Search CTL/CD8+ T-Cell Epitope Database

Found 6 matching records:

Displaying record number 58803

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HXB2 Location	Gag(162-172) p24(30-40) DNA(1273..1305)	Gag Epitope Map
Author Location
Epitope	`KAFSPEVIPMF`	Epitope Alignment
Epitope Name	B*57-KF11
Subtype	B
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	Other, Tetramer binding
Keywords

Notes

This study of post-ART TCR repertoire and clonal diversity was undertaken in 8 HIV-1 infected subjects using 14 HIV-specific CTL responses. It was noted that while circulating and memory CTL decreased along with a reduction in diversity of CTL responses, the overall hierarchy of TCR clonotypes was unchanged. A redistribution in memory phenotype did occur as well as decrease PD-1, CD38 expression, however PD-1 continued to be expressed more highly on dominant clonotypes. Therefore dominant clonotypes maintain their ability to recognize antigen post-ART, and TCR diversity also persists.
Both different clonotypes of epitope KF11 studied showed decreased numbers post-ART. Dominant clonotypes remained constant pre- and post-ART. Decreases in diversity of epitope-specificity of TCR were also seen pre- and post-ART in clonotypes.

References

Conrad2012 Joseph A. Conrad, Ramesh K. Ramalingam, Coley B. Duncan, Rita M. Smith, Jie Wei, Louise Barnett, Brenna C. Simons, Shelly L. Lorey, and Spyros A. Kalams. Antiretroviral Therapy Reduces the Magnitude and T Cell Receptor Repertoire Diversity of HIV-Specific T Cell Responses without Changing T Cell Clonotype Dominance. J. Virol., 86(8):4213-4221, Apr 2012. PubMed ID: 22258246. Show all entries for this paper.

Displaying record number 58781

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HXB2 Location	Gag(260-267) p24(128-135) DNA(1567..1590)	Gag Epitope Map
Author Location
Epitope	`EIYKRWII`	Epitope Alignment
Epitope Name	B*08-EI8
Subtype	B
Species (MHC/HLA)	human(B*08)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	Other, Tetramer binding
Keywords

Notes

This study of post-ART TCR repertoire and clonal diversity was undertaken in 8 HIV-1 infected subjects using 14 HIV-specific CTL responses. It was noted that while circulating and memory CTL decreased along with a reduction in diversity of CTL responses, the overall hierarchy of TCR clonotypes was unchanged. A redistribution in memory phenotype did occur as well as decrease PD-1, CD38 expression, however PD-1 continued to be expressed more highly on dominant clonotypes. Therefore dominant clonotypes maintain their ability to recognize antigen post-ART, and TCR diversity also persists.
All 3 different clonotypes of epitope EI8 studied showed decreased numbers post-ART. Dominant clonotypes also remained remarkably constant pre- and post-ART. Small decreases in diversity of epitope-specificity of TCR were also seen pre- and post-ART.

References

Displaying record number 58801

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HXB2 Location	Gag(269-277) p24(137-145) DNA(1594..1620)	Gag Epitope Map
Author Location
Epitope	`GLNKIVRMY`	Epitope Alignment
Epitope Name	B*15-GY9
Subtype	B
Species (MHC/HLA)	human(B*15)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	Other, Tetramer binding
Keywords

Notes

This study of post-ART TCR repertoire and clonal diversity was undertaken in 8 HIV-1 infected subjects using 14 HIV-specific CTL responses. It was noted that while circulating and memory CTL decreased along with a reduction in diversity of CTL responses, the overall hierarchy of TCR clonotypes was unchanged. A redistribution in memory phenotype did occur as well as decrease PD-1, CD38 expression, however PD-1 continued to be expressed more highly on dominant clonotypes. Therefore dominant clonotypes maintain their ability to recognize antigen post-ART, and TCR diversity also persists.
All 4 different clonotypes of epitope GY9 studied showed decreased numbers post-ART. Dominant clonotypes however, did not remain constant pre- and post-ART. Decreases in diversity of epitope-specificity of TCR were also seen pre- and post-ART in all 4 clonotypes.

References

Displaying record number 58804

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HXB2 Location	Gag(308-316) p24(176-184) DNA(1711..1737)	Gag Epitope Map
Author Location
Epitope	`QASQEVKNW`	Epitope Alignment
Epitope Name	B*57-QW9
Subtype	B
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	Other, Tetramer binding
Keywords	HAART, ART

Notes

This study of post-ART TCR repertoire and clonal diversity was undertaken in 8 HIV-1 infected subjects using 14 HIV-specific CTL responses. It was noted that while circulating and memory CTL decreased along with a reduction in diversity of CTL responses, the overall hierarchy of TCR clonotypes was unchanged. A redistribution in memory phenotype did occur as well as decrease PD-1, CD38 expression, however PD-1 continued to be expressed more highly on dominant clonotypes. Therefore dominant clonotypes maintain their ability to recognize antigen post-ART, and TCR diversity also persists.
One clonotype of epitope GY9 studied showed decreased numbers post-ART, but the other showed increased numbers. Dominant clonotypes however, did remain fairly constant pre- and post-ART. Decreases in diversity of epitope-specificity of TCR were also seen pre- and post-ART in clonotypes.

References

Displaying record number 58800

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HXB2 Location	Nef(90-97) DNA(9064..9087)	Nef Epitope Map
Author Location
Epitope	`FLKEKGGL`	Epitope Alignment
Epitope Name	B*08-FL8
Subtype	B
Species (MHC/HLA)	human(B*08)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	Other, Tetramer binding
Keywords

Notes

This study of post-ART TCR repertoire and clonal diversity was undertaken in 8 HIV-1 infected subjects using 14 HIV-specific CTL responses. It was noted that while circulating and memory CTL decreased along with a reduction in diversity of CTL responses, the overall hierarchy of TCR clonotypes was unchanged. A redistribution in memory phenotype did occur as well as decrease PD-1, CD38 expression, however PD-1 continued to be expressed more highly on dominant clonotypes. Therefore dominant clonotypes maintain their ability to recognize antigen post-ART, and TCR diversity also persists.
Both different clonotypes of epitope FL8 studied showed decreased numbers post-ART. Dominant clonotypes also remained remarkably constant pre- and post-ART. Small decreases in diversity of epitope-specificity of TCR were also seen pre- and post-ART in 1/2 clonotypes.

References

Displaying record number 58802

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HXB2 Location	Nef(117-127) DNA(9145..9177)	Nef Epitope Map
Author Location
Epitope	`TQGYFPDWQNY`	Epitope Alignment
Epitope Name	B*15-TY11
Subtype	B
Species (MHC/HLA)	human(B*15)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	Other, Tetramer binding
Keywords

Notes

This study of post-ART TCR repertoire and clonal diversity was undertaken in 8 HIV-1 infected subjects using 14 HIV-specific CTL responses. It was noted that while circulating and memory CTL decreased along with a reduction in diversity of CTL responses, the overall hierarchy of TCR clonotypes was unchanged. A redistribution in memory phenotype did occur as well as decrease PD-1, CD38 expression, however PD-1 continued to be expressed more highly on dominant clonotypes. Therefore dominant clonotypes maintain their ability to recognize antigen post-ART, and TCR diversity also persists.
Different clonotypes of epitope TY11 studied showed decreased numbers post-ART. Dominant clonotypes remained constant pre- and post-ART. Decreases in diversity of epitope-specificity of TCR were also seen pre- and post-ART in clonotypes.