Search CTL/CD8+ T-Cell Epitope Database

Found 33 matching records:

Displaying record number 55206

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HXB2 Location	Gag(28-36) p17(28-36) DNA(871..897)	Gag Epitope Map
Author Location
Epitope	`KYKLKHIVW`	Epitope Alignment
Species (MHC/HLA)	human(A24)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	supertype, HLA cross-presentation

Notes

100 HIV-infected subjects were tested for response to optimally-defined CTL epitopes regardless of the subject's HLA type. Half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Statistical and experimental methods were used to define additional HLA alleles associated with the epitopes.
In addition to its known HLA association (A24), an additional HLA (A23) was statistically predicted to be associated with this epitope.

References

Frahm2007b Nicole Frahm, Karina Yusim, Todd J. Suscovich, Sharon Adams, John Sidney, Peter Hraber, Hannah S. Hewitt, Caitlyn H. Linde, Daniel G. Kavanagh, Tonia Woodberry, Leah M. Henry, Kellie Faircloth, Jennifer Listgarten, Carl Kadie, Nebojsa Jojic, Kaori Sango, Nancy V. Brown, Eunice Pae, M. Tauheed Zaman, Florian Bihl, Ashok Khatri, Mina John, Simon Mallal, Francesco M. Marincola, Bruce D . Walker, Alessandro Sette, David Heckerman, Bette T. Korber, and Christian Brander. Extensive HLA Class I Allele Promiscuity among Viral CTL Epitopes. Eur. J. Immunol., 37(9):2419-2433, Sep 2007. PubMed ID: 17705138. Show all entries for this paper.

Displaying record number 55215

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HXB2 Location	Gag(36-44) p17(36-44) DNA(895..921)	Gag Epitope Map
Author Location
Epitope	`WASRELERF`	Epitope Alignment
Species (MHC/HLA)	human(B35)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	supertype, HLA cross-presentation, optimal epitope

Notes

100 HIV-infected subjects were tested for response to optimally-defined CTL epitopes regardless of the subject's HLA type. Half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Statistical and experimental methods were used to define additional HLA alleles associated with the epitopes.
In addition to its known HLA association (B35), an additional HLA (B53) was statistically predicted to be associated with this optimal epitope, WASRELERF.

References

Displaying record number 55189

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HXB2 Location	Gag(145-155) p24(13-23) DNA(1222..1254)	Gag Epitope Map
Author Location
Epitope	`QAISPRTLNAW`	Epitope Alignment
Species (MHC/HLA)	human(A25)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	supertype, HLA cross-presentation, optimal epitope

Notes

100 HIV-infected subjects were tested for response to optimally-defined CTL epitopes regardless of the subject's HLA type. Half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Statistical and experimental methods were used to define additional HLA alleles associated with the epitopes.
Based on a prediction of the minimum number of HLA alleles needed to cover the HLA representation in all responders to this optimal epitope, a minimum set of 6 alleles was found: 1 allele previously known to be associated (A25) and 5 additional alleles (A23, A68, B44, Cw04, Cw07).

References

Displaying record number 55212

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HXB2 Location	Gag(148-156) p24(16-24) DNA(1231..1257)	Gag Epitope Map
Author Location
Epitope	`SPRTLNAWV`	Epitope Alignment
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	supertype, HLA cross-presentation

Notes

100 HIV-infected subjects were tested for response to optimally-defined CTL epitopes regardless of the subject's HLA type. Half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Statistical and experimental methods were used to define additional HLA alleles associated with the epitopes.
In addition to its known HLA association (B07), an additional HLA (B42) was statistically predicted to be associated with this epitope.

References

Displaying record number 55211

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HXB2 Location	Gag(176-184) p24(44-52) DNA(1315..1341)	Gag Epitope Map
Author Location
Epitope	`SEGATPQDL`	Epitope Alignment
Species (MHC/HLA)	human(B40)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	supertype, HLA cross-presentation

Notes

100 HIV-infected subjects were tested for response to optimally-defined CTL epitopes regardless of the subject's HLA type. Half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Statistical and experimental methods were used to define additional HLA alleles associated with the epitopes.
In addition to its known HLA association (B40), an additional HLA (B44) was statistically predicted to be associated with this epitope.

References

Displaying record number 55194

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HXB2 Location	Gag(180-188) p24(48-56) DNA(1327..1353)	Gag Epitope Map
Author Location
Epitope	`TPQDLNTML`	Epitope Alignment
Species (MHC/HLA)	human(B42, B53, B7, B81)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	supertype, HLA cross-presentation

Notes

100 HIV-infected subjects were tested for response to optimally-defined CTL epitopes regardless of the subject's HLA type. Half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Statistical and experimental methods were used to define additional HLA alleles associated with the epitopes.
Based on a prediction of the minimum number of HLA alleles needed to cover the HLA representation in all responders to this epitope, a minimum set of 6 alleles was found: 4 alleles previously known to be associated (B07, B42, B53, B81) and 3 additional alleles (A02, A24, B14).

