Search CTL/CD8+ T-Cell Epitope Database

Found 25 matching records:

Displaying record number 57525

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HXB2 Location	Gag(148-156) p24(16-24) DNA(1231..1257)	Gag Epitope Map
Author Location	p24(16-24)
Epitope	`SPRTLNAWV`	Epitope Alignment
Epitope Name	S9WV
Species (MHC/HLA)	human, transgenic mouse(B*07)
Immunogen	HIV-1 infection, vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords	vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine strain	multiple epitope immunogen
Vaccine component	HIV-1

Notes

The study objective was to design a vaccine construct containing HIV-1 epitopes that would generate broad CD8+ responses. Among 14 known B7-restricted epitopes, 11 induced a response in B*07 transgenic mice. Among 11 novel candidate epitopes, all induced a response in B*07 mice, and all induced a response in at least 1 human B7+ donor. Immunological recognition of these epitopes was confirmed in HLA-B*0702 HIV-1-infected individuals.
SPRTLNAWV is a known B07 epitope that was recognized by 9/12 B*07 transgenic mice.
This epitope was recognized by 3/8 HLA-B*0702 HIV-1-infected individuals.

References

Cardinaud2009 Sylvain Cardinaud, Romain Bouziat, Pierre-Simon Rohrlich, Sophie Tourdot, Laurence Weiss, Pierre Langlade-Demoyen, Anne Burgevin, Susana Fiorentino, Peter van Endert, and François A. Lemonnier. Design of a HIV-1-Derived HLA-B07.02-Restricted Polyepitope Construct. AIDS, 23(15):1945-1954, 24 Sep 2009. PubMed ID: 19644347. Show all entries for this paper.

Displaying record number 57526

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HXB2 Location	Gag(180-187) p24(48-55) DNA(1327..1350)	Gag Epitope Map
Author Location	p24(48-55)
Epitope	`TPQDLNTM`	Epitope Alignment
Epitope Name	T8TM
Species (MHC/HLA)	human, transgenic mouse(B*07)
Immunogen	HIV-1 infection, vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords	vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine strain	multiple epitope immunogen
Vaccine component	HIV-1

Notes

The study objective was to design a vaccine construct containing HIV-1 epitopes that would generate broad CD8+ responses. Among 14 known B7-restricted epitopes, 11 induced a response in B*07 transgenic mice. Among 11 novel candidate epitopes, all induced a response in B*07 mice, and all induced a response in at least 1 human B7+ donor. Immunological recognition of these epitopes was confirmed in HLA-B*0702 HIV-1-infected individuals.
TPQDLNTM is a known B07 epitope that was not recognized by B*07 transgenic mice.

References

Displaying record number 57527

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HXB2 Location	Gag(180-188) p24(48-56) DNA(1327..1353)	Gag Epitope Map
Author Location	p24(48-56)
Epitope	`TPQDLNTML`	Epitope Alignment
Epitope Name	T9ML
Species (MHC/HLA)	human, transgenic mouse(B*07)
Immunogen	HIV-1 infection, vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords	vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine strain	multiple epitope immunogen
Vaccine component	HIV-1

Notes

The study objective was to design a vaccine construct containing HIV-1 epitopes that would generate broad CD8+ responses. Among 14 known B7-restricted epitopes, 11 induced a response in B*07 transgenic mice. Among 11 novel candidate epitopes, all induced a response in B*07 mice, and all induced a response in at least 1 human B7+ donor. Immunological recognition of these epitopes was confirmed in HLA-B*0702 HIV-1-infected individuals.
TPQDLNTML is a known B07 epitope that was recognized by 2/12 B*07 transgenic mice.
This epitope was recognized by 4/8 HLA-B*0702 HIV-1-infected individuals.

References

Displaying record number 57528

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HXB2 Location	Gag(355-363) p24(223-231) DNA(1852..1878)	Gag Epitope Map
Author Location	p24(223-231)
Epitope	`GPGHKARVL`	Epitope Alignment
Epitope Name	G9VL
Species (MHC/HLA)	human, transgenic mouse(B*07)
Immunogen	HIV-1 infection, vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords	vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine strain	multiple epitope immunogen
Vaccine component	HIV-1

Notes

The study objective was to design a vaccine construct containing HIV-1 epitopes that would generate broad CD8+ responses. Among 14 known B7-restricted epitopes, 11 induced a response in B*07 transgenic mice. Among 11 novel candidate epitopes, all induced a response in B*07 mice, and all induced a response in at least 1 human B7+ donor. Immunological recognition of these epitopes was confirmed in HLA-B*0702 HIV-1-infected individuals.
GPGHKARVL is a known B07 epitope that was not recognized by B*07 transgenic mice.

