Search CTL/CD8+ T-Cell Epitope Database

Found 9 matching records:

Displaying record number 59214

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HXB2 Location	Gag(20-28) p17(20-28) DNA(847..873)	Gag Epitope Map
Author Location	Gag(20-28)
Epitope	`RLRPGGKKK`	Epitope Alignment
Epitope Name	Gag 20-28
Subtype	B
Species (MHC/HLA)	human(A*03)
Immunogen	vaccine
Country	France
Experimental methods	CD8 T-cell Elispot - IFNγ, Degranulation, CD107a and b cell surface mobilization, Intracellular cytokine staining, Tetramer binding
Keywords	vaccine-induced immune responses

Vaccine Details

Vaccine type	lipopeptide

Notes

HIV-specific memory CTL responses from 16 lipopeptide-vaccinated uninfected unvaccinated subjects were fully characterized with respect to magnitude and multifunctionality, comparing them to FLU- or EBV-CTL. 62% of total secreting T cells produced IFN-γ in response to HIV (compared to 35% for FLU and EBV). HIV-specific CTL secreted either IFN-γ or TNF-α, not both as in FLU- and EBV-specific CTL. The more limited functional profile and magnitude of expanded CTL response against HIV mirrors its less effective vaccines.
Gag 20-28, RLRPGGKKK, lipopeptide was able to stimulate expanded effector CTLs that produced 120-480 SFC/10⁵ cells in EliSpot as opposed to none in 7 unvaccinated subjects.

References

Figueiredo2014 Suzanne Figueiredo, Benedicte Charmeteau, Mathieu Surenaud, Dominique Salmon, Odile Launay, Jean-Gérard Guillet, Anne Hosmalin, and Hanne Gahery. Memory CD8+ T Cells Elicited by HIV-1 Lipopeptide Vaccines Display Similar Phenotypic Profiles but Differences in Term of Magnitude and Multifunctionality Compared with FLU- or EBV-Specific Memory T Cells in Humans. Vaccine, 32(4):492-501, 16 Jan 2014. PubMed ID: 24291199. Show all entries for this paper.

Displaying record number 59205

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HXB2 Location	Gag(263-272) p24(131-140) DNA(1576..1605)	Gag Epitope Map
Author Location	Gag(263-272)
Epitope	`KRWIILGLNK`	Epitope Alignment
Epitope Name	Gag 263-272
Subtype	B
Species (MHC/HLA)	human(B*27)
Immunogen	vaccine
Country	France
Experimental methods	CD8 T-cell Elispot - IFNγ, Degranulation, CD107a and b cell surface mobilization, Intracellular cytokine staining, Tetramer binding
Keywords	vaccine-induced immune responses

Vaccine Details

Vaccine type	lipopeptide

Notes

HIV-specific memory CTL responses from 16 lipopeptide-vaccinated uninfected unvaccinated subjects were fully characterized with respect to magnitude and multifunctionality, comparing them to FLU- or EBV-CTL. 62% of total secreting T cells produced IFN-γ in response to HIV (compared to 35% for FLU and EBV). HIV-specific CTL secreted either IFN-γ or TNF-α, not both as in FLU- and EBV-specific CTL. The more limited functional profile and magnitude of expanded CTL response against HIV mirrors its less effective vaccines.
Gag 263-272, KRWIILGLNK, lipopeptide was able to stimulate expanded effector CTLs that produced 360-512 SFC/10⁵ cells in EliSpot as opposed to none in 3 unvaccinated subjects.

References

Displaying record number 59216

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HXB2 Location	Pol(313-321) RT(158-166) DNA(3021..3047)	Pol Epitope Map
Author Location	Pol(325-333)
Epitope	`AIFQSSMTK`	Epitope Alignment
Epitope Name	Pol 325-333
Subtype	B
Species (MHC/HLA)	human(A*03)
Immunogen	vaccine
Country	France
Experimental methods	CD8 T-cell Elispot - IFNγ, Degranulation, CD107a and b cell surface mobilization, Intracellular cytokine staining, Tetramer binding
Keywords	vaccine-induced immune responses

Vaccine Details

Vaccine type	lipopeptide

Notes

HIV-specific memory CTL responses from 16 lipopeptide-vaccinated uninfected unvaccinated subjects were fully characterized with respect to magnitude and multifunctionality, comparing them to FLU- or EBV-CTL. 62% of total secreting T cells produced IFN-γ in response to HIV (compared to 35% for FLU and EBV). HIV-specific CTL secreted either IFN-γ or TNF-α, not both as in FLU- and EBV-specific CTL. The more limited functional profile and magnitude of expanded CTL response against HIV mirrors its less effective vaccines.
Pol 325-333, AIFQSSMTK, lipopeptide was able to stimulate expanded effector CTLs that produced 163 SFC/10⁵ cells in EliSpot as opposed to none in 1 unvaccinated subject.

