Search CTL/CD8+ T-Cell Epitope Database

Found 19 matching records:

Displaying record number 55342

HXB2 Location	Gag(18-32) p17(18-32) DNA(841..885)	Gag Epitope Map
Author Location	Gag(17-31)
Epitope	`KIRLRPGGKKKYKLK`	Epitope Alignment
Epitope Name	KK15
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity

Notes

Impact of CTL escape mutations in HLA-B57 positive elite supressors was examined. Escape mutations in B57-restricted Gag epitopes were present in all viruses derived from plasma but were lacking in proviruses, suggesting a strong selective pressure acting upon virus in plasma. IFN-gamma responses were detected to both wild-type epitopes and mutant plasma virus epitopes. In some individuals, CD8 IL-2 secretion, rather than IFN-gamma responses, showed better correlation with the plasma viral variants.
One subject responded to peptide KK15 which had a K26R mutation, KIRLRPGGKrKYKLK, in a minority of plasma virus clones.

References

Bailey2006 Justin R. Bailey, Thomas M. Williams, Robert F. Siliciano, and Joel N. Blankson. Maintenance of Viral Suppression in HIV-1-Infected HLA-B*57+ Elite Suppressors Despite CTL Escape Mutations. J. Exp. Med., 203(5):1357-1369, 15 May 2006. PubMed ID: 16682496. Show all entries for this paper.

Displaying record number 54245

HXB2 Location	Gag(147-155) p24(15-23) DNA(1228..1254)	Gag Epitope Map
Author Location	Gag
Epitope	`ISPRTLNAW`	Epitope Alignment
Epitope Name	IW9
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity

Notes

Impact of CTL escape mutations in HLA-B57 positive elite supressors was examined. Escape mutations in B57-restricted Gag epitopes were present in all viruses derived from plasma but were lacking in proviruses, suggesting a strong selective pressure acting upon virus in plasma. IFN-gamma responses were detected to both wild-type epitopes and mutant plasma virus epitopes. In some individuals, CD8 IL-2 secretion, rather than IFN-gamma responses, showed better correlation with the plasma viral variants.
There was nearly equivalent IFN-γ response to [i/m]SPRTLNAW and to [i/l]SPRTLNAW in several subjects, compared to the wild type.

References

Displaying record number 54271

HXB2 Location	Gag(162-172) p24(30-40) DNA(1273..1305)	Gag Epitope Map
Author Location	Gag
Epitope	`KAFSPEVIPMF`	Epitope Alignment
Epitope Name	KF11
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	escape

Notes

Impact of CTL escape mutations in HLA-B57 positive elite supressors was examined. Escape mutations in B57-restricted Gag epitopes were present in all viruses derived from plasma but were lacking in proviruses, suggesting a strong selective pressure acting upon virus in plasma. IFN-gamma responses were detected to both wild-type epitopes and mutant plasma virus epitopes. In some individuals, CD8 IL-2 secretion, rather than IFN-gamma responses, showed better correlation with the plasma viral variants.
A163S mutation in this epitope can potentially act as a CTL escape mutation.

References

Displaying record number 55343

HXB2 Location	Gag(177-191) p24(45-59) DNA(1318..1362)	Gag Epitope Map
Author Location	Gag(178-192)
Epitope	`EGATPQDLNTMLNTV`	Epitope Alignment
Epitope Name	EV15
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

Impact of CTL escape mutations in HLA-B57 positive elite supressors was examined. Escape mutations in B57-restricted Gag epitopes were present in all viruses derived from plasma but were lacking in proviruses, suggesting a strong selective pressure acting upon virus in plasma. IFN-gamma responses were detected to both wild-type epitopes and mutant plasma virus epitopes. In some individuals, CD8 IL-2 secretion, rather than IFN-gamma responses, showed better correlation with the plasma viral variants.
One subject responded to peptide EV15, a non-B*57-restricted peptide.

References

Displaying record number 54217

HXB2 Location	Gag(240-249) p24(108-117) DNA(1507..1536)	Gag Epitope Map
Author Location	Gag
Epitope	`TSTLQEQIGW`	Epitope Alignment
Epitope Name	TW10
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	escape

Notes

Impact of CTL escape mutations in HLA-B57 positive elite supressors was examined. Escape mutations in B57-restricted Gag epitopes were present in all viruses derived from plasma but were lacking in proviruses, suggesting a strong selective pressure acting upon virus in plasma. IFN-gamma responses were detected to both wild-type epitopes and mutant plasma virus epitopes. In some individuals, CD8 IL-2 secretion, rather than IFN-gamma responses, showed better correlation with the plasma viral variants.
Several mutations in this epitope were found to potentially act as CTL escape mutations. These are: E245D, G248E, and a triple mutation Q244T/I247V/G248A.

