Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 64

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HXB2 Location	Gag(77-85) p17(77-85) DNA(1018..1044)	Gag Epitope Map
Author Location	p17(77-85 HXB2)
Epitope	SLYNTVATL	Epitope Alignment
		Show epitope variants
Epitope Name	SL9
Subtype	B
Species (MHC/HLA)	human(A*02:01)
Immunogen	HIV-1 infection
Experimental methods
Keywords	epitope processing, immunodominance, escape

Notes

• Multiple natural variations in the SL9 flanking regions of the immunodominant epitope SLYNTVATL were tested and found not to adversely affect CTL recognition or prevent epitope processing, suggesting that viral escape from the HLA-A*0201-restricted CTL response against SLYNTVATL is probably not linked to variations in the flanking regions of this epitope.
• The substitution Y79F was an escape mutation in that it interfered with CTL recognition by one CTL clone from an A*0201 infected individual, clone 13010.B17, but it was still recognized by another CTL clone, 115.D4.

References

Brander1999a C. Brander, O. O. Yang, N. G. Jones, Y. Lee, P. Goulder, R. P. Johnson, A. Trocha, D. Colbert, C. Hay, S. Buchbinder, C. C. Bergmann, H. J. Zweerink, S. Wolinsky, W. A. Blattner, S. A. Kalams, and B. D. Walker. Efficient Processing of the Immunodominant, HLA-A*0201-Restricted Human Immunodeficiency Virus Type 1 Cytotoxic T-Lymphocyte Epitope Despite Multiple Variations in the Epitope Flanking Sequences. J. Virol., 73:10191-10198, 1999. PubMed ID: 10559335. Show all entries for this paper.

Displaying record number 303

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HXB2 Location	Gag(275-282) p24(143-150) DNA(1612..1635)	Gag Epitope Map
Author Location	p24(273-283 IIIB)
Epitope	RMYSPTSI	Epitope Alignment
Epitope Name	SL9
Species (MHC/HLA)	human(B52)
Immunogen	HIV-1 infection
Experimental methods
Keywords	epitope processing, immunodominance, escape

Notes

• Multiple natural variations in the SL9 flanking regions of the immunodominant epitope SLYNTVATL were tested and found not to adversely affect CTL recognition or prevent epitope processing, suggesting that viral escape from the HLA-A*0201-restricted CTL response against SLYNTVATL is probably not linked to variations in the flanking regions of this epitope.
• The CTL response to RMYSPTSI was used as a control.

References

Brander1999a C. Brander, O. O. Yang, N. G. Jones, Y. Lee, P. Goulder, R. P. Johnson, A. Trocha, D. Colbert, C. Hay, S. Buchbinder, C. C. Bergmann, H. J. Zweerink, S. Wolinsky, W. A. Blattner, S. A. Kalams, and B. D. Walker. Efficient Processing of the Immunodominant, HLA-A*0201-Restricted Human Immunodeficiency Virus Type 1 Cytotoxic T-Lymphocyte Epitope Despite Multiple Variations in the Epitope Flanking Sequences. J. Virol., 73:10191-10198, 1999. PubMed ID: 10559335. Show all entries for this paper.