Search CTL/CD8+ T-Cell Epitope Database

Found 8 matching records:

Displaying record number 57595

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HXB2 Location	Gag(20-28) p17(20-28) DNA(847..873)	Gag Epitope Map
Author Location	p17
Epitope	RLRPGGKKK	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression, immunodominance, genital and mucosal immunity

Notes

• Rectal CD8+ T-cell responses to HIV Gag, Env and Nef were mapped at the peptide level in 4 groups: elite controllers, viremic controllers, non-controllers, and drug-treated subjects. In all patient groups, immunodominant responses were shared by blood and mucosa, with 2 exceptions. First, in HIV controllers, the magnitude of responses to B27- and B57-restricted epitopes was higher than responses to other alleles. Second, peptides recognized by T cells in both blood and mucosa elicited higher response than those recognized only by blood or only by mucosa.
• Gag-specific responses, particularly to p24 and p7, dominated in controllers, while responses in non-controllers were more evenly distributed among Gag, Env, and Nef.
• Peptides that included immunodominant epitope RLRPGGKKK were detected with high frequency in both controllers and non-controllers.

References

Ferre2010 April L. Ferre, Donna Lemongello, Peter W. Hunt, Megan M. Morris, Juan Carlos Garcia, Richard B. Pollard, Hal F. Yee, Jr., Jeffrey N. Martin, Steven G. Deeks, and Barbara L. Shacklett. Immunodominant HIV-Specific CD8+ T-Cell Responses Are Common to Blood and Gastrointestinal Mucosa, and Gag-Specific Responses Dominate in Rectal Mucosa of HIV Controllers. J. Virol., 84(19):10354-10365, Oct 2010. PubMed ID: 20668079. Show all entries for this paper.

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Displaying record number 57596

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HXB2 Location	Gag(77-85) p17(77-85) DNA(1018..1044)	Gag Epitope Map
Author Location	p17
Epitope	SLYNTVATL	Epitope Alignment
Epitope Name	SL9
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression, immunodominance, genital and mucosal immunity

Notes

• Rectal CD8+ T-cell responses to HIV Gag, Env and Nef were mapped at the peptide level in 4 groups: elite controllers, viremic controllers, non-controllers, and drug-treated subjects. In all patient groups, immunodominant responses were shared by blood and mucosa, with 2 exceptions. First, in HIV controllers, the magnitude of responses to B27- and B57-restricted epitopes was higher than responses to other alleles. Second, peptides recognized by T cells in both blood and mucosa elicited higher response than those recognized only by blood or only by mucosa.
• Gag-specific responses, particularly to p24 and p7, dominated in controllers, while responses in non-controllers were more evenly distributed among Gag, Env, and Nef.
• Peptides that included immunodominant epitope SLYNTVATL were detected with high frequency in both controllers and non-controllers.
• Epitope SLYNTVATL had a median IFN-γ responses of 296 (blood) and 386 (mucosa) SFC/million.

References

Ferre2010 April L. Ferre, Donna Lemongello, Peter W. Hunt, Megan M. Morris, Juan Carlos Garcia, Richard B. Pollard, Hal F. Yee, Jr., Jeffrey N. Martin, Steven G. Deeks, and Barbara L. Shacklett. Immunodominant HIV-Specific CD8+ T-Cell Responses Are Common to Blood and Gastrointestinal Mucosa, and Gag-Specific Responses Dominate in Rectal Mucosa of HIV Controllers. J. Virol., 84(19):10354-10365, Oct 2010. PubMed ID: 20668079. Show all entries for this paper.

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Displaying record number 57597

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HXB2 Location	Gag(147-155) p24(15-23) DNA(1228..1254)	Gag Epitope Map
Author Location	p24
Epitope	ISPRTNLAW	Epitope Alignment
Epitope Name	IW9
Subtype	B
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression, immunodominance, genital and mucosal immunity

Notes

• Rectal CD8+ T-cell responses to HIV Gag, Env and Nef were mapped at the peptide level in 4 groups: elite controllers, viremic controllers, non-controllers, and drug-treated subjects. In all patient groups, immunodominant responses were shared by blood and mucosa, with 2 exceptions. First, in HIV controllers, the magnitude of responses to B27- and B57-restricted epitopes was higher than responses to other alleles. Second, peptides recognized by T cells in both blood and mucosa elicited higher response than those recognized only by blood or only by mucosa.
• Gag-specific responses, particularly to p24 and p7, dominated in controllers, while responses in non-controllers were more evenly distributed among Gag, Env, and Nef.
• Peptides that included immunodominant epitope ISPRTNLAW were detected with high frequency in both controllers and non-controllers.
• Epitope ISPRTNLAW had a median IFN-γ responses of 268 (blood) and 245 (mucosa) SFC/million.