References

Displaying record number 54279

HXB2 Location	Gag(263-272) p24(131-140) DNA(1576..1605)	Gag Epitope Map
Author Location	Gag
Epitope	`KRWIILGLNK`	Epitope Alignment
Epitope Name	KK10
Species (MHC/HLA)	human(B*27)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	variant cross-reactivity

Notes

Impact of CTL escape mutations in HLA-B57 positive elite supressors was examined. Escape mutations in B57-restricted Gag epitopes were present in all viruses derived from plasma but were lacking in proviruses, suggesting a strong selective pressure acting upon virus in plasma. IFN-gamma responses were detected to both wild-type epitopes and mutant plasma virus epitopes. In some individuals, CD8 IL-2 secretion, rather than IFN-gamma responses, showed better correlation with the plasma viral variants.
Epitope KRWIILGLNK is B*27-, non-B*57-restricted.
An N271H variant, KRWIILGLhK, was found in resting CD4+ T cells and could elicit immune responses.
An L268M variant, KRWIImGLNK, found in plasma virus elicited at least as great immune response as wild type virus.

References

Displaying record number 55344

HXB2 Location	Gag(297-311) p24(165-179) DNA(1678..1722)	Gag Epitope Map
Author Location	Gag(297-311)
Epitope	`VDRFYKTLRAEQASQ`	Epitope Alignment
Epitope Name	VQ15
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	escape

Notes

Impact of CTL escape mutations in HLA-B57 positive elite supressors was examined. Escape mutations in B57-restricted Gag epitopes were present in all viruses derived from plasma but were lacking in proviruses, suggesting a strong selective pressure acting upon virus in plasma. IFN-gamma responses were detected to both wild-type epitopes and mutant plasma virus epitopes. In some individuals, CD8 IL-2 secretion, rather than IFN-gamma responses, showed better correlation with the plasma viral variants.
One subject responded to peptide VQ15, a non-B*57-restricted peptide.

References

Displaying record number 54379

HXB2 Location	Gag(308-316) p24(176-184) DNA(1711..1737)	Gag Epitope Map
Author Location	Gag
Epitope	`QASQEVKNW`	Epitope Alignment
Epitope Name	QW9
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	escape

Notes

Impact of CTL escape mutations in HLA-B57 positive elite supressors was examined. Escape mutations in B57-restricted Gag epitopes were present in all viruses derived from plasma but were lacking in proviruses, suggesting a strong selective pressure acting upon virus in plasma. IFN-gamma responses were detected to both wild-type epitopes and mutant plasma virus epitopes. In some individuals, CD8 IL-2 secretion, rather than IFN-gamma responses, showed better correlation with the plasma viral variants.
HLA-B*57-restricted optimal epitope QASQEVKNW was tested for immune response.

References

Displaying record number 55345

HXB2 Location	Pol(399-407) RT(244-252) DNA(3279..3305)	Pol Epitope Map
Author Location
Epitope	`IVLPEKDSW`	Epitope Alignment
Epitope Name	IW9
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

Impact of CTL escape mutations in HLA-B57 positive elite supressors was examined. Escape mutations in B57-restricted Gag epitopes were present in all viruses derived from plasma but were lacking in proviruses, suggesting a strong selective pressure acting upon virus in plasma. IFN-gamma responses were detected to both wild-type epitopes and mutant plasma virus epitopes. In some individuals, CD8 IL-2 secretion, rather than IFN-gamma responses, showed better correlation with the plasma viral variants.
Impact of CTL escape mutations in HLA-B57 positive elite supressors was examined. Escape mutations in B57-restricted Gag epitopes were present in all viruses derived from plasma but were lacking in proviruses, suggesting a strong selective pressure acting upon virus in plasma. IFN-gamma responses were detected to both wild-type epitopes and mutant plasma virus epitopes. In some individuals, CD8 IL-2 secretion, rather than IFN-gamma responses, showed better correlation with the plasma viral variants.
HLA-B*57-restricted optimal epitope IVLPEKDSW was tested for immune response.
No loss of recognition was seen for variants I147L (lVLPEKDSW) and I147M (mVLPEKDSW) in several subjects, none of whom had the I147M mutation.
I146P variant, iIVLPEKDSW, blocks presentation of epitope IW9.