References

Displaying record number 57529

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HXB2 Location	Gag(484-493) p2p7p1p6(121-130) DNA(2239..2268)	Gag Epitope Map
Author Location	p2p7p1p6(121-130)
Epitope	`YPLASLRSLF`	Epitope Alignment
Epitope Name	Y10LF
Species (MHC/HLA)	human, transgenic mouse(B*07)
Immunogen	HIV-1 infection, vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords	vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine strain	multiple epitope immunogen
Vaccine component	HIV-1

Notes

The study objective was to design a vaccine construct containing HIV-1 epitopes that would generate broad CD8+ responses. Among 14 known B7-restricted epitopes, 11 induced a response in B*07 transgenic mice. Among 11 novel candidate epitopes, all induced a response in B*07 mice, and all induced a response in at least 1 human B7+ donor. Immunological recognition of these epitopes was confirmed in HLA-B*0702 HIV-1-infected individuals.
YPLASLRSLF is a known B07 epitope that was recognized by 1/12 B*07 transgenic mice.
This epitope was recognized by 5/8 HLA-B*0702 HIV-1-infected individuals.

References

Displaying record number 57530

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HXB2 Location	Pol(311-320) RT(156-165) DNA(3015..3044)	Pol Epitope Map
Author Location	RT(156-165)
Epitope	`SPAIFQSSMT`	Epitope Alignment
Epitope Name	S10MT
Species (MHC/HLA)	human, transgenic mouse(B*07)
Immunogen	HIV-1 infection, vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords	vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine strain	multiple epitope immunogen
Vaccine component	HIV-1

Notes

The study objective was to design a vaccine construct containing HIV-1 epitopes that would generate broad CD8+ responses. Among 14 known B7-restricted epitopes, 11 induced a response in B*07 transgenic mice. Among 11 novel candidate epitopes, all induced a response in B*07 mice, and all induced a response in at least 1 human B7+ donor. Immunological recognition of these epitopes was confirmed in HLA-B*0702 HIV-1-infected individuals.
SPAIFQSSMT is a known B07 epitope that was not recognized by B*07 transgenic mice.

References

Displaying record number 57543

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HXB2 Location	Vif(46-55) DNA(5176..5205)	Vif Epitope Map
Author Location	Vif(46-55)
Epitope	`SPHPRISSEV`	Epitope Alignment
		Show epitope variants
Epitope Name	S10EV
Species (MHC/HLA)	human, transgenic mouse(B*07)
Immunogen	HIV-1 infection, vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords	subtype comparisons, vaccine-induced immune responses, variant cross-reactivity, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine strain	multiple epitope immunogen
Vaccine component	HIV-1

Notes

The study objective was to design a vaccine construct containing HIV-1 epitopes that would generate broad CD8+ responses. Among 14 known B7-restricted epitopes, 11 induced a response in B*07 transgenic mice. Among 11 novel candidate epitopes, all induced a response in B*07 mice, and all induced a response in at least 1 human B7+ donor. Immunological recognition of these epitopes was confirmed in HLA-B*0702 HIV-1-infected individuals.
SPHPRISSEV is a novel B07 epitope that was recognized by 6/6 B*07 transgenic mice.
This epitope was recognized by 5/8 HLA-B*0702 HIV-1-infected individuals.
Intersubtype variant StHPRISSEV exhibited good cross-recognition in mice immunized with SPHPRISSEV.

