Search CTL/CD8+ T-Cell Epitope Database

Found 18 matching records:

Displaying record number 55704

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HXB2 Location	Gag(20-29) p17(20-29) DNA(847..876)	Gag Epitope Map
Author Location	Gag
Epitope	`RLRPGGKKKK`	Epitope Alignment
Subtype	B, F
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Country	Argentina
Experimental methods
Keywords	dynamics, escape, HLA associated polymorphism

Notes

Dynamics of CTL escape mutations was studied theoretically by analyzing plasma samples from 302 subjects (collected over 20 years). HLA associated polymorphisms accumulated in a subtype-specific manner.
Epitope RLRPGGKKKK with anchor residues at R(L)RPGGKKK(K) contains polymorphisms RLRPGGKKKq and RLRPGGKKKr, that are strongly supported as escape by phylogenetic correction.

References

Dilernia2008 Dario Alberto Dilernia, Leandro Jones, Sabrina Rodriguez, Gabriela Turk, Andrea E Rubio, Sandra Pampuro, Manuel Gomez-Carrillo, Christian Bautista, Gabriel Deluchi, Jorge Benetucci, María Beatriz Lasala, Leonardo Lourtau, Marcelo Horacio Losso, Héctor Perez, Pedro Cahn, and Horacio Salomón. HLA-Driven Convergence of HIV-1 Viral Subtypes B and F Toward the Adaptation to Immune Responses in Human Populations. PLoS ONE, 3(10):e3429, 2008. PubMed ID: 18941505. Show all entries for this paper.

Displaying record number 55710

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HXB2 Location	Gag(24-32) p17(24-32) DNA(859..885)	Gag Epitope Map
Author Location	Gag
Epitope	`GGKKKYKLK`	Epitope Alignment
Epitope Name	GK9-B08
Subtype	B, F
Species (MHC/HLA)	human(B8)
Immunogen	HIV-1 infection
Country	Argentina
Experimental methods
Keywords	HLA associated polymorphism

Notes

Dynamics of CTL escape mutations was studied theoretically by analyzing plasma samples from 302 subjects (collected over 20 years). HLA associated polymorphisms accumulated in a subtype-specific manner.
Known epitope GGKKKYKLK with anchor residues at GG(K)K(K)YKLK contains polymorphism GGKKKYkLK. The consensus sequence is GGKKKYRLK.

References

Displaying record number 55703

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HXB2 Location	Gag(28-36) p17(28-36) DNA(871..897)	Gag Epitope Map
Author Location	Gag
Epitope	`KYKLKHIVW`	Epitope Alignment
Epitope Name	KW9-A24
Subtype	B, F
Species (MHC/HLA)	human(A24)
Immunogen	HIV-1 infection
Country	Argentina
Experimental methods
Keywords	dynamics, escape, HLA associated polymorphism

Notes

Dynamics of CTL escape mutations was studied theoretically by analyzing plasma samples from 302 subjects (collected over 20 years). HLA associated polymorphisms accumulated in a subtype-specific manner.
Known epitope KYKLKHIVW with anchor residues at K(Y)KLKHIV(W) contains polymorphism KYkLKHIVW which is moderately supported as escape by phylogenetic correction. Mutations in this position increased in time and KYrLKHIVW became a consensus.

References

Displaying record number 55713

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HXB2 Location	Gag(74-82) p17(74-82) DNA(1009..1035)	Gag Epitope Map
Author Location	Gag
Epitope	`ELRSLYNTV`	Epitope Alignment
Epitope Name	EV9-B08
Subtype	B, F
Species (MHC/HLA)	human(B8)
Immunogen	HIV-1 infection
Country	Argentina
Experimental methods
Keywords	dynamics, HLA associated polymorphism

Notes

Dynamics of CTL escape mutations was studied theoretically by analyzing plasma samples from 302 subjects (collected over 20 years). HLA associated polymorphisms accumulated in a subtype-specific manner.
Epitope ELRSLYNTV with anchor residues at EL(R)SLYNTV contains a polymorphism ELrSLYNTV. The variant ELkSLYNTV increases in time.

References

Displaying record number 55712

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HXB2 Location	Gag(76-86) p17(76-86) DNA(1015..1047)	Gag Epitope Map
Author Location	Gag
Epitope	`RSLYNTVAVLY`	Epitope Alignment
Epitope Name	RY11-A30
Subtype	B, F
Species (MHC/HLA)	human(A30)
Immunogen	HIV-1 infection
Country	Argentina
Experimental methods
Keywords	dynamics, escape

Notes

Dynamics of CTL escape mutations was studied theoretically by analyzing plasma samples from 302 subjects (collected over 20 years). HLA associated polymorphisms accumulated in a subtype-specific manner.
Epitope RSLYNTVAVLY with anchor residues at RSLYNTVAVL(Y) and a polymorphism rSLYNTVAVLY mutates to variant kSLYNTVAVLY which increases in time.

