HIV molecular immunology database
Found 6 matching records:
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| HXB2 Location | Gag(121-132) p17(121-132) DNA(1150..1185) |
Gag Epitope Map |
|---|---|---|
| Author Location | p17(121-132 HXB2R) | |
| Epitope |
DTGHSNQVSQNY
|
Epitope Alignment
|
| Species (MHC/HLA) | human(A33) | |
| Immunogen | HIV-1 infection | |
| Experimental methods | ||
| Keywords |
Buseyne1993 F. Buseyne, M. McChesney, F. Porrot, S. Kovarik, B. Guy, and Y. Riviere. Gag-Specific Cytotoxic T Lymphocytes from Human Immunodeficiency Virus Type 1-Infected Individuals: Gag Epitopes Are Clustered in Three Regions of the p24 Gag Protein. J. Virol., 67:694-702, 1993. Using autologous Epstein-Barr virus-transformed cells that were infected with vaccinia constructs carrying p18, p24 and p55 proteins of LAI, or truncations of p24, it was shown that epitopes within p24 were most commonly recognized in a set of cell lines derived from 29 infected subjects. The autologous transformed cells coated with synthetic peptides were used to identify several regions of p24 where CTL epitopes tended to cluster. HLA restriction was determined CTL-responsive to four of the peptides. Among the four epitopes that had determined HLA specificities were the two peptides in the study that proved to stimulate CTL from the highest fraction of the cell lines: peptide p24(263-272) HLA-B27 and peptide p24(256-270) HLA-A33; these peptides were each able to stimulate CTL response from 14\% of the cell lines. PubMed ID: 7678303. Show all entries for this paper.
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| HXB2 Location | Gag(169-184) p24(37-52) DNA(1294..1341) |
Gag Epitope Map |
|---|---|---|
| Author Location | p24(169-184 LAI) | |
| Epitope |
IPMFSALSEGATPQDL
|
Epitope Alignment
|
| Subtype | B | |
| Species (MHC/HLA) | human(B44) | |
| Immunogen | HIV-1 infection | |
| Experimental methods | ||
| Keywords |
Buseyne1993 F. Buseyne, M. McChesney, F. Porrot, S. Kovarik, B. Guy, and Y. Riviere. Gag-Specific Cytotoxic T Lymphocytes from Human Immunodeficiency Virus Type 1-Infected Individuals: Gag Epitopes Are Clustered in Three Regions of the p24 Gag Protein. J. Virol., 67:694-702, 1993. Using autologous Epstein-Barr virus-transformed cells that were infected with vaccinia constructs carrying p18, p24 and p55 proteins of LAI, or truncations of p24, it was shown that epitopes within p24 were most commonly recognized in a set of cell lines derived from 29 infected subjects. The autologous transformed cells coated with synthetic peptides were used to identify several regions of p24 where CTL epitopes tended to cluster. HLA restriction was determined CTL-responsive to four of the peptides. Among the four epitopes that had determined HLA specificities were the two peptides in the study that proved to stimulate CTL from the highest fraction of the cell lines: peptide p24(263-272) HLA-B27 and peptide p24(256-270) HLA-A33; these peptides were each able to stimulate CTL response from 14\% of the cell lines. PubMed ID: 7678303. Show all entries for this paper.
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| HXB2 Location | Gag(256-270) p24(124-138) DNA(1555..1599) |
Gag Epitope Map |
|---|---|---|
| Author Location | p24(256-270 LAI) | |
| Epitope |
IPVGEIYKRWIILGL
|
Epitope Alignment
|
| Subtype | B | |
| Species (MHC/HLA) | human(B8) | |
| Immunogen | HIV-1 infection | |
| Experimental methods | ||
| Keywords |
Buseyne1993 F. Buseyne, M. McChesney, F. Porrot, S. Kovarik, B. Guy, and Y. Riviere. Gag-Specific Cytotoxic T Lymphocytes from Human Immunodeficiency Virus Type 1-Infected Individuals: Gag Epitopes Are Clustered in Three Regions of the p24 Gag Protein. J. Virol., 67:694-702, 1993. Using autologous Epstein-Barr virus-transformed cells that were infected with vaccinia constructs carrying p18, p24 and p55 proteins of LAI, or truncations of p24, it was shown that epitopes within p24 were most commonly recognized in a set of cell lines derived from 29 infected subjects. The autologous transformed cells coated with synthetic peptides were used to identify several regions of p24 where CTL epitopes tended to cluster. HLA restriction was determined CTL-responsive to four of the peptides. Among the four epitopes that had determined HLA specificities were the two peptides in the study that proved to stimulate CTL from the highest fraction of the cell lines: peptide p24(263-272) HLA-B27 and peptide p24(256-270) HLA-A33; these peptides were each able to stimulate CTL response from 14\% of the cell lines. PubMed ID: 7678303. Show all entries for this paper.
