Search CTL/CD8+ T-Cell Epitope Database

Found 19 matching records:

Displaying record number 57575

HXB2 Location	Gag(20-28) p17(20-28) DNA(847..873)	Gag Epitope Map
Author Location	p17(20-28)
Epitope	RLRPGGKKK	Epitope Alignment
Epitope Name	RK9
Subtype	B
Species (MHC/HLA)	human(A*03)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	acute/early infection

Notes

• Responses to specific B57/58, B27, and B35-restricted epitopes were tested in a cohort of 45 subjects during primary infection. The presence of certain B57/58, B27, and B35-restricted T-cell responses during primary infection better defined disease progression than the HLA genotype alone, suggesting that it is the HIV-specific CD8+ T-cells and not the presence of a particular HLA allele, that determine disease progression.
• 5/10 A03-positive subjects responded to RLRPGGKKK, and 29% of the patients' total response magnitude was derived from this specific response. While numerous, the RK9 responses did not demonstrate a significant effect on HIV-1 disease progression.
• This epitope was moderately conserved: 45% conserved among M-group sequences and 65% conserved among B-subtype sequences.

References

Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.

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Displaying record number 57590

HXB2 Location	Gag(147-155) p24(15-23) DNA(1228..1254)	Gag Epitope Map
Author Location	p24(15-23)
Epitope	ISPRTLNAW	Epitope Alignment
Epitope Name	ISW9
Subtype	B
Species (MHC/HLA)	(B*57, B*58)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	acute/early infection

Notes

• Responses to specific B57/58, B27, and B35-restricted epitopes were tested in a cohort of 45 subjects during primary infection. The presence of certain B57/58, B27, and B35-restricted T-cell responses during primary infection better defined disease progression than the HLA genotype alone, suggesting that it is the HIV-specific CD8+ T-cells and not the presence of a particular HLA allele, that determine disease progression.
• 4/9 B57/58-positive subjects responded to ISPRTLNAW, and 20% of the patients' total response magnitude was derived from this specific response.
• This epitope was 59% conserved among M-group sequences and 70% conserved among B-subtype sequences.

References

Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.

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Displaying record number 57592

HXB2 Location	Gag(162-172) p24(30-40) DNA(1273..1305)	Gag Epitope Map
Author Location	p24(30-40)
Epitope	KAFSPEVIPMF	Epitope Alignment
Epitope Name	KF11
Subtype	B
Species (MHC/HLA)	(B*57, B*58)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	acute/early infection

Notes

• Responses to specific B57/58, B27, and B35-restricted epitopes were tested in a cohort of 45 subjects during primary infection. The presence of certain B57/58, B27, and B35-restricted T-cell responses during primary infection better defined disease progression than the HLA genotype alone, suggesting that it is the HIV-specific CD8+ T-cells and not the presence of a particular HLA allele, that determine disease progression.
• 6/9 B57/58-positive subjects responded to KAFSPEVIPMF, and 34% of the patients' total response magnitude was derived from this specific response.
• This epitope was 84% conserved among M-group sequences and 97% conserved among B-subtype sequences.
• Epitope-specific HLA-B responses to TW10 and KF11 delayed declines in CD4+ T-cell counts more than 8 years in HLA-B57/58-positive subjects.
• The presence of responses to KF11 delayed declines in CD4+ T-cell counts to 3.5 to 8.2 times longer or more than 8 years in HLA-B57/58-positive subjects.

References

Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.

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Displaying record number 57593

HXB2 Location	Gag(240-249) p24(108-117) DNA(1507..1536)	Gag Epitope Map
Author Location	p24(108-117)
Epitope	TSTLQEQIGW	Epitope Alignment
Epitope Name	TW10
Subtype	B
Species (MHC/HLA)	(B*57, B*58)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	acute/early infection

