Search CTL/CD8+ T-Cell Epitope Database

Found 3 matching records:

Displaying record number 1582

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HXB2 Location	Gag(291-300) p24(159-168) DNA(1660..1689)	Gag Epitope Map
Author Location	Gag(291-300)
Epitope	EPFRDYVDRF	Epitope Alignment
Species (MHC/HLA)	mouse(H-2d)
Immunogen	vaccine
Experimental methods
Keywords	Th1

Vaccine Details

Notes

• DNA vaccinated BALB/c mice primed and boosted with the multiepitopic vaccine with IL18 showed lymphoproliferative responses 7 weeks post immunization.
• Strong but non-lasting HIV-specific CTL responses were detected by a Cr-release assay and DNA prime/DNA boost was more effective than DNA prime protein boost.
• Immunization with either the multiepitopic DNA or with the mixed DNA vaccine induced HIV-1 specific Th1 cytokines (IL-2 and IFN-gamma)
• Co-administration of IL18 increased T-cell responses but decreased anti-HIV antibody levels.

References

BillautMulot2001 O. Billaut-Mulot, T. Idziorek, M. Loyens, A. Capron, and G. M. Bahr. Modulation of cellular and humoral immune responses to a multiepitopic HIV-1 DNA vaccine by interleukin-18 DNA immunization/viral protein boost. Vaccine, 19(20-22):2803-11, 6 Apr 2001. PubMed ID: 11282190. Show all entries for this paper.

Displaying record number 1583

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HXB2 Location	Tat(49-57) DNA(5975..6001)	Tat Epitope Map
Author Location	Tat(49-57)
Epitope	RKKRRQRRR	Epitope Alignment
Species (MHC/HLA)	mouse(H-2d)
Immunogen	vaccine
Experimental methods
Keywords	Th1

Vaccine Details

Notes

• DNA vaccinated BALB/c mice primed and boosted with the multiepitopic vaccine with IL18 showed lymphoproliferative responses 7 weeks post immunization.
• Strong but non-lasting HIV-specific CTL responses were detected by a Cr-release assay and DNA prime/DNA boost was more effective than DNA prime protein boost.
• Immunization with either the multiepitopic DNA or with the mixed DNA vaccine induced HIV-1 specific Th1 cytokines (IL-2 and IFN-gamma)
• Co-administration of IL18 increased T-cell responses but decreased anti-HIV antibody levels.

References

BillautMulot2001 O. Billaut-Mulot, T. Idziorek, M. Loyens, A. Capron, and G. M. Bahr. Modulation of cellular and humoral immune responses to a multiepitopic HIV-1 DNA vaccine by interleukin-18 DNA immunization/viral protein boost. Vaccine, 19(20-22):2803-11, 6 Apr 2001. PubMed ID: 11282190. Show all entries for this paper.

Displaying record number 1584

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HXB2 Location	Nef(132-147) DNA(9190..9237)	Nef Epitope Map
Author Location	Nef(132-147)
Epitope	GVRYPLTFGWCYKLVP	Epitope Alignment
Species (MHC/HLA)	mouse(H-2d)
Immunogen	vaccine
Experimental methods
Keywords	Th1

Vaccine Details

Notes

• DNA vaccinated BALB/c mice primed and boosted with the multiepitopic vaccine with IL18 showed lymphoproliferative responses 7 weeks post immunization.
• Strong but non-lasting HIV-specific CTL responses were detected by a Cr-release assay and DNA prime/DNA boost was more effective than DNA prime protein boost.
• Immunization with either the multiepitopic DNA or with the mixed DNA vaccine induced HIV-1 specific Th1 cytokines (IL-2 and IFN-gamma)
• Co-administration of IL18 increased T-cell responses but decreased anti-HIV antibody levels.

References

BillautMulot2001 O. Billaut-Mulot, T. Idziorek, M. Loyens, A. Capron, and G. M. Bahr. Modulation of cellular and humoral immune responses to a multiepitopic HIV-1 DNA vaccine by interleukin-18 DNA immunization/viral protein boost. Vaccine, 19(20-22):2803-11, 6 Apr 2001. PubMed ID: 11282190. Show all entries for this paper.