References

Ferre2010 April L. Ferre, Donna Lemongello, Peter W. Hunt, Megan M. Morris, Juan Carlos Garcia, Richard B. Pollard, Hal F. Yee, Jr., Jeffrey N. Martin, Steven G. Deeks, and Barbara L. Shacklett. Immunodominant HIV-Specific CD8+ T-Cell Responses Are Common to Blood and Gastrointestinal Mucosa, and Gag-Specific Responses Dominate in Rectal Mucosa of HIV Controllers. J. Virol., 84(19):10354-10365, Oct 2010. PubMed ID: 20668079. Show all entries for this paper.

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Displaying record number 57598

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HXB2 Location	Gag(162-172) p24(30-40) DNA(1273..1305)	Gag Epitope Map
Author Location	p24
Epitope	KAFSPEVIPMF	Epitope Alignment
Epitope Name	KF11
Subtype	B
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression, immunodominance, genital and mucosal immunity

Notes

• Rectal CD8+ T-cell responses to HIV Gag, Env and Nef were mapped at the peptide level in 4 groups: elite controllers, viremic controllers, non-controllers, and drug-treated subjects. In all patient groups, immunodominant responses were shared by blood and mucosa, with 2 exceptions. First, in HIV controllers, the magnitude of responses to B27- and B57-restricted epitopes was higher than responses to other alleles. Second, peptides recognized by T cells in both blood and mucosa elicited higher response than those recognized only by blood or only by mucosa.
• Gag-specific responses, particularly to p24 and p7, dominated in controllers, while responses in non-controllers were more evenly distributed among Gag, Env, and Nef.
• Peptides that included immunodominant epitope KAFSPEVIPMF were detected with high frequency in both controllers and non-controllers.
• Epitope KAFSPEVIPMF had a median IFN-γ responses of 678 (blood) and 824 (mucosa) SFC/million.

References

Ferre2010 April L. Ferre, Donna Lemongello, Peter W. Hunt, Megan M. Morris, Juan Carlos Garcia, Richard B. Pollard, Hal F. Yee, Jr., Jeffrey N. Martin, Steven G. Deeks, and Barbara L. Shacklett. Immunodominant HIV-Specific CD8+ T-Cell Responses Are Common to Blood and Gastrointestinal Mucosa, and Gag-Specific Responses Dominate in Rectal Mucosa of HIV Controllers. J. Virol., 84(19):10354-10365, Oct 2010. PubMed ID: 20668079. Show all entries for this paper.

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Displaying record number 57599

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HXB2 Location	Gag(240-249) p24(108-117) DNA(1507..1536)	Gag Epitope Map
Author Location	p24
Epitope	TSTLQEQIGW	Epitope Alignment
Epitope Name	TW10
Subtype	B
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression, immunodominance, genital and mucosal immunity

Notes

• Rectal CD8+ T-cell responses to HIV Gag, Env and Nef were mapped at the peptide level in 4 groups: elite controllers, viremic controllers, non-controllers, and drug-treated subjects. In all patient groups, immunodominant responses were shared by blood and mucosa, with 2 exceptions. First, in HIV controllers, the magnitude of responses to B27- and B57-restricted epitopes was higher than responses to other alleles. Second, peptides recognized by T cells in both blood and mucosa elicited higher response than those recognized only by blood or only by mucosa.
• Gag-specific responses, particularly to p24 and p7, dominated in controllers, while responses in non-controllers were more evenly distributed among Gag, Env, and Nef.
• Peptides that included immunodominant epitope TSTLQEQIGW were detected with high frequency in both controllers and non-controllers.
• Epitope TSTLQEQIGW had a median IFN-γ responses of 210 (blood) and 732.5 (mucosa) SFC/million.

References

Ferre2010 April L. Ferre, Donna Lemongello, Peter W. Hunt, Megan M. Morris, Juan Carlos Garcia, Richard B. Pollard, Hal F. Yee, Jr., Jeffrey N. Martin, Steven G. Deeks, and Barbara L. Shacklett. Immunodominant HIV-Specific CD8+ T-Cell Responses Are Common to Blood and Gastrointestinal Mucosa, and Gag-Specific Responses Dominate in Rectal Mucosa of HIV Controllers. J. Virol., 84(19):10354-10365, Oct 2010. PubMed ID: 20668079. Show all entries for this paper.

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Displaying record number 57600

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HXB2 Location	Gag(259-267) p24(127-135) DNA(1564..1590)	Gag Epitope Map
Author Location	p24
Epitope	GEIYKRWII	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B8)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression, immunodominance, genital and mucosal immunity

Notes

• Rectal CD8+ T-cell responses to HIV Gag, Env and Nef were mapped at the peptide level in 4 groups: elite controllers, viremic controllers, non-controllers, and drug-treated subjects. In all patient groups, immunodominant responses were shared by blood and mucosa, with 2 exceptions. First, in HIV controllers, the magnitude of responses to B27- and B57-restricted epitopes was higher than responses to other alleles. Second, peptides recognized by T cells in both blood and mucosa elicited higher response than those recognized only by blood or only by mucosa.
• Gag-specific responses, particularly to p24 and p7, dominated in controllers, while responses in non-controllers were more evenly distributed among Gag, Env, and Nef.
• Peptides that included immunodominant epitope GEIYKRWII were detected with high frequency in both controllers and non-controllers.