References

Displaying record number 55711

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HXB2 Location	Gag(76-86) p17(76-86) DNA(1015..1047)	Gag Epitope Map
Author Location	Gag
Epitope	`RSLYNTVATLY`	Epitope Alignment
Epitope Name	RY11-A30
Subtype	B, F
Species (MHC/HLA)	human(A30)
Immunogen	HIV-1 infection
Country	Argentina
Experimental methods
Keywords	HLA associated polymorphism

Notes

Dynamics of CTL escape mutations was studied theoretically by analyzing plasma samples from 302 subjects (collected over 20 years). HLA associated polymorphisms accumulated in a subtype-specific manner.
Epitope RSLYNTVATLY with anchor residues at RSLYNTVATL(Y) contains a polymorphism RSLYNTVvTLY.

References

Displaying record number 55693

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HXB2 Location	Gag(77-85) p17(77-85) DNA(1018..1044)	Gag Epitope Map
Author Location	Gag
Epitope	`SLYNTVATL`	Epitope Alignment
Epitope Name	SL9-A02
Subtype	B, F
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Country	Argentina
Experimental methods
Keywords	dynamics, escape, HLA associated polymorphism

Notes

Dynamics of CTL escape mutations was studied theoretically by analyzing plasma samples from 302 subjects (collected over 20 years). HLA associated polymorphisms accumulated in a subtype-specific manner.
Epitope SLYNTVATL has an anchor residues at SL(Y)NTVAT(L). One mutation to SLYNTVvTL is a known escape, diminishing affinity for the restricting HLA molecule. This epitope tends to the consensus in subtype B. Another mutation, SLYNTVAvL increases over time in subtype F.

References

Displaying record number 55715

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HXB2 Location	Gag(84-92) p17(84-92) DNA(1039..1065)	Gag Epitope Map
Author Location	Gag
Epitope	`TLYCVHQRI`	Epitope Alignment
Epitope Name	TI9-A11
Subtype	B, F
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Country	Argentina
Experimental methods
Keywords	dynamics, HLA associated polymorphism

Notes

Dynamics of CTL escape mutations was studied theoretically by analyzing plasma samples from 302 subjects (collected over 20 years). HLA associated polymorphisms accumulated in a subtype-specific manner.
Epitope TLYCVHQRI with anchor residues at TLYCVHQ(R)I and a polymorphism tLYCVHQRI, mutates to variant vLYCVHQRI which increases in time.

References

Displaying record number 55714

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HXB2 Location	Gag(92-101) p17(92-101) DNA(1063..1092)	Gag Epitope Map
Author Location	Gag
Epitope	`IEIKDTKEAL`	Epitope Alignment
Epitope Name	IL10-B40
Subtype	B, F
Species (MHC/HLA)	human(B40)
Immunogen	HIV-1 infection
Country	Argentina
Experimental methods
Keywords	dynamics, HLA associated polymorphism

Notes

Dynamics of CTL escape mutations was studied theoretically by analyzing plasma samples from 302 subjects (collected over 20 years). HLA associated polymorphisms accumulated in a subtype-specific manner.
Epitope IEIKDTKEAL with anchor residues at I(E)IKDTKEAL mutates to variant IEIrDTKEAL. The consensus epitope IEIkDTKEAL and a polymorphism IEIkDTKEAL increases over time.

References

Displaying record number 55709

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HXB2 Location	Gag(114-122) p17(114-122) DNA(1129..1155)	Gag Epitope Map
Author Location	Gag
Epitope	`KTQQAAADK`	Epitope Alignment
Subtype	B, F
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Country	Argentina
Experimental methods
Keywords	dynamics, escape, HLA associated polymorphism

Notes

Dynamics of CTL escape mutations was studied theoretically by analyzing plasma samples from 302 subjects (collected over 20 years). HLA associated polymorphisms accumulated in a subtype-specific manner.
Epitope KTQQAAADK with anchor residues at KTQQAAAD(K) mutates to KTQQkAADK, KTQQmAADK, KTQQtAADK and KTQQvAADK. These mutations are strongly supported as escape by phylogenetic correction.

References

Displaying record number 55716

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HXB2 Location	Gag(207-215) p24(75-83) DNA(1408..1434)	Gag Epitope Map
Author Location	Gag
Epitope	`EEAAEWDRL`	Epitope Alignment
Epitope Name	EL9-B40
Subtype	B, F
Species (MHC/HLA)	human(B40)
Immunogen	HIV-1 infection
Country	Argentina
Experimental methods
Keywords	dynamics, escape, HLA associated polymorphism

Notes

Dynamics of CTL escape mutations was studied theoretically by analyzing plasma samples from 302 subjects (collected over 20 years). HLA associated polymorphisms accumulated in a subtype-specific manner.
Epitope EEAAEWDRL with anchor residues at E(E)AAEWDR(L) mutates to variant EEAAEWDRv. The consensus epitope EEAAEWDRl increases with time.

