Search CTL/CD8+ T-Cell Epitope Database

Found 27 matching records:

Displaying record number 24

HXB2 Location	Gag(20-28) p17(20-28) DNA(847..873)	Gag Epitope Map
Author Location	p17(20-28)
Epitope	RLRPGGKKK	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods
Keywords	immunodominance

Notes

• Only 4/11 HLA-A2+ HIV+ individuals had CTL that reacted to SLYNTVATL, calling into question whether it is immunodominant.
• 95 optimally-defined peptides from this database were used to screen for INFγ responses to other epitopes.
• Three of the four individuals that responded to SLYNTVATL recognized HIV epitopes, and one individual who was A*0201, A31 and B51 and B58w4 recognized this epitope (previously described as HLA A3.1), as well as one other.

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.

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Displaying record number 1114

HXB2 Location	Gag(20-29) p17(20-29) DNA(847..876)	Gag Epitope Map
Author Location	p17(20-29)
Epitope	RLRPGGKKKY	Epitope Alignment
Species (MHC/HLA)	human(A*0301, A30)
Immunogen	HIV-1 infection
Experimental methods
Keywords	immunodominance

Notes

• Only 4/11 HLA-A2+ HIV+ individuals had CTL that reacted to SLYNTVATL, calling into question whether it is immunodominant.
• 95 optimally-defined peptides from this database were used to screen for INFγ responses to other epitopes.
• 1/11 of the A2+ individuals was A30, and one was A3, and both responded to RLRPGGKKKY.
• The A2+ A3 individual also reacted with two other A3.1 epitopes.

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.

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Displaying record number 68

HXB2 Location	Gag(77-85) p17(77-85) DNA(1018..1044)	Gag Epitope Map
Author Location	p17(77-85)
Epitope	SLYNTVATL	Epitope Alignment
Species (MHC/HLA)	human(A*0201)
Immunogen	HIV-1 infection
Experimental methods
Keywords	immunodominance

Notes

• Only 4/11 HLA-A2+ HIV+ individuals had CTL that reacted to SLYNTVATL, calling into question whether it is immunodominant.
• 95 optimally-defined peptides from this database were used to screen for INFγ responses to other epitopes.
• Individuals who did not respond to SLYNTVATL recognized other HIV epitopes, and 2/4 SLYNTVATL responders had stronger responses to epitopes restricted by other class I alleles.
• SLYNTVATL was the only response detected in a one individual that was HLA A*0201, B44, B70.

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.

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Displaying record number 132

HXB2 Location	Gag(140-149) p24(8-17) DNA(1207..1236)	Gag Epitope Map
Author Location	p24(140-149)
Epitope	GQMVHQAISP	Epitope Alignment
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Experimental methods
Keywords	immunodominance

Notes

• Only 4/11 HLA-A2+ HIV+ individuals had CTL that reacted to SLYNTVATL, calling into question whether it is immunodominant.
• 95 optimally-defined peptides from this database were used to screen for INFγ responses to other epitopes.
• 1/11 of the A2+ individuals was HLA A*0201, A1, B57 and responded to four B57 epitopes and two others.

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.

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Displaying record number 136

HXB2 Location	Gag(145-155) p24(13-23) DNA(1222..1254)	Gag Epitope Map
Author Location	p24(145-155)
Epitope	QAISPRTLNAW	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods
Keywords	immunodominance

Notes

• Only 4/11 HLA-A2+ HIV+ individuals had CTL that reacted to SLYNTVATL, calling into question whether it is immunodominant.
• 95 optimally-defined peptides from this database were used to screen for INFγ responses to other epitopes.
• 1/11 of the A2+ individuals was HLA A*0201, A1, B57 and responded to QAISPRTLNAW noted previously to be A25.

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.