Notes

• Responses to specific B57/58, B27, and B35-restricted epitopes were tested in a cohort of 45 subjects during primary infection. The presence of certain B57/58, B27, and B35-restricted T-cell responses during primary infection better defined disease progression than the HLA genotype alone, suggesting that it is the HIV-specific CD8+ T-cells and not the presence of a particular HLA allele, that determine disease progression.
• 6/9 B57/58-positive subjects responded to TSTLQEQIGW, and 42% of the patients' total response magnitude was derived from this specific response.
• This epitope was 40% conserved among M-group sequences and 73% conserved among B-subtype sequences.
• Epitope-specific HLA-B responses to TW10 and KF11 delayed declines in CD4+ T-cell counts more than 8 years in HLA-B57/58-positive subjects.
• The presence of TW10 responses delayed declines in CD4+ T-cell counts to 3.5 to 8.2 times longer or more than 8 years in HLA-positive subjects.

References

Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.

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Displaying record number 57577

HXB2 Location	Gag(260-267) p24(128-135) DNA(1567..1590)	Gag Epitope Map
Author Location	p24(128-135)
Epitope	EIYKRWII	Epitope Alignment
Epitope Name	EI8
Subtype	B
Species (MHC/HLA)	(B*08)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	acute/early infection

Notes

• Responses to specific B57/58, B27, and B35-restricted epitopes were tested in a cohort of 45 subjects during primary infection. The presence of certain B57/58, B27, and B35-restricted T-cell responses during primary infection better defined disease progression than the HLA genotype alone, suggesting that it is the HIV-specific CD8+ T-cells and not the presence of a particular HLA allele, that determine disease progression.
• 3/7 B08-positive subjects responded to EIYKRWII, and 17% of the patients' total response magnitude was derived from this specific response.
• This epitope was less conserved: 56% conserved among M-group sequences and 86% conserved among B-subtype sequences.

References

Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.

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Displaying record number 57582

HXB2 Location	Gag(263-272) p24(131-140) DNA(1576..1605)	Gag Epitope Map
Author Location	p24(131-140)
Epitope	KRWIILGLNK	Epitope Alignment
Epitope Name	KK10
Subtype	B
Species (MHC/HLA)	(B*27)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	acute/early infection

Notes

• Responses to specific B57/58, B27, and B35-restricted epitopes were tested in a cohort of 45 subjects during primary infection. The presence of certain B57/58, B27, and B35-restricted T-cell responses during primary infection better defined disease progression than the HLA genotype alone, suggesting that it is the HIV-specific CD8+ T-cells and not the presence of a particular HLA allele, that determine disease progression.
• 5/7 B27-positive subjects responded to KRWIILGLNK, and 67% of the patients' total response magnitude was derived from this specific response.
• This epitope was 87% conserved among M-group sequences and 82% conserved among B-subtype sequences.
• Epitope-specific HLA-B responses to KK10 and FY10 delayed declines in CD4+ T-cell counts more than 8 years in HLA-B27-positive subjects.

References

Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.

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Displaying record number 57586

HXB2 Location	Pol(330-338) RT(175-183) DNA(3072..3098)	Pol Epitope Map
Author Location	RT(175-183)
Epitope	NPDIVIYQY	Epitope Alignment
Epitope Name	NY9
Subtype	B
Species (MHC/HLA)	(B*35)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	acute/early infection

Notes

• Responses to specific B57/58, B27, and B35-restricted epitopes were tested in a cohort of 45 subjects during primary infection. The presence of certain B57/58, B27, and B35-restricted T-cell responses during primary infection better defined disease progression than the HLA genotype alone, suggesting that it is the HIV-specific CD8+ T-cells and not the presence of a particular HLA allele, that determine disease progression.
• 9/20 B35-positive subjects responded to NPDIVIYQY, and 11% of the patients' total response magnitude was derived from this specific response.
• This epitope was 24% conserved among M-group sequences and 66% conserved among B-subtype sequences.
• While numerous, the NY9 responses did not demonstrate a significant effect on HIV-1 disease progression.

References

Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.