References

Displaying record number 59215

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HXB2 Location	gp160(37-46) gp120(37-46) DNA(6333..6362)	gp160 Epitope Map
Author Location	Env(37-46)
Epitope	`TVYYGVPVWK`	Epitope Alignment
Epitope Name	Env 37-46
Subtype	B
Species (MHC/HLA)	human(A03, A11)
Immunogen	vaccine
Country	France
Experimental methods	CD8 T-cell Elispot - IFNγ, Degranulation, CD107a and b cell surface mobilization, Intracellular cytokine staining, Tetramer binding
Keywords	vaccine-induced immune responses

Vaccine Details

Vaccine type	lipopeptide

Notes

HIV-specific memory CTL responses from 16 lipopeptide-vaccinated uninfected unvaccinated subjects were fully characterized with respect to magnitude and multifunctionality, comparing them to FLU- or EBV-CTL. 62% of total secreting T cells produced IFN-γ in response to HIV (compared to 35% for FLU and EBV). HIV-specific CTL secreted either IFN-γ or TNF-α, not both as in FLU- and EBV-specific CTL. The more limited functional profile and magnitude of expanded CTL response against HIV mirrors its less effective vaccines.
Env 37-46, TVYYGVPVWK, lipopeptide was able to stimulate expanded effector CTLs that produced 172-445 SFC/10⁵ cells in EliSpot as opposed to none in 2 unvaccinated subjects.

References

Displaying record number 59218

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HXB2 Location	Nef(68-76) DNA(8998..9024)	Nef Epitope Map
Author Location	Nef(68-76)
Epitope	`FPVTPQVPL`	Epitope Alignment
Epitope Name	Nef 68-76
Subtype	B
Species (MHC/HLA)	human(B*35)
Immunogen	vaccine
Country	France
Experimental methods	CD8 T-cell Elispot - IFNγ, Degranulation, CD107a and b cell surface mobilization, Intracellular cytokine staining, Tetramer binding
Keywords	vaccine-induced immune responses

Vaccine Details

Vaccine type	lipopeptide

Notes

HIV-specific memory CTL responses from 16 lipopeptide-vaccinated uninfected unvaccinated subjects were fully characterized with respect to magnitude and multifunctionality, comparing them to FLU- or EBV-CTL. 62% of total secreting T cells produced IFN-γ in response to HIV (compared to 35% for FLU and EBV). HIV-specific CTL secreted either IFN-γ or TNF-α, not both as in FLU- and EBV-specific CTL. The more limited functional profile and magnitude of expanded CTL response against HIV mirrors its less effective vaccines.
Nef 68-76, FPVTPQVPL, lipopeptide was able to stimulate expanded effector CTLs that produced 97 - >600 SFC/10⁵ cells in EliSpot as opposed to none in 2 unvaccinated subject.

References

Displaying record number 59220

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HXB2 Location	Nef(71-79) DNA(9007..9033)	Nef Epitope Map
Author Location	Nef(71-79)
Epitope	`TPQVPLRPM`	Epitope Alignment
Epitope Name	Nef 71-79
Subtype	B
Species (MHC/HLA)	human(B*35)
Immunogen	vaccine
Country	France
Experimental methods	CD8 T-cell Elispot - IFNγ, Degranulation, CD107a and b cell surface mobilization, Intracellular cytokine staining, Tetramer binding
Keywords	vaccine-induced immune responses

Vaccine Details

Vaccine type	lipopeptide

Notes

HIV-specific memory CTL responses from 16 lipopeptide-vaccinated uninfected unvaccinated subjects were fully characterized with respect to magnitude and multifunctionality, comparing them to FLU- or EBV-CTL. 62% of total secreting T cells produced IFN-γ in response to HIV (compared to 35% for FLU and EBV). HIV-specific CTL secreted either IFN-γ or TNF-α, not both as in FLU- and EBV-specific CTL. The more limited functional profile and magnitude of expanded CTL response against HIV mirrors its less effective vaccines.
Nef 71-79, TPQVPLRPMTY, lipopeptide was able to stimulate expanded effector CTLs that produced >600 SFC/10⁵ cells in EliSpot as opposed to none in 1 unvaccinated subject.

