Search CTL/CD8+ T-Cell Epitope Database

Found 40 matching records:

Displaying record number 56086

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HXB2 Location	Gag(169-178) p24(37-46) DNA(1294..1323)	Gag Epitope Map
Author Location	Gag
Epitope	`IPMFSALSEG`	Epitope Alignment
Epitope Name	Gag1166
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Epitope IPMFSALSEG elicits IFN-gamma ELISpot responses in 3/7 subjects; and bound HLA-B7 with low and high affinities in soluble and cell-based assays respectively. Previously published HLA restrictions of this epitope include A2, B21, B61, B60 associations (LANL database), DRB1*0101, DRB1*0401, DRB1*0404, DRB1*0405 (Immune Epitope Database).

References

DeGroot2008 Anne S. De Groot, Daniel S. Rivera, Julie A. McMurry, Soren Buus, and William Martin. Identification of Immunogenic HLA-B7 ``Achilles' Heel'' Epitopes within Highly Conserved Regions of HIV. Vaccine, 26(24):3059-3071, 6 Jun 2008. PubMed ID: 18206276. Show all entries for this paper.

Displaying record number 56088

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HXB2 Location	Gag(216-224) p24(84-92) DNA(1435..1461)	Gag Epitope Map
Author Location	Gag
Epitope	`HPVHAGPVA`	Epitope Alignment
Epitope Name	Gag1156
Subtype	C
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Epitope HPVHAGPVA elicits IFN-gamma ELISpot responses in 2/7 subjects; and bound HLA-B7 with high affinity in cell-based assays. Previously published HLA restriction of this epitope includes B7 (LANL database).

References

Displaying record number 56085

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HXB2 Location	Gag(253-261) p24(121-129) DNA(1546..1572)	Gag Epitope Map
Author Location	Gag
Epitope	`NPPIPVGEI`	Epitope Alignment
Epitope Name	Gag1144
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Epitope NPPIPVGEI elicits IFN-gamma ELISpot responses in 1/7 subjects; and bound HLA-B7 with low affinity in cell-based assays. Previously published HLA restrictions of this epitope include a B8 association (LANL db), A*0201 restriction (Immune Epitope Database).

References

Displaying record number 56087

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HXB2 Location	Gag(288-296) p24(156-164) DNA(1651..1677)	Gag Epitope Map
Author Location	Gag
Epitope	`GPKEPFRDY`	Epitope Alignment
Epitope Name	Gag1164
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Previously published epitope GPKEPFRDY elicits IFN-gamma ELISpot responses in 5/7 subjects; and bound HLA-B7 with low affinity in cell-based assays.

References

Displaying record number 56089

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HXB2 Location	Gag(355-363) p24(223-231) DNA(1852..1878)	Gag Epitope Map
Author Location	Gag
Epitope	`GPSHKARVL`	Epitope Alignment
Epitope Name	Gag1150
Subtype	C
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Epitope GPSHKARVL elicits IFN-gamma ELISpot responses in 5/7 subjects; and bound HLA-B7 with high affinities in soluble and cell-based assays. Previously published HLA restriction of this epitope includes HLA-B (LANL database).

References

Displaying record number 56092

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HXB2 Location	Gag(452-460) p2p7p1p6(89-97) DNA(2143..2169)	Gag Epitope Map
Author Location	Gag
Epitope	`RPEPTAPPA`	Epitope Alignment
Epitope Name	Gag1159
Subtype	C
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Novel Gag epitope RPEPTAPPA elicits IFN-gamma ELISpot responses in 2/7 subjects; and bound HLA-B7 with low and high affinities in soluble and cell-based assays respectively.

References

Displaying record number 56090

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HXB2 Location	Gag(454-463) p2p7p1p6(91-100) DNA(2149..2178)	Gag Epitope Map
Author Location	Gag
Epitope	`EPTAPPAESF`	Epitope Alignment
Epitope Name	Gag1162
Subtype	C
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Novel Gag epitope EPTAPPAESF elicits IFN-gamma ELISpot responses in 1/7 subjects; and bound HLA-B7 with low and medium affinities in soluble and cell-based assays respectively.