References

Displaying record number 55718

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HXB2 Location	Gag(210-218) p24(78-86) DNA(1417..1443)	Gag Epitope Map
Author Location	Gag
Epitope	`AEWDRLHPV`	Epitope Alignment
Epitope Name	AV9-B40
Subtype	B, F
Species (MHC/HLA)	human(B40)
Immunogen	HIV-1 infection
Country	Argentina
Experimental methods
Keywords	dynamics, HLA associated polymorphism

Notes

Dynamics of CTL escape mutations was studied theoretically by analyzing plasma samples from 302 subjects (collected over 20 years). HLA associated polymorphisms accumulated in a subtype-specific manner.
Epitope AEWDRLHPV with anchor residues at A(E)WDRLHP(V) mutates to variant AEWDRLHPa. The consensus epitope AEWDRLHPl increases with time.

References

Displaying record number 55720

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HXB2 Location	Gag(216-224) p24(84-92) DNA(1435..1461)	Gag Epitope Map
Author Location	Gag
Epitope	`HPVHAGPIA`	Epitope Alignment
Epitope Name	HA9-B09
Subtype	B, F
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Country	Argentina
Experimental methods
Keywords	dynamics, HLA associated polymorphism

Notes

Dynamics of CTL escape mutations was studied theoretically by analyzing plasma samples from 302 subjects (collected over 20 years). HLA associated polymorphisms accumulated in a subtype-specific manner.
Epitope HPVHAGPIA with anchor residues at H(P)VHAGPIA mutates to variant HPaHAGPvA and HPVHAGPvA; the latter increases over time.

References

Displaying record number 55707

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HXB2 Location	Gag(240-250) p24(108-118) DNA(1507..1539)	Gag Epitope Map
Author Location	Gag
Epitope	`TSTLQEQIGWF`	Epitope Alignment
Subtype	B, F
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Country	Argentina
Experimental methods
Keywords	dynamics, escape, HLA associated polymorphism

Notes

Dynamics of CTL escape mutations was studied theoretically by analyzing plasma samples from 302 subjects (collected over 20 years). HLA associated polymorphisms accumulated in a subtype-specific manner.
Epitope TSTLQEQIGWF with anchor residues at T(S)TLQEQIGW(F) mutates to TSnLQEQIGWF. This mutation is strongly supported as escape by phylogenetic correction.

References

Displaying record number 55722

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HXB2 Location	Gag(274-282) p24(142-150) DNA(1609..1635)	Gag Epitope Map
Author Location	Gag
Epitope	`VRMYSPVSI`	Epitope Alignment
Epitope Name	VI9-Cw18
Subtype	B, F
Species (MHC/HLA)	human(C*18)
Immunogen	HIV-1 infection
Country	Argentina
Experimental methods
Keywords	dynamics, escape, HLA associated polymorphism

Notes

Dynamics of CTL escape mutations was studied theoretically by analyzing plasma samples from 302 subjects (collected over 20 years). HLA associated polymorphisms accumulated in a subtype-specific manner.
Epitope VRMYSPVSI mutates to variant VRMYSPtSI with time.

References

Displaying record number 55719

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HXB2 Location	Gag(275-282) p24(143-150) DNA(1612..1635)	Gag Epitope Map
Author Location	Gag
Epitope	`RMYSPTSI`	Epitope Alignment
Epitope Name	RI8-B*52
Subtype	B, F
Species (MHC/HLA)	human(B52)
Immunogen	HIV-1 infection
Country	Argentina
Experimental methods
Keywords	HLA associated polymorphism

Notes

Dynamics of CTL escape mutations was studied theoretically by analyzing plasma samples from 302 subjects (collected over 20 years). HLA associated polymorphisms accumulated in a subtype-specific manner.
Epitope RMYSPTSI contains a polymorphism RMYSPtSI.

References

Displaying record number 55705

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HXB2 Location	Gag(352-361) p24(220-229) DNA(1843..1872)	Gag Epitope Map
Author Location	Gag
Epitope	`GVGGPGHKAR`	Epitope Alignment
Subtype	B, F
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Country	Argentina
Experimental methods
Keywords	dynamics, escape, HLA associated polymorphism

Notes

Dynamics of CTL escape mutations was studied theoretically by analyzing plasma samples from 302 subjects (collected over 20 years). HLA associated polymorphisms accumulated in a subtype-specific manner.
Epitope GVGGPGHKAR with anchor residues at GVGGPGHKA(R) mutates to GVGGPsHKAR which is moderately supported as escape by phylogenetic correction.

References

Displaying record number 55706

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HXB2 Location	Gag(355-363) p24(223-231) DNA(1852..1878)	Gag Epitope Map
Author Location	Gag
Epitope	`GPGHKARVL`	Epitope Alignment
Subtype	B, F
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Country	Argentina
Experimental methods
Keywords	dynamics, escape

Notes

Dynamics of CTL escape mutations was studied theoretically by analyzing plasma samples from 302 subjects (collected over 20 years). HLA associated polymorphisms accumulated in a subtype-specific manner.
Epitope GPGHKARVL with anchor residues at G(P)GHKARV(L) mutates to GPsHKARVL which is moderately supported as escape by phylogenetic correction.