References

Displaying record number 57544

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HXB2 Location	Vif(48-57) DNA(5182..5211)	Vif Epitope Map
Author Location	Vif(48-57)
Epitope	`HPRISSEVHI`	Epitope Alignment
		Show epitope variants
Epitope Name	H10HI
Species (MHC/HLA)	human, transgenic mouse(B*07)
Immunogen	HIV-1 infection, vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords	subtype comparisons, vaccine-induced immune responses, variant cross-reactivity, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine strain	multiple epitope immunogen
Vaccine component	HIV-1

Notes

The study objective was to design a vaccine construct containing HIV-1 epitopes that would generate broad CD8+ responses. Among 14 known B7-restricted epitopes, 11 induced a response in B*07 transgenic mice. Among 11 novel candidate epitopes, all induced a response in B*07 mice, and all induced a response in at least 1 human B7+ donor. Immunological recognition of these epitopes was confirmed in HLA-B*0702 HIV-1-infected individuals.
HPRISSEVHI is a novel B07 epitope that was recognized by 6/6 B*07 transgenic mice.
This epitope was recognized by 7/8 HLA-B*0702 HIV-1-infected individuals.
Intersubtype variants HPkISSEVHI and HPRvSSEVHI exhibited low cross-recognition in mice immunized with HPRISSEVHI.

References

Displaying record number 57545

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HXB2 Location	Vif(57-66) DNA(5209..5238)	Vif Epitope Map
Author Location	Vif(57-66)
Epitope	`IPLGDARLVI`	Epitope Alignment
		Show epitope variants
Epitope Name	I10VI
Species (MHC/HLA)	human, transgenic mouse(B*07)
Immunogen	HIV-1 infection, vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords	subtype comparisons, vaccine-induced immune responses, variant cross-reactivity, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine strain	multiple epitope immunogen
Vaccine component	HIV-1

Notes

The study objective was to design a vaccine construct containing HIV-1 epitopes that would generate broad CD8+ responses. Among 14 known B7-restricted epitopes, 11 induced a response in B*07 transgenic mice. Among 11 novel candidate epitopes, all induced a response in B*07 mice, and all induced a response in at least 1 human B7+ donor. Immunological recognition of these epitopes was confirmed in HLA-B*0702 HIV-1-infected individuals.
IPLGDARLVI is a novel B07 epitope that was recognized by 4/6 B*07 transgenic mice.
This epitope was recognized by 2/8 HLA-B*0702 HIV-1-infected individuals.
Intersubtype variant IPLGDARLVv exhibited good cross-recognition in mice immunized with IPLGDARLVI.

References

Displaying record number 57547

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HXB2 Location	Vif(155-163) DNA(5503..5529)	Vif Epitope Map
Author Location	Vif(155-163)
Epitope	`TPKKIKPPL`	Epitope Alignment
Epitope Name	T9PL
Species (MHC/HLA)	human, transgenic mouse(B*07)
Immunogen	HIV-1 infection, vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords	vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine strain	multiple epitope immunogen
Vaccine component	HIV-1

Notes

The study objective was to design a vaccine construct containing HIV-1 epitopes that would generate broad CD8+ responses. Among 14 known B7-restricted epitopes, 11 induced a response in B*07 transgenic mice. Among 11 novel candidate epitopes, all induced a response in B*07 mice, and all induced a response in at least 1 human B7+ donor. Immunological recognition of these epitopes was confirmed in HLA-B*0702 HIV-1-infected individuals.
TPKKIKPPL is a novel B07 epitope that was recognized by 5/6 B*07 transgenic mice.
This epitope was recognized by 3/8 HLA-B*0702 HIV-1-infected individuals.

References

Displaying record number 57546

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HXB2 Location	Vif(160-169) DNA(5518..5547)	Vif Epitope Map
Author Location	Vif(160-169)
Epitope	`KPPLPSVTKL`	Epitope Alignment
Epitope Name	K10KL
Species (MHC/HLA)	human, transgenic mouse(B*07)
Immunogen	HIV-1 infection, vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords	vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine strain	multiple epitope immunogen
Vaccine component	HIV-1

Notes

The study objective was to design a vaccine construct containing HIV-1 epitopes that would generate broad CD8+ responses. Among 14 known B7-restricted epitopes, 11 induced a response in B*07 transgenic mice. Among 11 novel candidate epitopes, all induced a response in B*07 mice, and all induced a response in at least 1 human B7+ donor. Immunological recognition of these epitopes was confirmed in HLA-B*0702 HIV-1-infected individuals.
KPPLPSVTKL is a novel B07 epitope that was recognized by 2/6 B*07 transgenic mice.
This epitope was recognized by 5/8 HLA-B*0702 HIV-1-infected individuals.