References

Displaying record number 56091

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HXB2 Location	Gag(457-465) p2p7p1p6(94-102) DNA(2158..2184)	Gag Epitope Map
Author Location	Gag
Epitope	`APPAESFRF`	Epitope Alignment
Epitope Name	Gag1147
Subtype	C
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Novel Gag epitope APPAESFRF elicits IFN-gamma ELISpot responses in 2/7 subjects; and bound HLA-B7 with low and high affinities in soluble and cell-based assays respectively.

References

Displaying record number 56110

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HXB2 Location	Pol(94-103) Protease(38-47) DNA(2364..2393)	Pol Epitope Map
Author Location	Pol
Epitope	`LPGRWKPKMI`	Epitope Alignment
Epitope Name	Pol1134
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Novel Pol epitope LPGRWKPKMI elicits IFN-gamma ELISpot responses in 4/7 subjects; and bound HLA-B7 with low and high affinities in soluble and cell-based assays respectively.

References

Displaying record number 56104

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HXB2 Location	Pol(136-145) Protease(80-89) DNA(2490..2519)	Pol Epitope Map
Author Location	Pol
Epitope	`TPVNIIGRNL`	Epitope Alignment
Epitope Name	Pol1151
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Epitope TPVNIIGRNL elicits IFN-gamma ELISpot responses in 3/7 subjects; and bound HLA-B7 with low and high affinities in soluble and cell-based assays respectively. Previously published HLA restrictions of this epitope include B63, B57, B58 (LANL database).

References

Displaying record number 56101

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HXB2 Location	Pol(249-257) RT(94-102) DNA(2829..2855)	Pol Epitope Map
Author Location	Pol
Epitope	`IPHPAGLKK`	Epitope Alignment
Epitope Name	Pol1167
Subtype	C
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Epitope IPHPAGLKK elicits IFN-gamma ELISpot responses in 1/7 subjects; and bound HLA-B7 with low and high affinities in soluble and cell-based assays respectively. Previously published HLA restriction of this epitope includes A11 (LANL database).

References

Displaying record number 56107

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HXB2 Location	Pol(287-296) RT(132-141) DNA(2943..2972)	Pol Epitope Map
Author Location	Pol
Epitope	`IPSTNNETPG`	Epitope Alignment
Epitope Name	Pol1165
Subtype	A1
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Novel Pol epitope IPSTNNETPG elicits IFN-gamma ELISpot responses in 1/7 subjects; and bound HLA-B7 with high affinity in cell-based assays.

References

Displaying record number 56106

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HXB2 Location	Pol(294-303) RT(139-148) DNA(2964..2993)	Pol Epitope Map
Author Location	Pol
Epitope	`TPGIRYQYNV`	Epitope Alignment
Epitope Name	Pol1157
Subtype	C
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Novel Pol epitope TPGIRYQYNV elicits IFN-gamma ELISpot responses in 1/7 subjects; and bound HLA-B7 with low and high affinities in soluble and cell-based assays respectively.

References

Displaying record number 56098

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HXB2 Location	Pol(401-409) RT(246-254) DNA(3285..3311)	Pol Epitope Map
Author Location	Pol
Epitope	`LPEKDSWTV`	Epitope Alignment
Epitope Name	Pol1145
Subtype	C
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Previously published epitope LPEKDSWTV elicits IFN-gamma ELISpot responses in 1/7 subjects; and bound HLA-B7 with low affinity in cell-based assays.

References

Displaying record number 56105

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HXB2 Location	Pol(426-434) RT(271-279) DNA(3360..3386)	Pol Epitope Map
Author Location	Pol
Epitope	`YPGIKVKQL`	Epitope Alignment
Epitope Name	Pol1153
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Novel Pol epitope YPGIKVKQL elicits IFN-gamma ELISpot responses in 1/7 subjects; and bound HLA-B7 with low and high affinities in soluble and cell-based assays respectively.

