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Displaying record number 1250

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HXB2 Location	gp160(435-443) gp120(435-443) DNA(7527..7553)	gp160 Epitope Map
Author Location	gp41( 89.6)
Epitope	`YAPPISGQI`	Epitope Alignment
Epitope Name	p41A
Species (MHC/HLA)	macaque(Mamu-A*01)
Immunogen	SHIV infection, vaccine
Experimental methods
Keywords	immunodominance

Vaccine Details

Vaccine type	DNA, modified vaccinia Ankara (MVA)
Vaccine strain	B clade 89.6, B clade HXBc2
Vaccine component	Env, Gag
Adjuvant	IL-2/Ig

Notes

Mamu-A*01+ rhesus monkeys infected with SHIV-89.6 and SHIV-HXBc2 make immunodominant responses to SIV Gag p11C epitope (CTPYDINQM) and a subdominant response to HIV-1 Env p41A epitope (YAPPISGQI)
The binding affinities are the same for the two Mamu A*01 epitopes, so that is not what dictates the dominance.
Monkeys vaccinated with MVA vectors carrying SIV gag/pol and HIV-1 env showed the same p11C epitope dominance and p41A epitope subdominance, but co-dominance was observed and the response to p41A increased when DNA vaccination was done using the SIV and HIV genes under CMV promotor control with IL2-IG adjuvant.

References

Barouch2001 D. H. Barouch, A. Craiu, S. Santra, M. A. Egan, J. E. Schmitz, M. J. Kuroda, T. M. Fu, J. H. Nam, L. S. Wyatt, M. A. Lifton, G. R. Krivulka, C. E. Nickerson, C. I. Lord, B. Moss, M. G. Lewis, V. M. Hirsch, J. W. Shiver, and N. L. Letvin. Elicitation of high-frequency cytotoxic T-lymphocyte responses against both dominant and subdominant simian-human immunodeficiency virus epitopes by DNA vaccination of rhesus monkeys. J. Virol., 75(5):2462-7, Mar 2001. URL: http://jvi.asm.org/cgi/content/full/75/5/2462. PubMed ID: 11160750. Show all entries for this paper.