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Displaying record number 1635

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HXB2 Location	gp160(435-443) gp120(435-443) DNA(7527..7553)	gp160 Epitope Map
Author Location	Env( 89.6)
Epitope	YAPPISGQI	Epitope Alignment
Epitope Name	p41A
Species (MHC/HLA)	macaque
Immunogen	vaccine
Experimental methods
Keywords	immunodominance

Vaccine Details

Notes

• Different HIV strains were used for different regions: SIVmac239 Gag/Pol and HIV-1 89.6P Env
• Four monkeys were vaccinated with a modified vaccinia Ankara (MVA) vaccine that elicited strong CTL to the immunodominant SIV gag epitope in 4/4 animals, and 1/4 made a response to the HIV Env epitope YAPPISGQI, as determined by tetramer staining and chromium release assays.
• The animals were infected when challenged with pathogenic SHIV-89.6P, but had potent CTL responses, secondary NAb responses upon challenge, partial preservation of CD4+ T-cell counts, lower viral loads, and no evidence of disease or mortality by day 168 after challenge -- monkeys that got a sham vaccine had high viral load, progressed to disease, and 2/4 were dead by day 168.

References

Barouch2001b D. H. Barouch, S. Santra, M. J. Kuroda, J. E. Schmitz, R. Plishka, A. Buckler-White, A. E. Gaitan, R. Zin, J. H. Nam, L. S. Wyatt, M. A. Lifton, C. E. Nickerson, B. Moss, D. C. Montefiori, V. M. Hirsch, and N. L. Letvin. Reduction of simian-human immunodeficiency virus 89.6P viremia in rhesus monkeys by recombinant modified vaccinia virus Ankara vaccination. J. Virol., 75(11):5151-8, Jun 2001. URL: http://jvi.asm.org/cgi/content/full/75/11/5151. PubMed ID: 11333896. Show all entries for this paper.