References

Displaying record number 56102

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HXB2 Location	Pol(571-580) RT(416-425) DNA(3795..3824)	Pol Epitope Map
Author Location	Pol
Epitope	`FVNTPPLVKL`	Epitope Alignment
Epitope Name	Pol1152
Subtype	C
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Epitope FVNTPPLVKL elicits IFN-gamma ELISpot responses in 2/7 subjects; and bound HLA-B7 with low affinity in cell-based assays. Previously published HLA restrictions of this epitope include DRB1*0101, DRB1*0401, DRB1*0405, DRB1*0701, DRB1*0802, DRB1*0901, DRB1*1101, DRB1*1302, DRB1*1501, DRB5*0101 (Immune Epitope Database).

References

Displaying record number 56099

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HXB2 Location	Pol(743-751) Integrase(28-36) DNA(4311..4337)	Pol Epitope Map
Author Location	Pol
Epitope	`LPPIVAKEI`	Epitope Alignment
Epitope Name	Pol1130
Subtype	C
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Epitope LPPIVAKEI elicits IFN-gamma ELISpot responses in 2/7 subjects; and bound HLA-B7 with low and high affinities in soluble and cell-based assays respectively. Previously published HLA restrictions of this epitope include B*0705, B*4201, B*5101 (LANL database).

References

Displaying record number 56108

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HXB2 Location	Pol(856-865) Integrase(141-150) DNA(4650..4679)	Pol Epitope Map
Author Location	Pol
Epitope	`IPYNPQSQGV`	Epitope Alignment
Epitope Name	Pol1128
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Novel Pol epitope IPYNPQSQGV elicits IFN-gamma ELISpot responses in 2/7 subjects; and bound HLA-B7 with low and high affinities in soluble and cell-based assays respectively.

References

Displaying record number 56109

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HXB2 Location	Pol(947-956) Integrase(232-241) DNA(4923..4952)	Pol Epitope Map
Author Location	Pol
Epitope	`DPIWKGPAKL`	Epitope Alignment
Epitope Name	Pol1143
Subtype	C
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Novel Pol epitope DPIWKGPAKL elicits IFN-gamma ELISpot responses in 2/7 subjects; and bound HLA-B7 with low affinity in cell-based assays.

References

Displaying record number 56103

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HXB2 Location	Pol(975-983) Integrase(260-268) DNA(5007..5033)	Pol Epitope Map
Author Location	Pol
Epitope	`VPRRKAKII`	Epitope Alignment
Epitope Name	Pol1132
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Previously published epitope VPRRKAKII elicits IFN-gamma ELISpot responses in 3/7 subjects; and bound HLA-B7 with medium and high affinities in soluble and cell-based assays respectively.

References

Displaying record number 56113

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HXB2 Location	Vif(48-57) DNA(5182..5211)	Vif Epitope Map
Author Location	Vif
Epitope	`HPRISSEVHI`	Epitope Alignment
Epitope Name	Vif1136
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Previously published epitope HPRISSEVHI elicits IFN-gamma ELISpot responses in 5/7 subjects; and bound HLA-B7 with high affinities in soluble and cell-based assays.

References

Displaying record number 56115

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HXB2 Location	Vif(57-65) DNA(5209..5235)	Vif Epitope Map
Author Location	Vif
Epitope	`IPLGEAKLV`	Epitope Alignment
Epitope Name	Vif1154
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Novel Vif epitope IPLGEAKLV elicits IFN-gamma ELISpot responses in 1/7 subjects; and bound HLA-B7 with low and medium affinities in soluble and cell-based assays respectively.

References

Displaying record number 56117

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HXB2 Location	Vif(57-66) DNA(5209..5238)	Vif Epitope Map
Author Location	Vif
Epitope	`IPLGDARLVI`	Epitope Alignment
Epitope Name	Vif1135
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Novel Vif epitope IPLGDARLVI elicits IFN-gamma ELISpot responses in 2/7 subjects; and bound HLA-B7 with low and high affinities in soluble and cell-based assays respectively.

References

Displaying record number 56114

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HXB2 Location	Vif(155-163) DNA(5503..5529)	Vif Epitope Map
Author Location	Vif
Epitope	`TPKKIKPPL`	Epitope Alignment
Epitope Name	Vif1138
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Novel Vif epitope TPKKIKPPL elicits IFN-gamma ELISpot responses in 1/7 subjects; and bound HLA-B7 with medium and high affinities in soluble and cell-based assays respectively.

