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Displaying record number 752

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HXB2 Location	gp160(311-320) gp120(311-320) DNA(7155..7184)	gp160 Epitope Map
Author Location	gp160( IIIB)
Epitope	`RGPGRAFVTI`	Epitope Alignment
Species (MHC/HLA)	mouse(H-2D^d)
Immunogen	vaccine
Experimental methods
Keywords

Vaccine Details

Vaccine type	non-replicating adenovirus
Vaccine strain	B clade IIIB
Vaccine component	Env, Rev

Notes

A good HIV-1 Env immune response using non-replicating adenovirus vectors in BALB/c mice is dependent upon the presence of the stimulatory tat/rev 5'splice-donor site sequence and the presence of Rev.
Administration of monocistronic RAd501 expressing env and RAd46 expressing rev resulted in a positive CTL response, but required two immunizations for a CTL response comparable to that induced by the bicistronic virus RAd142.
Administration of RAd501 alone gave a low CTL response, but no humoral response, suggesting a lower level of antigen may be required to stimulate CTL.

References

Bruce1999 C. B. Bruce, A. Akrigg, S. A. Sharpe, T. Hanke, G. W. Wilkinson, and M. P. Cranage. Replication-Deficient Recombinant Adenoviruses Expressing the Human Immunodeficiency Virus Env Antigen Can Induce Both Humoral and CTL Immune Responses in Mice. J. Gen. Virol., 80(Pt 10):2621-2628, 1999. PubMed ID: 10573155. Show all entries for this paper.