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Displaying record number 57591

HXB2 Location	Pol(399-407) RT(244-252) DNA(3279..3305)	Pol Epitope Map
Author Location	RT(244-252)
Epitope	IVLPEKDSW	Epitope Alignment
Epitope Name	IVW9
Subtype	B
Species (MHC/HLA)	(B*57, B*58)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	acute/early infection

Notes

• Responses to specific B57/58, B27, and B35-restricted epitopes were tested in a cohort of 45 subjects during primary infection. The presence of certain B57/58, B27, and B35-restricted T-cell responses during primary infection better defined disease progression than the HLA genotype alone, suggesting that it is the HIV-specific CD8+ T-cells and not the presence of a particular HLA allele, that determine disease progression.
• 7/9 B57/58-positive subjects responded to IVLPEKDSW, and 27% of the patients' total response magnitude was derived from this specific response.
• This epitope was 14% conserved among M-group sequences and 62% conserved among B-subtype sequences.

References

Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.

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Displaying record number 57585

HXB2 Location	Pol(448-456) RT(293-301) DNA(3426..3452)	Pol Epitope Map
Author Location	RT(293-301)
Epitope	IPLTEEAEL	Epitope Alignment
Epitope Name	IL9
Subtype	B
Species (MHC/HLA)	(B*35)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	acute/early infection

Notes

• Responses to specific B57/58, B27, and B35-restricted epitopes were tested in a cohort of 45 subjects during primary infection. The presence of certain B57/58, B27, and B35-restricted T-cell responses during primary infection better defined disease progression than the HLA genotype alone, suggesting that it is the HIV-specific CD8+ T-cells and not the presence of a particular HLA allele, that determine disease progression.
• 6/12 B35-positive subjects responded to IPLTEEAEL, and 37% of the patients' total response magnitude was derived from this specific response.
• This epitope was 9% conserved among M-group sequences and 34% conserved among B-subtype sequences.
• Prevalent responses to variable B35-restricted DL9 (DPNPQEVVL) and IL9 (IPLTEEAEL) epitopes were associated with more rapid disease progression, suggesting that these CTL responses to variable regions were ineffective at limiting disease progression.

References

Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.

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Displaying record number 57588

HXB2 Location	Pol(743-751) Integrase(28-36) DNA(4311..4337)	Pol Epitope Map
Author Location	Integrase(28-36)
Epitope	LPPVVAKEI	Epitope Alignment
Epitope Name	LI9
Subtype	B
Species (MHC/HLA)	(B*51)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	acute/early infection

Notes

• Responses to specific B57/58, B27, and B35-restricted epitopes were tested in a cohort of 45 subjects during primary infection. The presence of certain B57/58, B27, and B35-restricted T-cell responses during primary infection better defined disease progression than the HLA genotype alone, suggesting that it is the HIV-specific CD8+ T-cells and not the presence of a particular HLA allele, that determine disease progression.
• 3/4 B51-positive subjects responded to LPPVVAKEI, and 55% of the patients' total response magnitude was derived from this specific response.
• This epitope was 37% conserved among M-group sequences and 72% conserved among B-subtype sequences.

References

Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.

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Displaying record number 57581

HXB2 Location	Pol(900-909) Integrase(185-194) DNA(4782..4811)	Pol Epitope Map
Author Location	Integrase(185-194)
Epitope	FKRKGGIGGY	Epitope Alignment
Epitope Name	FY10
Subtype	B
Species (MHC/HLA)	(B*27)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	acute/early infection

Notes

• Responses to specific B57/58, B27, and B35-restricted epitopes were tested in a cohort of 45 subjects during primary infection. The presence of certain B57/58, B27, and B35-restricted T-cell responses during primary infection better defined disease progression than the HLA genotype alone, suggesting that it is the HIV-specific CD8+ T-cells and not the presence of a particular HLA allele, that determine disease progression.
• 4/7 B27-positive subjects responded to FKRKGGIGGY, and 26% of the patients' total response magnitude was derived from this specific response.
• This epitope was 86% conserved among M-group sequences and 80% conserved among B-subtype sequences.
• Epitope-specific HLA-B responses to KK10 and FY10 delayed declines in CD4+ T-cell counts more than 8 years in HLA-B27-positive subjects.

References

Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.

