Search CTL/CD8+ T-Cell Epitope Database

Found 4 matching records:

Displaying record number 53636

Download this epitope record as JSON.

HXB2 Location	Gag(147-155) p24(15-23) DNA(1228..1254)	Gag Epitope Map
Author Location	p24(147-155)
Epitope	ISPRTLNAW	Epitope Alignment
		Show epitope variants
Epitope Name	IW9
Subtype	C
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Country	Ethiopia
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	immunodominance, escape, variant cross-reactivity

Notes

• Epitope sequence variation and CD8 T-cell responses were analyzed in C subtype infected HLA-B57-positive individuals from Ethiopia. KF11 was the immunodominant response.
• ISPRTLNAW had a variant lSPRTLNAW in 7/10 B57+ subjects, and 4/9 B57- subjects; 2 other variants were observed, but there was no apparent sequence selection in this epitope.

References

Currier2005 Jeffrey R. Currier, Matthew E. Harris, Josephine H. Cox, Francine E. McCutchan, Deborah L. Birx, Shlomo Maayan, and Guido Ferrari. Immunodominance and Cross-Reactivity of B5703-Restricted CD8 T Lymphocytes from HIV Type 1 Subtype C-Infected Ethiopians. AIDS Res. Hum. Retroviruses, 21(3):239-245, Mar 2005. PubMed ID: 15795531. Show all entries for this paper.

Displaying record number 53635

Download this epitope record as JSON.

HXB2 Location	Gag(162-172) p24(30-40) DNA(1273..1305)	Gag Epitope Map
Author Location	p24(162-172)
Epitope	KAFSPEVIPMF	Epitope Alignment
		Show epitope variants
Epitope Name	KF11
Subtype	C
Species (MHC/HLA)	human(B*57:03)
Immunogen	HIV-1 infection
Country	Ethiopia
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression, immunodominance, escape, variant cross-reactivity

Notes

• HLA-B57 is associated with slow progression. Epitope sequence variation and CD8 T-cell responses were analyzed in HLA-B*5703-positive individuals from Ethiopia. KF11 epitope and its variants were found to be immunodominant in these subjects. Two HLA-B*5702 subjects did not respond to the KF11 epitope or its variants.
• 5 variants of the epitope were observed: KAFSPEVIPMF, KnFSPEVIPMF, rAFSPEVIPMF, KgFnPEVIPMF. Depending on the subject, different versions of these variants were more or less susceptible to their CD8+ T cells, i.e., one person's escape form was another person's susceptible form.
• Responses against KnFSPEVIPMF were strong but subdominant in subjects carrying KAFSPEVIPMF and KnFSPEVIPMF and there was little or no response in subjects carrying KgFnPEVIPMF.
• Responses against rAFSPEVIPMF were among maximal in subjects carrying KAFSPEVIPMF, KnFSPEVIPMF and rAFSPEVIPMF but there was little or no response in subjects carrying KgFnPEVIPMF.
• Responses against KgFnPEVIPMF were strong but subdominant in subjects carrying KAFSPEVIPMF and KnFSPEVIPMF. In subjects carrying KgFnPEVIPMF there was a strong response against the index peptide but little or no response against other peptides. Subject carrying provirus with rAFSPEVIPMF showed dramatic nonrecognition of KgFnPEVIPMF.

References

Currier2005 Jeffrey R. Currier, Matthew E. Harris, Josephine H. Cox, Francine E. McCutchan, Deborah L. Birx, Shlomo Maayan, and Guido Ferrari. Immunodominance and Cross-Reactivity of B5703-Restricted CD8 T Lymphocytes from HIV Type 1 Subtype C-Infected Ethiopians. AIDS Res. Hum. Retroviruses, 21(3):239-245, Mar 2005. PubMed ID: 15795531. Show all entries for this paper.

Displaying record number 53637

Download this epitope record as JSON.

HXB2 Location	Gag(240-249) p24(108-117) DNA(1507..1536)	Gag Epitope Map
Author Location	p24(240-249)
Epitope	TSTLQEQIAW	Epitope Alignment
Epitope Name	TW10
Subtype	C
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Country	Ethiopia
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	immunodominance, escape, variant cross-reactivity

Notes

• Epitope sequence variation and CD8 T-cell responses were analyzed in C subtype infected HLA-B57-positive individuals from Ethiopia. KF11 was the immunodominant response.
• 9/10 B57 subjects had the T3N TSnLQEQIAW substitution relative to the C consensus, while this form was found in only 2/9 B57- subjects, so it appears to be selected and an immune escape form (p=0.001). Both forms of the TW10 epitope (TSTLQEQIAW and TSnLQEQIAW) were tested in 2 B57-positive subjects; neither responded. The authors suggest this may be due to the dominance of the TW10 response in acute infection, as the response may have been lost by the time of sampling.

References

Currier2005 Jeffrey R. Currier, Matthew E. Harris, Josephine H. Cox, Francine E. McCutchan, Deborah L. Birx, Shlomo Maayan, and Guido Ferrari. Immunodominance and Cross-Reactivity of B5703-Restricted CD8 T Lymphocytes from HIV Type 1 Subtype C-Infected Ethiopians. AIDS Res. Hum. Retroviruses, 21(3):239-245, Mar 2005. PubMed ID: 15795531. Show all entries for this paper.

Displaying record number 53638

Download this epitope record as JSON.

HXB2 Location	Gag(308-316) p24(176-184) DNA(1711..1737)	Gag Epitope Map
Author Location	p24(308-316)
Epitope	QATQDVKNW	Epitope Alignment
Epitope Name	QW9
Subtype	C
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Country	Ethiopia
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	immunodominance, escape, variant cross-reactivity

Notes

• Epitope sequence variation and CD8 T-cell responses were analyzed in C subtype infected HLA-B57-positive individuals from Ethiopia. KF11 was the immunodominant response.
• QATQDVKNW had a single variant, D5E (QATQEVKNW) in 1 subject; there was no apparent immune selection in this epitope. The QW9 peptide was tested in 2 B57-positive subjects; neither responded.

References

Currier2005 Jeffrey R. Currier, Matthew E. Harris, Josephine H. Cox, Francine E. McCutchan, Deborah L. Birx, Shlomo Maayan, and Guido Ferrari. Immunodominance and Cross-Reactivity of B5703-Restricted CD8 T Lymphocytes from HIV Type 1 Subtype C-Infected Ethiopians. AIDS Res. Hum. Retroviruses, 21(3):239-245, Mar 2005. PubMed ID: 15795531. Show all entries for this paper.