Search CTL/CD8+ T-Cell Epitope Database

Found 4 matching records:

Displaying record number 57983

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HXB2 Location	Pol(978-986) Integrase(263-271) DNA(5016..5042)	Pol Epitope Map
Author Location	Integrase(263-271)
Epitope	`RKAKIIRDY`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B*15:03)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	acute/early infection

Notes

In a patient with severe clinical presentation of acute HIV infection, strong responses were detected to 4 HIV-1 epitopes. The upper limit of CD8 expansion during acute infection may be higher than previously reported and was likely driven by the narrow HIV-specific response.
The patient had a strong EliSpot response to RKAKIIRDY at 18 days after hospital admission for acute infection.

References

Arnoczy2011 Gretchen S. Arnoczy, Guido Ferrari, Nilu Goonetilleke, Tumena Corrah, Hui Li, Joann Kuruc, John L. Schmitz, Kara McGee, Charles Hicks, and Joseph J. Eron. Massive CD8 T Cell Response to Primary HIV Infection in the Setting of Severe Clinical Presentation. AIDS Res. Hum. Retroviruses, 19 Oct 2011. PubMed ID: 22011008. Show all entries for this paper.

Displaying record number 57982

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HXB2 Location	gp160(585-593) gp41(74-82) DNA(7977..8003)	gp160 Epitope Map
Author Location	gp160(585-593)
Epitope	`RYLKDQQLL`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(C*07:02)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	acute/early infection

Notes

In a patient with severe clinical presentation of acute HIV infection, strong responses were detected to 4 HIV-1 epitopes. The upper limit of CD8 expansion during acute infection may be higher than previously reported and was likely driven by the narrow HIV-specific response.
The patient had a strong EliSpot response to RYLKDQQLL at 18 days after hospital admission for acute infection.

References

Displaying record number 57985

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HXB2 Location	gp160(637-645) gp41(126-134) DNA(8133..8159)	gp160 Epitope Map
Author Location	Env(637-645)
Epitope	`NYTSLIYNL`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(C*07:02)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	acute/early infection

Notes

In a patient with severe clinical presentation of acute HIV infection, strong responses were detected to 4 HIV-1 epitopes. The upper limit of CD8 expansion during acute infection may be higher than previously reported and was likely driven by the narrow HIV-specific response.
The patient had a strong EliSpot response to NYTSLIYNL at 18 days after hospital admission for acute infection.

References

Displaying record number 57984

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HXB2 Location	Nef(135-143) DNA(9199..9225)	Nef Epitope Map
Author Location	Nef(135-143)
Epitope	`YPLTFGWCY`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B*07:02)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	acute/early infection

Notes

In a patient with severe clinical presentation of acute HIV infection, strong responses were detected to 4 HIV-1 epitopes. The upper limit of CD8 expansion during acute infection may be higher than previously reported and was likely driven by the narrow HIV-specific response.
The patient had a strong EliSpot response to YPLTFGWCY at 18 days after hospital admission for acute infection. 9% of the patients CD3+/CD8+ T cells were responding to this single epitope.