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Displaying record number 57587

HXB2 Location	Vpr(29-37) DNA(5643..5669)	Vpr Epitope Map
Author Location	Vpr(29-37)
Epitope	EAVRHFPRI	Epitope Alignment
Epitope Name	EI9
Subtype	B
Species (MHC/HLA)	(B*51)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	acute/early infection

Notes

• Responses to specific B57/58, B27, and B35-restricted epitopes were tested in a cohort of 45 subjects during primary infection. The presence of certain B57/58, B27, and B35-restricted T-cell responses during primary infection better defined disease progression than the HLA genotype alone, suggesting that it is the HIV-specific CD8+ T-cells and not the presence of a particular HLA allele, that determine disease progression.
• 3/4 B51-positive subjects responded to EAVRHFPRI, and 47% of the patients' total response magnitude was derived from this specific response.
• This epitope was 13% conserved among M-group sequences and 33% conserved among B-subtype sequences.

References

Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.

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Displaying record number 57583

HXB2 Location	Vpr(31-39) DNA(5649..5675)	Vpr Epitope Map
Author Location	Vpr(31-39)
Epitope	VRHFPRIWL	Epitope Alignment
Epitope Name	VL9
Subtype	B
Species (MHC/HLA)	(B*27)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	acute/early infection

Notes

• Responses to specific B57/58, B27, and B35-restricted epitopes were tested in a cohort of 45 subjects during primary infection. The presence of certain B57/58, B27, and B35-restricted T-cell responses during primary infection better defined disease progression than the HLA genotype alone, suggesting that it is the HIV-specific CD8+ T-cells and not the presence of a particular HLA allele, that determine disease progression.
• 3/7 B27-positive subjects responded to VRHFPRIWL, and 19% of the patients' total response magnitude was derived from this specific response.
• This epitope was 12% conserved among M-group sequences and 33% conserved among B-subtype sequences.

References

Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.

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Displaying record number 57584

HXB2 Location	gp160(78-86) gp120(78-86) DNA(6456..6482)	gp160 Epitope Map
Author Location	gp160(78-86)
Epitope	DPNPQEVVL	Epitope Alignment
Epitope Name	DL9
Subtype	B
Species (MHC/HLA)	(B*35)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	acute/early infection

Notes

• Responses to specific B57/58, B27, and B35-restricted epitopes were tested in a cohort of 45 subjects during primary infection. The presence of certain B57/58, B27, and B35-restricted T-cell responses during primary infection better defined disease progression than the HLA genotype alone, suggesting that it is the HIV-specific CD8+ T-cells and not the presence of a particular HLA allele, that determine disease progression.
• 9/12 B35-positive subjects responded to DPNPQEVVL, and 36% of the patients' total response magnitude was derived from this specific response.
• This epitope was 12% conserved among M-group sequences and 38% conserved among B-subtype sequences.
• Prevalent responses to variable B35-restricted DL9 (DPNPQEVVL) and IL9 (IPLTEEAEL) epitopes were associated with more rapid disease progression, suggesting that these CTL responses to variable regions were ineffective at limiting disease progression.

References

Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.

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Displaying record number 57576

HXB2 Location	gp160(209-217) gp120(209-217) DNA(6849..6875)	gp160 Epitope Map
Author Location	gp160(209-217)
Epitope	SFEPIPIHY	Epitope Alignment
Epitope Name	SY9
Subtype	B
Species (MHC/HLA)	(A*29)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	acute/early infection

Notes

• Responses to specific B57/58, B27, and B35-restricted epitopes were tested in a cohort of 45 subjects during primary infection. The presence of certain B57/58, B27, and B35-restricted T-cell responses during primary infection better defined disease progression than the HLA genotype alone, suggesting that it is the HIV-specific CD8+ T-cells and not the presence of a particular HLA allele, that determine disease progression.
• 3/3 A29-positive subjects responded to SFEPIPIHY, and 67% of the patients' total response magnitude was derived from this specific response.
• This epitope was less conserved: 35% conserved among M-group sequences and 75% conserved among B-subtype sequences.

References

Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.