References

Displaying record number 55198

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HXB2 Location	Gag(193-201) p24(61-69) DNA(1366..1392)	Gag Epitope Map
Author Location
Epitope	`GHQAAMQML`	Epitope Alignment
Species (MHC/HLA)	human(B39)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	supertype, HLA cross-presentation

Notes

100 HIV-infected subjects were tested for response to optimally-defined CTL epitopes regardless of the subject's HLA type. Half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Statistical and experimental methods were used to define additional HLA alleles associated with the epitopes.
In addition to its known HLA association (B39), 2 additional HLAs (A03, B38) were statistically predicted to be associated with this epitope.

References

Displaying record number 55200

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HXB2 Location	Gag(216-224) p24(84-92) DNA(1435..1461)	Gag Epitope Map
Author Location
Epitope	`HPVHAGPIA`	Epitope Alignment
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	supertype, HLA cross-presentation, optimal epitope

Notes

100 HIV-infected subjects were tested for response to optimally-defined CTL epitopes regardless of the subject's HLA type. Half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Statistical and experimental methods were used to define additional HLA alleles associated with the epitopes.
In addition to its known HLA association (B07), an additional HLA (B55) was statistically predicted to be associated with this optimal epitope, HPVHAGPIA.

References

Displaying record number 55188

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HXB2 Location	Gag(306-316) p24(174-184) DNA(1705..1737)	Gag Epitope Map
Author Location
Epitope	`AEQASQDVKNW`	Epitope Alignment
Species (MHC/HLA)	human(B44)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	supertype, HLA cross-presentation

Notes

100 HIV-infected subjects were tested for response to optimally-defined CTL epitopes regardless of the subject's HLA type. Half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Statistical and experimental methods were used to define additional HLA alleles associated with the epitopes.
In addition to its known HLA association (B44), an additional HLA (B45) was statistically predicted to be associated with this epitope.

References

Displaying record number 55208

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HXB2 Location	Gag(308-316) p24(176-184) DNA(1711..1737)	Gag Epitope Map
Author Location
Epitope	`QASQEVKNW`	Epitope Alignment
Species (MHC/HLA)	human(B53, B57, Cw4)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	supertype, HLA cross-presentation, optimal epitope

Notes

100 HIV-infected subjects were tested for response to optimally-defined CTL epitopes regardless of the subject's HLA type. Half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Statistical and experimental methods were used to define additional HLA alleles associated with the epitopes.
In addition to its known HLA associations (B53, B57, Cw04), an additional HLA (B58) was statistically predicted to be associated with this optimal epitope, QASQEVKNW.

References

Displaying record number 55199

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HXB2 Location	Gag(355-363) p24(223-231) DNA(1852..1878)	Gag Epitope Map
Author Location
Epitope	`GPGHKARVL`	Epitope Alignment
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	supertype, HLA cross-presentation

Notes

100 HIV-infected subjects were tested for response to optimally-defined CTL epitopes regardless of the subject's HLA type. Half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Statistical and experimental methods were used to define additional HLA alleles associated with the epitopes.
In addition to its known HLA association (B07), an additional HLA (B40) was statistically predicted to be associated with this epitope.

References

Displaying record number 55213

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HXB2 Location	Pol(283-290) RT(128-135) DNA(2931..2954)	Pol Epitope Map
Author Location
Epitope	`TAFTIPSI`	Epitope Alignment
Species (MHC/HLA)	human(B51)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	supertype, HLA cross-presentation

Notes

100 HIV-infected subjects were tested for response to optimally-defined CTL epitopes regardless of the subject's HLA type. Half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Statistical and experimental methods were used to define additional HLA alleles associated with the epitopes.
In addition to its known HLA association (B51), 2 additional HLAs (B35, B40) were statistically predicted to be associated with this epitope.

References

Displaying record number 58677

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HXB2 Location	Pol(311-319) RT(156-164) DNA(3015..3041)	Pol Epitope Map
Author Location
Epitope	`SPAIFQSSM`	Epitope Alignment
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	supertype, HLA cross-presentation, optimal epitope

Notes

100 HIV-infected subjects were tested for response to optimally-defined CTL epitopes regardless of the subject's HLA type. Half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Statistical and experimental methods were used to define additional HLA alleles associated with the epitopes.
In addition to its known HLA association (B07), 2 additional HLAs (B42, B81) were statistically predicted to be associated with this optimal epitope, SPAIFQSSM.