References

Displaying record number 56116

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HXB2 Location	Vif(161-169) DNA(5521..5547)	Vif Epitope Map
Author Location	Vif
Epitope	`PPLPSVRKL`	Epitope Alignment
Epitope Name	Vif1155
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Novel Vif epitope PPLPSVRKL elicits IFN-gamma ELISpot responses in 1/7 subjects; and bound HLA-B7 with low and medium affinities in soluble and cell-based assays respectively.

References

Displaying record number 56118

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HXB2 Location	Vpr(34-42) DNA(5658..5684)	Vpr Epitope Map
Author Location	Vpr
Epitope	`FPRPWLHGL`	Epitope Alignment
Epitope Name	Vpr1125
Subtype	C
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Epitope FPRPWLHGL elicits IFN-gamma ELISpot responses in 3/7 subjects; and bound HLA-B7 with high affinities in soluble and cell-based assays. Previously published HLA restrictions of this epitope include A*0204, A*0201 (LANL database).

References

Displaying record number 56111

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HXB2 Location	Tat(2-11) DNA(5834..5863)	Tat Epitope Map
Author Location	Tat
Epitope	`EPVDPNLEPW`	Epitope Alignment
Epitope Name	Tat1140
Subtype	C
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Previously published Tat epitope EPVDPNLEPW elicits IFN-gamma ELISpot responses in 2/7 subjects; and bound HLA-B7 with low affinities in soluble and cell-based assays respectively.

References

Displaying record number 56112

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HXB2 Location	Tat(17-26) DNA(5879..5908)	Tat Epitope Map
Author Location	Tat
Epitope	`QPKTACTNCY`	Epitope Alignment
Epitope Name	Tat1160
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Novel Tat epitope QPKTACTNCY elicits IFN-gamma ELISpot responses in 1/7 subjects; and bound HLA-B7 with low affinity in cell-based assays.

References

Displaying record number 56081

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HXB2 Location	gp160(75-84) gp120(75-84) DNA(6447..6476)	gp160 Epitope Map
Author Location	Env
Epitope	`VPTDPNPQEI`	Epitope Alignment
Epitope Name	Env1129
Subtype	C
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Novel Env epitope VPTDPNPQEI elicits IFN-gamma ELISpot responses in 1/7 subjects; and bound HLA-B7 with low affinity in cell-based assays.

References

Displaying record number 56083

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HXB2 Location	gp160(123-132) gp120(123-132) DNA(6591..6620)	gp160 Epitope Map
Author Location	Env
Epitope	`TPLCVTLNCT`	Epitope Alignment
Epitope Name	Env1148
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Novel Env epitope TPLCVTLNCT elicits IFN-gamma ELISpot responses in 2/7 subjects; and bound HLA-B7 with low affinity in cell-based assays.

References

Displaying record number 55754

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HXB2 Location	gp160(213-221) gp120(213-221) DNA(6861..6887)	gp160 Epitope Map
Author Location	Env
Epitope	`IPIHYCAPA`	Epitope Alignment
Epitope Name	Env1161
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Epitope IPIHYCAPA elicits IFN-gamma ELISpot responses in 1/7 subjects; and bound HLA-B7 with medium and high affinities in soluble and cell-based assays respectively. Previously published HLA restrictions of this epitope include A3 (LANL database), B*0702 and DRB4*0101, DRB1*0101, DRB1*0401, DRB1*0701, DRB1*0901 (Immune Epitope Database).

References

Displaying record number 56084

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HXB2 Location	gp160(237-245) gp120(237-245) DNA(6933..6959)	gp160 Epitope Map
Author Location	Env
Epitope	`GPCTNVSTV`	Epitope Alignment
Epitope Name	Env1158
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Novel Env epitope GPCTNVSTV elicits IFN-gamma ELISpot responses in 2/7 subjects; and bound HLA-B7 with low and medium affinities in soluble and cell-based assays respectively.

