Search CTL/CD8+ T-Cell Epitope Database

Found 3 matching records:

Displaying record number 57506

Download this epitope record as JSON.

HXB2 Location	Gag(150-158) p24(18-26) DNA(1237..1263)	Gag Epitope Map
Author Location
Epitope	RLLNAWVKV	Epitope Alignment
Epitope Name	Gag150
Species (MHC/HLA)	transgenic mouse(A2)
Immunogen	vaccine
Experimental methods	T-cell Elispot
Keywords	vaccine-induced immune responses, adjuvant comparison, vaccine antigen design

Vaccine Details

Notes

• 15 conserved CD8 epitopes from multiple proteins and 2 helper epitopes were included to the vaccine candidate AFO18 with a novel cationic CAF01 adjuvant. AFO18- CAF01 vaccine candidate was tested in HLA-A2 transgenic mice.
• T-cell responses to the included peptides were tested in IFN-γ ELISPOT, and responses were found to both CD4 and CD8 peptides.
• This CD8 peptide was included in the vaccine and induced positive responses in 8/9 transgenic HLA-A2 mice.

References

Fomsgaard2011 Anders Fomsgaard, Ingrid Karlsson, Gregers Gram, Christian Schou, Sheila Tang, Peter Bang, Ingrid Kromann, Peter Andersen, and Lars Vibe Andreasen. Development and Preclinical Safety Evaluation of a New Therapeutic HIV-1 Vaccine Based on 18 T-Cell Minimal Epitope Peptides Applying a Novel Cationic Adjuvant CAF01. Vaccine, 29(40):7067-7074, Sep 16 2011. PubMed ID: 21767590. Show all entries for this paper.

Displaying record number 57507

Download this epitope record as JSON.

HXB2 Location	Gag(433-440) p2p7p1p6(70-77) DNA(2086..2109)	Gag Epitope Map
Author Location
Epitope	FLGKIWPS	Epitope Alignment
Epitope Name	Gag433
Species (MHC/HLA)	transgenic mouse(A2)
Immunogen	vaccine
Experimental methods	T-cell Elispot
Keywords	vaccine-induced immune responses, adjuvant comparison, vaccine antigen design

Vaccine Details

Notes

• 15 conserved CD8 epitopes from multiple proteins and 2 helper epitopes were included to the vaccine candidate AFO18 with a novel cationic CAF01 adjuvant. AFO18- CAF01 vaccine candidate was tested in HLA-A2 transgenic mice.
• T-cell responses to the included peptides were tested in IFN-γ ELISPOT, and responses were found to both CD4 and CD8 peptides.
• This CD8 peptide was included in the vaccine and induced positive responses in 5/9 transgenic HLA-A2 mice.

References

Fomsgaard2011 Anders Fomsgaard, Ingrid Karlsson, Gregers Gram, Christian Schou, Sheila Tang, Peter Bang, Ingrid Kromann, Peter Andersen, and Lars Vibe Andreasen. Development and Preclinical Safety Evaluation of a New Therapeutic HIV-1 Vaccine Based on 18 T-Cell Minimal Epitope Peptides Applying a Novel Cationic Adjuvant CAF01. Vaccine, 29(40):7067-7074, Sep 16 2011. PubMed ID: 21767590. Show all entries for this paper.

Displaying record number 57508

Download this epitope record as JSON.

HXB2 Location	Vif(23-31) DNA(5107..5133)	Vif Epitope Map
Author Location
Epitope	SLVKHHMYV	Epitope Alignment
Epitope Name	Vif23
Species (MHC/HLA)	transgenic mouse(A2)
Immunogen	vaccine
Experimental methods	T-cell Elispot
Keywords	vaccine-induced immune responses, adjuvant comparison, vaccine antigen design

Vaccine Details

Notes

• 15 conserved CD8 epitopes from multiple proteins and 2 helper epitopes were included to the vaccine candidate AFO18 with a novel cationic CAF01 adjuvant. AFO18- CAF01 vaccine candidate was tested in HLA-A2 transgenic mice.
• T-cell responses to the included peptides were tested in IFN-γ ELISPOT, and responses were found to both CD4 and CD8 peptides.
• This CD8 peptide was included in the vaccine and induced positive responses in 4/9 transgenic HLA-A2 mice.

References

Fomsgaard2011 Anders Fomsgaard, Ingrid Karlsson, Gregers Gram, Christian Schou, Sheila Tang, Peter Bang, Ingrid Kromann, Peter Andersen, and Lars Vibe Andreasen. Development and Preclinical Safety Evaluation of a New Therapeutic HIV-1 Vaccine Based on 18 T-Cell Minimal Epitope Peptides Applying a Novel Cationic Adjuvant CAF01. Vaccine, 29(40):7067-7074, Sep 16 2011. PubMed ID: 21767590. Show all entries for this paper.