Search CTL/CD8+ T-Cell Epitope Database

Found 7 matching records:

Displaying record number 59207

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HXB2 Location	Gag(147-155) p24(15-23) DNA(1228..1254)	Gag Epitope Map
Author Location	Gag(147-155)
Epitope	`ISPRTLNAW`	Epitope Alignment
		Show epitope variants
Epitope Name	ISW9
Subtype	B
Species (MHC/HLA)	human(B*57:01)
Immunogen	HIV-1 infection
Patient MHC/HLA	P1: B57:01; P3: B57:01; P4: B57:01; P5: B57:01; P6: B*57:01
Country	United States
Experimental methods	Other
Keywords	dynamics, rate of progression, elite controllers

Notes

Variations at 4 Gag and 2 Nef epitopes in 6 B*5701+ ART-naive males from the Options cohort - 3 high-risk progressors (HRPs) and 3 very low-risk progressors (LRPs) - were tested for correlation to polyfunctional T cell responses. Subjects were followed from infection to 7 years post-infection and 6 markers (IFN-γ, IL-2, MIP-1β, TNF, CD107a and perforin) were measured. While LRPs maintained a directed functional response against emerging variants, emerging epitopes in HRPs correlated with a decrease in IL-2-producing cells, functional avidity and polyfunctional sensitivity.
Variants (lSPRTLNAW, IaPRTLNAW, IlPRTLNAW, ItPRTLNAW, ltPRTLNAW) of ISPRTLNAW, ISW9, were seen in all LRPs and 2/3 HRPs, over 3 time points. LRPs were able to preserve response against all emerging variants to ISW9.

References

Buggert2014 Marcus Buggert, Melissa M. Norström, Marco Salemi, Frederick M. Hecht, and Annika C. Karlsson. Functional Avidity and IL-2/Perforin Production Is Linked to the Emergence of Mutations within HLA-B*5701-Restricted Epitopes and HIV-1 Disease Progression. J. Immunol., 192(10):4685-4696, 15 May 2014. PubMed ID: 24740510. Show all entries for this paper.

Displaying record number 59208

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HXB2 Location	Gag(162-172) p24(30-40) DNA(1273..1305)	Gag Epitope Map
Author Location	Gag(162-172)
Epitope	`KAFSPEVIPMF`	Epitope Alignment
		Show epitope variants
Epitope Name	KF11
Subtype	B
Species (MHC/HLA)	human(B*57:01)
Immunogen	HIV-1 infection
Patient MHC/HLA	P1: B57:01; P6: B57:01
Country	United States
Experimental methods	Other
Keywords	dynamics, rate of progression, elite controllers

Notes

Variations at 4 Gag and 2 Nef epitopes in 6 B*5701+ ART-naive males from the Options cohort - 3 high-risk progressors (HRPs) and 3 very low-risk progressors (LRPs) - were tested for correlation to polyfunctional T cell responses. Subjects were followed from infection to 7 years post-infection and 6 markers (IFN-γ, IL-2, MIP-1β, TNF, CD107a and perforin) were measured. While LRPs maintained a directed functional response against emerging variants, emerging epitopes in HRPs correlated with a decrease in IL-2-producing cells, functional avidity and polyfunctional sensitivity.
Variants (KAFSPEVIPMs, KAFSPEiIPMF, KAFSPEVIPMt, KAsSPEVIPMF) of KAFSPEVIPMF, KF11, were seen in 1/3 LRPs and 1/3 HRPs, over 3 time points. Magnitude of KF11-specific response was not a predictive factor for emergence of variants.

References

Displaying record number 59210

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HXB2 Location	Gag(240-249) p24(108-117) DNA(1507..1536)	Gag Epitope Map
Author Location	Gag(240-249)
Epitope	`TSTLQEQIGW`	Epitope Alignment
		Show epitope variants
Epitope Name	TW10
Subtype	B
Species (MHC/HLA)	human(B*57:01)
Immunogen	HIV-1 infection
Patient MHC/HLA	P1: B57:01; P2: B57:01; P3: B57:01; P4: B57:01; P5: B57:01; P6: B57:01
Country	United States
Experimental methods	Other
Keywords	dynamics, rate of progression, immunodominance, escape, elite controllers

Notes

Variations at 4 Gag and 2 Nef epitopes in 6 B*5701+ ART-naive males from the Options cohort - 3 high-risk progressors (HRPs) and 3 very low-risk progressors (LRPs) - were tested for correlation to polyfunctional T cell responses. Subjects were followed from infection to 7 years post-infection and 6 markers (IFN-γ, IL-2, MIP-1β, TNF, CD107a and perforin) were measured. While LRPs maintained a directed functional response against emerging variants, emerging epitopes in HRPs correlated with a decrease in IL-2-producing cells, functional avidity and polyfunctional sensitivity.
Variants (TSTLrEQIGW, TSTLQEQIeW, TSnLQEQIGW, TSsLQEQIGW, TSnLQEQIrW, TSnLQEQItW, TSnLQEQIaW, TSTLQEQIaW) of TSTLQEQIGW, TW10, were seen in all subjects, over 3 time points. For TW10, early immunodominant CTL response was associated with development of escapes TW10-3N and TW10-3N-9A.