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Displaying record number 57579

HXB2 Location	gp160(848-856) gp41(337-345) DNA(8766..8792)	gp160 Epitope Map
Author Location	gp160(848-856)
Epitope	RQGLERALL	Epitope Alignment
Epitope Name	RL9
Subtype	B
Species (MHC/HLA)	(B*08)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	acute/early infection

Notes

• Responses to specific B57/58, B27, and B35-restricted epitopes were tested in a cohort of 45 subjects during primary infection. The presence of certain B57/58, B27, and B35-restricted T-cell responses during primary infection better defined disease progression than the HLA genotype alone, suggesting that it is the HIV-specific CD8+ T-cells and not the presence of a particular HLA allele, that determine disease progression.
• 3/7 B08-positive subjects responded to RQGLERALL, and 13% of the patients' total response magnitude was derived from this specific response.
• This epitope was 33% conserved among M-group sequences and 53% conserved among B-subtype sequences.

References

Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.

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Displaying record number 57578

HXB2 Location	Nef(90-97) DNA(9064..9087)	Nef Epitope Map
Author Location	Nef(90-97)
Epitope	FLKEKGGL	Epitope Alignment
Epitope Name	FL8
Subtype	B
Species (MHC/HLA)	(B*08)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	acute/early infection

Notes

• Responses to specific B57/58, B27, and B35-restricted epitopes were tested in a cohort of 45 subjects during primary infection. The presence of certain B57/58, B27, and B35-restricted T-cell responses during primary infection better defined disease progression than the HLA genotype alone, suggesting that it is the HIV-specific CD8+ T-cells and not the presence of a particular HLA allele, that determine disease progression.
• 3/7 B08-positive subjects responded to FLKEKGGL, and 21% of the patients' total response magnitude was derived from this specific response.
• This epitope was highly conserved: 91% conserved among M-group sequences and 78% conserved among B-subtype sequences.
• Response to this epitope has been previously associated with long-term nonprogression, and escape mutations have been associated with lower CD4+ T-cell counts and higher viral loads.

References

Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.

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Displaying record number 57580

HXB2 Location	Nef(106-114) DNA(9112..9138)	Nef Epitope Map
Author Location	Nef(106-114)
Epitope	RQDILDLWI	Epitope Alignment
Epitope Name	RI9
Subtype	B
Species (MHC/HLA)	(B*13)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	acute/early infection

Notes

• Responses to specific B57/58, B27, and B35-restricted epitopes were tested in a cohort of 45 subjects during primary infection. The presence of certain B57/58, B27, and B35-restricted T-cell responses during primary infection better defined disease progression than the HLA genotype alone, suggesting that it is the HIV-specific CD8+ T-cells and not the presence of a particular HLA allele, that determine disease progression.
• 3/3 B13-positive subjects responded to RQDILDLWI, and 58% of the patients' total response magnitude was derived from this specific response.
• This epitope was 5% conserved among M-group sequences and 20% conserved among B-subtype sequences.

References

Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.

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Displaying record number 57589

HXB2 Location	Nef(116-124) DNA(9142..9168)	Nef Epitope Map
Author Location	Nef(116-124)
Epitope	HTQGYFPDW	Epitope Alignment
Epitope Name	HW9
Subtype	B
Species (MHC/HLA)	(B*57, B*58)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	acute/early infection

Notes

• Responses to specific B57/58, B27, and B35-restricted epitopes were tested in a cohort of 45 subjects during primary infection. The presence of certain B57/58, B27, and B35-restricted T-cell responses during primary infection better defined disease progression than the HLA genotype alone, suggesting that it is the HIV-specific CD8+ T-cells and not the presence of a particular HLA allele, that determine disease progression.
• 4/9 B57/58-positive subjects responded to HTQGYFPDW, and 13% of the patients' total response magnitude was derived from this specific response.
• This epitope was 36% conserved among M-group sequences and 74% conserved among B-subtype sequences.

References

Dinges2010 Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, and Helen Horton. Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype. J. Virol., 84(9):4461-4468, May 2010. PubMed ID: 20147397. Show all entries for this paper.

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