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Displaying record number 140

HXB2 Location	Gag(147-155) p24(15-23) DNA(1228..1254)	Gag Epitope Map
Author Location	p24(147-155)
Epitope	ISPRTLNAW	Epitope Alignment
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Experimental methods
Keywords	immunodominance

Notes

• Only 4/11 HLA-A2+ HIV+ individuals had CTL that reacted to SLYNTVATL, calling into question whether it is immunodominant.
• 95 optimally-defined peptides from this database were used to screen for INFγ responses to other epitopes.
• 1/11 of the A2+ individuals was HLA A*0201, A1, B57 and responded to four B57 epitopes and two others, but not SLYNTVATL.

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.

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Displaying record number 164

HXB2 Location	Gag(162-172) p24(30-40) DNA(1273..1305)	Gag Epitope Map
Author Location	p24(162-172)
Epitope	KAFSPEVIPMF	Epitope Alignment
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Experimental methods
Keywords	immunodominance

Notes

• Only 4/11 HLA-A2+ HIV+ individuals had CTL that reacted to SLYNTVATL, calling into question whether it is immunodominant.
• 95 optimally-defined peptides from this database were used to screen for INFγ responses to other epitopes.
• 1/11 of the A2+ individuals was HLA A*0201, A1, B57 and responded to four B57 epitopes and two others.

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.

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Displaying record number 170

HXB2 Location	Gag(167-175) p24(35-43) DNA(1288..1314)	Gag Epitope Map
Author Location	p24(167-175)
Epitope	EVIPMFSAL	Epitope Alignment
Species (MHC/HLA)	human(A26)
Immunogen	HIV-1 infection
Experimental methods
Keywords	immunodominance

Notes

• Only 4/11 HLA-A2+ HIV+ individuals had CTL that reacted to SLYNTVATL, calling into question whether it is immunodominant.
• 95 optimally-defined peptides from this database were used to screen for INFγ responses to other epitopes.
• 1/11 of the A2+ individuals that didn't respond to SLYNTVATL reacted with seven other epitopes including this epitope.

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.

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Displaying record number 173

HXB2 Location	Gag(168-175) p24(36-43) DNA(1291..1314)	Gag Epitope Map
Author Location	p24(168-175)
Epitope	VIPMFSAL	Epitope Alignment
Species (MHC/HLA)	human(Cw1, Cw2)
Immunogen	HIV-1 infection
Experimental methods
Keywords	immunodominance

Notes

• Only 4/11 HLA-A2+ HIV+ individuals had CTL that reacted to SLYNTVATL, calling into question whether it is immunodominant.
• 95 optimally-defined peptides from this database were used to screen for INFγ responses to other epitopes.
• 1/11 of the A2+ individuals that didn't respond to SLYNTVATL reacted with seven other epitopes including this epitope.

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.

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Displaying record number 251

HXB2 Location	Gag(259-267) p24(127-135) DNA(1564..1590)	Gag Epitope Map
Author Location	p24(259-267)
Epitope	GEIYKRWII	Epitope Alignment
Species (MHC/HLA)	human(B8)
Immunogen	HIV-1 infection
Experimental methods
Keywords	immunodominance

Notes

• Only 4/11 HLA-A2+ HIV+ individuals had CTL that reacted to SLYNTVATL, calling into question whether it is immunodominant.
• 95 optimally-defined peptides from this database were used to screen for INFγ responses to other epitopes.
• 1/11 of the HLA A2+ was HLA A*0201, A31, B8, B51 and responded to this epitope as well as seven others.

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.

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Displaying record number 259

HXB2 Location	Gag(261-270) p24(129-138) DNA(1570..1599)	Gag Epitope Map
Author Location	p24(263-272)
Epitope	IYKRWIILGL	Epitope Alignment
Species (MHC/HLA)	human(B27)
Immunogen	HIV-1 infection
Experimental methods
Keywords	immunodominance

Notes

• Only 4/11 HLA-A2+ HIV+ individuals had CTL that reacted to SLYNTVATL, calling into question whether it is immunodominant.
• 95 optimally-defined peptides from this database were used to screen for INFγ responses to other epitopes.
• 1/11 of the A2+ individuals was B27 and responded to IYKRWIILGL.

