map
Author Location	gp160(37-46)
Epitope	`TVYYGVPVWK`	Epitope Alignment
Epitope Name	TK10
Subtype	A1, B, C
Species (MHC/HLA)	human(A11, A3)
Immunogen	vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	vaccine-induced immune responses

Vaccine Details

Vaccine type	adenovirus
Vaccine strain	B clade HXB2, A clade 92RW020, C clade 97ZA012
Vaccine component	Env, Gag-Pol

Notes

The study evaluated vaccine-induced T-cell responses in 40 uninfected volunteers. 12 epitopes were targeted. Certain HLA alleles (B27, B57, B35, B14) were preferentially utilized, while other alleles (A02, B07) were rarely utilized. This preference was explained by 4 factors: higher affinity of specific peptides to specific HLAs, higher avidity of certain T-cell receptors, HLA and peptide interactions, and higher surface expression of certain HLAs.
9/16 A3,A11-positive vaccinees responded to TVYYGVPVWK. This epitope sequence is an exact match for 68% of M-clade and 92% of B-clade sequences in the LANL HIV sequence database.

References

Displaying record number 57946

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HXB2 Location	gp160(78-86) gp120(78-86) DNA(6456..6482)	gp160 Epitope Map
Author Location	gp160(78-86)
Epitope	`DPNPQEVVL`	Epitope Alignment
Epitope Name	DL9
Subtype	A1, B, C
Species (MHC/HLA)	human(B35)
Immunogen	vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	vaccine-induced immune responses

Vaccine Details

Vaccine type	adenovirus
Vaccine strain	B clade HXB2, A clade 92RW020, C clade 97ZA012
Vaccine component	Env, Gag-Pol

Notes

The study evaluated vaccine-induced T-cell responses in 40 uninfected volunteers. 12 epitopes were targeted. Certain HLA alleles (B27, B57, B35, B14) were preferentially utilized, while other alleles (A02, B07) were rarely utilized. This preference was explained by 4 factors: higher affinity of specific peptides to specific HLAs, higher avidity of certain T-cell receptors, HLA and peptide interactions, and higher surface expression of certain HLAs.
4/4 B35-positive vaccinees responded to DPNPQEVVL. This epitope sequence is an exact match for 12% of M-clade and 38% of B-clade sequences in the LANL HIV sequence database.

References

Displaying record number 57943

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HXB2 Location	gp160(584-592) gp41(73-81) DNA(7974..8000)	gp160 Epitope Map
Author Location	gp41(73-81)
Epitope	`ERYLKDQQL`	Epitope Alignment
Epitope Name	EL9
Subtype	A1, B, C
Species (MHC/HLA)	human(B14)
Immunogen	vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	vaccine-induced immune responses

Vaccine Details

Vaccine type	adenovirus
Vaccine strain	B clade HXB2, A clade 92RW020, C clade 97ZA012
Vaccine component	Env, Gag-Pol

Notes

The study evaluated vaccine-induced T-cell responses in 40 uninfected volunteers. 12 epitopes were targeted. Certain HLA alleles (B27, B57, B35, B14) were preferentially utilized, while other alleles (A02, B07) were rarely utilized. This preference was explained by 4 factors: higher affinity of specific peptides to specific HLAs, higher avidity of certain T-cell receptors, HLA and peptide interactions, and higher surface expression of certain HLAs.
5/5 B14-positive vaccinees responded to ERYLKDQQL. This epitope sequence is an exact match for 51% of M-clade and 51% of B-clade sequences in the LANL HIV sequence database.