References

Displaying record number 54380

HXB2 Location	Pol(399-407) RT(244-252) DNA(3279..3305)	Pol Epitope Map
Author Location
Epitope	`IVLPEKDSW`	Epitope Alignment
Epitope Name	IW9
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

Impact of CTL escape mutations in HLA-B57 positive elite supressors was examined. Escape mutations in B57-restricted Gag epitopes were present in all viruses derived from plasma but were lacking in proviruses, suggesting a strong selective pressure acting upon virus in plasma. IFN-gamma responses were detected to both wild-type epitopes and mutant plasma virus epitopes. In some individuals, CD8 IL-2 secretion, rather than IFN-gamma responses, showed better correlation with the plasma viral variants.
HLA-B*57-restricted optimal epitope IVLPEKDSW was tested for immune response.
No loss of recognition was seen for variants I147L (lVLPEKDSW) and I147M (mVLPEKDSW) in several subjects, none of whom had the I147M mutation.
I146P variant, iIVLPEKDSW, blocks presentation of epitope IW9.

References

Displaying record number 54381

HXB2 Location	Pol(529-538) RT(374-383) DNA(3669..3698)	Pol Epitope Map
Author Location
Epitope	`KITTESIVIW`	Epitope Alignment
Epitope Name	KW10
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	escape

Notes

Impact of CTL escape mutations in HLA-B57 positive elite supressors was examined. Escape mutations in B57-restricted Gag epitopes were present in all viruses derived from plasma but were lacking in proviruses, suggesting a strong selective pressure acting upon virus in plasma. IFN-gamma responses were detected to both wild-type epitopes and mutant plasma virus epitopes. In some individuals, CD8 IL-2 secretion, rather than IFN-gamma responses, showed better correlation with the plasma viral variants.
HLA-B*57-restricted optimal epitope KITTESIVIW was tested for immune response.

References

Displaying record number 54383

HXB2 Location	Pol(838-846) Integrase(123-131) DNA(4596..4622)	Pol Epitope Map
Author Location
Epitope	`STTVKAACW`	Epitope Alignment
Epitope Name	SW9
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	escape

Notes

Impact of CTL escape mutations in HLA-B57 positive elite supressors was examined. Escape mutations in B57-restricted Gag epitopes were present in all viruses derived from plasma but were lacking in proviruses, suggesting a strong selective pressure acting upon virus in plasma. IFN-gamma responses were detected to both wild-type epitopes and mutant plasma virus epitopes. In some individuals, CD8 IL-2 secretion, rather than IFN-gamma responses, showed better correlation with the plasma viral variants.
HLA-B*57-restricted optimal epitope STTVKAACW was tested for immune response.

References

Displaying record number 54382

HXB2 Location	Pol(888-896) Integrase(173-181) DNA(4746..4772)	Pol Epitope Map
Author Location
Epitope	`KTAVQMAVF`	Epitope Alignment
Epitope Name	KF9
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	escape

Notes

Impact of CTL escape mutations in HLA-B57 positive elite supressors was examined. Escape mutations in B57-restricted Gag epitopes were present in all viruses derived from plasma but were lacking in proviruses, suggesting a strong selective pressure acting upon virus in plasma. IFN-gamma responses were detected to both wild-type epitopes and mutant plasma virus epitopes. In some individuals, CD8 IL-2 secretion, rather than IFN-gamma responses, showed better correlation with the plasma viral variants.
HLA-B*57-restricted optimal epitope KTAVQMAVF was tested for immune response.

References

Displaying record number 54385

HXB2 Location	Vif(31-39) DNA(5131..5157)	Vif Epitope Map
Author Location
Epitope	`ISKKAKGWF`	Epitope Alignment
Epitope Name	IF9
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	escape

Notes

Impact of CTL escape mutations in HLA-B57 positive elite supressors was examined. Escape mutations in B57-restricted Gag epitopes were present in all viruses derived from plasma but were lacking in proviruses, suggesting a strong selective pressure acting upon virus in plasma. IFN-gamma responses were detected to both wild-type epitopes and mutant plasma virus epitopes. In some individuals, CD8 IL-2 secretion, rather than IFN-gamma responses, showed better correlation with the plasma viral variants.
HLA-B*57-restricted optimal epitope ISKKAKGWF was tested for immune response.