References

Displaying record number 59209

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HXB2 Location	Gag(308-316) p24(176-184) DNA(1711..1737)	Gag Epitope Map
Author Location	Gag(308-316)
Epitope	`QASQEVKNW`	Epitope Alignment
		Show epitope variants
Epitope Name	QW9
Subtype	B
Species (MHC/HLA)	human(B*57:01)
Immunogen	HIV-1 infection
Patient MHC/HLA	P1: B57:01; P2: B57:01; P3: B*57:01
Country	United States
Experimental methods	Other
Keywords	dynamics, rate of progression, elite controllers

Notes

Variations at 4 Gag and 2 Nef epitopes in 6 B*5701+ ART-naive males from the Options cohort - 3 high-risk progressors (HRPs) and 3 very low-risk progressors (LRPs) - were tested for correlation to polyfunctional T cell responses. Subjects were followed from infection to 7 years post-infection and 6 markers (IFN-γ, IL-2, MIP-1β, TNF, CD107a and perforin) were measured. While LRPs maintained a directed functional response against emerging variants, emerging epitopes in HRPs correlated with a decrease in IL-2-producing cells, functional avidity and polyfunctional sensitivity.
Variants (QASQdVKNW, QASQtVKNW) of QASQEVKNW, QW9, were seen in all 3 HRPs and no LRPs, over 3 time points.

References

Displaying record number 59211

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HXB2 Location	Nef(82-91) DNA(9040..9069)	Nef Epitope Map
Author Location	Nef(82-91)
Epitope	`KAALDLSHFL`	Epitope Alignment
		Show epitope variants
Epitope Name	KL10
Subtype	B
Species (MHC/HLA)	human(B*57:01)
Immunogen	HIV-1 infection
Patient MHC/HLA	P2: B57:01; P3: B57:01; P4: B57:01; P6: B57:01
Country	United States
Experimental methods	Other
Keywords	dynamics, rate of progression, elite controllers

Notes

Variations at 4 Gag and 2 Nef epitopes in 6 B*5701+ ART-naive males from the Options cohort - 3 high-risk progressors (HRPs) and 3 very low-risk progressors (LRPs) - were tested for correlation to polyfunctional T cell responses. Subjects were followed from infection to 7 years post-infection and 6 markers (IFN-γ, IL-2, MIP-1β, TNF, CD107a and perforin) were measured. While LRPs maintained a directed functional response against emerging variants, emerging epitopes in HRPs correlated with a decrease in IL-2-producing cells, functional avidity and polyfunctional sensitivity.
Variants (KAALDLSHlL, KgALDLSHFL, rAALDLSHFL, KAAvDLSHFL, rAAvDLSHFL, rAALDLSHlL) of KAALDLSHFL, KL10, were seen in 2/3 HRPs and 2/3 LRPs, over 3 time points.

References

Displaying record number 59212

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HXB2 Location	Nef(116-125) DNA(9142..9171)	Nef Epitope Map
Author Location	Nef(116-125)
Epitope	`HTQGYFPDWQ`	Epitope Alignment
		Show epitope variants
Epitope Name	HQ10
Subtype	B
Species (MHC/HLA)	human(B*57:01)
Immunogen	HIV-1 infection
Patient MHC/HLA	P1: B57:01; P2: B57:01; P3: B57:01; P4: B57:01; P5: B57:01; P6: B57:01
Country	United States
Experimental methods	Other
Keywords	dynamics, rate of progression, elite controllers

Notes

Variations at 4 Gag and 2 Nef epitopes in 6 B*5701+ ART-naive males from the Options cohort - 3 high-risk progressors (HRPs) and 3 very low-risk progressors (LRPs) - were tested for correlation to polyfunctional T cell responses. Subjects were followed from infection to 7 years post-infection and 6 markers (IFN-γ, IL-2, MIP-1β, TNF, CD107a and perforin) were measured. While LRPs maintained a directed functional response against emerging variants, emerging epitopes in HRPs correlated with a decrease in IL-2-producing cells, functional avidity and polyfunctional sensitivity.
Variant (nTQGYFPDWQ) of HTQGYFPDWQ, HQ10, was seen in 2/3 HRPs and all 3 LRPs, over 3 time points.

References

Displaying record number 59213

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HXB2 Location	Nef(120-128) DNA(9154..9180)	Nef Epitope Map
Author Location	Nef(120-128)
Epitope	`YFPDWQNYT`	Epitope Alignment
		Show epitope variants
Epitope Name	YT9
Subtype	B
Species (MHC/HLA)	human(B*57:01)
Immunogen	HIV-1 infection
Patient MHC/HLA	P1: B57:01; P2: B57:01; P4: B*57:01
Country	United States
Experimental methods	Other
Keywords	dynamics, rate of progression, elite controllers

Notes

Variations at 4 Gag and 2 Nef epitopes in 6 B*5701+ ART-naive males from the Options cohort - 3 high-risk progressors (HRPs) and 3 very low-risk progressors (LRPs) - were tested for correlation to polyfunctional T cell responses. Subjects were followed from infection to 7 years post-infection and 6 markers (IFN-γ, IL-2, MIP-1β, TNF, CD107a and perforin) were measured. While LRPs maintained a directed functional response against emerging variants, emerging epitopes in HRPs correlated with a decrease in IL-2-producing cells, functional avidity and polyfunctional sensitivity.
Variants (YFPDWQcYT, YFPDWQchT) of YFPDWQNYT, YT9, were seen in 1/3 HRPs and 1/3 LRPs, over 3 time points.