References

Displaying record number 57535

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HXB2 Location	Vpr(34-42) DNA(5658..5684)	Vpr Epitope Map
Author Location	Vpr(34-42)
Epitope	`FPRIWLHGL`	Epitope Alignment
		Show epitope variants
Epitope Name	F9GL
Species (MHC/HLA)	human, transgenic mouse(B*07)
Immunogen	HIV-1 infection, vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords	subtype comparisons, vaccine-induced immune responses, variant cross-reactivity, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine strain	multiple epitope immunogen
Vaccine component	HIV-1

Notes

The study objective was to design a vaccine construct containing HIV-1 epitopes that would generate broad CD8+ responses. Among 14 known B7-restricted epitopes, 11 induced a response in B*07 transgenic mice. Among 11 novel candidate epitopes, all induced a response in B*07 mice, and all induced a response in at least 1 human B7+ donor. Immunological recognition of these epitopes was confirmed in HLA-B*0702 HIV-1-infected individuals.
FPRIWLHGL is a known B07 epitope that was recognized by 6/12 B*07 transgenic mice.
This epitope was recognized by 6/8 HLA-B*0702 HIV-1-infected individuals.
Intersubtype variants FPRpWLHGL and FPRIWLHsL exhibited good cross-recognition in mice immunized with FPRIWLHGL.

References

Displaying record number 57541

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HXB2 Location	Tat(58-67) DNA(6002..6031)	Tat Epitope Map
Author Location	Tat(58-67)
Epitope	`PPQGSQTHQV`	Epitope Alignment
Epitope Name	P10QV
Species (MHC/HLA)	human, transgenic mouse(B*07)
Immunogen	HIV-1 infection, vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords	vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine strain	multiple epitope immunogen
Vaccine component	HIV-1

Notes

The study objective was to design a vaccine construct containing HIV-1 epitopes that would generate broad CD8+ responses. Among 14 known B7-restricted epitopes, 11 induced a response in B*07 transgenic mice. Among 11 novel candidate epitopes, all induced a response in B*07 mice, and all induced a response in at least 1 human B7+ donor. Immunological recognition of these epitopes was confirmed in HLA-B*0702 HIV-1-infected individuals.
PPQGSQTHQV is a novel B07 epitope that was recognized by 2/6 B*07 transgenic mice.
This epitope was recognized by 4/8 HLA-B*0702 HIV-1-infected individuals.

References

Displaying record number 57548

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HXB2 Location	Rev(73-81) DNA(8519..8545)	Rev Epitope Map
Author Location	Rev(73-81)
Epitope	`LPLPPLDRL`	Epitope Alignment
Epitope Name	L9RL
Species (MHC/HLA)	human, transgenic mouse(B*07)
Immunogen	HIV-1 infection, vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords	vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine strain	multiple epitope immunogen
Vaccine component	HIV-1

Notes

The study objective was to design a vaccine construct containing HIV-1 epitopes that would generate broad CD8+ responses. Among 14 known B7-restricted epitopes, 11 induced a response in B*07 transgenic mice. Among 11 novel candidate epitopes, all induced a response in B*07 mice, and all induced a response in at least 1 human B7+ donor. Immunological recognition of these epitopes was confirmed in HLA-B*0702 HIV-1-infected individuals.
LPLPPLDRL is a novel B07 epitope that was recognized by 3/6 B*07 transgenic mice.
This epitope was recognized by 3/8 HLA-B*0702 HIV-1-infected individuals.

References

Displaying record number 57549

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HXB2 Location	Rev(75-83) DNA(8525..8551)	Rev Epitope Map
Author Location	Rev(75-83)
Epitope	`LPPLDRLTL`	Epitope Alignment
Epitope Name	L9TL
Species (MHC/HLA)	human, transgenic mouse(B*07)
Immunogen	HIV-1 infection, vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords	vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine strain	multiple epitope immunogen
Vaccine component	HIV-1

Notes

The study objective was to design a vaccine construct containing HIV-1 epitopes that would generate broad CD8+ responses. Among 14 known B7-restricted epitopes, 11 induced a response in B*07 transgenic mice. Among 11 novel candidate epitopes, all induced a response in B*07 mice, and all induced a response in at least 1 human B7+ donor. Immunological recognition of these epitopes was confirmed in HLA-B*0702 HIV-1-infected individuals.
LPPLDRLTL is a novel B07 epitope that was recognized by 4/6 B*07 transgenic mice.
This epitope was recognized by 1/8 HLA-B*0702 HIV-1-infected individuals.