References

Displaying record number 59219

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HXB2 Location	Nef(71-81) DNA(9007..9039)	Nef Epitope Map
Author Location	Nef(71-81)
Epitope	`TPQVPLRPMTY`	Epitope Alignment
Epitope Name	Nef 71-81
Subtype	B
Species (MHC/HLA)	human(B07, B35)
Immunogen	vaccine
Country	France
Experimental methods	CD8 T-cell Elispot - IFNγ, Degranulation, CD107a and b cell surface mobilization, Intracellular cytokine staining, Tetramer binding
Keywords	vaccine-induced immune responses

Vaccine Details

Vaccine type	lipopeptide

Notes

HIV-specific memory CTL responses from 16 lipopeptide-vaccinated uninfected unvaccinated subjects were fully characterized with respect to magnitude and multifunctionality, comparing them to FLU- or EBV-CTL. 62% of total secreting T cells produced IFN-γ in response to HIV (compared to 35% for FLU and EBV). HIV-specific CTL secreted either IFN-γ or TNF-α, not both as in FLU- and EBV-specific CTL. The more limited functional profile and magnitude of expanded CTL response against HIV mirrors its less effective vaccines.
Nef 71-81, TPQVPLRPMTY, lipopeptide was able to stimulate expanded effector CTLs that produced 152 SFC/10⁵ cells in EliSpot as opposed to none in 1 unvaccinated subject.

References

Displaying record number 59217

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HXB2 Location	Nef(84-92) DNA(9046..9072)	Nef Epitope Map
Author Location	Nef(84-92)
Epitope	`AVDLSHFLK`	Epitope Alignment
Epitope Name	nef 84-92
Subtype	B
Species (MHC/HLA)	human(A*11)
Immunogen	vaccine
Country	France
Experimental methods	CD8 T-cell Elispot - IFNγ, Degranulation, CD107a and b cell surface mobilization, Intracellular cytokine staining, Tetramer binding
Keywords	vaccine-induced immune responses

Vaccine Details

Vaccine type	lipopeptide

Notes

HIV-specific memory CTL responses from 16 lipopeptide-vaccinated uninfected unvaccinated subjects were fully characterized with respect to magnitude and multifunctionality, comparing them to FLU- or EBV-CTL. 62% of total secreting T cells produced IFN-γ in response to HIV (compared to 35% for FLU and EBV). HIV-specific CTL secreted either IFN-γ or TNF-α, not both as in FLU- and EBV-specific CTL. The more limited functional profile and magnitude of expanded CTL response against HIV mirrors its less effective vaccines.
Nef 84-92, AVDLSHFLK, lipopeptide was able to stimulate expanded effector CTLs that produced 228 - 260 SFC/10⁵ cells in EliSpot as opposed to none in 2 unvaccinated subjects.

References

Displaying record number 59221

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HXB2 Location	Nef(135-143) DNA(9199..9225)	Nef Epitope Map
Author Location	Nef(135-143)
Epitope	`YPLTFGWCY`	Epitope Alignment
Epitope Name	Nef 135-143
Subtype	B
Species (MHC/HLA)	human(B07, B35)
Immunogen	vaccine
Country	France
Experimental methods	CD8 T-cell Elispot - IFNγ, Degranulation, CD107a and b cell surface mobilization, Intracellular cytokine staining, Tetramer binding
Keywords	vaccine-induced immune responses

Vaccine Details

Vaccine type	lipopeptide

Notes

HIV-specific memory CTL responses from 16 lipopeptide-vaccinated uninfected unvaccinated subjects were fully characterized with respect to magnitude and multifunctionality, comparing them to FLU- or EBV-CTL. 62% of total secreting T cells produced IFN-γ in response to HIV (compared to 35% for FLU and EBV). HIV-specific CTL secreted either IFN-γ or TNF-α, not both as in FLU- and EBV-specific CTL. The more limited functional profile and magnitude of expanded CTL response against HIV mirrors its less effective vaccines.
Nef 135-143, YPLTFGWCY, lipopeptide was able to stimulate expanded effector CTLs that produced 111 SFC/10⁵ cells in EliSpot as opposed to none in 1 unvaccinated subject.