Search CTL/CD8+ T-Cell Epitope Database

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Displaying record number 763

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HXB2 Location	gp160(311-320) gp120(311-320) DNA(7155..7184)	gp160 Epitope Map
Author Location	gp160(318-327 IIIB)
Epitope	`RGPGRAFVTI`	Epitope Alignment
Species (MHC/HLA)	mouse(H-2^d)
Immunogen	vaccine
Experimental methods
Keywords	Th1, Th2

Vaccine Details

Vaccine type	DNA
Vaccine strain	B clade IIIB
Vaccine component	gp160

Notes

Low-dosage 8 Br-cAMP given in combination with a DNA vaccine to BALB/c mice increased IgG and sIgA levels, and enhanced Th1, Th2 and CTL activity -- the adjuvant activity may be mediated by activation of the CMV promotor in the DNA vaccine.

References

Arai2000 H. Arai, K. Q. Xin, K. Hamajima, Y. Lu, S. Watabe, T. Takahashi, S. Toda, K. Okuda, I. Kudoh, M. Suzuki, and K. Okuda. 8 Br-cAMP enhances both humoral and cell-mediated immune responses induced by an HIV-1 DNA vaccine. Gene Ther., 7(8):694-702, Apr 2000. PubMed ID: 10800093. Show all entries for this paper.