References

Displaying record number 55205

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HXB2 Location	Pol(328-336) RT(173-181) DNA(3066..3092)	Pol Epitope Map
Author Location
Epitope	`KQNPDIVIY`	Epitope Alignment
Species (MHC/HLA)	human(A30)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	supertype, HLA cross-presentation

Notes

100 HIV-infected subjects were tested for response to optimally-defined CTL epitopes regardless of the subject's HLA type. Half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Statistical and experimental methods were used to define additional HLA alleles associated with the epitopes.
In addition to its known HLA association (A30), an additional HLA (A6801) was statistically predicted to be associated with this epitope, KQNPDIVIY.

References

Displaying record number 58679

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HXB2 Location	Pol(330-337) RT(175-182) DNA(3072..3095)	Pol Epitope Map
Author Location
Epitope	`NPDIVIQYQ`	Epitope Alignment
Species (MHC/HLA)	human(A30)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	supertype, HLA cross-presentation, optimal epitope

Notes

100 HIV-infected subjects were tested for response to optimally-defined CTL epitopes regardless of the subject's HLA type. Half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Statistical and experimental methods were used to define additional HLA alleles associated with the epitopes.
In addition to peptide KQNPDIVIQYQ's known HLA association (A30), additional HLA (B35) is associated with the optimal embedded epitope, NPDIVIQYQ.

References

Displaying record number 55201

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HXB2 Location	Pol(357-365) RT(202-210) DNA(3153..3179)	Pol Epitope Map
Author Location
Epitope	`IEELRQHLL`	Epitope Alignment
Species (MHC/HLA)	human(B40)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	supertype, HLA cross-presentation

Notes

100 HIV-infected subjects were tested for response to optimally-defined CTL epitopes regardless of the subject's HLA type. Half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Statistical and experimental methods were used to define additional HLA alleles associated with the epitopes.
In addition to its known HLA association (B40), an additional HLA (B37) was statistically predicted to be associated with this epitope.

References

Displaying record number 55202

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HXB2 Location	Pol(399-407) RT(244-252) DNA(3279..3305)	Pol Epitope Map
Author Location
Epitope	`IVLPEKDSW`	Epitope Alignment
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	supertype, HLA cross-presentation

Notes

100 HIV-infected subjects were tested for response to optimally-defined CTL epitopes regardless of the subject's HLA type. Half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Statistical and experimental methods were used to define additional HLA alleles associated with the epitopes.
In addition to its known HLA association (B57), an additional HLA (B58) was statistically predicted to be associated with this epitope.

References

Displaying record number 58680

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HXB2 Location	Pol(496-504) RT(341-349) DNA(3570..3596)	Pol Epitope Map
Author Location
Epitope	`IYQEPFKNL`	Epitope Alignment
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	supertype, HLA cross-presentation, optimal epitope

Notes

100 HIV-infected subjects were tested for response to optimally-defined CTL epitopes regardless of the subject's HLA type. Half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Statistical and experimental methods were used to define additional HLA alleles associated with the epitopes.
In addition to peptide IYQEPFKNLK's known HLA association (A11), additional HLA (A24) is associated with this optimal embedded epitope, IYQEPFKNL.

References

Displaying record number 55207

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HXB2 Location	Pol(547-556) RT(392-401) DNA(3723..3752)	Pol Epitope Map
Author Location
Epitope	`PIQKETWETW`	Epitope Alignment
Species (MHC/HLA)	human(A32)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	supertype, HLA cross-presentation

Notes

100 HIV-infected subjects were tested for response to optimally-defined CTL epitopes regardless of the subject's HLA type. Half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Statistical and experimental methods were used to define additional HLA alleles associated with the epitopes.
In addition to its known HLA association (A32), an additional HLA (A24) was statistically predicted to be associated with this epitope.

References

Displaying record number 55197

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HXB2 Location	Vpr(34-42) DNA(5658..5684)	Vpr Epitope Map
Author Location
Epitope	`FPRIWLHGL`	Epitope Alignment
Species (MHC/HLA)	human(B7, B81)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	supertype, HLA cross-presentation

Notes

100 HIV-infected subjects were tested for response to optimally-defined CTL epitopes regardless of the subject's HLA type. Half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Statistical and experimental methods were used to define additional HLA alleles associated with the epitopes.
In addition to its known HLA associations (B07, B81), an additional HLA (B42) was statistically predicted to be associated with this epitope.