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.

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Displaying record number 348

HXB2 Location	Gag(325-333) p24(193-201) DNA(1762..1788)	Gag Epitope Map
Author Location	p24(325-333)
Epitope	NANPDCKTI?	Epitope Alignment
Species (MHC/HLA)	human(B51)
Immunogen	HIV-1 infection
Experimental methods
Keywords	immunodominance

Notes

• Only 4/11 HLA-A2+ HIV+ individuals had CTL that reacted to SLYNTVATL, calling into question whether it is immunodominant.
• 95 optimally-defined peptides from this database were used to screen for INFγ responses to other epitopes.
• 3/11 of the HLA A2+ individuals were HLA B51 and two of these responded to this epitope as well as to other epitopes.

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.

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Displaying record number 435

HXB2 Location	Pol(283-290) RT(128-135) DNA(2931..2954)	Pol Epitope Map
Author Location	RT(295-302)
Epitope	TAFTIPSI	Epitope Alignment
Species (MHC/HLA)	human(B51)
Immunogen	HIV-1 infection
Experimental methods
Keywords	immunodominance

Notes

• Only 4/11 HLA-A2+ HIV+ individuals had CTL that reacted to SLYNTVATL, calling into question whether it is immunodominant.
• 95 optimally-defined peptides from this database were used to screen for INFγ responses to other epitopes.
• Three of the four individuals that responded to SLYNTVATL recognized additional HIV epitopes, and all three were also HLA B51 and recognized this epitope as well as other epitopes.

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.

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Displaying record number 1118

HXB2 Location	Pol(313-321) RT(158-166) DNA(3021..3047)	Pol Epitope Map
Author Location	RT(325-333)
Epitope	AIFQSSMTK	Epitope Alignment
Species (MHC/HLA)	human(A*0301)
Immunogen	HIV-1 infection
Experimental methods
Keywords	immunodominance

Notes

• Only 4/11 HLA-A2+ HIV+ individuals had CTL that reacted to SLYNTVATL, calling into question whether it is immunodominant.
• 95 optimally-defined peptides from this database were used to screen for INFγ responses to other epitopes.
• 1/11 of the A2+ individuals was HLA A3 and reacted with this epitope as well as two other A3.1 epitopes.

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.

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Displaying record number 508

HXB2 Location	Pol(464-472) RT(309-317) DNA(3474..3500)	Pol Epitope Map
Author Location	RT(476-484)
Epitope	ILKEPVHGV	Epitope Alignment
Species (MHC/HLA)	human(A*0201)
Immunogen	HIV-1 infection
Experimental methods
Keywords	immunodominance

Notes

• Only 4/11 HLA-A2+ HIV+ individuals had CTL that reacted to SLYNTVATL, calling into question whether it is immunodominant.
• 95 optimally-defined peptides from this database were used to screen for INFγ responses to other epitopes.
• 2/11 of the A2+ individuals responded to ILKEPVHGV, and neither of these two responded to SLYNTVATL.

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.

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Displaying record number 1135

HXB2 Location	gp160(419-427) gp120(419-427) DNA(7479..7505)	gp160 Epitope Map
Author Location	gp120(419-427)
Epitope	RIKQIINMW?	Epitope Alignment
Species (MHC/HLA)	human(A29, A32)
Immunogen	HIV-1 infection
Experimental methods
Keywords	immunodominance

Notes

• Only 4/11 HLA-A2+ HIV+ individuals had CTL that reacted to SLYNTVATL, calling into question whether it is immunodominant.
• 95 optimally-defined peptides from this database were used to screen for INFγ responses to other epitopes.
• 1/11 of the A2+ individuals was A29 and responded to RIKQIINMW, and another responder was A32 and these are thought to be presenting molecules.
• The sequence is unclear -- Betts calls both peptide 30 and peptide 32 gp120 419--427 and the peptide sequences are not provided.