References

Displaying record number 54384

HXB2 Location	Vpr(30-38) DNA(5646..5672)	Vpr Epitope Map
Author Location
Epitope	`AVRHFPRIW`	Epitope Alignment
Epitope Name	AW9
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	escape

Notes

Impact of CTL escape mutations in HLA-B57 positive elite supressors was examined. Escape mutations in B57-restricted Gag epitopes were present in all viruses derived from plasma but were lacking in proviruses, suggesting a strong selective pressure acting upon virus in plasma. IFN-gamma responses were detected to both wild-type epitopes and mutant plasma virus epitopes. In some individuals, CD8 IL-2 secretion, rather than IFN-gamma responses, showed better correlation with the plasma viral variants.
HLA-B*57-restricted optimal epitope AVRHFPRIW was tested for immune response.

References

Displaying record number 54386

HXB2 Location	Rev(14-23) DNA(6009..6038)	Rev Epitope Map
Author Location
Epitope	`KAVRLIKFLY`	Epitope Alignment
Epitope Name	KY10
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	escape

Notes

Impact of CTL escape mutations in HLA-B57 positive elite supressors was examined. Escape mutations in B57-restricted Gag epitopes were present in all viruses derived from plasma but were lacking in proviruses, suggesting a strong selective pressure acting upon virus in plasma. IFN-gamma responses were detected to both wild-type epitopes and mutant plasma virus epitopes. In some individuals, CD8 IL-2 secretion, rather than IFN-gamma responses, showed better correlation with the plasma viral variants.
HLA-B*57-restricted optimal epitope KAVRLIKFLY was tested for immune response.

References

Displaying record number 54387

HXB2 Location	Nef(116-125) DNA(9142..9171)	Nef Epitope Map
Author Location
Epitope	`HTQGYFPDWQ`	Epitope Alignment
Epitope Name	HQ10
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	escape

Notes

Impact of CTL escape mutations in HLA-B57 positive elite supressors was examined. Escape mutations in B57-restricted Gag epitopes were present in all viruses derived from plasma but were lacking in proviruses, suggesting a strong selective pressure acting upon virus in plasma. IFN-gamma responses were detected to both wild-type epitopes and mutant plasma virus epitopes. In some individuals, CD8 IL-2 secretion, rather than IFN-gamma responses, showed better correlation with the plasma viral variants.
HLA-B*57-restricted optimal epitope HTQGYFPDWQ was tested for immune response.

References

Displaying record number 54388

HXB2 Location	Nef(120-128) DNA(9154..9180)	Nef Epitope Map
Author Location
Epitope	`YFPDWQNYT`	Epitope Alignment
Epitope Name	YT9
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	escape

Notes

Impact of CTL escape mutations in HLA-B57 positive elite supressors was examined. Escape mutations in B57-restricted Gag epitopes were present in all viruses derived from plasma but were lacking in proviruses, suggesting a strong selective pressure acting upon virus in plasma. IFN-gamma responses were detected to both wild-type epitopes and mutant plasma virus epitopes. In some individuals, CD8 IL-2 secretion, rather than IFN-gamma responses, showed better correlation with the plasma viral variants.
HLA-B*57-restricted optimal epitope YFPDWQNYT was tested for immune response.

References

Displaying record number 54389

HXB2 Location	Nef(130-143) DNA(9184..9225)	Nef Epitope Map
Author Location
Epitope	`GPGIRYPLTFGWCF`	Epitope Alignment
Epitope Name	GF14
Species (MHC/HLA)	human(B*57)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	escape

Notes

Impact of CTL escape mutations in HLA-B57 positive elite supressors was examined. Escape mutations in B57-restricted Gag epitopes were present in all viruses derived from plasma but were lacking in proviruses, suggesting a strong selective pressure acting upon virus in plasma. IFN-gamma responses were detected to both wild-type epitopes and mutant plasma virus epitopes. In some individuals, CD8 IL-2 secretion, rather than IFN-gamma responses, showed better correlation with the plasma viral variants.
HLA-B*57-restricted peptide GPGIRYPLTFGWCF was tested for immune response.