References

Displaying record number 55191

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HXB2 Location	gp160(557-565) gp41(46-54) DNA(7893..7919)	gp160 Epitope Map
Author Location
Epitope	`RAIEAQQHL`	Epitope Alignment
Species (MHC/HLA)	human(C*15, Cw3)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	supertype, HLA cross-presentation, optimal epitope

Notes

100 HIV-infected subjects were tested for response to optimally-defined CTL epitopes regardless of the subject's HLA type. Half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Statistical and experimental methods were used to define additional HLA alleles associated with the epitopes.
Based on a prediction of the minimum number of HLA alleles needed to cover the HLA representation in all responders to this optimal epitope,RAIEAQQHL, a minimum set of 6 alleles was found: 2 alleles previously known to be associated (Cw03, Cw15) and 4 additional alleles (A02, A30, B58, Cw04).

References

Displaying record number 55210

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HXB2 Location	gp160(585-593) gp41(74-82) DNA(7977..8003)	gp160 Epitope Map
Author Location
Epitope	`RYLKDQQLL`	Epitope Alignment
Species (MHC/HLA)	human(A24)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	supertype, HLA cross-presentation, optimal epitope

Notes

100 HIV-infected subjects were tested for response to optimally-defined CTL epitopes regardless of the subject's HLA type. Half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Statistical and experimental methods were used to define additional HLA alleles associated with the epitopes.
In addition to its known HLA association (A24), an additional HLA (A23) was statistically predicted to be associated with this optimal epitope, RYLKDQQLL.

References

Displaying record number 55192

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HXB2 Location	gp160(770-780) gp41(259-269) DNA(8532..8564)	gp160 Epitope Map
Author Location
Epitope	`RLRDLLLIVTR`	Epitope Alignment
Species (MHC/HLA)	human(A3, A31)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	supertype, HLA cross-presentation

Notes

100 HIV-infected subjects were tested for response to optimally-defined CTL epitopes regardless of the subject's HLA type. Half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Statistical and experimental methods were used to define additional HLA alleles associated with the epitopes.
Based on a prediction of the minimum number of HLA alleles needed to cover the HLA representation in all responders to this epitope, a minimum set of 6 alleles was found: 2 alleles previously known to be associated (A03, A31) and 4 additional alleles (A02, A74, B44, Cw04).

References

Displaying record number 55214

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HXB2 Location	Nef(71-79) DNA(9007..9033)	Nef Epitope Map
Author Location
Epitope	`TPQVPLRPM`	Epitope Alignment
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	supertype, HLA cross-presentation, optimal epitope

Notes

100 HIV-infected subjects were tested for response to optimally-defined CTL epitopes regardless of the subject's HLA type. Half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Statistical and experimental methods were used to define additional HLA alleles associated with the epitopes.
In addition to its known HLA association (B07), AN additional HLA (B42) was statistically predicted to be associated with this optimal epitope.

References

Displaying record number 55190

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HXB2 Location	Nef(73-82) DNA(9013..9042)	Nef Epitope Map
Author Location
Epitope	`QVPLRPMTYK`	Epitope Alignment
Species (MHC/HLA)	human(A11, A3)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	supertype, HLA cross-presentation

Notes

100 HIV-infected subjects were tested for response to optimally-defined CTL epitopes regardless of the subject's HLA type. Half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Statistical and experimental methods were used to define additional HLA alleles associated with the epitopes.
Based on a prediction of the minimum number of HLA alleles needed to cover the HLA representation in all responders to this epitope, a minimum set of 6 alleles was found: 2 alleles previously known to be associated (A03, A11) and 4 additional alleles (A02, A33, B44, Cw07).
In addition to its known HLA associations (A03, A11), an additional HLA (A34) was statistically predicted to be associated with this epitope.

References

Displaying record number 58678

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HXB2 Location	Nef(77-85) DNA(9025..9051)	Nef Epitope Map
Author Location
Epitope	`RPMTYKAAV`	Epitope Alignment
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	supertype, HLA cross-presentation, optimal epitope

Notes

100 HIV-infected subjects were tested for response to optimally-defined CTL epitopes regardless of the subject's HLA type. Half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Statistical and experimental methods were used to define additional HLA alleles associated with the epitopes.
In addition to its known HLA association (B07), 2 additional HLAs (B42, B39) were statistically predicted to be associated with this optimal epitope, RPMTYKAAV.

References

Displaying record number 55203

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HXB2 Location	Nef(82-91) DNA(9040..9069)	Nef Epitope Map
Author Location
Epitope	`KAAVDLSHFL`	Epitope Alignment
Species (MHC/HLA)	human(Cw8)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	supertype, HLA cross-presentation

Notes

100 HIV-infected subjects were tested for response to optimally-defined CTL epitopes regardless of the subject's HLA type. Half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Statistical and experimental methods were used to define additional HLA alleles associated with the epitopes.
In addition to its known HLA association (Cw08), an additional HLA (Cw03) was statistically predicted to be associated with this epitope.

