Search CTL/CD8+ T-Cell Epitope Database

Found 3 matching records:

Displaying record number 62161

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HXB2 Location	Pol(358-366) RT(203-211) DNA(3156..3182)	Pol Epitope Map
Author Location	RT(203-211)
Epitope	EELRQHLLK	Epitope Alignment
Species (MHC/HLA)	human(B*44)
Immunogen	HIV-1 infection
Country	Australia, Canada, United States
Experimental methods	Other
Keywords	escape, HLA associated polymorphism

Notes

• Though no immunological assays were used in this study, several associations were detected that exist within already known and immunologically verified epitopes. In RT, Mexican and HOMER consensus were K211, an escaped form while B consensus was R211, an escape form. This falls within epitope B*44-EELRQHLLK.

References

Avila-Rios2009 Santiago Avila-Rios, Christopher E. Ormsby, Jonathan M. Carlson, Humberto Valenzuela-Ponce, Juan Blanco-Heredia, Daniela Garrido-Rodriguez, Claudia Garcia-Morales, David Heckerman, Zabrina L. Brumme, Simon Mallal, Mina John, Enrique Espinosa, and Gustavo Reyes-Teran. Unique Features of HLA-Mediated HIV Evolution in a Mexican Cohort: A Comparative Study. Retrovirology, 6:72, 2009. PubMed ID: 19664284. Show all entries for this paper.

Displaying record number 62160

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HXB2 Location	Pol(424-432) RT(269-277) DNA(3354..3380)	Pol Epitope Map
Author Location	RT(269-277)
Epitope	QIYPGIKVK	Epitope Alignment
		Show epitope variants
Species (MHC/HLA)	human(A*03)
Immunogen	HIV-1 infection
Country	Australia, Canada, United States
Experimental methods	Other
Keywords	escape, HLA associated polymorphism

Notes

• Though no immunological assays were used in this study, several associations were detected that exist within already known and immunologically verified epitopes. In RT, Mexican and B consensus were K277 and HOMER consensus was R277, an escape form. This falls within epitope A*03-QIYPGIKVK.

References

Avila-Rios2009 Santiago Avila-Rios, Christopher E. Ormsby, Jonathan M. Carlson, Humberto Valenzuela-Ponce, Juan Blanco-Heredia, Daniela Garrido-Rodriguez, Claudia Garcia-Morales, David Heckerman, Zabrina L. Brumme, Simon Mallal, Mina John, Enrique Espinosa, and Gustavo Reyes-Teran. Unique Features of HLA-Mediated HIV Evolution in a Mexican Cohort: A Comparative Study. Retrovirology, 6:72, 2009. PubMed ID: 19664284. Show all entries for this paper.

Displaying record number 62162

Download this epitope record as JSON.

HXB2 Location	Pol(424-432) RT(269-277) DNA(3354..3380)	Pol Epitope Map
Author Location	RT(269-277)
Epitope	QIYPGIKVK	Epitope Alignment
		Show epitope variants
Species (MHC/HLA)	human(B*08, B*42)
Immunogen	HIV-1 infection
Country	Australia, Canada, United States
Experimental methods	Other
Keywords	escape, HLA associated polymorphism

Notes

• Though no immunological assays were used in this study, several associations were detected that exist within already known and immunologically verified epitopes. P272 is seen in the Mexican consensus while A272 is seen in HOMER and B consensus, restricted by B*08 mostly in the Mexican cohort and mostly B*42 in the HOMER. This falls within epitope A*03-QIYPGIKVK. The escape is QIYsGIKVK.

References

Avila-Rios2009 Santiago Avila-Rios, Christopher E. Ormsby, Jonathan M. Carlson, Humberto Valenzuela-Ponce, Juan Blanco-Heredia, Daniela Garrido-Rodriguez, Claudia Garcia-Morales, David Heckerman, Zabrina L. Brumme, Simon Mallal, Mina John, Enrique Espinosa, and Gustavo Reyes-Teran. Unique Features of HLA-Mediated HIV Evolution in a Mexican Cohort: A Comparative Study. Retrovirology, 6:72, 2009. PubMed ID: 19664284. Show all entries for this paper.