References

Displaying record number 56079

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HXB2 Location	gp160(298-307) gp120(298-307) DNA(7116..7145)	gp160 Epitope Map
Author Location	Env
Epitope	`RPNNNTRKSI`	Epitope Alignment
Epitope Name	Env1146
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Epitope RPNNNTRKSI elicits IFN-gamma ELISpot responses in 2/7 subjects; and bound HLA-B7 with high affinities in soluble and cell-based assays. Previously published HLA restriction of this epitope is HLA-B7 (LANL database).

References

Displaying record number 56082

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HXB2 Location	gp160(713-721) gp41(202-210) DNA(8361..8387)	gp160 Epitope Map
Author Location	Env
Epitope	`SPLSFQTRL`	Epitope Alignment
Epitope Name	Env1131
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Novel Env epitope SPLSFQTRL elicits IFN-gamma ELISpot responses in 1/7 subjects; and bound HLA-B7 with high affinities in soluble and cell-based assays.

References

Displaying record number 56080

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HXB2 Location	gp160(843-851) gp41(332-340) DNA(8751..8777)	gp160 Epitope Map
Author Location	Env
Epitope	`IPRRIRQGL`	Epitope Alignment
Epitope Name	Env1137
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Epitope IPRRIRQGL elicits IFN-gamma ELISpot responses in 5/7 subjects; and bound HLA-B7 with high and medium affinities in soluble and cell-based assays respectively. The authors claim previously published HLA restrictions of this epitope include B7, A2, A26 and B38 (LANL database), B*0702 (Immune Epitope Database).

References

Displaying record number 56095

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HXB2 Location	Nef(68-76) DNA(8998..9024)	Nef Epitope Map
Author Location	Nef
Epitope	`FPVRPQVPL`	Epitope Alignment
Epitope Name	Nef1124
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Epitope FPVRPQVPL elicits IFN-gamma ELISpot responses in 5/7 subjects; and bound HLA-B7 with high affinity in cell-based assays. The authors claim previously published HLA restrictions of this epitope include B*0702, A*2902, B*5102, B*5103 (LANL database), B*3501,B*5101, B*5301, B*5401 (LANL and Immune Epitope Databases).

References

Displaying record number 56093

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HXB2 Location	Nef(74-83) DNA(9016..9045)	Nef Epitope Map
Author Location	Nef
Epitope	`VPLRPMTYKA`	Epitope Alignment
Epitope Name	Nef1163
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Epitope VPLRPMTYKA elicits IFN-gamma ELISpot responses in 4/7 subjects; and bound HLA-B7 with high affinity in cell-based assays. The authors claim previously published HLA restrictions of this epitope include B61 and a questionable B60 (LANL database).

References

Displaying record number 56094

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HXB2 Location	Nef(128-137) DNA(9178..9207)	Nef Epitope Map
Author Location	Nef
Epitope	`TPGPGIRYPL`	Epitope Alignment
Epitope Name	Nef1133
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Previously published epitope TPGPGIRYPL elicits IFN-gamma ELISpot responses in 5/7 subjects; and bound HLA-B7 with high affinities in soluble and cell-based assays.

References

Displaying record number 56097

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HXB2 Location	Nef(130-139) DNA(9184..9213)	Nef Epitope Map
Author Location	Nef
Epitope	`GPGTRFPLTR`	Epitope Alignment
Epitope Name	Nef1139
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Previously published epitope GPGTRFPLTR elicits IFN-gamma ELISpot responses in 5/7 subjects; and bound HLA-B7 with low and high affinities in soluble and cell-based assays respectively.

References

Displaying record number 56096

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HXB2 Location	Nef(135-143) DNA(9199..9225)	Nef Epitope Map
Author Location	Nef
Epitope	`YPLTFGWCF`	Epitope Alignment
Epitope Name	Nef1127
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

45 highly conserved, putative HLA-B7-restricted epitopes were identified with EpiMatrix and evaluated for HLA binding and ELISpot assays. 40 epitopes were functional and 18 of them are novel, 7 were not previously described as HLA-B7-restricted.
Epitope YPLTFGWCF elicits IFN-gamma ELISpot responses in 1/7 subjects; and bound HLA-B7 with low and high affinities in soluble and cell-based assays respectively. The authors claim previously published HLA restrictions of this epitope include B57 (LANL database), A*2402 (Immune Epitope Database).