References

Displaying record number 57542

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HXB2 Location	Vpu(2-12) DNA(6065..6097)	Vpu Epitope Map
Author Location	Vpu(2-12)
Epitope	`QPIQIAIAAL`	Epitope Alignment
Epitope Name	Q10AL
Species (MHC/HLA)	human, transgenic mouse(B*07)
Immunogen	HIV-1 infection, vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords	vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine strain	multiple epitope immunogen
Vaccine component	HIV-1

Notes

The study objective was to design a vaccine construct containing HIV-1 epitopes that would generate broad CD8+ responses. Among 14 known B7-restricted epitopes, 11 induced a response in B*07 transgenic mice. Among 11 novel candidate epitopes, all induced a response in B*07 mice, and all induced a response in at least 1 human B7+ donor. Immunological recognition of these epitopes was confirmed in HLA-B*0702 HIV-1-infected individuals.
QPIQIAIAAL is a novel B07 epitope that was recognized by 6/6 B*07 transgenic mice.
This epitope was recognized by 4/8 HLA-B*0702 HIV-1-infected individuals.

References

Displaying record number 57536

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HXB2 Location	gp160(117-126) gp120(117-126) DNA(6573..6602)	gp160 Epitope Map
Author Location	gp160(117-126)
Epitope	`KPCVKLTPLC`	Epitope Alignment
Epitope Name	K10LC
Species (MHC/HLA)	human, transgenic mouse(B*07)
Immunogen	HIV-1 infection, vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords	vaccine-induced immune responses, variant cross-reactivity, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine strain	multiple epitope immunogen
Vaccine component	HIV-1

Notes

The study objective was to design a vaccine construct containing HIV-1 epitopes that would generate broad CD8+ responses. Among 14 known B7-restricted epitopes, 11 induced a response in B*07 transgenic mice. Among 11 novel candidate epitopes, all induced a response in B*07 mice, and all induced a response in at least 1 human B7+ donor. Immunological recognition of these epitopes was confirmed in HLA-B*0702 HIV-1-infected individuals.
KPCVKLTPLC is a known B07 epitope that was recognized by 9/12 B*07 transgenic mice.
KPCVKLTPLC induced a response in 10/12 B*7 transgenic mice following immunization with polyepitope vaccines.

References

Displaying record number 57539

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HXB2 Location	gp160(252-261) gp120(252-261) DNA(6978..7007)	gp160 Epitope Map
Author Location	gp160(252-261)
Epitope	`RPVVSTQLLL`	Epitope Alignment
		Show epitope variants
Epitope Name	R10LL
Species (MHC/HLA)	human, transgenic mouse(B*07)
Immunogen	HIV-1 infection, vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords	subtype comparisons, vaccine-induced immune responses, variant cross-reactivity, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine strain	multiple epitope immunogen
Vaccine component	HIV-1

Notes

The study objective was to design a vaccine construct containing HIV-1 epitopes that would generate broad CD8+ responses. Among 14 known B7-restricted epitopes, 11 induced a response in B*07 transgenic mice. Among 11 novel candidate epitopes, all induced a response in B*07 mice, and all induced a response in at least 1 human B7+ donor. Immunological recognition of these epitopes was confirmed in HLA-B*0702 HIV-1-infected individuals.
RPVVSTQLLL is a novel B07 epitope that was recognized by 2/6 B*07 transgenic mice.
This epitope was recognized by 5/8 HLA-B*0702 HIV-1-infected individuals.
Intersubtype variant kPVVSTQLLL exhibited low cross-recognition in mice immunized with RPVVSTQLLL.