Download this epitope record as JSON.
| HXB2 Location | Gag(263-272) p24(131-140) DNA(1576..1605) |
Gag Epitope Map |
|---|---|---|
| Author Location | p24(263-272 LAI) | |
| Epitope |
KRWIILGLNK
|
Epitope Alignment
|
| Subtype | B | |
| Species (MHC/HLA) | human(B27) | |
| Immunogen | HIV-1 infection | |
| Experimental methods | ||
| Keywords |
Buseyne1993 F. Buseyne, M. McChesney, F. Porrot, S. Kovarik, B. Guy, and Y. Riviere. Gag-Specific Cytotoxic T Lymphocytes from Human Immunodeficiency Virus Type 1-Infected Individuals: Gag Epitopes Are Clustered in Three Regions of the p24 Gag Protein. J. Virol., 67:694-702, 1993. Using autologous Epstein-Barr virus-transformed cells that were infected with vaccinia constructs carrying p18, p24 and p55 proteins of LAI, or truncations of p24, it was shown that epitopes within p24 were most commonly recognized in a set of cell lines derived from 29 infected subjects. The autologous transformed cells coated with synthetic peptides were used to identify several regions of p24 where CTL epitopes tended to cluster. HLA restriction was determined CTL-responsive to four of the peptides. Among the four epitopes that had determined HLA specificities were the two peptides in the study that proved to stimulate CTL from the highest fraction of the cell lines: peptide p24(263-272) HLA-B27 and peptide p24(256-270) HLA-A33; these peptides were each able to stimulate CTL response from 14\% of the cell lines. PubMed ID: 7678303. Show all entries for this paper.
Download this epitope record as JSON.
| HXB2 Location | Gag(263-277) p24(131-145) DNA(1576..1620) |
Gag Epitope Map |
|---|---|---|
| Author Location | p24(263-277 LAI) | |
| Epitope |
KRWIILGLNKIVMRY
|
Epitope Alignment
|
| Subtype | B | |
| Species (MHC/HLA) | human(A33) | |
| Immunogen | HIV-1 infection | |
| Experimental methods | ||
| Keywords |
Buseyne1993 F. Buseyne, M. McChesney, F. Porrot, S. Kovarik, B. Guy, and Y. Riviere. Gag-Specific Cytotoxic T Lymphocytes from Human Immunodeficiency Virus Type 1-Infected Individuals: Gag Epitopes Are Clustered in Three Regions of the p24 Gag Protein. J. Virol., 67:694-702, 1993. Using autologous Epstein-Barr virus-transformed cells that were infected with vaccinia constructs carrying p18, p24 and p55 proteins of LAI, or truncations of p24, it was shown that epitopes within p24 were most commonly recognized in a set of cell lines derived from 29 infected subjects. The autologous transformed cells coated with synthetic peptides were used to identify several regions of p24 where CTL epitopes tended to cluster. HLA restriction was determined CTL-responsive to four of the peptides. Among the four epitopes that had determined HLA specificities were the two peptides in the study that proved to stimulate CTL from the highest fraction of the cell lines: peptide p24(263-272) HLA-B27 and peptide p24(256-270) HLA-A33; these peptides were each able to stimulate CTL response from 14\% of the cell lines. PubMed ID: 7678303. Show all entries for this paper.
Download this epitope record as JSON.
| HXB2 Location | Nef(86-100) DNA(9052..9096) |
Nef Epitope Map |
|---|---|---|
| Author Location | Nef(86-100 LAI) | |
| Epitope |
DLSHFLKEKGGLEGL
|
Epitope Alignment
|
| Subtype | B | |
| Species (MHC/HLA) | human(B35) | |
| Immunogen | HIV-1 infection | |
| Experimental methods | ||
| Keywords |
Buseyne1993 F. Buseyne, M. McChesney, F. Porrot, S. Kovarik, B. Guy, and Y. Riviere. Gag-Specific Cytotoxic T Lymphocytes from Human Immunodeficiency Virus Type 1-Infected Individuals: Gag Epitopes Are Clustered in Three Regions of the p24 Gag Protein. J. Virol., 67:694-702, 1993. Using autologous Epstein-Barr virus-transformed cells that were infected with vaccinia constructs carrying p18, p24 and p55 proteins of LAI, or truncations of p24, it was shown that epitopes within p24 were most commonly recognized in a set of cell lines derived from 29 infected subjects. The autologous transformed cells coated with synthetic peptides were used to identify several regions of p24 where CTL epitopes tended to cluster. HLA restriction was determined CTL-responsive to four of the peptides. Among the four epitopes that had determined HLA specificities were the two peptides in the study that proved to stimulate CTL from the highest fraction of the cell lines: peptide p24(263-272) HLA-B27 and peptide p24(256-270) HLA-A33; these peptides were each able to stimulate CTL response from 14\% of the cell lines. PubMed ID: 7678303. Show all entries for this paper.