HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 3 matching records:

Displaying record number 981

HXB2 Location Nef(73-82)
DNA(9013..9042)
Nef Epitope Map
Author Location Nef(73-82 LAI)
Epitope QVPLRPMTYK Epitope Alignment
QVPLRPMTYK epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Experimental methods  
Keywords review, escape

Notes

References

Couillin1994 I. Couillin, B. Culmann-Penciolelli, E. Gomard, J. Choppin, J. P Levy, J. G. Guillet, and S. Sarasgosti. Impaired Cytotoxic T Lymphocyte Recognition Due to Genetic Variations in the Main Immunogenic Region of the Human Immunodeficiency Virus 1 NEF Protein. J. Exp. Med., 180:1129-11234, 1994. HIV-1 HLA-A11 and -B18 restricted epitopes were sequenced from donors who do and do not express the HLA-A11 and B18 molecule. Selective variations were only detected in virus isolated from individuals expressing the appropriate HLA type. Variant peptides with single substitutions within the minimal epitope did not always completely abrogate HLA binding, suggesting that multiple alterations within a particular epitope may need to accumulate during disease progression to allow viral escape. PubMed ID: 7520468. Show all entries for this paper.

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.


Displaying record number 1007

HXB2 Location Nef(84-92)
DNA(9046..9072)
Nef Epitope Map
Author Location Nef(84-92 LAI)
Epitope AVDLSHFLK Epitope Alignment
AVDLSHFLK epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(A11)
Immunogen HIV-1 infection
Experimental methods  
Keywords review, escape, variant cross-reactivity

Notes

References

Couillin1994 I. Couillin, B. Culmann-Penciolelli, E. Gomard, J. Choppin, J. P Levy, J. G. Guillet, and S. Sarasgosti. Impaired Cytotoxic T Lymphocyte Recognition Due to Genetic Variations in the Main Immunogenic Region of the Human Immunodeficiency Virus 1 NEF Protein. J. Exp. Med., 180:1129-11234, 1994. HIV-1 HLA-A11 and -B18 restricted epitopes were sequenced from donors who do and do not express the HLA-A11 and B18 molecule. Selective variations were only detected in virus isolated from individuals expressing the appropriate HLA type. Variant peptides with single substitutions within the minimal epitope did not always completely abrogate HLA binding, suggesting that multiple alterations within a particular epitope may need to accumulate during disease progression to allow viral escape. PubMed ID: 7520468. Show all entries for this paper.

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.


Displaying record number 1066

HXB2 Location Nef(134-144)
DNA(9196..9228)
Nef Epitope Map
Author Location Nef(134-144 LAI)
Epitope RYPLTFGWCYK Epitope Alignment
RYPLTFGWCYK epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B18)
Immunogen HIV-1 infection
Experimental methods  
Keywords review, escape

Notes

References

Couillin1994 I. Couillin, B. Culmann-Penciolelli, E. Gomard, J. Choppin, J. P Levy, J. G. Guillet, and S. Sarasgosti. Impaired Cytotoxic T Lymphocyte Recognition Due to Genetic Variations in the Main Immunogenic Region of the Human Immunodeficiency Virus 1 NEF Protein. J. Exp. Med., 180:1129-11234, 1994. HIV-1 HLA-A11 and -B18 restricted epitopes were sequenced from donors who do and do not express the HLA-A11 and B18 molecule. Selective variations were only detected in virus isolated from individuals expressing the appropriate HLA type. Variant peptides with single substitutions within the minimal epitope did not always completely abrogate HLA binding, suggesting that multiple alterations within a particular epitope may need to accumulate during disease progression to allow viral escape. PubMed ID: 7520468. Show all entries for this paper.

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.


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