References

Displaying record number 55187

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HXB2 Location	Nef(84-92) DNA(9046..9072)	Nef Epitope Map
Author Location
Epitope	`AVDLSHFLK`	Epitope Alignment
Species (MHC/HLA)	human(A11, A3)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	supertype, HLA cross-presentation

Notes

100 HIV-infected subjects were tested for response to optimally-defined CTL epitopes regardless of the subject's HLA type. Half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Statistical and experimental methods were used to define additional HLA alleles associated with the epitopes.
Based on a prediction of the minimum number of HLA alleles needed to cover the HLA representation in all responders to this epitope, a minimum set of 6 alleles was found: 2 alleles previously known to be associated (A03 and A11) and 4 additional alleles (A02, A23, A30, B44).

References

Displaying record number 55204

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HXB2 Location	Nef(92-100) DNA(9070..9096)	Nef Epitope Map
Author Location
Epitope	`KEKGGLEGL`	Epitope Alignment
Species (MHC/HLA)	human(B40)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	supertype, HLA cross-presentation

Notes

100 HIV-infected subjects were tested for response to optimally-defined CTL epitopes regardless of the subject's HLA type. Half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Statistical and experimental methods were used to define additional HLA alleles associated with the epitopes.
In addition to its known HLA association (B40), an additional HLA (B49) was statistically predicted to be associated with this epitope.

References

Displaying record number 55195

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HXB2 Location	Nef(120-128) DNA(9154..9180)	Nef Epitope Map
Author Location
Epitope	`YFPDWQNYT`	Epitope Alignment
Species (MHC/HLA)	human(B37, B57)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	supertype, HLA cross-presentation

Notes

100 HIV-infected subjects were tested for response to optimally-defined CTL epitopes regardless of the subject's HLA type. Half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Statistical and experimental methods were used to define additional HLA alleles associated with the epitopes.
Based on a prediction of the minimum number of HLA alleles needed to cover the HLA representation in all responders to this epitope, a minimum set of 6 alleles was found: 2 alleles previously known to be associated (B37, B57) and 5 additional alleles (A01, A02, A23, Cw02, Cw06).

References

Displaying record number 55193

Download this epitope record as JSON.

HXB2 Location	Nef(134-141) DNA(9196..9219)	Nef Epitope Map
Author Location
Epitope	`RYPLTFGW`	Epitope Alignment
Species (MHC/HLA)	human(A24)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	supertype, HLA cross-presentation, optimal epitope

Notes

100 HIV-infected subjects were tested for response to optimally-defined CTL epitopes regardless of the subject's HLA type. Half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Statistical and experimental methods were used to define additional HLA alleles associated with the epitopes.
Based on a prediction of the minimum number of HLA alleles needed to cover the HLA representation in all responders to this optimal epitope, a minimum set of 6 alleles was found: 1 allele previously known to be associated (A24) and 5 additional alleles (A01, A02, A23, Cw04, Cw07).

References

Displaying record number 55216

Download this epitope record as JSON.

HXB2 Location	Nef(135-143) DNA(9199..9225)	Nef Epitope Map
Author Location
Epitope	`YPLTFGWCY`	Epitope Alignment
Species (MHC/HLA)	human(B18)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	supertype, HLA cross-presentation

Notes

100 HIV-infected subjects were tested for response to optimally-defined CTL epitopes regardless of the subject's HLA type. Half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Statistical and experimental methods were used to define additional HLA alleles associated with the epitopes.
In addition to its known HLA association (B18), 2 additional HLAs (B35, B53) were statistically predicted to be associated with this epitope.

References

Displaying record number 55196

Download this epitope record as JSON.

HXB2 Location	Nef(135-143) DNA(9199..9225)	Nef Epitope Map
Author Location
Epitope	`YPLTFGWCY`	Epitope Alignment
Species (MHC/HLA)	human(B18)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	supertype, HLA cross-presentation

Notes

100 HIV-infected subjects were tested for response to optimally-defined CTL epitopes regardless of the subject's HLA type. Half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Statistical and experimental methods were used to define additional HLA alleles associated with the epitopes.
Based on a prediction of the minimum number of HLA alleles needed to cover the HLA representation in all responders to this epitope, a minimum set of 6 alleles was found: 1 allele previously known to be associated (B18) and 5 additional alleles (A02, A11, A23, A24, Cw04).