Search CTL/CD8+ T-Cell Epitope Database

Found 4 matching records:

Displaying record number 52917

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HXB2 Location	Gag(147-155) p24(15-23) DNA(1228..1254)	Gag Epitope Map
Author Location	Gag(147-155)
Epitope	ISPRTLNAW	Epitope Alignment
		Show epitope variants
Epitope Name	ISW9
Subtype	B, C
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords	epitope processing, escape

Notes

• The A146P mutation flanking the ISW9 epitope (Pisprtlnaw) is positively selected in HLA-B57+ persons and it prevents trimming of the optimal epitope by the endoplasmic reticulum aminopeptidase I. The A146P processing escape mutation does not influence replicative capacity of the virus in vitro and is accumulated over time in the human population.

References

Draenert2004a Rika Draenert, Sylvie Le Gall, Katja J. Pfafferott, Alasdair J. Leslie, Polan Chetty, Christian Brander, Edward C. Holmes, Shih-Chung Chang, Margaret E. Feeney, Marylyn M. Addo, Lidia Ruiz, Danni Ramduth, Prakash Jeena, Marcus Altfeld, Stephanie Thomas, Yanhua Tang, Cori L. Verrill, Catherine Dixon, Julia G. Prado, Photini Kiepiela, Javier Martinez-Picado, Bruce D. Walker, and Philip J. R. Goulder. Immune Selection for Altered Antigen Processing Leads to Cytotoxic T Lymphocyte Escape in Chronic HIV-1 Infection. J. Exp. Med., 199(7):905-915, 5 Apr 2004. PubMed ID: 15067030. Show all entries for this paper.

Displaying record number 52920

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HXB2 Location	Gag(162-172) p24(30-40) DNA(1273..1305)	Gag Epitope Map
Author Location	p24
Epitope	KAFSPEVIPMF	Epitope Alignment
Epitope Name	KF11
Subtype	C
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords	epitope processing, escape

Notes

• This study characterizes the N-terminal flanking position of the epitope ISPRTLNAW, and mutations in this position are thought to impact processing. The B57 epitope KAFSPEVIPMF was used as a positive control in this study.

References

Draenert2004a Rika Draenert, Sylvie Le Gall, Katja J. Pfafferott, Alasdair J. Leslie, Polan Chetty, Christian Brander, Edward C. Holmes, Shih-Chung Chang, Margaret E. Feeney, Marylyn M. Addo, Lidia Ruiz, Danni Ramduth, Prakash Jeena, Marcus Altfeld, Stephanie Thomas, Yanhua Tang, Cori L. Verrill, Catherine Dixon, Julia G. Prado, Photini Kiepiela, Javier Martinez-Picado, Bruce D. Walker, and Philip J. R. Goulder. Immune Selection for Altered Antigen Processing Leads to Cytotoxic T Lymphocyte Escape in Chronic HIV-1 Infection. J. Exp. Med., 199(7):905-915, 5 Apr 2004. PubMed ID: 15067030. Show all entries for this paper.

Displaying record number 52918

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HXB2 Location	Gag(240-249) p24(108-117) DNA(1507..1536)	Gag Epitope Map
Author Location	Gag(147-155)
Epitope	TSTLQEQIAW	Epitope Alignment
		Show epitope variants
Epitope Name	TW10
Subtype	C
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords	epitope processing, escape

Notes

• 174 people who have C clade infections were studied -- those who carried B57 have 2 positions in which their HIV Gag consensus is different than the C consensus. One mutation is within this epitope, TW10, at position 3, and is believed to be a TCR contact residue. The mutation is not specified in the study. The other is in the N-terminal flanking position of the epitope ISPRTLNAW and is thought to impact processing.

References

Draenert2004a Rika Draenert, Sylvie Le Gall, Katja J. Pfafferott, Alasdair J. Leslie, Polan Chetty, Christian Brander, Edward C. Holmes, Shih-Chung Chang, Margaret E. Feeney, Marylyn M. Addo, Lidia Ruiz, Danni Ramduth, Prakash Jeena, Marcus Altfeld, Stephanie Thomas, Yanhua Tang, Cori L. Verrill, Catherine Dixon, Julia G. Prado, Photini Kiepiela, Javier Martinez-Picado, Bruce D. Walker, and Philip J. R. Goulder. Immune Selection for Altered Antigen Processing Leads to Cytotoxic T Lymphocyte Escape in Chronic HIV-1 Infection. J. Exp. Med., 199(7):905-915, 5 Apr 2004. PubMed ID: 15067030. Show all entries for this paper.

Displaying record number 52919

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HXB2 Location	gp160(770-780) gp41(259-269) DNA(8532..8564)	gp160 Epitope Map
Author Location	Env
Epitope	RLRDLLLIVTR	Epitope Alignment
Epitope Name	RR11
Subtype	C
Species (MHC/HLA)	human(A31)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords	epitope processing, escape

Notes

• This study characterizes the N-terminal flanking position of the epitope ISPRTLNAW, and mutations in this position are thought to impact processing. The A31 epitope RLRDLLLIVTR was used as a negative control in this study.

References

Draenert2004a Rika Draenert, Sylvie Le Gall, Katja J. Pfafferott, Alasdair J. Leslie, Polan Chetty, Christian Brander, Edward C. Holmes, Shih-Chung Chang, Margaret E. Feeney, Marylyn M. Addo, Lidia Ruiz, Danni Ramduth, Prakash Jeena, Marcus Altfeld, Stephanie Thomas, Yanhua Tang, Cori L. Verrill, Catherine Dixon, Julia G. Prado, Photini Kiepiela, Javier Martinez-Picado, Bruce D. Walker, and Philip J. R. Goulder. Immune Selection for Altered Antigen Processing Leads to Cytotoxic T Lymphocyte Escape in Chronic HIV-1 Infection. J. Exp. Med., 199(7):905-915, 5 Apr 2004. PubMed ID: 15067030. Show all entries for this paper.