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Displaying record number 52843

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HXB2 Location	gp160(311-320) gp120(311-320) DNA(7155..7184)	gp160 Epitope Map
Author Location	gp120 (V3)
Epitope	`RGPGRAFVTI`	Epitope Alignment
Epitope Name	P18-I10
Species (MHC/HLA)	mouse(H-2D^d)
Immunogen	vaccine
Experimental methods	Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords	dendritic cells, Th1, Th2, genital and mucosal immunity

Vaccine Details

Vaccine type	peptide, vaccinia
Vaccine strain	B clade 89.6, B clade IIIB
Vaccine component	gp160ΔV3
Adjuvant	Cholera toxin (CT), E. coli mutant heat labile enterotoxin (LT-R72), Incomplete Freund's Adjuvant (IFA), CpG immunostimulatory sequence (ISS)

Notes

Transcutaneous immunization (TCI) of BALB/c mice induced adjuvant-dependent HIV-1 specific CTL responses in the spleen and the gut mucosa that resulted in protection against mucosal challenge against a recombinant vaccina virus carrying HIV-1 env. Activated DCs from skin were shown to migrate to immune-inductive sites in gut mucosa and to present antigen directly to resident lymphocytes.

References

Belyakov2004 Igor M. Belyakov, Scott A. Hammond, Jeffrey D. Ahlers, Gregory M. Glenn, and Jay A. Berzofsky. Transcutaneous Immunization Induces Mucosal CTLs and Protective Immunity by Migration of Primed Skin Dendritic Cells. J. Clin. Invest., 113(7):998-1007, Apr 2004. PubMed ID: 15057306. Show all entries for this paper.