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.

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Displaying record number 807

HXB2 Location	gp160(557-565) gp41(46-54) DNA(7893..7919)	gp160 Epitope Map
Author Location	gp41(557-565)
Epitope	RAIEAQQHL	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods
Keywords	immunodominance

Notes

• Only 4/11 HLA-A2+ HIV+ individuals had CTL that reacted to SLYNTVATL, calling into question whether it is immunodominant.
• 95 optimally-defined peptides from this database were used to screen for INFγ responses to other epitopes.
• 1/11 of the A2+ individuals was HLA A*0201, A32, B60, B78, and responded to RAIEAQQHL, previously noted to be B51.

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.

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Displaying record number 1122

HXB2 Location	gp160(770-780) gp41(259-269) DNA(8532..8564)	gp160 Epitope Map
Author Location	gp41(775-785)
Epitope	RLRDLLLIVTR	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods
Keywords	immunodominance

Notes

• Only 4/11 HLA-A2+ HIV+ individuals had CTL that reacted to SLYNTVATL, calling into question whether it is immunodominant.
• 95 optimally-defined peptides from this database were used to screen for INFγ responses to other epitopes.
• 1/11 of the HLA A2+ was HLA A*0201, A31, B8, B51 and responded to this epitope that has been previously noted to be HLA A3.1, as well as seven others.

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.

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Displaying record number 1105

HXB2 Location	gp160(813-822) gp41(302-311) DNA(8661..8690)	gp160 Epitope Map
Author Location	gp41(818-827)
Epitope	SLLNATDIAV	Epitope Alignment
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Experimental methods
Keywords	immunodominance

Notes

• Only 4/11 HLA-A2+ HIV+ individuals had CTL that reacted to SLYNTVATL, calling into question whether it is immunodominant.
• 95 optimally-defined peptides from this database were used to screen for INFγ responses to other epitopes.
• 1/11 of the A2+ individuals that didn't respond to SLYNTVATL reacted with seven other epitopes, including this epitope.

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.

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Displaying record number 953

HXB2 Location	Nef(13-20) DNA(8833..8856)	Nef Epitope Map
Author Location	Nef(13-20)
Epitope	WPTVRERM	Epitope Alignment
Species (MHC/HLA)	human(B8)
Immunogen	HIV-1 infection
Experimental methods
Keywords	immunodominance

Notes

• Only 4/11 HLA-A2+ HIV+ individuals had CTL that reacted to SLYNTVATL, calling into question whether it is immunodominant.
• 95 optimally-defined peptides from this database were used to screen for INFγ responses to other epitopes.
• 1/11 of the HLA A2+ was HLA A*0201, A31, B8, B51 and responded to this epitope as well as seven others.

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.

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Displaying record number 1123

HXB2 Location	Nef(73-82) DNA(9013..9042)	Nef Epitope Map
Author Location	Nef(73-82)
Epitope	QVPLRPMTYK	Epitope Alignment
Species (MHC/HLA)	human(A*0301)
Immunogen	HIV-1 infection
Experimental methods
Keywords	immunodominance

Notes

• Only 4/11 HLA-A2+ HIV+ individuals had CTL that reacted to SLYNTVATL, calling into question whether it is immunodominant.
• 95 optimally-defined peptides from this database were used to screen for INFγ responses to other epitopes.
• 1/11 of the A2+ individuals was A3, and responded to QVPLRPMTYK as well as two other A3.1 epitopes.

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.