References

Displaying record number 57537

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HXB2 Location	gp160(298-307) gp120(298-307) DNA(7116..7145)	gp160 Epitope Map
Author Location	gp160(298-307)
Epitope	`RPNNNTRKSI`	Epitope Alignment
		Show epitope variants
Epitope Name	R10SI
Species (MHC/HLA)	human, transgenic mouse(B*07)
Immunogen	HIV-1 infection, vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords	subtype comparisons, vaccine-induced immune responses, variant cross-reactivity, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine strain	multiple epitope immunogen
Vaccine component	HIV-1

Notes

The study objective was to design a vaccine construct containing HIV-1 epitopes that would generate broad CD8+ responses. Among 14 known B7-restricted epitopes, 11 induced a response in B*07 transgenic mice. Among 11 novel candidate epitopes, all induced a response in B*07 mice, and all induced a response in at least 1 human B7+ donor. Immunological recognition of these epitopes was confirmed in HLA-B*0702 HIV-1-infected individuals.
RPNNNTRKSI is a known B07 epitope that was recognized by 4/12 B*07 transgenic mice.
This epitope was recognized by 4/8 HLA-B*0702 HIV-1-infected individuals.
Intersubtype variant RPNNNTRKgI exhibited good cross-recognition in mice immunized with RPNNNTRKSI.

References

Displaying record number 57540

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HXB2 Location	gp160(497-506) gp120(497-506) DNA(7713..7742)	gp160 Epitope Map
Author Location	gp160(497-506)
Epitope	`APTKAKRRVV`	Epitope Alignment
Epitope Name	A10VV
Species (MHC/HLA)	human, transgenic mouse(B*07)
Immunogen	HIV-1 infection, vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords	vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine strain	multiple epitope immunogen
Vaccine component	HIV-1

Notes

The study objective was to design a vaccine construct containing HIV-1 epitopes that would generate broad CD8+ responses. Among 14 known B7-restricted epitopes, 11 induced a response in B*07 transgenic mice. Among 11 novel candidate epitopes, all induced a response in B*07 mice, and all induced a response in at least 1 human B7+ donor. Immunological recognition of these epitopes was confirmed in HLA-B*0702 HIV-1-infected individuals.
APTKAKRRVV is a novel B07 epitope that was recognized by 2/6 B*07 transgenic mice.
This epitope was recognized by 5/8 HLA-B*0702 HIV-1-infected individuals.

References

Displaying record number 57538

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HXB2 Location	gp160(843-851) gp41(332-340) DNA(8751..8777)	gp160 Epitope Map
Author Location	gp160(843-851)
Epitope	`IPRRIRQGL`	Epitope Alignment
		Show epitope variants
Epitope Name	I9GL
Species (MHC/HLA)	human, transgenic mouse(B*07)
Immunogen	HIV-1 infection, vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords	subtype comparisons, vaccine-induced immune responses, variant cross-reactivity, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine strain	multiple epitope immunogen
Vaccine component	HIV-1

Notes

The study objective was to design a vaccine construct containing HIV-1 epitopes that would generate broad CD8+ responses. Among 14 known B7-restricted epitopes, 11 induced a response in B*07 transgenic mice. Among 11 novel candidate epitopes, all induced a response in B*07 mice, and all induced a response in at least 1 human B7+ donor. Immunological recognition of these epitopes was confirmed in HLA-B*0702 HIV-1-infected individuals.
IPRRIRQGL is a known B07 epitope that was recognized by 7/12 B*07 transgenic mice.
This epitope was recognized by 4/8 HLA-B*0702 HIV-1-infected individuals.
Intersubtype variant IPRRIRQGf exhibited good cross-recognition in mice immunized with IPRRIRQGL.

References

Displaying record number 57531

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HXB2 Location	Nef(68-76) DNA(8998..9024)	Nef Epitope Map
Author Location	Nef(68-76)
Epitope	`FPVTPQVPL`	Epitope Alignment
Epitope Name	F9PL
Species (MHC/HLA)	human, transgenic mouse(B*07)
Immunogen	HIV-1 infection, vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords	vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine strain	multiple epitope immunogen
Vaccine component	HIV-1

Notes

The study objective was to design a vaccine construct containing HIV-1 epitopes that would generate broad CD8+ responses. Among 14 known B7-restricted epitopes, 11 induced a response in B*07 transgenic mice. Among 11 novel candidate epitopes, all induced a response in B*07 mice, and all induced a response in at least 1 human B7+ donor. Immunological recognition of these epitopes was confirmed in HLA-B*0702 HIV-1-infected individuals.
FPVTPQVPL is a known B07 epitope that was recognized by3/12 B*07 transgenic mice.

