Search CTL/CD8+ T-Cell Epitope Database

Found 3 matching records:

Displaying record number 52933

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HXB2 Location	Gag(19-27) p17(19-27) DNA(844..870)	Gag Epitope Map
Author Location	Gag
Epitope	IRLRPGGKK	Epitope Alignment
Epitope Name	IK9
Species (MHC/HLA)	human(B27)
Immunogen	HIV-1 infection
Patient MHC/HLA	A26, B27
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	responses in children, rate of progression, immunodominance, escape

Notes

• Viral load in a perinatally infected child remained low until emergence of an escape variant (kTwiilglnk) in the immunodominant CTL epitope KRWIILGLNK when the child was 7.4 years old. The emergence of this escape mutation was followed by an increase in viremia and an increase in the number of targeted CTL epitopes, measured again when the child was 9.2 years old. A low level response to IK9 was the only other epitope recognized prior to the loss of immune control and broadening of the response, and was detected in the 7.4 year sample.

References

Feeney2004 M. E. Feeney, Y. Tang, K. A. Roosevelt, A. J. Leslie, K. McIntosh, N. Karthas, B. D. Walker, and P. J. R. Goulder. Immune Escape Precedes Breakthrough Human Immunodeficiency Virus Type 1 Viremia and Broadening of the Cytotoxic T-Lymphocyte Response in an HLA-B27-Positive Long-Term-Nonprogressing Child. J. Virol., 78(16):8927-8930, Aug 2004. PubMed ID: 15280502. Show all entries for this paper.

Displaying record number 52934

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HXB2 Location	Gag(167-175) p24(35-43) DNA(1288..1314)	Gag Epitope Map
Author Location	Gag
Epitope	EVIPMFSAL	Epitope Alignment
Epitope Name	EL9
Species (MHC/HLA)	human(A26)
Immunogen	HIV-1 infection
Patient MHC/HLA	A26, B27
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	responses in children, rate of progression, immunodominance, escape

Notes

• Viral load in a perinatally infected child remained low until emergence of an escape variant (kTwiilglnk) in the immunodominant CTL epitope KRWIILGLNK when the child was 7.4 years old. The emergence of this escape mutation was followed by an increase in viremia and an increase in the number of targeted CTL epitopes, measured again when the child was 9.2 years old. The EL9 response was not observed until after the escape mutation occurred in the immunodominant epitope, and was detected in the 9.2 year sample for the first time.

References

Feeney2004 M. E. Feeney, Y. Tang, K. A. Roosevelt, A. J. Leslie, K. McIntosh, N. Karthas, B. D. Walker, and P. J. R. Goulder. Immune Escape Precedes Breakthrough Human Immunodeficiency Virus Type 1 Viremia and Broadening of the Cytotoxic T-Lymphocyte Response in an HLA-B27-Positive Long-Term-Nonprogressing Child. J. Virol., 78(16):8927-8930, Aug 2004. PubMed ID: 15280502. Show all entries for this paper.

Displaying record number 52932

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HXB2 Location	Gag(263-272) p24(131-140) DNA(1576..1605)	Gag Epitope Map
Author Location	Gag
Epitope	KRWIILGLNK	Epitope Alignment
		Show epitope variants
Epitope Name	KK10
Species (MHC/HLA)	human(B27)
Immunogen	HIV-1 infection
Patient MHC/HLA	A26, B27
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	responses in children, rate of progression, immunodominance, escape

Notes

• Viral load in a perinatally infected child remained low until emergence of an escape variant (kTwiilglnk) in the immunodominant CTL epitope KRWIILGLNK when the child was 7.4 years old. The emergence of this escape mutation was followed by an increase in viremia and an increase in the number of targeted CTL epitopes, measured again when the child was 9.2 years old. The timing suggests that the loss of recognition of this epitope may have resulted in the subsequent loss of immune control.
• The mutation krwillMglnk has been suggested to be compensatory and required for the emergence of the previously described escape mutation kKwillMglnk (Kelleher 2001). The L136M mutation does appear in this child, but not in conjunction with the R132T escape mutation.

References

Feeney2004 M. E. Feeney, Y. Tang, K. A. Roosevelt, A. J. Leslie, K. McIntosh, N. Karthas, B. D. Walker, and P. J. R. Goulder. Immune Escape Precedes Breakthrough Human Immunodeficiency Virus Type 1 Viremia and Broadening of the Cytotoxic T-Lymphocyte Response in an HLA-B27-Positive Long-Term-Nonprogressing Child. J. Virol., 78(16):8927-8930, Aug 2004. PubMed ID: 15280502. Show all entries for this paper.