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Displaying record number 1004

HXB2 Location	Nef(84-91) DNA(9046..9069)	Nef Epitope Map
Author Location	Nef(84-91)
Epitope	AVDLSHFL	Epitope Alignment
Species (MHC/HLA)	human(B62)
Immunogen	HIV-1 infection
Experimental methods
Keywords	immunodominance

Notes

• Only 4/11 HLA-A2+ HIV+ individuals had CTL that reacted to SLYNTVATL, calling into question whether it is immunodominant.
• 95 optimally-defined peptides from this database were used to screen for INFγ responses to other epitopes.
• 1/11 of the A2+ individuals that didn't respond to SLYNTVATL reacted with seven other epitopes including this epitope.

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.

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Displaying record number 1006

HXB2 Location	Nef(84-92) DNA(9046..9072)	Nef Epitope Map
Author Location	Nef(84-92)
Epitope	AVDLSHFLK	Epitope Alignment
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Experimental methods
Keywords	immunodominance

Notes

• Only 4/11 HLA-A2+ HIV+ individuals had CTL that reacted to SLYNTVATL, calling into question whether it is immunodominant.
• 95 optimally-defined peptides from this database were used to screen for INFγ responses to other epitopes.
• 1/11 of the A2+ individuals that didn't respond to SLYNTVATL reacted with seven other epitopes including this epitope.

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.

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Displaying record number 1014

HXB2 Location	Nef(90-97) DNA(9064..9087)	Nef Epitope Map
Author Location	Nef(89-97)
Epitope	FLKEKGGL	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods
Keywords	immunodominance

Notes

• Only 4/11 HLA-A2+ HIV+ individuals had CTL that reacted to SLYNTVATL, calling into question whether it is immunodominant.
• 95 optimally-defined peptides from this database were used to screen for INFγ responses to other epitopes.
• 1/11 of the A2+ individuals that responded to SLYNTVATL reacted with seven other epitopes including this epitope previously described as presented by B8.

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.

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Displaying record number 1034

HXB2 Location	Nef(116-125) DNA(9142..9171)	Nef Epitope Map
Author Location	Nef(116-125)
Epitope	HTQGYFPDWQ	Epitope Alignment
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Experimental methods
Keywords	immunodominance

Notes

• Only 4/11 HLA-A2+ HIV+ individuals had CTL that reacted to SLYNTVATL, calling into question whether it is immunodominant.
• 95 optimally-defined peptides from this database were used to screen for INFγ responses to other epitopes.
• One of the A2+ individuals was HLA A*0201, A1, B57 and responded to four B57 epitopes and two others.

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.

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Displaying record number 1042

HXB2 Location	Nef(117-127) DNA(9145..9177)	Nef Epitope Map
Author Location	Nef(117-127)
Epitope	TQGYFPDWQNY	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods
Keywords	immunodominance

Notes

• Only 4/11 HLA-A2+ HIV+ individuals had CTL that reacted to SLYNTVATL, calling into question whether it is immunodominant.
• 95 optimally-defined peptides from this database were used to screen for INFγ responses to other epitopes.
• 1/11 of the A2+ individuals was HLA A*0205/A*0208, A30, B27, B44 but responded to HLA Bw62 epitope TQGYFPDWQNY, and one of the other individuals that was A2+, but otherwise of unknown HLA type, reacted with seven epitopes including this one.

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.

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Displaying record number 1043

HXB2 Location	Nef(120-128) DNA(9154..9180)	Nef Epitope Map
Author Location	Nef(120-128)
Epitope	YFPDWQNYT	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods
Keywords	immunodominance

Notes

• Only 4/11 HLA-A2+ HIV+ individuals had CTL that reacted to SLYNTVATL, calling into question whether it is immunodominant.
• 95 optimally-defined peptides from this database were used to screen for INFγ responses to other epitopes.
• 1/11 of the A2+ individuals was HLA A*0205/A*0208, A30, B27, B44 but responded to HLA B37 epitope IYKRWIILGL, and one of the other individuals that was A2+, but otherwise of unknown HLA type, reacted with seven epitopes including this one.

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.

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