References

Displaying record number 57532

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HXB2 Location	Nef(68-77) DNA(8998..9027)	Nef Epitope Map
Author Location	Nef(68-77)
Epitope	`FPVTPQVPLR`	Epitope Alignment
		Show epitope variants
Epitope Name	F10LR
Species (MHC/HLA)	human, transgenic mouse(B*07)
Immunogen	HIV-1 infection, vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords	vaccine-induced immune responses, variant cross-reactivity, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine strain	multiple epitope immunogen
Vaccine component	HIV-1

Notes

The study objective was to design a vaccine construct containing HIV-1 epitopes that would generate broad CD8+ responses. Among 14 known B7-restricted epitopes, 11 induced a response in B*07 transgenic mice. Among 11 novel candidate epitopes, all induced a response in B*07 mice, and all induced a response in at least 1 human B7+ donor. Immunological recognition of these epitopes was confirmed in HLA-B*0702 HIV-1-infected individuals.
FPVTPQVPLR is a known B07 epitope that was recognized by 6/12 B*07 transgenic mice.
This epitope was recognized by 4/8 HLA-B*0702 HIV-1-infected individuals.
Intersubtype variant FPVrPQVPLR exhibited low cross-recognition in mice immunized with FPVTPQVPLR.

References

Displaying record number 57533

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HXB2 Location	Nef(77-85) DNA(9025..9051)	Nef Epitope Map
Author Location	Nef(77-85)
Epitope	`RPMTYKAAL`	Epitope Alignment
		Show epitope variants
Epitope Name	R9AL
Species (MHC/HLA)	human, transgenic mouse(B*07)
Immunogen	HIV-1 infection, vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords	subtype comparisons, vaccine-induced immune responses, variant cross-reactivity, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine strain	multiple epitope immunogen
Vaccine component	HIV-1

Notes

The study objective was to design a vaccine construct containing HIV-1 epitopes that would generate broad CD8+ responses. Among 14 known B7-restricted epitopes, 11 induced a response in B*07 transgenic mice. Among 11 novel candidate epitopes, all induced a response in B*07 mice, and all induced a response in at least 1 human B7+ donor. Immunological recognition of these epitopes was confirmed in HLA-B*0702 HIV-1-infected individuals.
RPMTYKAAL is a known B07 epitope that was recognized by11/12 B*07 transgenic mice.
This epitope was recognized by 5/8 HLA-B*0702 HIV-1-infected individuals.
Intersubtype variants RPMTYKgAL, RPMTYKAAv, RPMTfKAAL, RPMTYKfAL, and RPMTYKAAf exhibited good cross-recognition in mice immunized with RPMTYKAAL.

References

Displaying record number 57534

Download this epitope record as JSON.

HXB2 Location	Nef(128-137) DNA(9178..9207)	Nef Epitope Map
Author Location	Nef(128-137)
Epitope	`TPGPGVKYPL`	Epitope Alignment
		Show epitope variants
Epitope Name	T10PL
Species (MHC/HLA)	human, transgenic mouse(B*07)
Immunogen	HIV-1 infection, vaccine
Experimental methods	CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords	subtype comparisons, vaccine-induced immune responses, variant cross-reactivity, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine strain	multiple epitope immunogen
Vaccine component	HIV-1

Notes

The study objective was to design a vaccine construct containing HIV-1 epitopes that would generate broad CD8+ responses. Among 14 known B7-restricted epitopes, 11 induced a response in B*07 transgenic mice. Among 11 novel candidate epitopes, all induced a response in B*07 mice, and all induced a response in at least 1 human B7+ donor. Immunological recognition of these epitopes was confirmed in HLA-B*0702 HIV-1-infected individuals.
TPGPGVKYPL is a known B07 epitope that was recognized by 6/12 B*07 transgenic mice.
This epitope was recognized by 4/8 HLA-B*0702 HIV-1-infected individuals.
Intersubtype variant TPGPGiKYPL exhibited good cross-recognition in mice immunized with TPGPGVKYPL.