References

Ferre2010 April L. Ferre, Donna Lemongello, Peter W. Hunt, Megan M. Morris, Juan Carlos Garcia, Richard B. Pollard, Hal F. Yee, Jr., Jeffrey N. Martin, Steven G. Deeks, and Barbara L. Shacklett. Immunodominant HIV-Specific CD8+ T-Cell Responses Are Common to Blood and Gastrointestinal Mucosa, and Gag-Specific Responses Dominate in Rectal Mucosa of HIV Controllers. J. Virol., 84(19):10354-10365, Oct 2010. PubMed ID: 20668079. Show all entries for this paper.

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Displaying record number 57601

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HXB2 Location	Gag(263-272) p24(131-140) DNA(1576..1605)	Gag Epitope Map
Author Location	p24
Epitope	KRWIILGLNK	Epitope Alignment
Epitope Name	KK10
Subtype	B
Species (MHC/HLA)	human(B27)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression, immunodominance, genital and mucosal immunity

Notes

• Rectal CD8+ T-cell responses to HIV Gag, Env and Nef were mapped at the peptide level in 4 groups: elite controllers, viremic controllers, non-controllers, and drug-treated subjects. In all patient groups, immunodominant responses were shared by blood and mucosa, with 2 exceptions. First, in HIV controllers, the magnitude of responses to B27- and B57-restricted epitopes was higher than responses to other alleles. Second, peptides recognized by T cells in both blood and mucosa elicited higher response than those recognized only by blood or only by mucosa.
• Gag-specific responses, particularly to p24 and p7, dominated in controllers, while responses in non-controllers were more evenly distributed among Gag, Env, and Nef.
• Peptides that included immunodominant epitope KRWIILGLNK were detected with high frequency in both controllers and non-controllers.
• Epitope KRWIILGLNK had a median IFN-γ responses of 597 (blood) and 1361 (mucosa) SFC/million.

References

Ferre2010 April L. Ferre, Donna Lemongello, Peter W. Hunt, Megan M. Morris, Juan Carlos Garcia, Richard B. Pollard, Hal F. Yee, Jr., Jeffrey N. Martin, Steven G. Deeks, and Barbara L. Shacklett. Immunodominant HIV-Specific CD8+ T-Cell Responses Are Common to Blood and Gastrointestinal Mucosa, and Gag-Specific Responses Dominate in Rectal Mucosa of HIV Controllers. J. Virol., 84(19):10354-10365, Oct 2010. PubMed ID: 20668079. Show all entries for this paper.

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Displaying record number 57602

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HXB2 Location	Gag(308-316) p24(176-184) DNA(1711..1737)	Gag Epitope Map
Author Location	p24
Epitope	QASQEVKNW	Epitope Alignment
Epitope Name	QW9
Subtype	B
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression, immunodominance, genital and mucosal immunity

Notes

• Rectal CD8+ T-cell responses to HIV Gag, Env and Nef were mapped at the peptide level in 4 groups: elite controllers, viremic controllers, non-controllers, and drug-treated subjects. In all patient groups, immunodominant responses were shared by blood and mucosa, with 2 exceptions. First, in HIV controllers, the magnitude of responses to B27- and B57-restricted epitopes was higher than responses to other alleles. Second, peptides recognized by T cells in both blood and mucosa elicited higher response than those recognized only by blood or only by mucosa.
• Gag-specific responses, particularly to p24 and p7, dominated in controllers, while responses in non-controllers were more evenly distributed among Gag, Env, and Nef.
• Peptides that included immunodominant epitope QASQEVKNW were detected with high frequency in both controllers and non-controllers.
• Epitope QASQEVKNW had a median IFN-γ responses of 292.5 (blood) and 720 (mucosa) SFC/million.

References

Ferre2010 April L. Ferre, Donna Lemongello, Peter W. Hunt, Megan M. Morris, Juan Carlos Garcia, Richard B. Pollard, Hal F. Yee, Jr., Jeffrey N. Martin, Steven G. Deeks, and Barbara L. Shacklett. Immunodominant HIV-Specific CD8+ T-Cell Responses Are Common to Blood and Gastrointestinal Mucosa, and Gag-Specific Responses Dominate in Rectal Mucosa of HIV Controllers. J. Virol., 84(19):10354-10365, Oct 2010. PubMed ID: 20668079. Show all entries for this paper.

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